Inflammatory response and barrier properties of a new alveolar type 1-like cell line (TT1)

Pharmaceutical Research

Volumn 26, Issue 5, 2009, Pages 1172-1180

  Van Den Bogaard, Ellen H J ^a,b   Dailey, Lea Ann ^a   Thorley, Andrew J ^c   Tetley, Teresa D ^c   Forbes, Ben ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

^b RADBOUD UNIVERSITY NIJMEGEN   (Netherlands)

^c NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

Author keywords

Alveolar type 1 like cell line; Barrier properties; Inflammatory response; LPS; Tight junctions

Indexed keywords

FLUORESCEIN SODIUM; INTERLEUKIN 6; INTERLEUKIN 8; LIPOPOLYSACCHARIDE; PROTEIN ZO1;

ARTICLE; CELL CULTURE; CELL FUNCTION; CELL LINE; CELL MEMBRANE PERMEABILITY; CYTOKINE RELEASE; ELECTRIC RESISTANCE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; INFLAMMATION; LUNG ALVEOLUS CELL TYPE 1; PRIORITY JOURNAL; QUANTITATIVE ASSAY; TRANSEPITHELIAL ELECTRICAL RESISTANCE; TRANSFORMED TYPE I CELL LINE;

CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL MEMBRANE PERMEABILITY; CELLS, CULTURED; CYTOKINES; ELECTRIC IMPEDANCE; ESCHERICHIA COLI; HUMANS; LIPOPOLYSACCHARIDES; LUNG; PHARMACEUTICAL PREPARATIONS; PROTEINS; TIGHT JUNCTIONS;

EID: 63949085542     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-009-9838-x     Document Type: Article

References (42)

