Mechanisms underlying the impaired EDHF-type relaxation response in mesenteric arteries from Otsuka Long-Evans Tokushima Fatty (OLETF) rats

European Journal of Pharmacology

Volumn 538, Issue 1-3, 2006, Pages 132-140

  Matsumoto, Takayuki ^a   Kobayashi, Tsuneo ^a   Kamata, Katsuo ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

(Rat); Calcium activated K+ channel; cAMP; Endothelium derived hyperpolarizing factor; Mesenteric artery; Type 2 diabetes

Indexed keywords

1 ETHYL 2 BENZIMIDAZOLINONE; 18ALPHA GLYCYRRHETINIC ACID; 8 BROMO CYCLIC AMP; ACETYLCHOLINE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CILOSTAMIDE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; ENDOTHELIUM DERIVED HYPERPOLARIZING FACTOR; ISOBUTYLMETHYLXANTHINE; PHOSPHODIESTERASE III INHIBITOR; PHOSPHODIESTERASE INHIBITOR; POTASSIUM CHANNEL STIMULATING AGENT; RILUZOLE; SMALL CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL;

ANIMAL MODEL; ANIMAL TISSUE; ARTERY DILATATION; ARTICLE; CONTROLLED STUDY; DIABETIC ANGIOPATHY; DRUG EFFECT; DRUG SELECTIVITY; ENZYME ACTIVITY; MALE; MESENTERIC ARTERY; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION;

ACETYLCHOLINE; ANIMALS; BENZIMIDAZOLES; BIOLOGICAL FACTORS; BLOOD GLUCOSE; BODY WEIGHT; CALCIUM CHANNEL AGONISTS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIABETES MELLITUS, TYPE 2; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MESENTERIC ARTERIES; NITRIC OXIDE SYNTHASE; NITROARGININE; NITROPRUSSIDE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, INBRED OLETF; RATS, LONG-EVANS; VASODILATION; VASODILATOR AGENTS;

EID: 33646524026     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2006.04.006     Document Type: Article

References (62)

