Is inhibition of cyclooxygenase required for the chemopreventive effect of NSAIDs in colon cancer? A model reconciling the current contradiction

Medical Hypotheses

Volumn 54, Issue 2, 2000, Pages 210-215

  Rigas, B ^a   Shiff, S J ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; CYCLOOXYGENASE 2 INHIBITOR; DRUG METABOLITE; ENZYME INHIBITOR; INDOMETACIN; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; PROSTAGLANDIN SYNTHASE; SALICYLIC ACID; SULINDAC; SULINDAC SULFIDE;

CANCER CONTROL; CHEMOPROPHYLAXIS; COLON CARCINOGENESIS; DRUG EFFICACY; ENZYME INHIBITION; HUMAN; HUMAN CELL; MODEL; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0034062811     PISSN: 03069877     EISSN: None     Source Type: Journal    
DOI: 10.1054/mehy.1999.0023     Document Type: Article

References (40)

1. Shiff S. J., Rigas B. Nonsteroidal anti-inflammatory drugs and colorectal cancer: evolving concepts of their chemopreventive actions. Gastroenterology. 113:1997;1992-1998.
2. Smith W. L., Garavito R. M., DeWitt D. L. Prostaglandin endoperoxide H synthases (cyclooxygenases)-1 and -2. J Biol Chem. 271:1996;33157-33160.
3. Abramson S. B., Weissmann G. The mechanisms of action of nonsteroidal antiinflammatory drugs. Arthr Rheum. 32:1989;1-9.
4. Shiff S. J., Qiao L., Tsai L.-L., Rigas B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J Clin Invest. 96:1995;491-503.
5. Shiff S. J., Koutsos M. I., Qiao L., Rigas B. Nonsteroidal antiinflammatory drugs inhibit the proliferation of colon adenocarcinoma cells: effects on cell cycle and apoptosis. Exp Cell Res. 222:1996;179-188.
6. Goldberg Y., Nassif I. I., Pittas A. The anti-proliferative effect of sulindac and sulindac sulfide on HT-29 colon cancer cells: Alterations in tumor suppressor and cell cycle-regulatory proteins. Oncogene. 12:1996;893-901.
7. Qiao L., Shiff S. J., Rigas B. Sulindac sulfide inhibits the proliferation of colon cancer cells - diminished expression of the proliferation markers PCNA and Ki-67. Cancer Lett. 115:1997;229-234.
8. Qiao L., Hanif R., Sphicas E., Shiff S. J., Rigas B. Effect of aspirin on induction of apoptosis in HT-29 human colon adenocarcinoma cells. Biochem Pharmacol. 55:1998;53-64.
9. Qiao L., Shiff S. J., Rigas B. Sulindac sulfide induces several subpopulations of colon cancer cells, defined by PCNA/Ki-67 and DNA strand breaks. Biochim Biophys Acta-Mol Cell Res. 1359:1997;222-232.
10. Qiao L., Shiff S. J., Rigas B. Sulindac sulfide alters the expression of cyclin proteins in HT-29 colon adenocarcinoma cells. Int J Cancer. 76:1998;99-104.
11. Piazza G. A., Rahm A. L. K., Krutzsch M. Antineoplastic drugs sulindac sulfide and sulfone inhibit cell growth by inducing apoptosis. Cancer Res. 55:1995;3110-3116.
12. Elder D. J. E., Hague A., Hicks D. J., Paraskeva C. Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro -transformed adenoma relative to adenoma cell lines. Cancer Res. 56:1996;2273-2276.
13. Pasricha P. J., Bedi A., O'Connor K. The effects of sulindac on colorectal proliferation and apoptosis in familial adenomatous polyposis. Gastroenterology. 109:1995;994-998.
14. Spagnesi M. T., Tonelli F., Dolara P. Rectal proliferation and polyp occurrence in patients with familial adenomatous polyposis after sulindac treatment. Gastroenterology. 106:1994;362-366.
15. Winde G., Schmid K. W., Schlegel W., Fischer R., Osswald H., Bünte H. Complete reversion and prevention of rectal adenomas in colectomized patients with familial adenomatous polyposis by rectal low-dose sulindac maintenance treatment. Dis Colon Rectum. 38:1995;813-830.
16. Winde G., Schmid K. W., Brandt B., Muller O., Osswald H. Clinical and genomic influence of sulindac on rectal mucosa in familial adenomatous polyposis. Dis Colon Rectum. 40:1997;1156-1168.
17. Brenner, D. E. Ruffin, M. T. Aoki, T. Aspirin modulation of colonic biologic surrogates in the human colon, International Cancer Chemoprevention Conference: Short-term Clinical Trials. MinZu Hotel, Beijing, China, 71, 72.
