Type 2 diabetic mice have increased arteriolar tone and blood pressure: Enhanced release of COX-2-derived constrictor prostaglandins

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 25, Issue 8, 2005, Pages 1610-1616

  Bagi, Zsolt ^a,c   Erdei, Nora ^c   Toth, Attila ^c   Li, Wei ^a   Hintze, Thomas H ^d   Koller, Akos ^a,b   Kaley, Gabor ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b SEMMELWEIS UNIVERSITY   (Hungary)

^c UNIVERSITY OF DEBRECEN   (Hungary)

^d NONE

Author keywords

Basal arteriolar tone; Cyclooxygenase 2; Microvessels; Type 2 diabetes mellitus

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; 7 [3 [(4 PHENYLSEMICARBAZIDO)METHYL] 7 OXABICYCLO[2.2.1]HEPT 2 YL] 5 HEPTENOIC ACID; CALCIUM ION; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ISOENZYME; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; THROMBOXANE RECEPTOR BLOCKING AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTERIAL PRESSURE; ARTERIOLE; ARTERY DIAMETER; ARTERY TONE; ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; ECHOCARDIOGRAPHY; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GRACILIS MUSCLE; HEART OUTPUT; HYPERTENSION; MALE; MEAN ARTERIAL PRESSURE; MOUSE; MOUSE STRAIN; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROSTAGLANDIN RELEASE; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; SYSTOLIC BLOOD PRESSURE; VASCULAR RESISTANCE; VASOMOTOR REFLEX;

ANIMALS; AORTA; ARACHIDONIC ACID; ARTERIOLES; BLOOD PRESSURE; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; DIABETES MELLITUS, TYPE 2; DIABETIC ANGIOPATHIES; MALE; MICE; MICE, INBRED C57BL; MICE, MUTANT STRAINS; MUSCLE, SKELETAL; PROSTAGLANDINS; VASCULAR RESISTANCE; VASOCONSTRICTION;

EID: 23244461051     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000172688.26838.9f     Document Type: Article

References (37)

