메뉴 건너뛰기




Volumn 14, Issue 3, 2009, Pages 264-275

Bone-resorbing cells in multiple myeloma: Osteoclasts, myeloma cell polykaryons, or both?

Author keywords

Multiple myeloma; Myeloma bone disease; Osteoclasts; Polykaryons

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; COLONY STIMULATING FACTOR 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

EID: 63849262026     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2008-0087     Document Type: Article
Times cited : (26)

References (73)
  • 2
    • 84860459037 scopus 로고    scopus 로고
    • Pathophysiology of myeloma bone disease
    • Gahrton G, Durie BGM, Samson DM, eds, London: Arnold
    • Oyajobi BO, Mundy GR. Pathophysiology of myeloma bone disease. In: Gahrton G, Durie BGM, Samson DM, eds. Multiple Myeloma and Related Disorders. London: Arnold, 2004:74-88.
    • (2004) Multiple Myeloma and Related Disorders , pp. 74-88
    • Oyajobi, B.O.1    Mundy, G.R.2
  • 3
    • 0032512903 scopus 로고    scopus 로고
    • Myeloma bone disease
    • Mundy GR. Myeloma bone disease. Eur J Cancer 1998;34:246-251.
    • (1998) Eur J Cancer , vol.34 , pp. 246-251
    • Mundy, G.R.1
  • 5
    • 0025885099 scopus 로고
    • Role of bone marrow stromal cells in the growth of human multiple myeloma
    • Caligaris-Cappio F, Bergui L, Gregoretti MG et al. Role of bone marrow stromal cells in the growth of human multiple myeloma. Blood 1991;77: 2688-2693.
    • (1991) Blood , vol.77 , pp. 2688-2693
    • Caligaris-Cappio, F.1    Bergui, L.2    Gregoretti, M.G.3
  • 6
    • 64049103764 scopus 로고    scopus 로고
    • Terpos E, Politou M, Rahemtulla A. New insights into the pathophysiology
    • Terpos E, Politou M, Rahemtulla A. New insights into the pathophysiology
  • 7
    • 0346219279 scopus 로고    scopus 로고
    • and management of bone disease in multiple myeloma. Br J Haematol 2003;123:758-769.
    • and management of bone disease in multiple myeloma. Br J Haematol 2003;123:758-769.
  • 8
    • 0036829305 scopus 로고    scopus 로고
    • Role ofthe bone marrow microenvironmentin multiple myeloma
    • Roodman GD. Role ofthe bone marrow microenvironmentin multiple myeloma. J Bone Miner Res 2002;17:1921-1925.
    • (2002) J Bone Miner Res , vol.17 , pp. 1921-1925
    • Roodman, G.D.1
  • 9
    • 33751193178 scopus 로고    scopus 로고
    • Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition
    • Giuliani N, Rizzoli V, Roodman GD. Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition. Blood 2006;108:3992-3996.
    • (2006) Blood , vol.108 , pp. 3992-3996
    • Giuliani, N.1    Rizzoli, V.2    Roodman, G.D.3
  • 10
    • 0022476624 scopus 로고
    • Importance of quantitative histology of bone changes in monoclonal gammopathy
    • Bataille R, Chappard D, Alexandre C et al. Importance of quantitative histology of bone changes in monoclonal gammopathy. Br J Cancer 1986;53: 805-810.
    • (1986) Br J Cancer , vol.53 , pp. 805-810
    • Bataille, R.1    Chappard, D.2    Alexandre, C.3
  • 11
    • 14644420230 scopus 로고    scopus 로고
    • The role of markers of bone remodeling in multiple myeloma
    • Terpos E, Politou M, Rahemtulla A. The role of markers of bone remodeling in multiple myeloma. Blood Rev 2005;19:125-142.
