Protein kinase A is activated by the n-3 polyunsaturated fatty acid eicosapentaenoic acid in rat ventricular muscle

Journal of Physiology

Volumn 582, Issue 1, 2007, Pages 349-358

  Szentandrássy, Norbert ^a   Perez Bido M R ^b   Alonzo, E ^c   Negretti, N ^b   O'neill, Stephen C ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSIDAD CENTRAL DE VENEZUELA   (Venezuela)

^c HOSPITAL UNIVERSITARIO DE CARACAS   (Venezuela)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CALCIUM CHANNEL L TYPE; CALCIUM ION; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; ICOSAPENTAENOIC ACID; OMEGA 3 FATTY ACID; PHOSPHOLAMBAN; ADENOSINE TRIPHOSPHATASE (CALCIUM);

ANIMAL CELL; ANIMAL TISSUE; ANTIARRHYTHMIC ACTIVITY; ARTICLE; CELL ISOLATION; CELL SURVIVAL; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTOLIC DYSFUNCTION; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; HEART CONTRACTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE POTENTIAL; HEART PROTECTION; HEART VENTRICLE; ISOLATED HEART; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN PHOSPHORYLATION; RAT; WESTERN BLOTTING; ACTION POTENTIAL DURATION; ADULT; AMPLITUDE MODULATION; CALCIUM CURRENT; HEART MUSCLE RELAXATION; HEART VENTRICLE CONTRACTION; MALE; SARCOPLASMIC RETICULUM; SODIUM CALCIUM EXCHANGE;

ACTION POTENTIALS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CALCIUM CHANNELS, L-TYPE; CALCIUM SIGNALING; CALCIUM-BINDING PROTEINS; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DEPRESSION, CHEMICAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EICOSAPENTAENOIC ACID; ENZYME ACTIVATION; HEART; HEART VENTRICLES; ISOQUINOLINES; MALE; MICROFILAMENTS; MYOCARDIAL CONTRACTION; MYOCYTES, CARDIAC; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; RATS, WISTAR; SULFONAMIDES;

EID: 34347259575     PISSN: 00223751     EISSN: 14697793     Source Type: Journal    
DOI: 10.1113/jphysiol.2007.132753     Document Type: Article

References (40)

