Allopregnanolone (3α-Hydroxy-5α-pregnan-20-one) derivatives with a polar chain in position 16α: Synthesis and activity

Journal of Medicinal Chemistry

Volumn 52, Issue 7, 2009, Pages 2119-2125

  Slavíková, Barbora ^a   Krištofíková, Zdena ^b   Chodounská, Hana ^a   Buděšínský, Miloš ^a   Durán, Fernando J ^c   Veleiro, Adriana S ^c   Burton, Gerardo ^c   Kasal, Alexander ^a  

^a INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^b NATIONAL INSTITUTE OF MENTAL HEALTH   (Czech Republic)

^c UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

16ALPHA BIS(CARBAMOYLOXYMETHYL)METHYL 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 16ALPHA CARBAMOYLOXYETHYL 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 16ALPHA ETHYL 20 OXO 5ALPHA PREGNANE 3ALPHA,16B DIYL DICARBAMATE; 16ALPHA ETHYL 20 OXO 5ALPHA PREGNANE 3R,16B DIYL DICARBAMATE; 20,20 ETHYLENEDIOXY 16R BIS(METHOXYCARBONYL)METHYL 5ALPHA PREGNAN 3ALPHA OL; 3ALPHA HYDROXY 16ALPHA (2 HYDROXYETHOXY) 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY 16ALPHA (2,3 DIHYDROXYPROPOXY) 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY 16ALPHA [2 HYDROXY (2 ETHOXYETHOXY)] 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY 16ALPHA BIS(METHOXYCARBONYL)METHYL 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY 16ALPHA METHOXYCARBONYLMETHYL 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY 16ALPHA-BIS(HYDROXYMETHYL)METHYL 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA TERT BUTYLDIMETHYLSILYLOXY 16ALPHA ETHYL 20,20 ETHYLENEDIOXY 5ALPHA PREGNAN 16B OL; 3ALPHA TERT BUTYLDIMETHYLSILYLOXY 20,20 ETHYLENEDIOXY 16ALPHA BIS(HYDROXYMETHYL)METHYL 5ALPHA PREGNANE; 3BETA HYDROXY 16RALPHA (2' HYDROXYETHOXY) PREGN 5 EN 20 ONE; 3R TERT BUTYLDIMETHYLSILYLOXY 20,20 ETHYLENEDIOXY 16R BIS (METHOXYCARBONYL)METHYL 5ALPHA PREGNANE; 4 AMINOBUTYRIC ACID A RECEPTOR; UNCLASSIFIED DRUG; BENZODIAZEPINE RECEPTOR AFFECTING AGENT; DRUG DERIVATIVE; ELTANOLONE;

ARTICLE; BINDING SITE; DRUG ACTIVITY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; ANIMAL; BRAIN; IN VITRO STUDY; MALE; METABOLISM; RADIOASSAY; RAT; STRUCTURE ACTIVITY RELATION; SYNTHESIS; WISTAR RAT;

ANIMALS; BRAIN; GABA MODULATORS; MALE; PREGNANOLONE; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 64549085335     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm801454a     Document Type: Article

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