An essential role for Rxrα in the development of Th2 responses

European Journal of Immunology

Volumn 35, Issue 12, 2005, Pages 3414-3423

  Du, Xin ^a   Tabeta, Koichi ^a   Mann, Navjiwan ^a   Crozat, Karine ^a   Mudd, Suzanne ^a   Beutler, Bruce ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Allergy; Nuclear receptor; Retinoid X receptor ; Th1 Th2; Vitamin A

Indexed keywords

HETERODIMER; MESSENGER RNA; RETINOID X RECEPTOR ALPHA; RETINOL;

ALOPECIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTING CELL; ARTICLE; CELL PROLIFERATION; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE MUTATION; HOMOZYGOTE; LIGAND BINDING; LINKAGE ANALYSIS; MOUSE; MOUSE MUTANT; MUTAGENESIS; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FUNCTION; RETINOL DEFICIENCY; STATISTICAL ANALYSIS; T LYMPHOCYTE; TH1 CELL; TH2 CELL; WILD TYPE;

AGING; ALUM COMPOUNDS; ANIMALS; CELL PROLIFERATION; FEMALE; IMMUNITY, CELLULAR; IMMUNIZATION, PASSIVE; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; MUTAGENESIS, SITE-DIRECTED; OVALBUMIN; RETINOID X RECEPTOR ALPHA; TH1 CELLS; TH2 CELLS;

EID: 29744432867     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200535366     Document Type: Article

References (66)

1. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B. et al., The nuclear receptor superfamily: the second decade. Cell 1995. 83: 835-839.
2. Giguere, V., Orphan nuclear receptors: from gene to function. Endocr. Rev. 1999. 20: 689-725.
3. Evans, R. M., The steroid and thyroid hormone receptor superfamily. Science 1988. 240: 889-895.
4. Petkovich, M., Brand, N. J., Krust, A. and Chambon, P., A human retinoic acid receptor which belongs to the family of nuclear receptors. Nature 1987. 330: 444-450.
5. Giguere, V., Ong, E. S., Segui, P. and Evans, R. M., Identification of a receptor for the morphogen retinoic acid. Nature 1987. 330: 624-629.
6. Mangelsdorf, D. J. and Evans, R. M., The RXR heterodimers and orphan receptors. Cell 1995. 83: 841-850.
7. Laffitte, B. A., Joseph, S. B., Chen, M., Castrillo, A., Repa, J., Wilpitz, D., Mangelsdorf, D. J. and Tontonoz, P., The phospholipid transfer protein gene is a liver X receptor target expressed by macrophages in atherosclerotic lesions. Mol. Cell. Biol. 2003. 23: 2182-2191.
8. Berger, J. and Moller, D. E., The mechanisms of action of PPARs. Annu. Rev Med. 2002. 53: 409-435.
9. Sucov, H. M., Dyson, E., Gumeringer, C. L., Price, J., Chien, K. R. and Evans, R. M., RXR alpha mutant mice establish a genetic basis for vitamin A signaling in heart morphogenesis. Genes Dev. 1994. 8: 1007-1018.
10. Haussler, M. R., Whitfield, G. K., Haussler, C. A., Hsieh, J. C., Thompson, P. D., Selznick, S. H., Dominguez, C. E. and Jurutka, P. W., The nuclear vitamin D receptor: biological and molecular regulatory properties revealed. J. Bone Miner. Res. 1998. 13: 325-349.
11. Kastner, P., Grondona, J. M., Mark, M., Gansmuller, A., LeMeur, M., Decimo, D., Vonesch, J. L. et al., Genetic analysis of RXR alpha developmental function: convergence of RXR and RAR signaling pathways in heart and eye morphogenesis. Cell 1994. 78: 987-1003.
12. Abbas, A. K., Murphy, K. M. and Sher, A., Functional diversity of helper T lymphocytes. Nature 1996. 383: 787-793.
13. Agnello, D., Lankford, C. S., Bream, J., Morinobu, A., Gadina, M., O'Shea, J. J. and Frucht, D. M., Cytokines and transcription factors that regulate T helper cell differentiation: new players and new insights. J. Clin. Immunol. 2003. 23: 147-161.
14. Fearon, D. T. and Locksley, R. M., The instructive role of innate immunity in the acquired immune response. Science 1996. 272: 50-53.
15. Medzhitov, R. and Janeway, C. A., Jr., Innate immunity: impact on the adaptive immune response. Curr. Opin. Immunol. 1997. 9: 4-9.
16. Mosmann, T. R., Cytokine secretion phenotypes of TH cells: how many subsets, how much regulation? Res. Immunol. 1991. 142: 9-13.
17. Murphy, K. M. and Reiner, S. L., The lineage decisions of helper T cells. Nat. Rev. Immunol. 2002. 2: 933-944.
18. Wuthrich, B., Epidemiology of the allergic diseases: are they really on the increase? Int. Arch. Allergy Appl. Immunol. 1989. 90 Suppl 1: 3-10.
19. Ring, J., Kramer, U., Schafer, T. and Behrendt, H., Why are allergies increasing? Curr. Opin. Immunol. 2001. 13: 701-708.
20. Strachan, D. P., Hay fever, hygiene, and household size. BMJ 1989. 299: 1259-1260.
21. Szabo, S. J., Kim, S. T., Costa, G. L., Zhang, X., Fathman, C. G. and Glimcher, L. H., A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 2000. 100: 655-669.
22. Zheng, W. and Flavell, R. A., The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 1997. 89: 587-596.
23. Ho, I. C., Lo, D. and Glimcher, L. H., c-maf promotes T helper cell type 2 (Th2) and attenuates Th1 differentiation by both interleukin 4-dependent and -independent mechanisms. J. Exp. Med. 1998. 188: 1859-1866.
24. Ho, I. C., Hodge, M. R., Rooney, J. W. and Glimcher, L. H., The protooncogene c-maf is responsible for tissue-specific expression of interleukin-4. Cell 1996. 85: 973-983.
25. Pai, S. Y., Truitt, M. L. and Ho, I. C., GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl. Acad. Sci. U.S.A 2004. 101: 1993-1998.
26. Iwata, M., Eshima, Y. and Kagechika, H., Retinoic acids exert direct effects on T cells to suppress Th1 development and enhance Th2 development via retinoic acid receptors. Int. Immunol. 2003. 15: 1017-1025.
27. Stephensen, C. B., Rasooly, R., Jiang, X., Ceddia, M. A., Weaver, C. T., Chandraratna, R. A. and Bucy, R. P., Vitamin A enhances in vitro Th2 development via retinoid X receptor pathway. J. Immunol. 2002. 168: 4495-4503.
28. Boonstra, A., Barrat, F. J., Crain, C., Heath, V. L., Savelkoul, H. F. and O'Garra, A., 1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells. J. Immunol. 2001. 167: 4974-4980.
29. Li, M., Indra, A. K., Warot, X., Brocard, J., Messaddeq, N., Kato, S., Metzger, D. and Chambon, P., Skin abnormalities generated by temporally controlled RXRalpha mutations in mouse epidermis. Nature 2000. 407: 633-636.
30. Li, M., Chiba, H., Warot, X., Messaddeq, N., Gerard, C., Chambon, P. and Metzger, D., RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. Development 2001. 128: 675-688.
31. McCarthy, P. T. and Cerecedo, L. R., Vitamin A deficiency in the mouse. J. Nutr. 1952. 46: 361-376.
32. Pavlovitch, J. H., Galoppin, L., Rizk, M., Didierjean, L. and Balsan, S., Alterations in rat epidermis provoked by chronic vitamin D deficiency. Am. J. Physiol. 1984. 247: E228-E233.
33. Li, Y. C., Pirro, A. E., Amling, M., Delling, G., Baron, R., Bronson, R. and Demay, M. B., Targeted ablation of the vitamin D receptor: an animal model of vitamin D-dependent rickets type II with alopecia. Proc. Natl. Acad. Sci. USA 1997. 94: 9831-9835.
34. Bourguet, W., Ruff, M., Chambon, P., Gronemeyer, H. and Moras, D., Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha. Nature 1995. 375: 377-382.
