Functions of metallothionein generating interleukin-10-producing regulatory Cd4+ T cells potentiate suppression of collagen-induced arthritis

Journal of Microbiology and Biotechnology

Volumn 17, Issue 2, 2007, Pages 348-358

  Huh, Sungjin ^a   Lee, Kyuheon ^a   Yun, Hye Sun ^a   Paik, Doo Jin ^a   Kim, Jung Mogg ^a   Youn, Jeehee ^a  

^a Hanyang University   (South Korea)

Author keywords

Arthritis; Autoimmunity; Interleukin 10; Metallothionein; Regulatory T cells

Indexed keywords

CD4 ANTIGEN; COLLAGEN; CYSTEINE; HEAT SHOCK PROTEIN; INTERLEUKIN 10; INTERLEUKIN 4; METALLOTHIONEIN; REPRESSOR PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR GATA; TRANSCRIPTION FACTOR GATA 3; TRANSCRIPTION FACTOR T BET; TRANSFORMING GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; AUTOIMMUNITY; CD4+ T LYMPHOCYTE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DIAGNOSTIC VALUE; DISEASE PREDISPOSITION; DOWN REGULATION; DRUG TARGETING; ENZYME ACTIVITY; GENE OVEREXPRESSION; IMMUNOREGULATION; LYMPHOCYTE DIFFERENTIATION; LYMPHOCYTE PROLIFERATION; MOUSE; NONHUMAN; PROTEIN DEPLETION; PROTEIN INDUCTION; REGULATORY T LYMPHOCYTE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION; TH1 CELL; WILD TYPE;

ANIMALS; ARTHRITIS, EXPERIMENTAL; INTERLEUKIN-10; METALLOTHIONEIN; MICE; MICE, INBRED C57BL; MICE, INBRED DBA; NF-KAPPA B; REPRESSOR PROTEINS; T-BOX DOMAIN PROTEINS; T-LYMPHOCYTES, REGULATORY; TRANSCRIPTION FACTOR AP-1; TRANSFORMING GROWTH FACTOR BETA;

MUS; MUS MUSCULUS;

EID: 33947259358     PISSN: 10177825     EISSN: 17388872     Source Type: Journal    
DOI: None     Document Type: Article

References (55)

