-
1
-
-
33646859093
-
A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct
-
Arjunan P., Sax M., Brunskill A., Chandrasekhar K., Nemeria N., Zhang S., Jordan F., and Furey W. A thiamin-bound, pre-decarboxylation reaction intermediate analogue in the pyruvate dehydrogenase E1 subunit induces large scale disorder-to-order transformations in the enzyme and reveals novel structural features in the covalently bound adduct. J. Biol. Chem. 281 (2006) 15296-15303
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 15296-15303
-
-
Arjunan, P.1
Sax, M.2
Brunskill, A.3
Chandrasekhar, K.4
Nemeria, N.5
Zhang, S.6
Jordan, F.7
Furey, W.8
-
2
-
-
0024672742
-
Purification and characterization of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes
-
Baetz A.L., and Allison M.J. Purification and characterization of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes. J. Bacteriol. 171 (1989) 2605-2608
-
(1989)
J. Bacteriol.
, vol.171
, pp. 2605-2608
-
-
Baetz, A.L.1
Allison, M.J.2
-
3
-
-
29244469942
-
Structural basis for activation of the thiamin diphosphate-dependent enzyme oxalyl-CoA decarboxylase by adenosine diphosphate
-
Berthold C.L., Moussatche P., Richards N.G., and Lindqvist Y. Structural basis for activation of the thiamin diphosphate-dependent enzyme oxalyl-CoA decarboxylase by adenosine diphosphate. J. Biol. Chem. 280 (2005) 41645-41654
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 41645-41654
-
-
Berthold, C.L.1
Moussatche, P.2
Richards, N.G.3
Lindqvist, Y.4
-
4
-
-
33644838821
-
Detection and characterization of merohedral twinning in crystals of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes
-
Berthold C.L., Sidhu H., Ricagno S., Richards N.G., and Lindqvist Y. Detection and characterization of merohedral twinning in crystals of oxalyl-coenzyme A decarboxylase from Oxalobacter formigenes. Biochim. Biophys. Acta 1764 (2006) 122-128
-
(2006)
Biochim. Biophys. Acta
, vol.1764
, pp. 122-128
-
-
Berthold, C.L.1
Sidhu, H.2
Ricagno, S.3
Richards, N.G.4
Lindqvist, Y.5
-
5
-
-
3543012707
-
Crystallography & NMR system: a new software suite for macromolecular structure determination
-
Brünger A.T., Adams P.D., Clore G.M., DeLano W.L., Gros P., Grosse-Kunstleve R.W., Jiang J.S., Kuszewski J., Nilges M., Pannu N.S., et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54 (1998) 905-921
-
(1998)
Acta Crystallogr. D Biol. Crystallogr.
, vol.54
, pp. 905-921
-
-
Brünger, A.T.1
Adams, P.D.2
Clore, G.M.3
DeLano, W.L.4
Gros, P.5
Grosse-Kunstleve, R.W.6
Jiang, J.S.7
Kuszewski, J.8
Nilges, M.9
Pannu, N.S.10
-
6
-
-
0034622503
-
Effects of deletions at the carboxyl terminus of Zymomonas mobilis pyruvate decarboxylase on the kinetic properties and substrate specificity
-
Chang A.K., Nixon P.F., and Duggleby R.G. Effects of deletions at the carboxyl terminus of Zymomonas mobilis pyruvate decarboxylase on the kinetic properties and substrate specificity. Biochemistry 39 (2000) 9430-9437
-
(2000)
Biochemistry
, vol.39
, pp. 9430-9437
-
-
Chang, A.K.1
Nixon, P.F.2
Duggleby, R.G.3
-
7
-
-
0028103275
-
The CCP4 suite: programs for protein crystallography
-
CCP4 (Collaborative Computational Project, Number 4)
-
CCP4 (Collaborative Computational Project, Number 4). The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D Biol. Crystallogr. 50 (1994) 760-763
-
(1994)
Acta Crystallogr. D Biol. Crystallogr.