1. Turner RC, Millns H, Neil HA, Stratton IM, Manley SE, Matthews DR, Holman RR. Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom Prospective Diabetes Study (UKPDS: 23). BMJ. 1998;316:823-828.
2. Sowers JR, Epstein M, Frohlich ED. Diabetes, hypertension, and cardiovascular disease: an update. Hypertension. 2001;37:1053-1059.
3. Stehouwer CD, Lambert J, Donker AJ, van Hinsbergh VW. Endothelial dysfunction and pathogenesis of diabetic angiopathy. Cardiovasc Res. 1997;34:55-68.
4. De Vriese AS, Verbeuren TJ, Van de Voorde J, Lameire NH, Vanhoutte PM. Endothelial dysfunction in diabetes. Br J Pharmacol. 2000;130:963-974.
5. Frisbee JC, Maier KG, Stepp DW. Oxidant stress-induced increase in myogenic activation of skeletal muscle resistance arteries in obese Zucker rats. Am J Physiol Heart Circ Physiol. 2002;283:2160-2168.
6. Lagaud GJ, Masih-Khan E, Kai S, van Breemen C, Dube GP. Influence of type II diabetes on arterial tone and endothelial function in murine mesenteric resistance arteries. J Vasc Res. 2001;38:578-589.
7. Schofield I, Malik R, Izzard A, Austin C, Heagerty A. Vascular structural and functional changes in type 2 diabetes mellitus: evidence for the roles of abnormal myogenic responsiveness and dyslipidemia. Circulation. 2002;106:3037-3043.
8. Caballero AE, Arora S, Saouaf R, Lim SC, Smakowski P, Park JY, King GL, LoGerfo FW, Horton ES, Veves A. Microvascular and macrovascular reactivity is reduced in subjects at risk for type 2 diabetes. Diabetes. 1999;48:1856-1862.
9. Erdos B, Miller AW, Busija DW. Impaired endothelium-mediated relaxation in isolated cerebral arteries from insulin-resistant rats. Am J Physiol Heart Circ Physiol. 2002;282:2060-2065.
10. Pannirselvam M, Verma S, Anderson TJ, Triggle CR. Cellular basis of endothelial dysfunction in small mesenteric arteries from spontaneously diabetic (db/db -/-) mice: role of decreased tetrahydrobiopterin bioavailability. Br J Pharmacol. 2002;136:255-263.
11. Bagi Z, Koller A, Kaley G. Superoxide-NO interaction decreases flow- and agonist-induced dilation of coronary arterioles in type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol. 2003;285:H1404-H1410.
12. Caballero AE. Endothelial dysfunction, inflammation, and insulin resistance: a focus on subjects at risk for type 2 diabetes. Curr Diab Rep. 2004;4:237-246.
13. Helmersson J, Vessby B, Larsson A, Basu S. Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population. Circulation. 2004;109:1729-1734.
14. Higgs GA, Moncada S, Vane JR. Eicosanoids in inflammation. Ann Clin Res. 1984;16:287-299.
15. Koller A, Kaley G. Prostaglandins mediate arteriolar dilation to increased blood flow velocity in skeletal muscle microcirculation. Circ Res. 1990;67:529-534.
16. Koller A, Kaley G. A new role for prostaglandins in the regulation of peripheral resistance. Adv Prostaglandin Thromboxane Leukot Res 1991;595-598.
17. Myers TO, Messina EJ, Rodrigues AM, Gerritsen ME. Altered aortic and cremaster muscle prostaglandin synthesis in diabetic rats. Am J Physiol. 1985;249:374-379.
18. Sterin-Borda L, Franchi AM, Borda ES, Del Castillo E, Gimeno MF, Gimeno AL, Sterin Borda I. Augmented thromboxane generation by mesenteric arteries from pancreatectomized diabetic dogs is coincident with the vascular tone enhancement evoked by Na-arachidonate and prostacyclin. Eur J Pharmacol. 1984;103:211-221.
19. Okon EB, Szado T, Laher I, McManus B, van Breemen C. Augmented contractile response of vascular smooth muscle in a diabetic mouse model. J Vasc Res. 2003;40:520-530.
20. Mitchell JA, Warner TD. Cyclo-oxygenase-2: pharmacology, physiology, biochemistry and relevance to NSAID therapy. Br J Pharmacol. 1999;128:1121-1132.
21. Cosentino F, Eto M, De Paolis P, van der Loo B, Bachschmid M, Ullrich V, Kouroedov A, Delli Gatti C, Joch H, Volpe M, Luscher TF. High glucose causes upregulation of cyclooxygenase-2 and alters prostanoid profile in human endothelial cells: role of protein kinase C and reactive oxygen species. Circulation. 2003;107:1017-1023.
22. Quilley J, Chen Y-J. Role of COX-2 in the enhanced vasoconstrictor effect of arachidonic acid in the diabetic rat kidney. Hypertension. 2003;42:837-843.
23. Davidge ST. Prostaglandin H synthase and vascular function. Circ Res. 2001;89:650-660.
24. Bagi Z, Koller A, Kaley G. PPAR-γ activation, by reducing oxidative stress, increases NO bioavailability in coronary arterioles of mice with type 2 diabetes. Am J Physiol Heart Circ Physiol. 2004;286:H742-H748.
25. 2 and intracellular myoglobin. Am J Physiol Heart Circ Physiol. 2004;286:H47-H54.
26. Jackson PA, Duling BR. Myogenic response and wall mechanics of arterioles. Am J Physiol. 1989;257:H1147-H1155.
27. Sorof J, Daniels S. Obesity hypertension in children: a problem of epidemic proportions. Hypertension. 2002;40:441-447.
28. Davis MJ, Hill MA. Signaling mechanisms underlying the vascular myogenic response. Physiol Rev. 1999;79:387-423.
29. 2+ signaling pathways underlying myogenic reactivity. J Appl Physiol. 2001;91:973-983.
30. Jaap AJ, Shore AC, Tooke JE. The influence of hypertension on microvascular blood flow and resistance to flow in the skin of patients with type 2 (non-insulin-dependent) diabetes. Diabet Med. 1994;11:883-887.
31. Koller A. Signaling pathways of mechanotransduction in arteriolar endothelium and smooth muscle cells in hypertension. Microcirculation. 2002;9:277-294.
32. Parente L, Perretti M. Advances in the pathophysiology of constitutive and inducible cyclooxygenases: two enzymes in the spotlight. Biochem Pharmacol. 2003;65:153-159.
33. Kiritoshi S, Nishikawa T, Sonoda K, Kukidome D, Senokuchi T, Matsuo T, Matsumura T, Tokunaga H, Brownlee M, Araki E. Reactive oxygen species from mitochondria induce cyclooxygenase-2 gene expression in human mesangial cells: potential role in diabetic nephropathy. Diabetes. 2003;52:2570-2577.
34. Baber SR, Champion HC, Bivalacqua TJ, Hyman AL, Kadowitz PJ. Role of cyclooxygenase-2 in the generation of vasoactive prostanoids in the rat pulmonary and systemic vascular beds. Circulation. 2003;108:896-901.
35. Belton OA, Duffy A, Toomey S, Fitzgerald DJ. Cyclooxygenase isoforms and platelet vessel wall interactions in the apolipoprotein E knockout mouse model of atherosclerosis. Circulation. 2003;108:3017-3023.
36. Cseko C, Bagi Z, Koller A. Biphasic effect of hydrogen peroxide on skeletal muscle arteriolar tone via activation of endothelial and smooth muscle signaling pathways. J Appl Physiol. 2004;97:1130-1137.
37. Wang D, Chabrashvili T, Wilcox CS. Enhanced contractility of renal afferent arterioles from angiotensin-infused rabbits: roles of oxidative stress, thromboxane prostanoid receptors, and endothelium. Circ Res. 2004;94:1436-1442.