    • (2005) Blood Rev , vol.19 , pp. 125-142
    • Terpos, E.1    Politou, M.2    Rahemtulla, A.3
  • 12
    • 33845193025 scopus 로고    scopus 로고
    • Myeloma bone disease: Patho-genetic mechanisms and clinical assessment
    • Silvestris F, Lombardi L, De Matteo M et al. Myeloma bone disease: Patho-genetic mechanisms and clinical assessment. Leuk Res 2007;31:129 -138.
    • (2007) Leuk Res , vol.31 , pp. 129-138
    • Silvestris, F.1    Lombardi, L.2    De Matteo, M.3
  • 13
    • 0141482103 scopus 로고    scopus 로고
    • Receptor activator of nuclear factor kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo
    • Farrugia AN, Atkins GJ, To LB et al. Receptor activator of nuclear factor kappaB ligand expression by human myeloma cells mediates osteoclast formation in vitro and correlates with bone destruction in vivo. Cancer Res 2003;63:5438-5445.
    • (2003) Cancer Res , vol.63 , pp. 5438-5445
    • Farrugia, A.N.1    Atkins, G.J.2    To, L.B.3
  • 14
    • 3242662500 scopus 로고    scopus 로고
    • Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblastpathwayofosteoclaststimulation
    • Lai FP, Cole-Sinclair M, Cheng WJ et al. Myeloma cells can directly contribute to the pool of RANKL in bone bypassing the classic stromal and osteoblastpathwayofosteoclaststimulation. Br J Haematol 2004;126:192-201.
    • (2004) Br J Haematol , vol.126 , pp. 192-201
    • Lai, F.P.1    Cole-Sinclair, M.2    Cheng, W.J.3
  • 15
    • 4644261592 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Roodman GD. Mechanisms of bone metastasis. N Engl J Med 2004;350: 1655-1664.
    • (2004) N Engl J Med , vol.350 , pp. 1655-1664
    • Roodman, G.D.1
  • 16
    • 0020960066 scopus 로고
    • Direct bone resorbing activity of murine myeloma cells
    • McDonald DF, Schofield BH, Prezioso EM et al. Direct bone resorbing activity of murine myeloma cells. Cancer Lett 1983;19:119-124.
    • (1983) Cancer Lett , vol.19 , pp. 119-124
    • McDonald, D.F.1    Schofield, B.H.2    Prezioso, E.M.3
  • 17
    • 33846201640 scopus 로고    scopus 로고
    • Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: Anew type of cancer-host partnership?
    • Andersen TL, Boissy P, Sondergaard TE et al. Osteoclast nuclei of myeloma patients show chromosome translocations specific for the myeloma cell clone: Anew type of cancer-host partnership? J Pathol 2007;211:10-17.
    • (2007) J Pathol , vol.211 , pp. 10-17
    • Andersen, T.L.1    Boissy, P.2    Sondergaard, T.E.3
  • 18
    • 27244441444 scopus 로고    scopus 로고
    • Functional osteoclast-like transformation of cultured human myeloma cell lines
    • Calvani N, Cafforio P, Silvestris F et al. Functional osteoclast-like transformation of cultured human myeloma cell lines. Br J Haematol 2005;130: 926-938.
    • (2005) Br J Haematol , vol.130 , pp. 926-938
    • Calvani, N.1    Cafforio, P.2    Silvestris, F.3
  • 19
    • 0035808458 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis viacoupling ofTNF type 1 receptor and RANK signaling pathways
    • Zhang YH, Heulsmann A, Tondravi MM et al. Tumor necrosis factor-alpha (TNF) stimulates RANKL-induced osteoclastogenesis viacoupling ofTNF type 1 receptor and RANK signaling pathways. J Biol Chem 2001;276: 563-568.
    • (2001) J Biol Chem , vol.276 , pp. 563-568
    • Zhang, Y.H.1    Heulsmann, A.2    Tondravi, M.M.3
  • 20
    • 31044436261 scopus 로고    scopus 로고
    • M-CSF mediates TNF-induced inflammatory osteolysis
    • Kitaura H, Zhou P, Kim HJ et al. M-CSF mediates TNF-induced inflammatory osteolysis. J Clin Invest 2005;115:3418-3427.