, vol.50
, pp. 760-763
-
-
-
8
-
-
0003845223
-
-
DeLano Scientific LLC, Palo Alto, CA (http://www.pymol.org)
-
DeLano W.L. The PyMOL Molecular Graphics System (2002), DeLano Scientific LLC, Palo Alto, CA. http://www.pymol.org (http://www.pymol.org)
-
(2002)
The PyMOL Molecular Graphics System
-
-
DeLano, W.L.1
-
9
-
-
33748345821
-
Domain relationships in thiamine diphosphate-dependent enzymes
-
Duggleby R.G. Domain relationships in thiamine diphosphate-dependent enzymes. Acc. Chem. Res. 39 (2006) 550-557
-
(2006)
Acc. Chem. Res.
, vol.39
, pp. 550-557
-
-
Duggleby, R.G.1
-
10
-
-
0015195921
-
Stereochemical aspects of pyridoxal phosphate catalysis
-
Dunathan H.C. Stereochemical aspects of pyridoxal phosphate catalysis. Adv. Enzymol. Relat. Areas Mol. Biol. 35 (1971) 79-134
-
(1971)
Adv. Enzymol. Relat. Areas Mol. Biol.
, vol.35
, pp. 79-134
-
-
Dunathan, H.C.1
-
11
-
-
13244281317
-
Coot: model-building tools for molecular graphics
-
Emsley P., and Cowtan K. Coot: model-building tools for molecular graphics. Acta Crystallogr. D60 (2004) 2126-2132
-
(2004)
Acta Crystallogr.
, vol.D60
, pp. 2126-2132
-
-
Emsley, P.1
Cowtan, K.2
-
12
-
-
0037154146
-
Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae
-
Fiedler E., Thorell S., Sandalova T., Golbik R., Konig S., and Schneider G. Snapshot of a key intermediate in enzymatic thiamin catalysis: crystal structure of the alpha-carbanion of (alpha,beta-dihydroxyethyl)-thiamin diphosphate in the active site of transketolase from Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 99 (2002) 591-595
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 591-595
-
-
Fiedler, E.1
Thorell, S.2
Sandalova, T.3
Golbik, R.4
Konig, S.5
Schneider, G.6
-
13
-
-
7444244483
-
A molecular switch and proton wire synchronize the active sites in thiamine enzymes
-
Frank R.A., Titman C.M., Pratap J.V., Luisi B.F., and Perham R.N. A molecular switch and proton wire synchronize the active sites in thiamine enzymes. Science 306 (2004) 872-876
-
(2004)
Science
, vol.306
, pp. 872-876
-
-
Frank, R.A.1
Titman, C.M.2
Pratap, J.V.3
Luisi, B.F.4
Perham, R.N.5
-
14
-
-
2542515099
-
Structure and intersubunit information transfer in the E. coli pyruvate dehydrogenase multienzyme complex
-
Jordan F., and Patel M.S. (Eds), Marcel Dekker, New York
-
Furey W., Arjunan P., Brunskill A., Chandrasekhar K., Nemeria N., Wei W., Yan Y., Zhang Z., and Jordan F. Structure and intersubunit information transfer in the E. coli pyruvate dehydrogenase multienzyme complex. In: Jordan F., and Patel M.S. (Eds). Thiamine: Catalytic Mechanisms in Normal and Disease State (2004), Marcel Dekker, New York 407-432
-
(2004)
Thiamine: Catalytic Mechanisms in Normal and Disease State
, pp. 407-432
-
-
Furey, W.1
Arjunan, P.2
Brunskill, A.3
Chandrasekhar, K.4
Nemeria, N.5
Wei, W.6
Yan, Y.7
Zhang, Z.8
Jordan, F.9
-
16
-
-
0026055156
-
Analysis of the steric strain in the polypeptide backbone of protein molecules
-
Herzberg O., and Moult J. Analysis of the steric strain in the polypeptide backbone of protein molecules. Proteins Struct. Funct. Genet. 11 (1991) 223-229
-
(1991)
Proteins Struct. Funct. Genet.