18. Hall P. A., Coates P. J., Ansari B., Hopwood D. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J Cell Sci. 107:1994;3569-3577.
19. Bedi A., Pasricha P. J., Akhtar A. J. Inhibition of apoptosis during development of colorectal cancer. Cancer Res. 55:1995;1811-1816.
20. Lu X., Xie W., Reed D., Bradshaw W. S., Simmons D. L. Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts. Proc Natl Acad Sci USA. 92:1995;7961-7965.
21. Elder D. J. E., Halton D. E., Hague A., Paraskeva C. Induction of apoptotic cell death in human colorectal carcinoma cell lines by a cyclooxygenase-2 (COX-2)-selective nonsteroidal anti-inflammatory drug - independence from COX-2 protein expression. Clin Cancer Res. 3:1997;1679-1683.
22. Bennett A., Tacca M. D., Stamford I. F., Zebro T. Prostaglandins from tumours of human large bowel. Br J Cancer. 35:1997;881-884.
23. Kubota Y., Sunouchi K., Ono M., Sawada T., Muto T. Local immunity and metastasis of colorectal carcinoma. Dis Colon Rectum. 35:1992;645-650.
24. Nugent K. P., Spigelman A. D., Phillips R. K. S. Tissue prostaglandin levels in familial adenomatous polyposis patients treated with sulindac. Dis Colon Rectum. 39:1996;659-662.
25. Giardiello F. M., Spannhake E. W., DuBois R. N. Prostaglandin levels in human colorectal mucosa: effects of sulindac in patients with familial adenomatous polyposis. Dig Dis Sci. 43:1998;311-316.
26. Yang V. W., Shields J. M., Hamilton S. R. Size-dependent increase in prostanoid levels in adenomas of patients with familial adenomatous polyposis. Cancer Res. 58:1998;1750-1753.
27. Rigas B., Goldman I. S., Levine L. Altered eicosanoid levels in human colon cancer. J Lab Clin Med. 122:1993;518-523.
28. Qiao L., Kozoni V., Tsioulias G. J. Selected eicosanoids increase the proliferation rate of human colon carcinoma cell lines and mouse colonocytes in vivo. Biochim Biophys Acta. 1258:1995;215-223.
29. Bortuzzo C., Hanif R., Kashfi K., Staiano-Coico L., Shiff S. J., Rigas B. The effect of leukotrienes B and selected HETEs on the proliferation of colon cancer cells. Biochim Biophys Acta. 1300:1996;240-246.
30. Sheng H. M., Shao J. Y., Morrow J. D., Beauchamp R. D., Dubois R. N. Modulation of apoptosis and bcl-2 expression by prostaglandin E-2 in human colon cancer cells. Cancer Res. 58:1998;362-366.
31. DuBois R. N., Radhika A., Reddy B. S., Entingh A. J. Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors. Gastroenterology. 110:1996;1259-1262.
32. Kutchera W., Jones D. A., Matsunami N. Prostaglandin H synthase 2 is expressed abnormally in human colon cancer: evidence for a transcriptional effect. Proc Natl Acad Sci USA. 93:1996;4816-4820.
33. Levy G. N. Prostaglandin H synthases, nonsteroidal anti-inflammatory drugs, and colon cancer. FASEB J. 11:1997;234-247.
34. Tsujii M., DuBois R. N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 83:1995;493-501.
35. 716knockout mice by inhibition of cyclooxygenase 2 (COX-2). Cell. 87:1996;803-809.
36. Reddy B. S., Rao C. V., Seibert K. Evaluation of cyclooxygenase-2 inhibitor for potential chemopreventive properties in colon carcinogenesis. Cancer Res. 56:1996;4566-4569.
37. Sheng H., Shao J., Kirkland S. C. Inhibition of human colon cancer cell growth by selective inhibition of cyclooxygenase-2. J Clin Invest. 99:1997;2254-2259.
38. Shen T. Y., Winter C. A. Chemical and biological studies on indomethacin, sulindac and their analogs. Adv Drug Res. 12:1997;90-245.
39. Piazza G. A., Alberts D. S., Hixson L. J. Sulindac sulfone inhibits azoxymethane-induced colon carcinogenesis in rats without reducing prostaglandin levels. Cancer Res. 57:1997;2909-2915.
40. Hanif R., Pittas A., Feng Y. Effects of nonsteroidal antiinflammatory drugs on proliferation and on induction of apoptosis in colon cancer cells by a prostaglandin-independent pathway. Biochem Pharmacol. 52:1996;237-245.