1. Arita K, Kobuchi H, Utsumi T, Takehara Y, Akiyama J, Horton AA & Utsumi K (2001). Mechanism of apoptosis in HL-60 cells induced by n-3 and n-6 polyunsaturated fatty acids. Biochem Pharmacol 62, 821-828.
2. Bassani RA, Mattiazzi A & Bers DM (1995). CaMKII is responsible for activity-dependent acceleration of relaxation in rat ventricular myocytes. Am J Physiol Heart Circ Physiol 268, H703-H712.
3. 2+) in isolated rat cardiac myocytes. Br J Pharmacol 148, 1108-1115.
4. Brennan JP, Bardswell SC, Burgoyne JR, Fuller W, Schroder E, Wait R, Begum S, Kentish JC & Eaton P (2006). Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. J Biol Chem 281, 21827-21836.
5. Brum G, Osterrieder W & Trautwein W (1984). β-Adrenergic increase in the calcium conductance of cardiac myocytes studied with the patch clamp. Pflugers Arch 401, 111-118.
6. Capogrossi MC, Houser SR, Bahinski A & Lakatta EG (1987). Synchronous occurrence of spontaneous localised calcium release from the sarcoplasmic reticulum generates action potentials in rat cardiac ventricular myocytes at normal resting membrane potential. Circ Res 61, 498-503.
7. Chijiwa T, Mishima A, Hagiwara M, Sano M, Hayashi K, Inoue T, Naito K, Toshioka T & Hidaka H (1990). Inhibition of forskolin-induced neurite outgrowth and protein phosphorylation by a newly synthesized selective inhibitor of cyclic AMP-dependent protein kinase, N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (H-89), of PC12D pheochromocytoma cells. J Biol Chem 265, 5267-5272.
8. Dubois M, Picq M, Nemoz G, Lagarde M & Prigent AF (1993). Inhibition of the different phosphodiesterase isoforms of rat heart cytosol by free fatty acids. J Cardiovasc Pharmacol 21, 522-529.
9. Eisner DA, Nichols CG, O'Neill SC, Smith GL & Valdeolmillos M (1989). The effects of metabolic inhibition on intracellular calcium and pH in isolated rat ventricular cells. J Physiol 411, 393-418.
10. Ford DA, Hazen SL, Saffitz JE & Gross RW (1991). The rapid and reversible activation of a calcium-independent plasmalogen-selective phospholipase A2 during myocardial ischemia. J Clin Invest 88, 331-335.
11. Garcia-Dorado D, Theroux P, Duran JM, Solares J, Alonso J, Sanz E, Munoz R, Elizaga J, Botas J & Fernandez-Aviles F (1992). Selective inhibition of the contractile apparatus. A new approach to modification of infarct size, infarct composition, and infarct geometry during coronary artery occlusion and reperfusion. Circulation 85, 1160-1174.
12. 2+ transient decline in slowed relaxation during myocardial ischemia. J Mol Cell Cardiol 31, 1739-1748.
13. Hazen SL, Ford DA & Gross RW (1991). Activation of a membrane-associated phospholipase A2 during rabbit myocardial ischemia which is highly selective for plasmalogen substrate. J Biol Chem 266, 5629-5633.
14. Horn R & Marty A (1988). Muscarinic activation of ionic currents measured by a new whole-cell recording method. J Gen Physiol 92, 145-159.
15. Kang JG & Leaf A (1994). Effects of long chain polyusaturated fatty acids on the contraction of neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A 91, 9886-9890.
16. Kang JX, Xiao YF & Leaf A (1995). Free, long-chain polyunsaturated fatty acids reduce membrane electrical excitability in neonatal rat cardiac myocytes. Proc Natl Acad Sci U S A 92, 3997-4001.
17. Korge P & Campbell KB (1995). Regulation of calcium pump function in back inhibited vesicles by calcium-ATPase ligands. Cardiovasc Res 29, 512-519.
18. Kris-Etherton PM, Harris WS & Appel LJ (2002). Fish consumption, fish oil, omega-3 fatty acids, and cardiovascular disease. Circulation 106, 2747-2757.
19. Le Peuch CJ, Haiech J & Demaille JG (1979). Concerted regulation of cardiac sarcoplasmic reticulum calcium transport by cyclic adenosine monophosphate dependent and calcium-calmodulin-dependent phosphorylations. Biochemistry 18, 5150-5157.
20. Macleod JC, MacKnight ADC & Rodrigo GC (1998). The electrical and mechanical response of adult guinea pig and rat ventricular myocytes to omega-3 polyunsaturated fatty acids. Eur J Pharmacol 356, 261-270.
21. Maziere C, Conte MA, Degonville J, Ali D & Maziere JC (1999). Cellular enrichment with polyunsaturated fatty acids induces an oxidative stress and activates the transcription factors AP1 and NFkappaB. Biochem Biophys Res Commun 265, 116-122.
22. 2+-independent PLA2 in hypoxic ventricular myocytes. Am J Physiol Cell Physiol 274, C1727-C1737.
23. Mirnikjoo B, Brown SE, Kim HF, Marangell LB, Sweatt JD & Weeber EJ (2001). Protein kinase inhibition by omega-3 fatty acids. J Biol Chem 276, 10888-10896.
24. Nair SS, Leitch J, Falconer J & Garg ML (1999). Cardiac (n-3) non-esterified fatty acids are selectively increased in fish oil-fed pigs following myocardial ischemia. J Nutr 129, 1518-1523.
25. Negretti N, Perez MR, Walker D & O'Neill SC (2000). Inhibition of sarcoplasmic reticulum function by polyunsaturated fatty acids in intact, isolated myocytes from rat ventricular muscle. J Physiol 523, 367-375.
26. 2+ release during diastole and systole in isolated rat ventricular myocytes. J Physiol 430, 519-536.
27. O'Neill SC, Perez MR, Hammond KE, Sheader EA & Negretti N (2002). Direct and indirect modulation of rat cardiac sarcoplasmic reticulum function by n-3 polyunsaturated fatty acids. J Physiol 538, 179-184.
28. Ogita H, Node K, Asanuma H, Sanada S, Takashima S, Minamino T, Soma M, Kim J, Hori M & Kitakaze M (2003). Eicosapentaenoic acid reduces myocardial injury induced by ischemia and reperfusion in rabbit hearts. J Cardiovasc Pharmacol 41, 964-969.
29. Overend CL, Eisner DA & O'Neill SC (2001). Altered cardiac sarcoplasmic reticulum function of intact myocytes of rat ventricle during metabolic inhibition. Circ Res 88, 181-187.
30. 2 in changing beta-adrenoceptor and adenylyl cyclase in ischemia-reperfused hearts. Mol Cell Biochem 186, 99-106.
31. Picq M, Dubois M, Grynberg A, Lagarde M & Prigent AF (1996). Specific effects of n-3 fatty acids and 8-bromo-cGMP on the cyclic nucleotide phosphodiesterase activity in neonatal rat cardiac myocytes. J Mol Cell Cardiol 28, 2151-2161.
32. Roskoski R Jr (1983). Assays of protein kinase. Methods Enzymol 99, 3-6.
33. 2+ pump inactivation in sarcoplasmic reticulum. J Physiol 431, 427-444.
34. 2+-release and ryanodine receptor function. Cardiovasc Res 60, 337-346.
35. Takeo S, Nasa Y, Tanonaka K, Yabe K, Nojiri M, Hayashi M, Sasaki H, Ida K & Yanai K (1998). Effects of long-term treatment with eicosapentaenoic acid on the heart subjected to ischemia/reperfusion and hypoxia/reoxygenation in rats. Mol Cell Biochem 188, 199-208.
36. Valverde CA, Mundina-Weilenmann C, Said M, Ferrero P, Vittone L, Salas M, Palomeque J, Vila PM & Mattiazzi A (2005). Frequency-dependent acceleration of relaxation in mammalian heart: A property not relying on phospholamban and SERCA2 a phosphorylation. J Physiol 562, 801-813.
37. 2+ currents by polyunsaturated fatty acids in adult and neonatal rat ventricular myocytes. Proc Natl Acad Sci U S A 94, 4182-4187.
38. + channels of neonatal rat ventricular myocytes. Proc Natl Acad Sci U S A 92, 11000-11004.
39. + channels. Proc Natl Acad Sci U S A 98, 3606-3611.
40. Zhang R, Zhao J, Mandveno A & Potter JD (1995). Cardiac troponin I phosphorylation increases the rate of cardiac muscle relaxation. Circ Res 76, 1028-1035.