, vol.11
, pp. 223-229
-
-
Herzberg, O.1
Moult, J.2
-
17
-
-
0024520745
-
Site-directed mutagenesis by overlap extension using the polymerase chain reaction
-
Ho S.N., Hunt H.D., Horton R.M., Pullen J.K., and Pease L.R. Site-directed mutagenesis by overlap extension using the polymerase chain reaction. Gene 77 (1989) 51-59
-
(1989)
Gene
, vol.77
, pp. 51-59
-
-
Ho, S.N.1
Hunt, H.D.2
Horton, R.M.3
Pullen, J.K.4
Pease, L.R.5
-
18
-
-
4143147626
-
Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes
-
Jonsson S., Ricagno S., Lindqvist Y., and Richards N.G. Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes. J. Biol. Chem. 279 (2004) 36003-36012
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 36003-36012
-
-
Jonsson, S.1
Ricagno, S.2
Lindqvist, Y.3
Richards, N.G.4
-
19
-
-
2542536493
-
Yeast pyruvate decarboxylase: new features of the structure and mechanism
-
Jordan F., and Patel M.S. (Eds), Marcel Dekker, New York
-
Jordan F., Liu M., Sergienko E., Zhang Z., Brunskill A., Arjunan P., and Furey W. Yeast pyruvate decarboxylase: new features of the structure and mechanism. In: Jordan F., and Patel M.S. (Eds). Thiamine: Catalytic Mechanisms in Normal and Disease State (2004), Marcel Dekker, New York 173-215
-
(2004)
Thiamine: Catalytic Mechanisms in Normal and Disease State
, pp. 173-215
-
-
Jordan, F.1
Liu, M.2
Sergienko, E.3
Zhang, Z.4
Brunskill, A.5
Arjunan, P.6
Furey, W.7
-
20
-
-
18844421838
-
Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations
-
Jordan F., and Nemeria N.S. Experimental observation of thiamin diphosphate-bound intermediates on enzymes and mechanistic information derived from these observations. Bioorg. Chem. 33 (2005) 190-215
-
(2005)
Bioorg. Chem.
, vol.33
, pp. 190-215
-
-
Jordan, F.1
Nemeria, N.S.2
-
21
-
-
26644459701
-
Multiple modes of active center communication in thiamin diphosphate-dependent enzymes
-
Jordan F., Nemeria N.S., and Sergienko E. Multiple modes of active center communication in thiamin diphosphate-dependent enzymes. Acc. Chem. Res. 38 (2005) 755-763
-
(2005)
Acc. Chem. Res.
, vol.38
, pp. 755-763
-
-
Jordan, F.1
Nemeria, N.S.2
Sergienko, E.3
-
22
-
-
0031013992
-
How thiamine diphosphate is activated in enzymes
-
Kern D., Kern G., Neef H., Tittmann K., Killenberg-Jabs M., Wikner C., Schneider G., and Hubner G. How thiamine diphosphate is activated in enzymes. Science 275 (1997) 67-70
-
(1997)
Science
, vol.275
, pp. 67-70
-
-
Kern, D.1
Kern, G.2
Neef, H.3
Tittmann, K.4
Killenberg-Jabs, M.5
Wikner, C.6
Schneider, G.7
Hubner, G.8
-
23
-
-
0343118726
-
Role of Glu51 for cofactor binding and catalytic activity in pyruvate decarboxylase from yeast studied by site-directed mutagenesis
-
Killenberg-Jabs M., Konig S., Eberhardt I., Hohmann S., and Hubner G. Role of Glu51 for cofactor binding and catalytic activity in pyruvate decarboxylase from yeast studied by site-directed mutagenesis. Biochemistry 36 (1997) 1900-1905
-
(1997)
Biochemistry
, vol.36
, pp. 1900-1905
-
-
Killenberg-Jabs, M.1
Konig, S.2
Eberhardt, I.3
Hohmann, S.4
Hubner, G.5
-
24
-
-
9444292861
-
Effects of deletions at the C-terminus of tobacco acetohydroxyacid synthase on the enzyme activity and cofactor binding
-
Kim J., Beak D.G., Kim Y.T., Choi J.D., and Yoon M.Y. Effects of deletions at the C-terminus of tobacco acetohydroxyacid synthase on the enzyme activity and cofactor binding. Biochem. J. 384 (2004) 59-68
-
(2004)
Biochem. J.