1. Abdel-Mageed, A. B. and K. C. Agrawal. 1998. Activation of nuclear factor kappaB: Potential role in metallothionein-mediated mitogenic response. Cancer Res. 58: 2335-2338.
2. + T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma. J. Immunol. 173: 4352-4359.
3. + T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines. J. Exp. Med. 195: 603-616.
4. Basu, A. and J. S. Lazo. 1990. A hypothesis regarding the protective role of metallothionein against the toxicity of DNA interactive anticancer drug. Toxicol. Lett. 50: 123-135.
5. Bremner, I., R. K. Mehra, and M. Sato. 1987. Metallothionein in blood, bile, and urine. Experientia 52: 507-517.
6. Butcher, H. L., W A. Kennette, O. Collins, R. K. Zalups, and J. Koropatnick. 2004. Metallothionein mediates the level and activity of nuclear factor kappa B in murine fibroblasts. J. Pharmacol. Exp. Ther. 310: 589-598.
7. Chen, C., W. H, Lee, P. Yun, P. Snow, and C. P. Liu. 2003. Induction of autoantigen-specific Th2 and Tr1 regulatory T cells and modulation of autoimmune diabetes. J. Immunol. 171: 733-744.
8. Chen, H., E. C. Carlson, L. Pellet, J. T. Moritz, and P. N. Epstein. 2001. Overexpression of metallothionein in pancreatic β-cells reduces streptozotocin-induced DNA damage and diabetes. Diabetes 50: 2040-2046.
9. Cobbold, S. P., K. F. Nolan, L. Graca, R. Castejon, A. Le Moine, M. Frewin, S. Humm, E. Adams, S. Thompson, D. Zelenika, A. Paterson, S. Yates, P. J. Fairchild, and H. Waldmann. 2003. Regulatory T cells and dendritic cells in transplantation tolerance: Molecular markers and mechanisms. Immunol. Rev. 196: 109-124.
10. Coyle, P., J. C. Philcox, and A. M. Rofe. 1995. Metallothionein induction in cultured rat hepatocytes by arthritic rat serum, activated macrophages, interleukin-6, interleukin-1 and leukaemia inhibitory factor. Inflamm. Res. 44: 475-481.
11. Crowthers, K. C., V. Kline, C. Giardina, and M. A. Lyrics. 2000. Augmented humoral immune function in metallothioneinnull mice. Toxicol. Appl. Pharmacol. 166: 161-172.
12. Danielson, K. G., S. Ohi, and P. C. Huang. 1982. Immunochemical localization of metallothionein in rat liver and kidney. J. Histochem. Cytochem. 30: 1033-1039.
13. Davis, R. J. 2000. Signal transduction by the JNK group of MAP kinases. Cell 103: 239-252.
14. De Lisle, R. C., M. P. Sarras Jr., J. Hidalgo, and G. K. Andrews. 1996. Metallothionein is a component of exocrine pancreas secretion: Implications for zinc homeostasis. Am. J. Physiol. 271: C1103-C1110.
15. Durnam, D. M., J. S. Hoffman, C. J. Quaife, E. P. Benditt, H. Y. Chen, R. L. Brinster, and R. D. Palmiter. 1984. Induction of mouse metallothionein-I mRNA by bacterial endotoxin is independent of metals and glucocorticoid hormones. Proc. Natl. Acad. Sci. USA 81: 1053-1056.
16. El Refaey, H., M. Ebadi, C. A. Kuszynski, J. Sweeney, F. M. Hamada, and A. Hamed. 1997. Identification of metallothionein receptors in human astrocytes. Neurosci. Lett. 231: 131-134.
17. Farrar, J. D., M. Ouyang, M. Assenmacher, A. Radbrucher, A. Radbrush, O. Kanagawa, and K. M. Murphy. 2001. An instructive component in T helper cell type 2 (Th2) development mediated by GATA-3. J. Exp. Med. 193: 645-650.
18. Feng, R., Y. Lu, L. L. Bowman, Y. Qian, V. Castranova, and M. Ding. 2005. Inhibition of activator protein-1, NF-kappaB, and MAPKs and induction of phase 2 detoxifying enzyme activity by chlorogenic acid. J. Biol. Chem. 280: 27888-27895.
19. Fiore, F., B. Nuschak, S. Peola, S. Mariani, M. Muraro, M. Foglietta, M. Coscia, B. Bruno, M. Boccadoro, and M. Massaia. 2005. Exposure to myeloma cell lysates affects the immune competence of dendritic cells and favors the induction of Tr1-like regulatory T cells. Eur. J. Immunol. 35: 1155-1163.
20. Groux, H., A. O'Garra, M. Bigler, M. Rouleau, S. Antonenko, J. E. de Vries, and M. G. Roncarolo. 1997. A CD4' T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. Nature 389: 737-742.
21. Hamer, D. H. 1986. Metallothionein. Annu. Rev. Biochem. 55: 913-951.
22. Hart, B. A. and J. S. Garvey. 1986. Detection of metallothionein in bronchoalveolar cells and lavage fluid following repeated cadmium inhalation. Environ. Res. 40: 391-398.
23. Kawasaki, H., Y. Nakata, G. Suzuki, K. Chihara, T. Tokuhisa, and S. Shiozawa. 1999. Increased c-Fos/activator protein-1 confers resistance against anergy induction on antigen-specific T cell. Int. Immunol. 11: 1873-1880.
24. + cells with CD3 and CD46 induces a T-regulatory cell 1 phenotype. Nature 421: 388-392.
25. Kim, D. S., H. R. Kim, E. R. Woo, S. T. Hong, H. J. Chae, and S. W. Chae. 2005. Inhibitory effects of rosmarinic acid on adriamycin-induced apoptosis in H9c2 cardiac muscle cells by inhibiting reactive oxygen species and the activations of c-Jun N-terminal kinase and extracellular signal-regulated kinase. Biochem. Pharmacol. 70: 1066-1078.
26. Kim, I. S., H. S. Yun, H. Shimisu, E. Kitagawa, H. Iwahashi, and I. Jin. 2005. Elucidation of copper and asparagine transport systems in Saccharomyces cerevisiae KNU5377 through genome-wide transcriptional analysis. J. Microbiol. Biotechnol. 15: 1240-1249.
27. Kim, N. and G. E. Ji. 2006. Modulatory activity of Bifidobacterium sp. BGN4 cell fractions on immune cells. J. Microbiol. Biotechnol. 16: 584-589.
