Antitumor and antioxidant activity of spin labeled derivatives of podophyllotoxin (GP-1) and congeners

Life Sciences

Volumn 70, Issue 20, 2002, Pages 2433-2443

  Tian, Xuan ^a   Zhang, Fu min ^a   Li, Wen guang ^b  

^a LANZHOU UNIVERSITY   (China)

^b LANZHOU MEDICAL COLLEGE   (China)

Author keywords

Antioxidant activity; Antitumor activity; EPR measurement; Nitroxide; Podophyllotoxin congeners

Indexed keywords

FERROUS ASCORBATE; MALONALDEHYDE; PODOPHYLLIC ACID [4 (2,2,6,6 TETRAMETHYL 1 PIPERIDYL)]HYDRAZONE; PODOPHYLLIC ACID [4 (2,2,6,6 TETRAMETHYL 1 PIPERIDYLOXY)]HYDRAZONE; PODOPHYLLIC ACID [4 (2,2,6,6 TETRAMETHYL 1 PIPERIDYLOXYAMINE)]HYDRAZONE; PODOPHYLLOTOXIN DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CAROTID ARTERY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG SYNTHESIS; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE; IONIZATION; LIPOPHILICITY; LIVER HOMOGENATE; MALE; MOUSE; NONHUMAN; OXIDATION REDUCTION POTENTIAL; PARTITION COEFFICIENT; PEROXIDATION;

ANIMALS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; ANTIOXIDANTS; CHEMISTRY, PHYSICAL; ELECTROCHEMISTRY; ELECTRON SPIN RESONANCE SPECTROSCOPY; LETHAL DOSE 50; LIPID PEROXIDATION; MALE; MICE; OXIDATION-REDUCTION; PODOPHYLLOTOXIN; POTENTIOMETRY; RATS; RATS, WISTAR; SOLUBILITY; SPIN LABELS; STRUCTURE-ACTIVITY RELATIONSHIP; TUMOR CELLS, CULTURED;

RATTUS NORVEGICUS;

EID: 0037023256     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0024-3205(02)01482-0     Document Type: Article

References (19)

1. Spin-labeled medicines: Enzymes, biomembranes and possible pharmaceuticals. A Overview
2. In the search for new anticancer drugs 19. A predictive design of N,N:N′, N′: N″, N″-tri-1,2-ethanediyl phosphoric triamide (TEPA) analogues
3. In the search for new anticancer drugs 29. A study on the correaltion of lipophilicitied, ionization constants and anticancer activities of aminoxyl labeled TEPA congeners
4. Nitroxyl radical tempol as a modulator of 6-mercaptopurine toxicity and antitumor activity
5. Studies of structure-activity relationship of nitroxide free radicals and their precursors as modifiers against oxidative damage
6. Spin-labeled antitumor derivatives of podohyllotoxin
7. Anticancer drugs II Synthesis and biological evaluation of spin labeled derivatives of podophyllotoxin
8. Antitumor activity of a new immunosup pressive derivative of podophyllotoxin (GP-11) and its mechanisms
9. Synthesis and antitumor activity of spin labeled derivatives of podophyllotoxin
10. The quest for a predictive design of antiancer drugs
11. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
12. Direct evidence for in vivo nitroxide free radical production from a new antiarrhythmic drug by EPR spectroscopy
13. New antiarrhythmic agents,2,2,5,5-tetra-methyl-3-pyrroline-3-carboxamides and 2,2,5,5-tetramethylidine-3-carboxamides
14. Hemodynamic effect of the nitroxide superoxide dismutase mimics
15. Antioxidative actvity of 4-oxy-and 4-hydroxy-nitroxides in tissues and erythrocytes from rats
16. - or as SOD mimics?