1. J. D. Crapo B. E. Barry P. Gehr M. Bachofen E. R. Weibel 1982 Cell number and cell characteristics of the normal human lung Am. Rev. Respir Dis. 126 332 337
2. J. M. Cheek K. J. Kim E. D. Crandall 1989 Tight monolayers of rat alveolar epithelial cells: bioelectric properties and active sodium transport Am. J. Physiol. 256 C688 693
3. A. N. Dodoo S. S. Bansal D. J. Barlow F. Bennet R. C. Hider A. B. Lansley M. J. Lawrence C. Marriott 2000 Use of alveolar cell monolayers of varying electrical resistance to measure pulmonary peptide transport J. Pharm. Sci. 89 223 231
4. Y. Matsukawa H. Yamahara F. Yamashita V. H. Lee E. D. Crandall K. J. Kim 2000 Rates of protein transport across rat alveolar epithelial cell monolayers J. Drug Target. 7 335 342
5. M. D. Johnson J. H. Widdicombe L. Allen P. Barbry L. G. Dobbs 2002 Alveolar epithelial type I cells contain transport proteins and transport sodium, supporting an active role for type I cells in regulation of lung liquid homeostasis Proc. Natl. Acad. Sci. U. S. A. 99 1966 1971
6. H. Fehrenbach 2001 Alveolar epithelial type II cell: defender of the alveolus revisited Respir. Res. 2 33 46
7. G. Diamond D. Legarda L. K. Ryan 2000 The innate immune response of the respiratory epithelium Immunol. Rev. 173 27 38
8. E. L. Roggen N. K. Soni G. R. Verheyen 2006 Respiratory immunotoxicity: an in vitro assessment Toxicol. In Vitro. 20 1249 1264
9. S. J. Kemp A. J. Thorley J. Gorelik M. J. Seckl M. J. O'Hare A. Arcaro Y. Korchev P. Goldstraw T. D. Tetley 2008 Immortalisation of human alveolar epithelial cells to investigate nanoparticle uptake Am. J. Respir. Cell. Mol. Biol. 39 591 597
10. K. J. Kim Z. Borok E. D. Crandall 2001 A useful in vitro model for transport studies of alveolar epithelial barrier Pharm. Res. 18 253 255
11. F. Blank B. M. Rothen-Rutishauser S. Schurch P. Gehr 2006 An optimized in vitro model of the respiratory tract wall to study particle cell interactions J. Aerosol. Med. 19 392 405
12. L. Horalkova, S. Endter, R. Koslowski, and C. Ehrhardt. Characteristics of the rat alveolar epithelial type I-like cell line R3/1 for use as an in vitro model of pulmonary drug disposition. Eur. J. Pharm. Sci. (2008), doi: 10.1016/j.ejps.2008.11.010
13. R. Koslowski K. Barth A. Augstein T. Tschernig G. Bargsten M. Aufderheide M. Kasper 2004 A new rat type I-like alveolar epithelial cell line R3/1: bleomycin effects on caveolin expression Histochem. Cell. Biol. 121 509 519
14. A. Luhrmann G. Bargsten M. Kuzu R. Koslowski R. Pabst T. Tschernig 2007 The alveolar epithelial type I-like cell line as an adequate model for leukocyte migration studies in vitro Exp. Toxicol. Pathol. 58 277 283
15. M. P. Steele R. A. Levine M. Joyce-Brady J. S. Brody 1992 A rat alveolar type II cell line developed by adenovirus 12SE1A gene transfer Am. J. Respir. Cell. Mol. Biol. 6 50 56
16. K. J. Kim. Models for investigation of peptide and protein transport across cultured mammalian respiratory epithelial barriers. In R. T. Borchardt (ed.), Models for Assessing Drug Absorption and Metabolism, Plenum, New York, 1996, pp. 325-346.
17. A. Steimer H. Franke E. Haltner-Ukomado M. Laue C. Ehrhardt C.M. Lehr 2007 Monolayers of porcine alveolar epithelial cells in primary culture as an in vitro model for drug absorption studies Eur. J. Pharm. Biopharm. 66 372 382
18. M. Bur H. Huwer C. M. Lehr N. Hagen M. Guldbrandt K. J. Kim C. Ehrhardt 2006 Assessment of transport rates of proteins and peptides across primary human alveolar epithelial cell monolayers Eur. J. Pharm. Sci. 28 196 203
19. K. J. Elbert U. F. Schafer H. J. Schafers K. J. Kim V. H. Lee C. M. Lehr 1999 Monolayers of human alveolar epithelial cells in primary culture for pulmonary absorption and transport studies Pharm. Res. 16 601 608
20. M. I. Hermanns R. E. Unger K. Kehe K. Peters C. J. Kirkpatrick 2004 Lung epithelial cell lines in coculture with human pulmonary microvascular endothelial cells: development of an alveolo-capillary barrier in vitro Lab. Invest. 84 736 752
21. A. S. Fanning B. J. Jameson L. A. Jesaitis J. M. Anderson 1998 The tight junction protein ZO-1 establishes a link between the transmembrane protein occludin and the actin cytoskeleton J. Biol. Chem. 273 29745 29753
