Synthesis and GABAA receptor activity of oxygen-bridged neurosteroid analogs

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 7, 2008, Pages 3831-3838

  Alvarez, Lautaro D ^a   Veleiro, Adriana S ^a   Baggio, Ricardo F ^b   Garland, María T ^c   Edelsztein, Valeria C ^a,d   Coirini, Héctor ^d   Burton, Gerardo ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b LABORATORIO TANDAR   (Argentina)

^c DEPARTAMENTO DE FÍSICA   (Chile)

^d INST DE BIOL Y MED EXPERIMENTAL   (Argentina)

Author keywords

Aminobutyric acid; GABA; GABAA receptor; Neurosteroids; Steroids

Indexed keywords

3ALPHA HYDROXY 11,19 EPOXYPREGN 4 ENE 20 ONE; 3ALPHA HYDROXY 1ALPHA,11ALPHA EPOXY 5BETA PREGNAN 20 ONE; 3ALPHA HYDROXY 1BETA,11ALPHA EPOXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ELTANOLONE; NEUROSTEROID; OXYGEN; TERT BUTYLBICYCLOORTHOBENZOATE; TRITIUM; UNCLASSIFIED DRUG;

AB INITIO CALCULATION; ARTICLE; BIOLOGICAL ACTIVITY; CONTROLLED STUDY; DRUG CONFORMATION; DRUG RECEPTOR BINDING; DRUG STRUCTURE; IN VITRO STUDY; ISOTOPE LABELING; MALE; NONHUMAN; RAT; X RAY ANALYSIS;

ANIMALS; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NEURONS; OXYGEN; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GABA-A; STEROIDS;

EID: 41749124166     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.01.048     Document Type: Article

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