1. Ahluwalia A., and Hobbs A.J. Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor. Trends Pharmacol. Sci. 26 (2005) 162-167
2. Angulo J., Cuevas P., Fernandez A., Gabancho S., Allona A., Martin-Morales A., Moncada I., Videla S., and Saenz de Tejada I. Diabetes impairs endotheliumdependent relaxation of human penile vascular tissues mediated by NO and EDHF. Biochem. Biophys. Res. Commun. 312 (2003) 1202-1208
3. Busse R., Edwards G., Feletou M., Fleming I., Vanhoutte P.M., and Weston A.H. EDHF: bringing the concepts together. Trends Pharmacol. Sci. 23 (2002) 374-380
4. Chaytor A.T., Taylor H.J., and Griffith T.M. Gap junction-dependent and -independent EDHF-type relaxations may involve smooth muscle cAMP accumulation. Am. J. Physiol, Heart Circ. Physiol. 282 (2002) H1548-H1555
5. Cohen R.A. The role of nitric oxide and other endothelium-derived vasoactive substances in vascular disease. Prog. Cardiovasc. Dis. 38 (1995) 105-128
6. Cohen R.A., and Vanhoutte P.M. Endothelium-dependent hyperpolarization. Beyond nitric oxide and cyclic GMP. Circulation 92 (1995) 3337-3349
7. Crane G.J., and Garland C.J. Thromboxane receptor stimulation associated with loss of SKCa activity and reduced EDHF responses in the rat isolated mesenteric artery. Br. J. Pharmacol. 142 (2004) 43-50
8. De Vriese A.S., Van de Voorde J., Blom H.J., Vanhoutte P.M., Verbeke M., and Lameire N.H. The impaired renal vasodilator response attributed to endotheliumderived hyperpolarizing factor in streptozotocin-induced diabetic rats is restored by 5-methyltetrahydrofolate. Diabetologia 43 (2000) 1116-1125
9. De Vriese A.S., Verbeuren T.J., Van de Voorde J., Lameire N.H., and Vanhoutte P.M. Endothelial dysfunction in diabetes. Br. J. Pharmacol. 130 (2000) 963-974
10. Doughty J.M., Plane F., and Langton P.D. Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium. Am. J. Physiol. 276 (1999) H1107-H1112
11. + is an endothelium-derived hyperpolarizing factor in rat arteries. Nature 396 (1998) 269-272
12. Edwards G., Feletou M., Gardener M.J., Thollon C., Vanhoutte P.M., and Weston A.H. Role of gap junctions in the responses to EDHF in rat and guinea-pig small arteries. Br. J. Pharmacol. 128 (1999) 1788-1794
13. Edwards G., Gardener M.J., Feletou M., Brady G., Vanhoutte P.M., and Weston A.H. Further investigation of endothelium-derived hyperpolarizing factor (EDHF) in rat hepatic artery: studies using 1-EBIO and oubain. Br. J. Pharmacol. 128 (1999) 1064-1070
14. Epstein M., and Sowers J.R. Diabetes mellitus and hypertension. Hypertension 19 (1992) 403-418
15. Erdos B., Miller A.W., and Busija D.W. Alterations in KATP and KCa channel function in cerebral arteries of insulin-resistant rats. Am. J. Physiol, Heart Circ. Physiol. 283 (2002) H2472-H2477
16. Feletou M., and Vanhoutte P.M. EDHF: new therapeutic targets?. Pharmacol. Res. 49 (2004) 565-580
17. Fitzgerald S.M., Kemp-Harper B.K., Tare M., and Parkington H.C. Role of endothelium-derived hyperpolarizing factor in endothelial dysfunction during diabetes. Clin. Exp. Pharmacol. Physiol. 32 (2005) 482-487
18. Fukao M., Hattori Y., Kanno M., Sakuma I., and Kitabatake A. Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats. Br. J. Pharmacol. 121 (1997) 1383-1391
19. Furchgott R.F., and Zawadzki J.V. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 288 (1980) 373-376
20. Griffith T.M. Endothelium-dependent smooth muscle hyperpolarization: do gap junctions provide a unifying hypothesis?. Br. J. Pharmacol. 141 (2004) 881-903
21. Griffith T.M., Chaytor A.T., Taylor H.J., Giddings B.D., and Edwards D.H. cAMP facilitates EDHF-type relaxations in conduit arteries by enhancing electronic conduction via gap junctions. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 6392-6397
22. Haynes Jr. J., Robinson J., Saunders L., Taylor A.E., and Strada S.J. Role of cAMP-dependent protein kinase in cAMP-mediated vasodilation. Am. J. Physiol. 262 (1992) H511-H516
23. Hill C.E., Phillips J.K., and Sandow S.L. Heterogeneous control of blood flow amongst different vascular beds. Med. Res. Rev. 21 (2001) 1-60