35. Chambon, P., A decade of molecular biology of retinoic acid receptors. FASEB J. 1996. 10: 940-954.
36. Cantorna, M. T., Nashold, F. E. and Hayes, C. E., In vitamin A deficiency multiple mechanisms establish a regulatory T helper cell imbalance with excess Th1 and insufficient Th2 function. J. Immunol. 1994. 152: 1515-1522.
37. Cui, D., Moldoveanu, Z. and Stephensen, C. B., High-level dietary vitamin A enhances T-helper type 2 cytokine production and secretory immunoglobulin A response to influenza A virus infection in BALB/c mice. J. Nutr. 2000. 130: 1132-1139.
38. Overbergh, L., Decallonne, B., Waer, M., Rutgeerts, O., Valckx, D., Casteels, K. M., Laureys, J. et al., 1alpha,25-dihydroxyvitamin D3 induces an autoantigen-specific T-helper 1/T-helper 2 immune shift in NOD mice immunized with GAD65 (p524-543). Diabetes 2000. 49: 1301-1307.
39. Lemire, J. M., Archer, D. C., Beck, L. and Spiegelberg, H. L., Immunosuppressive actions of 1,25-dihydroxyvitamin D3: preferential inhibition of Th1 functions. J. Nutr. 1995. 125: 1704S-1708S.
40. Kuhn, R., Lohler, J., Rennick, D., Rajewsky, K. and Muller, W., Interleukin-10-deficient mice develop chronic enterocolitis. Cell 1993. 75: 263-274.
41. Belkaid, Y. and Rouse, B. T., Natural regulatory T cells in infectious disease. Nat. Immunol. 2005. 6: 353-360.
42. Mills, K. H., Regulatory T cells: friend or foe in immunity to infection? Nat. Rev. Immunol. 2004. 4: 841-855.
43. + regulatory T cells: their common role in controlling autoimmunity, tumor immunity, and transplantation tolerance. Immunol. Rev. 2001. 182: 18-32.
44. Sakaguchi, S., Sakaguchi, N., Asano, M., Itoh, M. and Toda, M., Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases. J. Immunol. 1995. 155: 1151-1164.
45. + regulatory T cells. Nat. Immunol. 2003. 4: 330-336.
46. Chao, C., Youssef, J., Rezaiekhaleigh, M., Birnbaum, L. S. and Badr, M., Senescence-associated decline in hepatic peroxisomal enzyme activities corresponds with diminished levels of retinoid X receptor alpha, but not peroxisome proliferator-activated receptor alpha. Mech. Ageing Dev. 2002. 123: 1469-1476.
47. Etchamendy, N., Enderlin, V., Marighetto, A., Vouimba, R. M., Pallet, V., Jaffard, R. and Higueret, P., Alleviation of a selective age-related relational memory deficit in mice by pharmacologically induced normalization of brain retinoid signaling. J. Neurosci. 2001. 21: 6423-6429.
48. Mangelsdorf, D. J., Borgmeyer, U., Heyman, R. A., Zhou, J. Y., Ong, E. S., Oro, A. E., Kakizuka, A. and Evans, R. M., Characterization of three RXR genes that mediate the action of 9-cis retinoic acid. Genes Dev. 1992. 6: 329-344.
49. Yoshizawa, T., Handa, Y., Uematsu, Y., Takeda, S., Sekine, K., Yoshihara, Y., Kawakami, T. et al., Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. Nat. Genet. 1997. 16: 391-396.
50. Stephensen, C. B., Jiang, X. and Freytag, T., Vitamin A deficiency increases the in vivo development of IL-10-positive Th2 cells and decreases development of Th1 cells in mice. J. Nutr. 2004. 134: 2660-2666.
51. Matheu, V., Back, O., Mondoc, E. and Issazadeh-Navikas, S., Dual effects of vitamin D-induced alteration of TH1/TH2 cytokine expression: enhancing IgE production and decreasing airway eosinophilia in murine allergic airway disease. J. Allergy Clin. Immunol. 2003. 112: 585-592.
52. Cao, S., Liu, J., Chesi, M., Bergsagel, P. L., Ho, I. C., Donnelly, R. P. and Ma, X., Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma. J. Immunol. 2002. 169: 5715-5725.
53. D'Ambrosio, D., Cippitelli, M., Cocciolo, M. G., Mazzeo, D., Di Lucia, P., Lang, R., Sinigaglia, F. and Panina-Bordignon, P., Inhibition of IL-12 production by 1,25-dihydroxyvitamin D3. Involvement of NF-kappaB downregulation in transcriptional repression of the p40 gene. J. Clin. Invest 1998. 101: 252-262.
54. Na, S. Y., Kang, B. Y., Chung, S. W., Han, S. J., Ma, X., Trinchieri, G., Im, S. Y. et al., Retinoids inhibit interleukin-12 production in macrophages through physical associations of retinoid X receptor and NFkappaB. J. Biol. Chem. 1999. 274: 7674-7680.
55. Grogan, J. L. and Locksley, R. M., T helper cell differentiation: on again, off again. Curr. Opin. Immunol. 2002. 14: 366-372.
56. + T cells. Nat. Immunol. 2002. 3: 549-557.
57. von Boehmer, H., Mechanisms of suppression by suppressor T cells. Nat. Immunol. 2005. 6: 338-344.
58. + suppressor T cells: more questions than answers. Nat. Rev. Immunol. 2002. 2: 389-400.
59. + regulatory T cells downregulate co-stimulatory molecules on antigen-presenting cells. Eur. J. Immunol. 2000. 30: 1538-1543.
60. + T cells. Biochem. Biophys. Res. Commun. 2005. 330: 226-232.
61. + regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J. Exp. Med. 2003. 198: 259-266.
62. Hesse, M., Piccirillo, C. A., Belkaid, Y., Prufer, J., Mentink-Kane, M., Leusink, M., Cheever, A. W. et al., The pathogenesis of schistosomiasis is controlled by cooperating IL-10-producing innate effector and regulatory T cells. J. Immunol. 2004. 172: 3157-3166.
63. + cells contribute to Th2 polarization during helminth infection by suppressing Th1 response development. J. Immunol. 2004. 173: 1224-1231.
64. Sommer, A., Vitamin A, infectious disease, and childhood mortality: a 2 solution? J. Infect. Dis. 1993. 167: 1003-1007.
65. Lutz, M. B., Kukutsch, N., Ogilvie, A. L., Rossner, S., Koch, F., Romani, N. and Schuler, G., An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow. J. Immunol. Methods 1999. 223: 77-92.
66. Du, X., Tabeta, K., Hoebe, K., Liu, H., Mann, N., Mudd, S., Crozat, K. et al., Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics 2004. 166: 331-340.