    • (2005) J Clin Invest , vol.115 , pp. 3418-3427
    • Kitaura, H.1    Zhou, P.2    Kim, H.J.3
  • 21
    • 0037443533 scopus 로고    scopus 로고
    • RANK ligand and osteoprotegerin in myeloma bone disease
    • Sezer O, Heider U, Zavrski I et al. RANK ligand and osteoprotegerin in myeloma bone disease. Blood 2003;101:2094-2098.
    • (2003) Blood , vol.101 , pp. 2094-2098
    • Sezer, O.1    Heider, U.2    Zavrski, I.3
  • 22
    • 0037108435 scopus 로고    scopus 로고
    • Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells
    • Standal T, Seidel C, Hjertner 0 et al. Osteoprotegerin is bound, internalized, and degraded by multiple myeloma cells. Blood 2002;100:3002-3007.
    • (2002) Blood , vol.100 , pp. 3002-3007
    • Standal, T.1    Seidel, C.2    Hjertner 03
  • 23
    • 0035496947 scopus 로고    scopus 로고
    • Nordic Myeloma Study Group. Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease
    • Seidel C, Hjertner 0, Abildgaard N et al.; Nordic Myeloma Study Group. Serum osteoprotegerin levels are reduced in patients with multiple myeloma with lytic bone disease. Blood 2001;98:2269-2271.
    • (2001) Blood , vol.98 , pp. 2269-2271
    • Seidel, C.1    Hjertner 02    Abildgaard, N.3
  • 24
    • 0043245842 scopus 로고    scopus 로고
    • Soluble receptor activator ofnuclear factor κB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal fora novel prognostic index
    • Terpos E, Szydlo R, Apperley JF et al. Soluble receptor activator ofnuclear factor κB ligand-osteoprotegerin ratio predicts survival in multiple myeloma: Proposal fora novel prognostic index. Blood 2003;102:1064-1069.
    • (2003) Blood , vol.102 , pp. 1064-1069
    • Terpos, E.1    Szydlo, R.2    Apperley, J.F.3
  • 25
    • 4544360663 scopus 로고    scopus 로고
    • Role ofreceptoractivatorof nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS)
    • Politou M, Terpos E, Anagnostopoulos A et al. Role ofreceptoractivatorof nuclear factor-kappa B ligand (RANKL), osteoprotegerin and macrophage protein 1-alpha (MIP-1a) in monoclonal gammopathy of undetermined significance (MGUS). Br J Haematol 2004;126:686-689.
    • (2004) Br J Haematol , vol.126 , pp. 686-689
    • Politou, M.1    Terpos, E.2    Anagnostopoulos, A.3
  • 26
    • 4143119930 scopus 로고    scopus 로고
    • Impaired osteoblastogenesis in myeloma bone disease: Role of upregulated apoptosis by cytokines and malignant plasma cells
    • Silvestris F, Cafforio P, Calvani N et al. Impaired osteoblastogenesis in myeloma bone disease: Role of upregulated apoptosis by cytokines and malignant plasma cells. Br J Haematol 2004;126:475-486.
    • (2004) Br J Haematol , vol.126 , pp. 475-486
    • Silvestris, F.1    Cafforio, P.2    Calvani, N.3
  • 27
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003;349:2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 28
    • 0345534770 scopus 로고    scopus 로고
    • Hepatocyte growthfactor (HGF) induces interleukin-11 secretion from osteoblasts: A possible role for HGF in myeloma-associated osteolytic bone disease
    • Hjertner O, Torgersen ML, Seidel C et al. Hepatocyte growthfactor (HGF) induces interleukin-11 secretion from osteoblasts: A possible role for HGF in myeloma-associated osteolytic bone disease. Blood 1999;94:3883-3888.