24. Kagota S., Yamaguchi Y., Nakamura K., and Kunitomo M. Altered endothelium-dependent responsiveness in the aortas and renal arteries of Otsuka Long-Evans Tokushima Fatty (OLETF) rats, a model of non-insulin-dependent diabetes mellitus. Gen. Pharmacol. 34 (2000) 201-209
25. Kamata K., Miyata N., and Kasuya Y. Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats. Br. J. Pharmacol. 97 (1989) 614-618
26. Kamata K., Umeda F., and Kasuya Y. Possible existence of novel endothelium-derived relaxing factor in the endothelium of rat mesenteric arterial bed. J. Cardiovasc. Pharmacol. 27 (1996) 601-606
27. Katakam P.V., Ujhelyi M.R., and Miller A.W. EDHF-mediated relaxation is impaired in fructose-fed rats. J. Cardiovasc. Pharmacol. 34 (1999) 461-467
28. Kawano K., Hirashima T., Mori S., Saitoh Y., Kurosumi M., and Natori T. Spontaneous long-term hyperglycemic rat with diabetic complications, Otsuka Long-Evans Tokushima Fatty (OLETF) strain. Diabetes 41 (1992) 1422-1428
29. Kawano K., Hirashima T., Mori S., and Natori T. OLETF (Otsuka Long-Evans Tokushima Fatty) rat: a new NIDDM rat strain. Diabetes Res. Clin. Pract. 24 (1994) S317-S320
30. Kim Y.K., Lee M.S., Son S.M., Kim I.J., Lee W.S., Rhim B.Y., Hong K.W., and Kim C.D. Vascular NADH oxidase is involved in impaired endothelium-dependent vasodilation in OLETF rats, a model of type 2 diabetes. Diabetes 51 (2002) 522-527
31. Kobayashi T., and Kamata K. Relationship among cholesterol, superoxide anion and endothelium-dependent relaxation in diabetic rats. Eur. J. Pharmacol. 367 (1999) 213-222
32. Kobayashi T., Matsumoto T., and Kamata K. Mechanisms underlying the chronic pravastatin treatment-induced improvement in the impaired endothelium-dependent aortic relaxation seen in streptozotocin-induced diabetic rats. Br. J. Pharmacol. 131 (2000) 231-238
33. Kobayashi T., Taguchi K., Yasuhiro T., Matsumoto T., and Kamata K. Impairment of PI3-K/Akt pathway underlies attenuated endothelial function in aorta of type 2 diabetic mouse model. Hypertension 44 (2004) 956-962
34. Kohler R., Eichler I., Schonfelder H., Grigic I., Heinau P., Si H., and Hoyer J. Impaired EDHF-mediated vasodilation and function of endothelial Ca-activated K channels in uremic rats. Kidney Int. 67 (2005) 2280-2287
35. Luscher T.F., Creager M.A., Beckman J.A., and Cosentino F. Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part II. Circulation 108 (2003) 1655-1661
36. Matsumoto T., Kobayashi T., and Kamata K. Alterations in EDHF-type relaxation and phosphodiesterase activity in mesenteric arteries from diabetic rats. Am. J. Physiol, Heart Circ. Physiol. 285 (2003) H283-H291
37. Matsumoto T., Kobayashi T., and Kamata K. Phosphodiesterases in the vascular system. J. Smooth Muscle Res. 39 (2003) 67-86
38. Matsumoto T., Sato A., Suenaga H., Kobayashi T., and Kamata K. Modulations of shear stress-induced contractile responses and agonist-induced vasodilation in hypercholesterolemic rats. Atherosclerosis 175 (2004) 31-38
39. Matsumoto T., Yoshiyama S., Wakabayashi K., Kobayashi T., and Kamata K. Effects of chronic insulin on endothelial dysfunction of basilar arteries from established streptozotocin-diabetic rats. Eur. J. Pharmacol. 504 (2004) 119-127
40. Matsumoto T., Yoshiyama S., Wakabayashi K., Kobayashi T., and Kamata K. Effects of chronic insulin on cromakalim-induced relaxation in established streptozotocin-diabetic rat basilar artery. Eur. J. Pharmacol. 504 (2004) 129-137
41. Matsumoto T., Wakabayashi K., Kobayashi T., and Kamata K. Diabetes-related changes in cAMP-dependent protein kinase activity and decrease in relaxation response in rat mesenteric artery. Am. J. Physiol, Heart Circ. Physiol. 287 (2004) H1064-H1071
42. Matsumoto T., Wakabayashi K., Kobayashi T., and Kamata K. Alterations in vascular endothelial function in the aorta and mesenteric artery in type II diabetic rats. Can. J. Physiol. Pharm. 82 (2004) 175-182
