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Volumn 11, Issue 5, 2009, Pages 1115-1118

An emissive C analog distinguishes between G, 8-oxoG, and t

Author keywords

[No Author keywords available]

Indexed keywords

8 HYDROXYGUANINE; 8-HYDROXYGUANINE; DRUG DERIVATIVE; FLUORESCENT DYE; GUANINE;

EID: 64349110335     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol802656n     Document Type: Article
Times cited : (53)

References (59)
  • 17
    • 64349088587 scopus 로고    scopus 로고
    • 8-oxoG's low cellular abundance, complex localization, and chemical degradation pathways make the development of small probes for its intracellular detection a formidable task.
    • 8-oxoG's low cellular abundance, complex localization, and chemical degradation pathways make the development of small probes for its intracellular detection a formidable task.
  • 25
    • 33847718732 scopus 로고    scopus 로고
    • For fluorescence-based kinetic analysis of 8-oxoG DNA glycosylase; see: Kuznetsov, N. A.; Koval, V. V.; Nevinsky, G. A.; Douglas, K. T.; Zharkov, D. O.; Fedorova, O. S. J. Biol. Chem. 2007, 282, 1029-1038.
    • For fluorescence-based kinetic analysis of 8-oxoG DNA glycosylase; see: Kuznetsov, N. A.; Koval, V. V.; Nevinsky, G. A.; Douglas, K. T.; Zharkov, D. O.; Fedorova, O. S. J. Biol. Chem. 2007, 282, 1029-1038.
  • 34
    • 34250725893 scopus 로고    scopus 로고
    • A modified G-clamp was reported to be quenched by 8-oxoG, but detecting the damaged base was limited to nucleosides in chloroform and micellar solutions. See: Nakagawa, O.; Ono, S.; Li, Z.; Tsujimoto, A.; Sasaki, S. Angew. Chem.. Int. Ed. 2007, 46, 4500-4503.
    • A modified G-clamp was reported to be quenched by 8-oxoG, but detecting the damaged base was limited to nucleosides in chloroform and micellar solutions. See: Nakagawa, O.; Ono, S.; Li, Z.; Tsujimoto, A.; Sasaki, S. Angew. Chem.. Int. Ed. 2007, 46, 4500-4503.
  • 35
    • 0034238088 scopus 로고    scopus 로고
    • For other emissive C analogs, see: a
    • For other emissive C analogs, see: (a) Godde, F.; Toulme, J. J.; Moreau, S. Nucleic Acids Res. 2000, 28, 2977-2985.
    • (2000) Nucleic Acids Res , vol.28 , pp. 2977-2985
    • Godde, F.1    Toulme, J.J.2    Moreau, S.3
  • 49
    • 33847298021 scopus 로고    scopus 로고
    • Srivatsan, S. G.; Tor, Y. J. Am. Chem. Soc. 2007, 129, 2044-2053. Srivatsan, S. G.; Tor, Y. Tetrahedron 2007, 63, 3601-3607.
    • (a) Srivatsan, S. G.; Tor, Y. J. Am. Chem. Soc. 2007, 129, 2044-2053. Srivatsan, S. G.; Tor, Y. Tetrahedron 2007, 63, 3601-3607.
  • 52
    • 64349124554 scopus 로고    scopus 로고
    • See Supporting Information for experimental details
    • See Supporting Information for experimental details.
  • 53
    • 64349111349 scopus 로고    scopus 로고
    • Note that, although relatively low, this is easily detected by standard benchtop fluorimeters with excellent signal-to-noise
    • Note that, although relatively low, this is easily detected by standard benchtop fluorimeters with excellent signal-to-noise.
  • 55
    • 84869268630 scopus 로고    scopus 로고
    • 2I (λ). See Lakowicz, J. R. Principles of Fluorescence Spectroscopy, 2nd ed.; Kluwer Academic/Plenum: New York, 1999.
    • 2I (λ). See Lakowicz, J. R. Principles of Fluorescence Spectroscopy, 2nd ed.; Kluwer Academic/Plenum: New York, 1999.
  • 59
    • 64349094473 scopus 로고    scopus 로고
    • To globally follow this pathway, an independent method, estimating the relative damaged/mutant population, might be needed
    • To globally follow this pathway, an independent method, estimating the relative damaged/mutant population, might be needed.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.