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33645170187
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note
-
See Supporting Information for experimental details.
-
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19
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0026000498
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Previous synthesis of 2a, 2b, and 2d: (a) Wigerinck, P.; Pannecouque, C.; Snoeck, R.; Claes, P.; De Clercq, E.; Herdewijn, P. J. Med Chem. 1991, 34, 2383-2389. 2d:
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33645185972
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note
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Commercial availability of 5-iodouridine makes RNA analogues possible.
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22
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33645177292
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note
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9
-
-
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23
-
-
33645184329
-
-
note
-
Aqueous buffer = 0.01 M sodium phosphate, 0.1 M NaCl, pH = 7.0.
-
-
-
-
24
-
-
33645177192
-
-
note
-
This behavior typically occurs in polar molecules that are likely to have enlarged dipoles and charge-transfer character in their excited state.
-
-
-
-
25
-
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33645179551
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note
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9
-
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26
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0025098897
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33645182042
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note
-
We are currently pursuing a high-resolution NMR structural elucidation of the modified duplex.
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-
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