28. Kim, W. U., W. K. Lee, J. W. Ryoo, S. H. Kim, J. Kim, J. Youn, S. Y. Min, E. Y. Bae, S. Y. Hwang, S. H. Park, C. S. Cho, J. S. Park, and H. Y. Kim. 2002. Suppression of collagen-induced arthritis by single administration of poly(lactic-co-glycolic acid) nanoparticles entrapping type II collagen: A novel treatment strategy for induction of oral tolerance. Arthritis Rheum. 46: 1109-1120.
29. Kurnari, M. V., M. Hiramatsu, and M. Ebadi. 1998. Free radical scavenging actions of metallothionein isoforms I and II. Free Radic. Res. 29: 93-101.
30. Lee, E. K., S. M. Kang, D. J. Paik, J. M. Kim, and J. Youn. 2005. Essential roles of Toll-like receptor-4 signaling in arthritis induced by type II collagen antibody and LPS. Int. Immunol. 17: 325-333.
31. Li, X., H. Cheri, and P. N. Epstein. 2004. Metallothionein protects islets from hypoxia and extends islet graft survival by scavenging most kinds of reactive oxygen species. J. Biol. Chem. 279: 765-771.
32. Lyrics, M. A., C. A. Richardson, R. McCabe, K. C. Crowthers, J. C. Lee, J. Youn, I. B. Schweitzer, and L. D. Shultz. 1999. Metallothionein-mediated alterations in autoimmune disease processes, pp. 437-444. In C. Klaassen (ed.), Metallothionein IV. Basel, Birkhauser.
33. Macian, F., F. Garcia-Cozar, S. H. Im, H. F. Horton, M. C. Byrne, and A. Rao. 2002. Transcriptional mechanisms underlying lymphocyte tolerance. Cell 109: 719-731.
34. Masters, B. A., E. J. Kelly, C. J. Quaife, R. L. Brinster, and R. D. Palmiter. 1994. Targeted disruption of metallothionein I and II genes increases sensitivity to cadmium. Proc. Natl Acad. Sci. USA 91: 584-588.
35. McKim, J. M. Jr., J. Liu, Y. P. Liu, and C. D. Klaassen. 1992. Induction of metallothionein by cadmium-metallothionein in rat liver: A proposed mechanism. Toxicol. Appl. Pharmacol. 112: 318-323.
36. Miesel, R. and M. Zuber. 1993. Copper-dependent antioxidase defenses in inflammatory and autoimmune rheumatic diseases. Inflammation 17: 283-294.
37. Mora, A. L., J. Youn, A. D. Keegan, and M. Boothby. 2001. NF-kappaB/Rel participation in the lymphokine-dependent proliferation of T lymphoid cells. J. Immunol. 166: 2218-2227.
38. + regulatory T cells. Arthritis Rheum. 52: 2212-2221.
39. Mullen, A. C., F. A. High, A. S. Hutchins, H. W Lee, A. V. Villarino, D. M. Livingston, A. L. Kung, N. Cereb, T. P. Yao, S. Y. Yang, and S. L. Reiner. 2001. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292: 1907-1910.
40. Murata. Y., M. Amao, J. Yoneda, and J. Hamuro. 2002. Intracellular thiol redox status of macrophages directs the Th1 skewing in thioredoxin transgenic mice during aging. Mol. Immunol. 38: 747-757.
41. Murata, Y., T. Shimamura, T. Tagami, F. Takatsuki, and J. Hamuro. 2002. The skewing to Th1 induced by lentinan is directed through the distinctive cytokine production by macrophages with elevated intracellular glutathione content. Int. Immunopharmacol. 2: 673-689.
42. Ohly, P., C. Dohle, J. Abel, J. Seissler, and H. Gleichmann. 2000. Zinc sulphate induces metallothionein in pancreatic islets of mice and protects against diabetes induced by multiple low doses of streptozotocin. Diabetologia 43: 1020-1030.
43. Palmiter, R. D., E. P. Sandgren, D. M. Koeller, and R. L. Brinster. 1993. Distal regulatory elements from the mouse metallothionein locus stimulate gene expression in transgenic mice. Mol. Cell. Biol. 13: 5266-5275.
44. Penkowa, M. and J. Hidalgo. 2000. Metallothionein I+II expression and their role in experimental autoimmune encephalomyelitis. Glia 32: 247-263.
45. Penkowa, M., C. Espejo, E. M. Martinez-Caceres, C. B. Poulsen, X. Montalban, and J. Hidalgo. 2001. Altered inflammatory response and increased neurodegeneration in metallothionein I+II deficient mice during experimental autoimmune encephalomyelitis. J. Neuroimmunol. 119: 248-260.
46. Peterson, J. D., L. A. Herzenberg, K. Vasquez, and C. Waltenbaugh. 1998. Glutathione levels in antigen-presenting cells modulate Th1 versus Th2 response patterns. Proc. Natl. Acad. Sci. USA 95: 3071-3076.
47. Prasad, A. S. 1998. Zinc and immunity. Mol. Cell. Biochem. 188: 63-69.
48. Rahman, I., J. Marwick, and P. Kirkham. 2004. Redox modulation of chromatin remodeling: Impact on historic acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression. Biochem. Pharmacol. 68: 1255-1267.
49. Sato, M. and I. Bremner. 1993. Oxygen-free radicals and metallothionein. Free Radic. Biol. Med. 14: 325-337.
50. + T cells have defective expression and function of the activating protein-1 transcription factor. J. Immunol. 161: 5930-5936.
51. Woo, E. S., Y. Kondo, S. C. Watkins, D. G. Hoyt, and J. S. Lazo. 1996. Nucleophilic distribution of metallothionein in human tumor cells. Exp. Cell Res. 224: 365-371.
52. Yim, S. B. and Y. H. Chung. 2004. Construction and production of concatameric human TNF receptor-immunoglobulin fusion proteins. J. Microbiol. Biotechnol. 14: 81-89.
53. Yin, X., D. A. Knecht, and M. A. Lyrics. 2005. Metallothionein mediates leukocyte chemotaxis. BMC Immunol. 6: 21.
54. Youn, J., S. H. Hwang, Z. Y. Ryoo, M. A. Lynes, D. J. Paik, H. S. Chung, and H. Y. Kim. 2002. Metallothionein suppresses collagen-induced arthritis via induction of TGF-beta and down-regulation of proinflammatory mediators. Clin. Exp. Immunol. 129: 232-239.
55. + T regulatory 1 cells to suppress antitumor immunity. J. Immunol. 175: 2931-2937.