    • (1999) Blood , vol.94 , pp. 3883-3888
    • Hjertner, O.1    Torgersen, M.L.2    Seidel, C.3
  • 29
    • 0033034054 scopus 로고    scopus 로고
    • Potential role ofinsulin-like growthfac- tor binding protein-4 in the uncoupling of bone turnover in multiple myeloma
    • Feliers D, WoodruffK, Abboud S. Potential role ofinsulin-like growthfac- tor binding protein-4 in the uncoupling of bone turnover in multiple myeloma. Br J Haematol 1999;104:715-722.
    • (1999) Br J Haematol , vol.104 , pp. 715-722
    • Feliers, D.1    Woodruff, K.2    Abboud, S.3
  • 30
    • 33745219872 scopus 로고    scopus 로고
    • Myeloma and bone disease: "The dangerous tango."Clin Adv
    • Epstein J, Walker R. Myeloma and bone disease: "The dangerous tango."Clin Adv Hematol Oncol 2006;4:300-306.
    • (2006) Hematol Oncol , vol.4 , pp. 300-306
    • Epstein, J.1    Walker, R.2
  • 31
    • 0015915188 scopus 로고
    • The cellular basis of metabolic bone disease
    • Rasmussen H, Bordier P. The cellular basis of metabolic bone disease. N Engl J Med 1973;289:25-32.
    • (1973) N Engl J Med , vol.289 , pp. 25-32
    • Rasmussen, H.1    Bordier, P.2
  • 32
    • 0016811449 scopus 로고
    • Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells
    • Walker DG. Bone resorption restored in osteopetrotic mice by transplants of normal bone marrow and spleen cells. Science 1975;190:784-785.
    • (1975) Science , vol.190 , pp. 784-785
    • Walker, D.G.1
  • 33
    • 0023928381 scopus 로고
    • Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures
    • Takahashi N, Yamana H, Yoshiki S et al. Osteoclast-like cell formation and its regulation by osteotropic hormones in mouse bone marrow cultures. Endocrinology 1988;122:1373-1382.
    • (1988) Endocrinology , vol.122 , pp. 1373-1382
    • Takahashi, N.1    Yamana, H.2    Yoshiki, S.3
  • 34
    • 0031005576 scopus 로고    scopus 로고
    • Osteoprotegerin: A novel secreted protein involved in the regulation of bone density
    • Simonet WS, Lacey DL, Dunstan CR et al. Osteoprotegerin: A novel secreted protein involved in the regulation of bone density. Cell 1997;89: 309 -319.
    • (1997) Cell , vol.89 , pp. 309-319
    • Simonet, W.S.1    Lacey, D.L.2    Dunstan, C.R.3
  • 35
    • 0031439265 scopus 로고    scopus 로고
    • TRANCE (tumor necrosis factor [TNF]- related activation-induced cytokine), a new TNF family member predominantly expressed inTcells, is a dendriticcell-specificsurvival factor
    • Wong BR, Josien R, Lee SY et al. TRANCE (tumor necrosis factor [TNF]- related activation-induced cytokine), a new TNF family member predominantly expressed inTcells, is a dendriticcell-specificsurvival factor. J Exp Med 1997;186:2075-2080.
    • (1997) J Exp Med , vol.186 , pp. 2075-2080
    • Wong, B.R.1    Josien, R.2    Lee, S.Y.3
  • 36
    • 0032540319 scopus 로고    scopus 로고
    • Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation
    • Lacey DL, Timms E, Tan HL et al. Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 1998;93:165-176.
    • (1998) Cell , vol.93 , pp. 165-176
    • Lacey, D.L.1    Timms, E.2    Tan, H.L.3
  • 37
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature 2003;423:337-342.
    • (2003) Nature , vol.423 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 38
    • 0025332897 scopus 로고
    • The murine mutation osteopetro- sis is in the coding region of the macrophage colony stimulating factor gene
    • Yoshida H, Hayashi SI, Kunisada T et al. The murine mutation osteopetro- sis is in the coding region of the macrophage colony stimulating factor gene. Nature 1990;345:442-444.