22. G. Imanidis C. Waldner C. Mettler H. Leuenberger 1996 An improved diffusion cell design for determining drug transport parameters across cultured cell monolayers J. Pharm. Sci. 85 1196 1203
23. Q. M. Ningand X. R. Wang 2007 Response of alveolar type II epithelial cells to mechanical stretch and lipopolysaccharide Respiration. 74 579 585
24. C. Schulz L. Farkas K. Wolf K. Kratzel G. Eissner M. Pfeifer 2002 Differences in LPS-induced activation of bronchial epithelial cells (BEAS-2B) and type II-like pneumocytes (A-549) Scand. J. Immunol. 56 294 302
25. C. Monteiller L. Tran W. MacNee S. Faux A. Jones B. Miller K. Donaldson 2007 The pro-inflammatory effects of low-toxicity low-solubility particles, nanoparticles and fine particles, on epithelial cells in vitro: the role of surface area Occup. Environ. Med. 64 609 615
26. C. M. Sayes K. L. Reed D. B. Warheit 2007 Assessing toxicity of fine and nanoparticles: comparing in vitro measurements to in vivo pulmonary toxicity profiles Toxicol. Sci. 97 163 180
27. C. C. dos Santos B. Han C. F. Andrade X. Bai S. Uhlig R. Hubmayr M. Tsang M. Lodyga S. Keshavjee A. S. Slutsky M. Liu 2004 DNA microarray analysis of gene expression in alveolar epithelial cells in response to TNFalpha, LPS, and cyclic stretch Physiol. Genomics. 19 331 342
28. A. J. Thorley P. A. Ford M. A. Giembycz P. Goldstraw A. Young T. D. Tetley 2007 Differential regulation of cytokine release and leukocyte migration by lipopolysaccharide-stimulated primary human lung alveolar type II epithelial cells and macrophages J. Immunol. 178 463 473
29. J. M. Sallenave 2002 Antimicrobial activity of antiproteinases Biochem. Soc. Trans. 30 111 115
30. P. S. Hiemstra R. J. Maassen J. Stolk R. Heinzel-Wieland G. J. Steffens J. H. Dijkman 1996 Antibacterial activity of antileukoprotease Infect. Immun. 64 4520 4524
31. A. J. Simpson A. I. Maxwell J. R. Govan C. Haslett J. M. Sallenave 1999 Elafin (elastase-specific inhibitor) has anti-microbial activity against Gram-positive and Gram-negative respiratory pathogens FEBS Lett. 452 309 313
32. L. Bingle T. D. Tetley C. D. Bingle 2001 Cytokine-mediated induction of the human elafin gene in pulmonary epithelial cells is regulated by nuclear factor-kappaB Am. J. Respir. Cell. Mol. Biol. 25 84 91
33. J. M. Sallenave J. Shulmann J. Crossley M. Jordana J. Gauldie 1994 Regulation of secretory leukocyte proteinase inhibitor (SLPI) and elastase-specific inhibitor (ESI/elafin) in human airway epithelial cells by cytokines and neutrophilic enzymes Am. J. Respir. Cell. Mol. Biol. 11 733 741
34. P. A. Dickinson J. P. Evans S. J. Farr I. W. Kellaway T. P. Appelqvist A. C. Hann R. J. Richards 1996 Putrescine uptake by alveolar epithelial cell monolayers exhibiting differing transepithelial electrical resistances J. Pharm. Sci. 85 1112 1116
35. C. I. Grainger L. L. Greenwell D. J. Lockley G. P. Martin B. Forbes 2006 Culture of Calu-3 cells at the air interface provides a representative model of the airway epithelial barrier Pharm. Res. 23 1482 1490
36. W. Yang J. I. Peters R. O. Williams III 2008 Inhaled nanoparticles-a current review Int. J. Pharm. 356 239 247
37. P. G. A. Rogueda, and D. Traini. The nanoscale in pulmonary delivery. Part 1: deposition, fate toxicology and effects. Expert Opin. Drug Deliv. 4(6):595-606.
38. U. B. Endter N. Daum H. Huwer C. M. Lehr M. Gumbleton C. Ehrhardt 2007 P-glycoprotein (MDR1) functional activity in human alveolar epithelial cell monolayers Cell Tissue. Res. 328 77 84
39. D. C. Gruenert C. B. Basbaum M. J. Welsh M. Li W. E. Finkbeiner J. A. Nadel 1988 Characterization of human tracheal epithelial cells transformed by an origin-defective simian virus 40 Proc. Natl. Acad. Sci. U. S. A. 85 5951 5955
40. D. M. Jefferson J. D. Valentich F. C. Marini S. A. Grubman M. C. Iannuzzi H. L. Dorkin M. Li K. W. Klinger M. J. Welsh 1990 Expression of normal and cystic fibrosis phenotypes by continuous airway epithelial cell lines Am. J. Physiol. 259 L496 505
41. U. Hopfer J. W. Jacobberger D. C. Gruenert R. L. Eckert P. S. Jat J. A. Whitsett 1996 Immortalization of epithelial cells Am. J. Physiol. 270 C1 11
42. K. Lee K. Choi O. M. Quellette 2004 Use of exogenous hTERT to immortalize primary human cells Cytotechnology. 45 33 38