, vol.384
, pp. 59-68
-
-
Kim, J.1
Beak, D.G.2
Kim, Y.T.3
Choi, J.D.4
Yoon, M.Y.5
-
26
-
-
23844537501
-
Studies on thiamine diphosphate-dependent enzymes
-
Leeper F.J., Hawksley D., Mann S., Perez Melero C., and Wood M.D. Studies on thiamine diphosphate-dependent enzymes. Biochem. Soc. Trans. 33 (2005) 772-775
-
(2005)
Biochem. Soc. Trans.
, vol.33
, pp. 772-775
-
-
Leeper, F.J.1
Hawksley, D.2
Mann, S.3
Perez Melero, C.4
Wood, M.D.5
-
27
-
-
34447271442
-
-
Leslie, A.G.W. (1992). Recent changes to the MOSFLM package for processing film and image plate data. Joint CCP4 and ESF-EAMCB Newsletter on Protein Crystallography, No. 26.
-
-
-
-
28
-
-
0026762799
-
Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution
-
Lindqvist Y., Schneider G., Ermler U., and Sundstrom M. Three-dimensional structure of transketolase, a thiamine diphosphate dependent enzyme, at 2.5 A resolution. EMBO J. 11 (1992) 2373-2379
-
(1992)
EMBO J.
, vol.11
, pp. 2373-2379
-
-
Lindqvist, Y.1
Schneider, G.2
Ermler, U.3
Sundstrom, M.4
-
29
-
-
32044466028
-
A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase
-
Machius M., Wynn R.M., Chuang J.L., Li J., Kluger R., Yu D., Tomchick D.R., Brautigam C.A., and Chuang D.T. A versatile conformational switch regulates reactivity in human branched-chain alpha-ketoacid dehydrogenase. Structure 14 (2006) 287-298
-
(2006)
Structure
, vol.14
, pp. 287-298
-
-
Machius, M.1
Wynn, R.M.2
Chuang, J.L.3
Li, J.4
Kluger, R.5
Yu, D.6
Tomchick, D.R.7
Brautigam, C.A.8
Chuang, D.T.9
-
30
-
-
3042826869
-
Inhibition of thiamin diphosphate dependent enzymes by 3-deazathiamin diphosphate
-
Mann S., Perez Melero C., Hawksley D., and Leeper F.J. Inhibition of thiamin diphosphate dependent enzymes by 3-deazathiamin diphosphate. Org. Biomol. Chem. 2 (2004) 1732-1741
-
(2004)
Org. Biomol. Chem.
, vol.2
, pp. 1732-1741
-
-
Mann, S.1
Perez Melero, C.2
Hawksley, D.3
Leeper, F.J.4
-
32
-
-
1642355234
-
Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography
-
Nakai T., Nakagawa N., Maoka N., Masui R., Kuramitsu S., and Kamiya N. Ligand-induced conformational changes and a reaction intermediate in branched-chain 2-oxo acid dehydrogenase (E1) from Thermus thermophilus HB8, as revealed by X-ray crystallography. J. Mol. Biol. 337 (2004) 1011-1033
-
(2004)