43. Matsumoto T., Kobayashi T., Wakabayashi K., and Kamata K. Cilostazol improves endothelium-derived hyperpolarizing factor-type relaxation in mesenteric arteries from diabetic rats. Am. J. Physiol, Heart Circ. Physiol. 289 (2005) H1933-H1940
44. Matsumoto T., Wakabayashi K., Kobayashi T., and Kamata K. Functional changes in adenylyl cyclases and associated decreases in relaxation responses in mesenteric arteries from diabetic rats. Am. J. Physiol, Heart Circ. Physiol. 289 (2005) H2234-H2243
45. Mayhan W.G. Impairment of endothelium-dependent dilatation of the basilar artery during diabetes mellitus. Brain Res. 580 (1992) 297-302
46. Minami A., Ishimura N., Harada N., Sakamoto S., Niwa Y., and Nakaya Y. Exercise training improves acetylcholine-induced endothelium-dependent hyperpolarization in type 2 diabetic rats, Otsuka Long-Evans Tokushima fatty rats. Atherosclerosis 162 (2002) 85-92
47. Murray K.J. Cyclic AMP and mechanisms of vasodilation. Pharmacol. Ther. 47 (1990) 329-345
48. Nilius B., and Droogmans G. Ion channels and their functional role in vascular endothelium. Physiol. Rev. 81 (2001) 1415-1459
49. Onaka U., Fujii K., Abe I., and Fujishima M. Antihypertensive treatment improves endothelium-dependent hyperpolarization in the mesenteric artery of spontaneously hypertensive rats. Circulation 98 (1998) 175-182
50. Ozkan M.H., and Uma S. Inhibition of acetylcholine-induced EDHF response by elevated glucose in rat mesenteric artery. Life Sci. 78 (2005) 14-21
51. Pieper G.M. Review of alterations in endothelial nitric oxide production in diabetes: protective role of arginine on endothelial dysfunction. Hypertension 31 (1998) 1047-1060
52. Poston L., and Taylor P.D. Endothelium-mediated vascular function in insulindependent diabetes mellitus. Clin. Sci. (Lond) 88 (1995) 245-255
53. Rummery N.H., and Hill C.E. Vascular gap junctions and implications for hypertension. Clin. Exp. Pharmacol. Physiol. 31 (2004) 659-667
54. Sakamoto S., Minami K., Niwa Y., Ohnaka M., Nakaya Y., Mizuno A., Kuwajima M., and Shima K. Effects of exercise training and food restriction on endothelium-dependent relaxation in the Otsuka Long-Evans Tokushima Fatty rat, a model of spontaneous NIDDM. Diabetes 47 (1998) 82-86
55. Sandow S.L. Factors, fiction and endothelium-derived hyperpolarizing factor. Clin. Exp. Pharmacol. Physiol. 31 (2004) 563-570
56. Shimokawa H., Yasutake H., Fujii K., Owada M.K., Nakaike R., Fukumoto Y., Takaganagi T., Nagao T., Egashira K., Fujishima M., and Takeshita A. The importance of the hyperpolarizing mechanism increase as the vessel size decreases in endothelium-dependent relaxations in rat mesenteric circulation. J. Cardiovasc. Pharmacol. 28 (1996) 703-711
57. Smits P., Kapma J.A., Jacobs M.C., Lutterman J., and Thien T. Endothelium-dependent vascular relaxation in patients with type I diabetes. Diabetes 42 (1993) 148-153
58. Taylor H.J., Chaytor A.T., Edwards D.H., and Griffith T.M. Gap junction-dependent increases in smooth muscle cAMP underpin the EDHF phenomenon in rabbit arteries. Biochem. Biophys. Res. Commun. 283 (2001) 583-589
59. Taylor M.S., Bonev A.D., Gross T.P., Eckman D.M., Brayden J.E., Bond C.T., Adelman J.P., and Nelson M.T. Altered expression of small-conductance Ca2+-activated K+(SK3) channels modulates arterial tone and blood pressure. Circ. Res. 93 (2003) 124-131
60. Ting H.H., Timimi F.K., Boles K.S., Creager S.J., Ganz P., and Creager M.A. Vitamin C improves endothelium-dependent vasodilatation in patients with non-insulin-dependent diabetes mellitus. J. Clin. Invest. 97 (1996) 22-28
61. Walker S.D., Dora K.A., Ings N.T., Crane G.J., and Garland C.J. Activation of endothelial cell IK(Ca) with 1-ethyl-2-benzimidazolinone evokes smooth muscle hyperpolarization in rat isolated mesenteric artery. Br. J. Pharmacol. 34 (2001) 1548-1554
62. Wigg S.J., Tare M., Tonta M.A., O'Brien R.C., Meredith I.T., and Parkington H.C. Comparison of effects of diabetes mellitus on an EDHF-dependent and an EDHF-independent artery. Am. J. Physiol, Heart Circ. Physiol. 281 (2001) H232-H240