Enhanced corneal absorption of erythromycin by modulating P-glycoprotein and MRP mediated efflux with corticosteroids

Pharmaceutical Research

Volumn 26, Issue 5, 2009, Pages 1270-1282

  Hariharan, Sudharshan ^a   Gunda, Sriram ^a   Mishra, Gyan P ^a   Pal, Dhananjay ^a   Mitra, Ashim K ^a  

^a UNIVERSITY OF MISSOURI KANSAS CITY   (United States)

Author keywords

Corneal epithelium; Corticosteroids; Erythromycin; Microdialysis; Multidrug resistance associated protein (MRP); Ocular pharmacokinetics; P glycoprotein (P gp)

Indexed keywords

6ALPHA METHYL PREDNISOLONE; CORTICOSTEROID; ERYTHROMYCIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 2; UNCLASSIFIED DRUG;

AQUEOUS HUMOR; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN; CORNEA EPITHELIUM; DRUG ABSORPTION; DRUG INHIBITION; MAXIMUM PLASMA CONCENTRATION; PKA; PRIORITY JOURNAL; RABBIT; SINGLE DRUG DOSE;

ABSORPTION; ADRENAL CORTEX HORMONES; ANIMALS; BIOLOGICAL TRANSPORT; CELL LINE; CELL PROLIFERATION; CELLS, CULTURED; EPITHELIUM, CORNEAL; ERYTHROMYCIN; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; P-GLYCOPROTEIN; RABBITS; UP-REGULATION;

EID: 63849344988     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-008-9741-x     Document Type: Article

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