J. Mol. Biol.
, vol.337
, pp. 1011-1033
-
-
Nakai, T.1
Nakagawa, N.2
Maoka, N.3
Masui, R.4
Kuramitsu, S.5
Kamiya, N.6
-
33
-
-
33846041174
-
The 1′4′-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes
-
Nemeria N., Chakraborty S., Baykal A., Korotchkina L.G., Patel M.S., and Jordan F. The 1′4′-iminopyrimidine tautomer of thiamin diphosphate is poised for catalysis in asymmetric active centers on enzymes. Proc. Natl. Acad. Sci. USA 104 (2007) 78-82
-
(2007)
Proc. Natl. Acad. Sci. USA
, vol.104
, pp. 78-82
-
-
Nemeria, N.1
Chakraborty, S.2
Baykal, A.3
Korotchkina, L.G.4
Patel, M.S.5
Jordan, F.6
-
34
-
-
0013140574
-
Synthesis and crystal structure of an analogue of 2-(a-lactyl)thiamin, racemic methyl 2-hydroxy-2-(2-thiamin ethylphosphonate chloride trihydrate: a conformation for a least-motion, maximum-overlap mechanism for thiamin catalysis
-
Turano A., Furey W., Pletcher J., Sax M., Pike D., and Kluger R. Synthesis and crystal structure of an analogue of 2-(a-lactyl)thiamin, racemic methyl 2-hydroxy-2-(2-thiamin ethylphosphonate chloride trihydrate: a conformation for a least-motion, maximum-overlap mechanism for thiamin catalysis. J. Am. Chem. Soc. 104 (1982) 3089-3095
-
(1982)
J. Am. Chem. Soc.
, vol.104
, pp. 3089-3095
-
-
Turano, A.1
Furey, W.2
Pletcher, J.3
Sax, M.4
Pike, D.5
Kluger, R.6
-
35
-
-
0000560808
-
MOLREP: an automated program for molecular replacement
-
Vagin A., and Teplyakov A. MOLREP: an automated program for molecular replacement. J. Appl. Crystallogr. 30 (1997) 1022-1025
-
(1997)
J. Appl. Crystallogr.
, vol.30
, pp. 1022-1025
-
-
Vagin, A.1
Teplyakov, A.2
-
36
-
-
0028575439
-
Analysis of an invariant cofactor-protein interaction in thiamin diphosphate-dependent enzymes by site-directed mutagenesis: glutamic acid 418 in transketolase is essential for catalysis
-
Wikner C., Meshalkina L., Nilsson U., Nikkola M., Lindqvist Y., Sundstrom M., and Schneider G. Analysis of an invariant cofactor-protein interaction in thiamin diphosphate-dependent enzymes by site-directed mutagenesis: glutamic acid 418 in transketolase is essential for catalysis. J. Biol. Chem. 269 (1994) 32144-32150
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 32144-32150
-
-
Wikner, C.1
Meshalkina, L.2
Nilsson, U.3
Nikkola, M.4
Lindqvist, Y.5
Sundstrom, M.6
Schneider, G.7
-
37
-
-
33646894143
-
The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography
-
Wille G., Meyer D., Steinmetz A., Hinze E., Golbik R., and Tittmann K. The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography. Nat. Chem. Biol. 2 (2006) 324-328
-
(2006)
Nat. Chem. Biol.
, vol.2
, pp. 324-328
-
-
Wille, G.1
Meyer, D.2
Steinmetz, A.3
Hinze, E.4
Golbik, R.5
Tittmann, K.6
-
38
-
-
14044251561
-
Evidence for dramatic acceleration of a C-H bond ionization rate in thiamin diphosphate enzymes by the protein environment
-
Zhang S., Zhou L., Nemeria N., Yan Y., Zhang Z., Zou Y., and Jordan F. Evidence for dramatic acceleration of a C-H bond ionization rate in thiamin diphosphate enzymes by the protein environment. Biochemistry 44 (2005) 2237-2243
-
(2005)
Biochemistry
, vol.44
, pp. 2237-2243
-
-
Zhang, S.1
Zhou, L.2
Nemeria, N.3
Yan, Y.4
Zhang, Z.5
Zou, Y.6
Jordan, F.7
|