    • (1990) Nature , vol.345 , pp. 442-444
    • Yoshida, H.1    Hayashi, S.I.2    Kunisada, T.3
  • 39
    • 11144355389 scopus 로고    scopus 로고
    • The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRy) regulate development of functional osteoclasts through the Syk tyrosine kinase
    • Mocsai A, Humphrey MB, Van Ziffle JA et al. The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRy) regulate development of functional osteoclasts through the Syk tyrosine kinase. Proc Natl Acad SciUSA 2004;101:6158-6163.
    • (2004) Proc Natl Acad SciUSA , vol.101 , pp. 6158-6163
    • Mocsai, A.1    Humphrey, M.B.2    Van Ziffle, J.A.3
  • 40
    • 11144354330 scopus 로고    scopus 로고
    • Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis
    • KogaT, Inui M, Inoue K et al. Costimulatory signals mediated by the ITAM motif cooperate with RANKL for bone homeostasis. Nature 2004;428: 758 -763.
    • (2004) Nature , vol.428 , pp. 758-763
    • Koga, T.1    Inui, M.2    Inoue, K.3
  • 41
    • 85047685623 scopus 로고    scopus 로고
    • TNFalpha potently activates oste- oclasts, througha direct action independentofand strongly synergistic with RANKL
    • Fuller K, Murphy C, Kirstein B et al. TNFalpha potently activates oste- oclasts, througha direct action independentofand strongly synergistic with RANKL. Endocrinology 2002;143:1108 -1118.
    • (2002) Endocrinology , vol.143 , pp. 1108-1118
    • Fuller, K.1    Murphy, C.2    Kirstein, B.3
  • 42
    • 0034523328 scopus 로고    scopus 로고
    • TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand
    • Lam J, Takeshita S, Barker JE et al. TNF-alpha induces osteoclastogenesis by direct stimulation of macrophages exposed to permissive levels of RANK ligand. J Clin Invest 2000;106:1481-1488.
    • (2000) J Clin Invest , vol.106 , pp. 1481-1488
    • Lam, J.1    Takeshita, S.2    Barker, J.E.3
  • 43
    • 0041731907 scopus 로고    scopus 로고
    • Faccio R, Novack DV, Zallone A et al. Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin. J Cell Biol 2003;162:499-509.
    • Faccio R, Novack DV, Zallone A et al. Dynamic changes in the osteoclast cytoskeleton in response to growth factors and cell attachment are controlled by β3 integrin. J Cell Biol 2003;162:499-509.
  • 44
    • 0033621890 scopus 로고    scopus 로고
    • Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts
    • McHugh KP, Hodivala-Dilke K, Zheng MH et al. Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts. J Clin Invest 2000; 105:433-440.
    • (2000) J Clin Invest , vol.105 , pp. 433-440
    • McHugh, K.P.1    Hodivala-Dilke, K.2    Zheng, M.H.3
  • 45
    • 33748107509 scopus 로고    scopus 로고
    • Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells
    • Yagi M, Miyamoto T, Toyama Y et al. Role of DC-STAMP in cellular fusion of osteoclasts and macrophage giant cells. J Bone Miner Metab 2006; 24:355-358.
    • (2006) J Bone Miner Metab , vol.24 , pp. 355-358
    • Yagi, M.1    Miyamoto, T.2    Toyama, Y.3
  • 47
    • 34548248999 scopus 로고    scopus 로고
    • Induction of DC-STAMP by alternative activation and downstream signalling mechanisms
    • Yagi M, Ninomiya K, Fujita N et al. Induction of DC-STAMP by alternative activation and downstream signalling mechanisms. J Bone Miner Res 2007;22:992-1001.
    • (2007) J Bone Miner Res , vol.22 , pp. 992-1001
    • Yagi, M.1    Ninomiya, K.2    Fujita, N.3
  • 48
    • 23744459835 scopus 로고    scopus 로고
    • DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells
    • Yagi M, Miyamoto T, Sawatani Y et al. DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med 2005;202: 345-351.
