Synthesis and pharmacological evaluations of new steroidal anti-inflammatory antedrugs: 9α-Fluoro-11β,17α,21-trihydroxy-3, 20-dioxo-pregna-1,4-diene-16α-carboxylate (FP16CM) and its derivatives

Steroids

Volumn 71, Issue 1, 2006, Pages 83-89

  Park, Kwan Kyun ^a   Ko, Dong Hoon ^a   You, Zhengqing ^a   Heiman, Ann S ^a   Lee, Henry Joung ^a  

^a FLORIDA A AND M UNIVERSITY   (United States)

Author keywords

Antedrug; Anti inflammatory agent; Drug design; Hydrolysis; NO inhibition; Receptor binding

Indexed keywords

ANTIINFLAMMATORY AGENT; BENZYL 9ALPHA FLUORO 11BETA,17ALPHA,21 TRIHYDROXY 3,20 DIOXOPREGNA 1,4 DIENE 16ALPHA CARBOXYLATE; CARBONYL DERIVATIVE; CORTICOSTERONE; CROTON OIL; ETHYL 9ALPHA FLUORO 11BETA 17ALPHA,20 TRIHYDROXY 3,20 DIOXOPREGNA 1,4 DIENE 16ALPHA CARBOXYLATE; GLUCOCORTICOID RECEPTOR; LIPOPOLYSACCHARIDE; METHYL 9ALPHA FLUORO 11BETA,17ALPHA,21 TRIHYDROXY 3,20 DIOXOPREGNA 1,4 DIENE 16ALPHA CARBOXYLATE; NITRIC OXIDE; PREDNISOLONE; PRODRUG; PROPYL 9ALPHA FLUORO 11BETA,17ALPHA,20 TRIHYDROXY 3,20 DIOXOPREGNA 1,4 DIENE 16ALPHA CARBOXYLATE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; DRUG HYDROLYSIS; DRUG SYNTHESIS; EAR; EDEMA; LIVER CYTOSOL; MACROPHAGE; MALE; METABOLITE; NONHUMAN; RAT; RECEPTOR BINDING; SYSTEMIC CIRCULATION; THYMUS ATROPHY;

ANIMALS; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; EAR DISEASES; EDEMA; ESTERIFICATION; HYDROLYSIS; MACROPHAGES; MALE; MICE; NITRIC OXIDE; PREGNADIENETRIOLS; PROTEIN BINDING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID;

ANIMALIA;

EID: 28544441523     PISSN: 0039128X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.steroids.2005.08.005     Document Type: Article

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