    • (2005) J Exp Med , vol.202 , pp. 345-351
    • Yagi, M.1    Miyamoto, T.2    Sawatani, Y.3
  • 49
    • 0141707692 scopus 로고    scopus 로고
    • Serum levels of macrophage inflammatory protein-1 alpha (MIP-1α) correlate with the extent of bone disease and survival in patients with multiple myeloma
    • Terpos E, Politou M, Szydlo R et al. Serum levels of macrophage inflammatory protein-1 alpha (MIP-1α) correlate with the extent of bone disease and survival in patients with multiple myeloma. Br J Haematol 2003;123: 106 -109.
    • (2003) Br J Haematol , vol.123 , pp. 106-109
    • Terpos, E.1    Politou, M.2    Szydlo, R.3
  • 50
    • 16844377831 scopus 로고    scopus 로고
    • Mechanistic insight into osteoclast differentiation in osteo-immunology
    • Takayanagi H. Mechanistic insight into osteoclast differentiation in osteo-immunology. J Mol Med 2005;83:170-179.
    • (2005) J Mol Med , vol.83 , pp. 170-179
    • Takayanagi, H.1
  • 51
    • 33644558753 scopus 로고    scopus 로고
    • Inhibitory effects ofosteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
    • Yaccoby S, WezemanMJ, Zangari M et al. Inhibitory effects ofosteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica 2006;91:192-199.
    • (2006) Haematologica , vol.91 , pp. 192-199
    • Yaccoby, S.1    Wezeman, M.J.2    Zangari, M.3
  • 52
    • 0030728888 scopus 로고    scopus 로고
    • Non-secretory multiple myeloma with multinucleated giant plasma cells
    • Ghevaert C, Fournier M, Bernardi F et al. Non-secretory multiple myeloma with multinucleated giant plasma cells. Leuk Lymphoma 1997;27:185- 189.
    • (1997) Leuk Lymphoma , vol.27 , pp. 185-189
    • Ghevaert, C.1    Fournier, M.2    Bernardi, F.3
  • 53
    • 0025267281 scopus 로고
    • Plasma cell myeloma with cleaved, multilobated, and monocytoid nuclei
    • Zukerberg LR, Ferry JA, Conlon M et al. Plasma cell myeloma with cleaved, multilobated, and monocytoid nuclei. Am J Clin Pathol 1990;93: 657-661.
    • (1990) Am J Clin Pathol , vol.93 , pp. 657-661
    • Zukerberg, L.R.1    Ferry, J.A.2    Conlon, M.3
  • 54
    • 0024371883 scopus 로고
    • Ultrastructure of multinucleated giant myeloma cells: Report of one case
    • Kurabayashi H, Miyawaki S, Murakami H et al. Ultrastructure of multinucleated giant myeloma cells: Report of one case. Am J Hematol 1989;31: 284-285.
    • (1989) Am J Hematol , vol.31 , pp. 284-285
    • Kurabayashi, H.1    Miyawaki, S.2    Murakami, H.3
  • 56
    • 0024549325 scopus 로고
    • Myelomonocytic myeloma cell line (LB 84-1)
    • Durie BGM, Grogan TM, Spier C et al. Myelomonocytic myeloma cell line (LB 84-1). Blood 1989;73:770-776.
    • (1989) Blood , vol.73 , pp. 770-776
    • Durie, B.G.M.1    Grogan, T.M.2    Spier, C.3
  • 57
    • 0024505031 scopus 로고
    • Phenotypic analysis of human myeloma cell lines
    • Duperray C, Klein B, Durie BGM et al. Phenotypic analysis of human myeloma cell lines. Blood 1989;73:566-572.
    • (1989) Blood , vol.73 , pp. 566-572
    • Duperray, C.1    Klein, B.2    Durie, B.G.M.3
  • 58
    • 33846653850 scopus 로고    scopus 로고
    • Induction of multilineage markers in human myeloma cells and their down-regulation by interleukin 6
    • Liu S, Otsuyama K, Ma Z et al. Induction of multilineage markers in human myeloma cells and their down-regulation by interleukin 6. Int J Hematol 2007;85:49-58.
    • (2007) Int J Hematol , vol.85 , pp. 49-58
    • Liu, S.1    Otsuyama, K.2    Ma, Z.3
  • 59
    • 0037082473 scopus 로고    scopus 로고
    • Negative regulation of erythroblast maturation by Fas-L( + )/TRAIL( +) highly malignant plasma cells: A major pathogenetic mechanism of anemia in multiple myeloma
    • Silvestris F, Cafforio P, Tucci M et al. Negative regulation of erythroblast maturation by Fas-L( + )/TRAIL( +) highly malignant plasma cells: A major pathogenetic mechanism of anemia in multiple myeloma. Blood 2002; 99:1305-1313.
    • (2002) Blood , vol.99 , pp. 1305-1313
    • Silvestris, F.1    Cafforio, P.2    Tucci, M.3
  • 60
    • 0032890449 scopus 로고    scopus 로고
    • Osteoclast markers accumulate on cells developing from human peripheral blood mononuclear precursors
    • Faust J, Lacey DL, Hunt P et al. Osteoclast markers accumulate on cells developing from human peripheral blood mononuclear precursors. J Cell Biochem 1999;72:67-80.
    • (1999) J Cell Biochem , vol.72 , pp. 67-80
    • Faust, J.1    Lacey, D.L.2    Hunt, P.3
  • 61
    • 39049101272 scopus 로고    scopus 로고
    • Expression and function of the calcitonin receptor by myeloma cells in their osteoclast-like activity in vitro
    • Silvestris F, Cafforio P, De Matteo M et al. Expression and function of the calcitonin receptor by myeloma cells in their osteoclast-like activity in vitro. Leuk Res 2008;32:611-623.
    • (2008) Leuk Res , vol.32 , pp. 611-623
    • Silvestris, F.1    Cafforio, P.2    De Matteo, M.3
  • 62
    • 33750448666 scopus 로고    scopus 로고
    • In-vitro functional phenotypes of plasma cell lines from patients with multiple myeloma
    • Silvestris F, Cafforio P, Calvani N et al. In-vitro functional phenotypes of plasma cell lines from patients with multiple myeloma. Leuk Lymphoma 2006;47:1921-1931.
    • (2006) Leuk Lymphoma , vol.47 , pp. 1921-1931
    • Silvestris, F.1    Cafforio, P.2    Calvani, N.3
  • 63
    • 0018120428 scopus 로고
    • Directresorption of bone by human breast cancer cells in vitro
    • Eilon G, Mundy GR. Directresorption of bone by human breast cancer cells in vitro. Nature 1978;276:726-728.
    • (1978) Nature , vol.276 , pp. 726-728
    • Eilon, G.1    Mundy, G.R.2
  • 64
    • 0030747949 scopus 로고    scopus 로고
    • Direct osteolysis induced by metastatic murine melanoma cells: Role of matrix metalloproteinases
    • Sanchez-Sweatman OH, Lee J, Orr FW et al. Direct osteolysis induced by metastatic murine melanoma cells: Role of matrix metalloproteinases. Eur J Cancer 1997;33:918-925.
    • (1997) Eur J Cancer , vol.33 , pp. 918-925
    • Sanchez-Sweatman, O.H.1    Lee, J.2    Orr, F.W.3
  • 65
    • 0030791806 scopus 로고    scopus 로고
    • Mechanisms of bone lesions in multiple myeloma and lymphoma
    • Roodman GD. Mechanisms of bone lesions in multiple myeloma and lymphoma. Cancer 1997;80:1557-1563.
    • (1997) Cancer , vol.80 , pp. 1557-1563
    • Roodman, G.D.1
  • 66
    • 3343001310 scopus 로고    scopus 로고
    • Evidence of a role for RANKL in the development of myeloma bone disease
    • De Leenheer E, Mueller GS, Vanderkerken K et al. Evidence of a role for RANKL in the development of myeloma bone disease. Curr Opin Pharmacol 2004;4:340-346.
    • (2004) Curr Opin Pharmacol , vol.4 , pp. 340-346
    • De Leenheer, E.1    Mueller, G.S.2    Vanderkerken, K.3
  • 67
    • 0026728085 scopus 로고
    • The relationshipbetweenthe numberofnuclei of an osteoclast and its resorptive capability in vitro
    • PiperK, Boyde A, Jones SJ. The relationshipbetweenthe numberofnuclei of an osteoclast and its resorptive capability in vitro. Anat Embryol (Berl) 1992;186:291-299.
    • (1992) Anat Embryol (Berl) , vol.186 , pp. 291-299
    • Piper, K.1    Boyde, A.2    Jones, S.J.3
  • 68
    • 0035128622 scopus 로고    scopus 로고
    • Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films
    • Lees RL, Sabharwal VK, Heersche JNM. Resorptive state and cell size influence intracellular pH regulation in rabbit osteoclasts cultured on collagen-hydroxyapatite films. Bone 2001;28:187-194.
    • (2001) Bone , vol.28 , pp. 187-194
    • Lees, R.L.1    Sabharwal, V.K.2    Heersche, J.N.M.3
  • 69
    • 2542455620 scopus 로고    scopus 로고
    • Stepwise reprogramming of B cells into mac-rophages
    • Xie HF, Ye M, Feng R et al. Stepwise reprogramming of B cells into mac-rophages. Cell 2004;117:663-676.
    • (2004) Cell , vol.117 , pp. 663-676
    • Xie, H.F.1    Ye, M.2    Feng, R.3
  • 70
    • 34548559114 scopus 로고    scopus 로고
    • Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma
    • Breitkreutz I, Raab MS, Vallet S et al. Targeting MEK1/2 blocks osteoclast differentiation, function and cytokine secretion in multiple myeloma. Br J Haematol 2007;139:55-63.
    • (2007) Br J Haematol , vol.139 , pp. 55-63
    • Breitkreutz, I.1    Raab, M.S.2    Vallet, S.3
  • 71
    • 64049112545 scopus 로고    scopus 로고
    • AlphaVBeta3 + (AvB3) adhesion molecule drives the osteoclast (OC)-like functional differentiation of myeloma cells
    • Presented at the, Greece, June 25-30
    • Lombardi L, Tucci L, Quatraro C et al. AlphaVBeta3 + (AvB3) adhesion molecule drives the osteoclast (OC)-like functional differentiation of myeloma cells. Presented at the XI International Myeloma Workshop, Kos Island, Greece, June 25-30, 2007.
    • (2007) XI International Myeloma Workshop, Kos Island
    • Lombardi, L.1    Tucci, L.2    Quatraro, C.3
  • 72
    • 0037817454 scopus 로고    scopus 로고
    • Spontaneously formed tumori- genic hybrids of Meth A sarcoma cells and macrophages in vivo
    • Busund LTR, Killie MK, Bartnes K et al. Spontaneously formed tumori- genic hybrids of Meth A sarcoma cells and macrophages in vivo. Int J Cancer 2003;106:153-159.
    • (2003) Int J Cancer , vol.106 , pp. 153-159
    • Busund, L.T.R.1    Killie, M.K.2    Bartnes, K.3
  • 73
    • 0028270892 scopus 로고
    • New model for bone resorption study in vitro: Human osteoclast-like cells from giant cell tumors of bone
    • Grano M, Colucci S, De Bellis M et al. New model for bone resorption study in vitro: Human osteoclast-like cells from giant cell tumors of bone. J Bone Miner Res 1994;9:1013-1020.
    • (1994) J Bone Miner Res , vol.9 , pp. 1013-1020
    • Grano, M.1    Colucci, S.2    De Bellis, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.