메뉴 건너뛰기




Volumn 108, Issue 13, 2006, Pages 3992-3996

Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition

Author keywords

[No Author keywords available]

Indexed keywords

BORTEZOMIB; EPOXOMICIN; GLYCOGEN SYNTHASE KINASE 3 INHIBITOR; INTERLEUKIN 3; PROTEASOME INHIBITOR; PROTEIN INHIBITOR; PS1; TRANSCRIPTION FACTOR RUNX2; UBIQUITIN; WNT PROTEIN; WNT PROTEIN INHIBITOR;

EID: 33751193178     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-05-026112     Document Type: Review
Times cited : (265)

References (60)
  • 2
    • 1542330894 scopus 로고    scopus 로고
    • Pathogenesis of myeloma bone disease
    • Roodman GD. Pathogenesis of myeloma bone disease. Blood Cells Mol Dis. 2004;32:290-292.
    • (2004) Blood Cells Mol Dis , vol.32 , pp. 290-292
    • Roodman, G.D.1
  • 3
    • 18144451007 scopus 로고    scopus 로고
    • New insights in myeloma-induced osteolysis
    • Barille-Nion S, Bataille R. New insights in myeloma-induced osteolysis. Leuk Lymphoma. 2003;44:1463-1467.
    • (2003) Leuk Lymphoma , vol.44 , pp. 1463-1467
    • Barille-Nion, S.1    Bataille, R.2
  • 4
    • 4143082697 scopus 로고    scopus 로고
    • New insight in the mechanism of osteoclast activation and formation in multiple myeloma: Focus on the receptor activator of NF-kappaB ligand (RANKL)
    • Giuliani N, Colla S, Rizzoli V. New insight in the mechanism of osteoclast activation and formation in multiple myeloma: focus on the receptor activator of NF-kappaB ligand (RANKL). Exp Hematol. 2004;32:685-691.
    • (2004) Exp Hematol , vol.32 , pp. 685-691
    • Giuliani, N.1    Colla, S.2    Rizzoli, V.3
  • 5
    • 0024786736 scopus 로고
    • Mechanisms of bone destruction in multiple myeloma: The importance of an unbalanced process in determining the severity of lytic bone disease
    • Bataille R, Chappard D, Marcelli C, et al. Mechanisms of bone destruction in multiple myeloma: the importance of an unbalanced process in determining the severity of lytic bone disease. J Clin Oncol. 1989;7:1909-1914.
    • (1989) J Clin Oncol , vol.7 , pp. 1909-1914
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3
  • 6
    • 0025678591 scopus 로고
    • Osteoblast stimulation in multiple myeloma lacking lytic bone lesions
    • Bataille R, Chappard D, Marcelli C, et al. Osteoblast stimulation in multiple myeloma lacking lytic bone lesions. Br J Haematol. 1990;76:484-487.
    • (1990) Br J Haematol , vol.76 , pp. 484-487
    • Bataille, R.1    Chappard, D.2    Marcelli, C.3
  • 7
    • 0030939407 scopus 로고    scopus 로고
    • Abnormal bone turnover in monoclonal gammopathy of undetermined significance: Analyses of type I collagen telopeptide, osteocalcin, bone-specific alkaline phosphatase and propeptides of type I and type III procollagens
    • Vejlgaard T, Abildgaard N, Jans H, Nielsen JL, Heickendorff L. Abnormal bone turnover in monoclonal gammopathy of undetermined significance: analyses of type I collagen telopeptide, osteocalcin, bone-specific alkaline phosphatase and propeptides of type I and type III procollagens. Eur J Haematol. 1997;58:104-108.
    • (1997) Eur J Haematol , vol.58 , pp. 104-108
    • Vejlgaard, T.1    Abildgaard, N.2    Jans, H.3    Nielsen, J.L.4    Heickendorff, L.5
  • 8
    • 0032930729 scopus 로고    scopus 로고
    • Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice
    • Hjorth-Hansen H, Seifert MF, Borset M, et al. Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency mice. J Bone Miner Res. 1999;14:256-263.
    • (1999) J Bone Miner Res , vol.14 , pp. 256-263
    • Hjorth-Hansen, H.1    Seifert, M.F.2    Borset, M.3
  • 9
    • 14244265834 scopus 로고    scopus 로고
    • Minireview: Transcriptional regulation in development of bone
    • Kobayashi T, Kronenberg H. Minireview: transcriptional regulation in development of bone. Endocrinology. 2005;146:1012-1017.
    • (2005) Endocrinology , vol.146 , pp. 1012-1017
    • Kobayashi, T.1    Kronenberg, H.2
  • 10
    • 0030678549 scopus 로고    scopus 로고
    • Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation
    • Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation. Cell. 1997;89:747-754.
    • (1997) Cell , vol.89 , pp. 747-754
    • Ducy, P.1    Zhang, R.2    Geoffroy, V.3    Ridall, A.L.4    Karsenty, G.5
  • 11
    • 0037441529 scopus 로고    scopus 로고
    • Regulation of the osteoblast-specific transcription factor, Runx2: Responsiveness to multiple signal transduction pathways
    • Franceschi RT, Xiao G. Regulation of the osteoblast-specific transcription factor, Runx2: responsiveness to multiple signal transduction pathways. J Cell Biochem. 2003;88:446-454.
    • (2003) J Cell Biochem , vol.88 , pp. 446-454
    • Franceschi, R.T.1    Xiao, G.2
  • 12
    • 0033035286 scopus 로고    scopus 로고
    • Cbfa1 as a regulator of osteoblast differentiation and function
    • Karsenty G, Ducy P, Starbuck M, et al. Cbfa1 as a regulator of osteoblast differentiation and function. Bone. 1999;25:107-108.
    • (1999) Bone , vol.25 , pp. 107-108
    • Karsenty, G.1    Ducy, P.2    Starbuck, M.3
  • 13
    • 0036352427 scopus 로고    scopus 로고
    • Runx2, a multifunctional transcription factor in skeletal development
    • Komori T. Runx2, a multifunctional transcription factor in skeletal development. J Cell Biochem. 2002;87:1-8.
    • (2002) J Cell Biochem , vol.87 , pp. 1-8
    • Komori, T.1
  • 14
    • 0030684749 scopus 로고    scopus 로고
    • Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts
    • Komori T, Yagi H, Nomura S, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblasts. Cell. 1997;89:755-764.
    • (1997) Cell , vol.89 , pp. 755-764
    • Komori, T.1    Yagi, H.2    Nomura, S.3
  • 15
    • 0036333736 scopus 로고    scopus 로고
    • High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage
    • Geoffroy V, Kneissel M, Fournier B, Boyde A, Matthias P. High bone resorption in adult aging transgenic mice overexpressing cbfa1/runx2 in cells of the osteoblastic lineage. Mol Cell Biol. 2002;22:6222-6233.
    • (2002) Mol Cell Biol , vol.22 , pp. 6222-6233
    • Geoffroy, V.1    Kneissel, M.2    Fournier, B.3    Boyde, A.4    Matthias, P.5
  • 16
    • 0034482638 scopus 로고    scopus 로고
    • Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts
    • Prince M, Banerjee C, Javed A, et al. Expression and regulation of Runx2/Cbfa1 and osteoblast phenotypic markers during the growth and differentiation of human osteoblasts. J Cell Biochem. 2001;80:424-440.
    • (2001) J Cell Biochem , vol.80 , pp. 424-440
    • Prince, M.1    Banerjee, C.2    Javed, A.3
  • 17
    • 12244296438 scopus 로고    scopus 로고
    • Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells
    • Shui C, Spelsberg TC, Riggs BL, Khosla S. Changes in Runx2/Cbfa1 expression and activity during osteoblastic differentiation of human bone marrow stromal cells. J Bone Miner Res. 2003;18:213-221.
    • (2003) J Bone Miner Res , vol.18 , pp. 213-221
    • Shui, C.1    Spelsberg, T.C.2    Riggs, B.L.3    Khosla, S.4
  • 18
    • 23744498205 scopus 로고    scopus 로고
    • Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation
    • Giuliani N, Colla S, Morandi F, et al. Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiation. Blood. 2005;106:2472-2483.
    • (2005) Blood , vol.106 , pp. 2472-2483
    • Giuliani, N.1    Colla, S.2    Morandi, F.3
  • 19
    • 0034682834 scopus 로고    scopus 로고
    • The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function
    • Thirunavukkarasu K, Halladay DL, Miles RR, et al. The osteoblast-specific transcription factor Cbfa1 contributes to the expression of osteoprotegerin, a potent inhibitor of osteoclast differentiation and function. J Biol Chem. 2000;275:25163-25172.
    • (2000) J Biol Chem , vol.275 , pp. 25163-25172
    • Thirunavukkarasu, K.1    Halladay, D.L.2    Miles, R.R.3
  • 20
    • 0028810948 scopus 로고
    • Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin
    • Barille S, Collette M, Bataille R, Amiot M. Myeloma cells upregulate interleukin-6 secretion in osteoblastic cells through cell-to-cell contact but downregulate osteocalcin. Blood. 1995;86:3151-3159.
    • (1995) Blood , vol.86 , pp. 3151-3159
    • Barille, S.1    Collette, M.2    Bataille, R.3    Amiot, M.4
  • 21
    • 0034284054 scopus 로고    scopus 로고
    • Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast- stimulating activity
    • Michigami T, Shimizu N, Williams PJ, et al. Cell-cell contact between marrow stromal cells and myeloma cells via VCAM-1 and alpha(4)beta(1)-integrin enhances production of osteoclast-stimulating activity. Blood. 2000;96:1953-1960.
    • (2000) Blood , vol.96 , pp. 1953-1960
    • Michigami, T.1    Shimizu, N.2    Williams, P.J.3
  • 22
    • 4644357296 scopus 로고    scopus 로고
    • Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis
    • Mori Y, Shimizu N, Dallas M, et al. Anti-alpha4 integrin antibody suppresses the development of multiple myeloma and associated osteoclastic osteolysis. Blood. 2004;104:2149-2154.
    • (2004) Blood , vol.104 , pp. 2149-2154
    • Mori, Y.1    Shimizu, N.2    Dallas, M.3
  • 23
    • 0028241065 scopus 로고
    • Production of fibronectin and adherence to fibronectin by human myeloma cell lines
    • van Riet I, de Greef C, del Favero H, Demanet C, Van Camp B. Production of fibronectin and adherence to fibronectin by human myeloma cell lines. Br J Haematol. 1994;87:258-265.
    • (1994) Br J Haematol , vol.87 , pp. 258-265
    • Van Riet, I.1    De Greef, C.2    Del Favero, H.3    Demanet, C.4    Van Camp, B.5
  • 24
    • 0036112623 scopus 로고    scopus 로고
    • Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation
    • Ely SA, Knowles DM. Expression of CD56/neural cell adhesion molecule correlates with the presence of lytic bone lesions in multiple myeloma and distinguishes myeloma from monoclonal gammopathy of undetermined significance and lymphomas with plasmacytoid differentiation. Am J Pathol. 2002;160:1293-1299.
    • (2002) Am J Pathol , vol.160 , pp. 1293-1299
    • Ely, S.A.1    Knowles, D.M.2
  • 25
    • 0036897349 scopus 로고    scopus 로고
    • Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency
    • Weitzmann MN, Roggia C, Toraldo G, Weitzmann L, Pacifici R. Increased production of IL-7 uncouples bone formation from bone resorption during estrogen deficiency. J Clin Invest. 2002;110:1643-1650.
    • (2002) J Clin Invest , vol.110 , pp. 1643-1650
    • Weitzmann, M.N.1    Roggia, C.2    Toraldo, G.3    Weitzmann, L.4    Pacifici, R.5
  • 26
    • 0037114636 scopus 로고    scopus 로고
    • Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: A potential role in multiple myeloma bone disease
    • Giuliani N, Colla S, Sala R, et al. Human myeloma cells stimulate the receptor activator of nuclear factor-kappa B ligand (RANKL) in T lymphocytes: a potential role in multiple myeloma bone disease. Blood. 2002;100:4615-4621.
    • (2002) Blood , vol.100 , pp. 4615-4621
    • Giuliani, N.1    Colla, S.2    Sala, R.3
  • 27
    • 22644440847 scopus 로고    scopus 로고
    • Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo
    • Zhao Z, Zhao M, Xiao G, Franceschi RT. Gene transfer of the Runx2 transcription factor enhances osteogenic activity of bone marrow stromal cells in vitro and in vivo. Mol Ther. 2005;12:247-253.
    • (2005) Mol Ther , vol.12 , pp. 247-253
    • Zhao, Z.1    Zhao, M.2    Xiao, G.3    Franceschi, R.T.4
  • 28
    • 22844450849 scopus 로고    scopus 로고
    • The SCID-hu myeloma model
    • Epstein J, Yaccoby S. The SCID-hu myeloma model. Methods Mol Med. 2005;113:183-190.
    • (2005) Methods Mol Med , vol.113 , pp. 183-190
    • Epstein, J.1    Yaccoby, S.2
  • 30
    • 5044228112 scopus 로고    scopus 로고
    • Wnt signaling in osteoblasts and bone diseases
    • Westendorf JJ, Kahler RA, Schroeder TM. Wnt signaling in osteoblasts and bone diseases. Gene. 2004;341:19-39.
    • (2004) Gene , vol.341 , pp. 19-39
    • Westendorf, J.J.1    Kahler, R.A.2    Schroeder, T.M.3
  • 31
    • 0142241118 scopus 로고    scopus 로고
    • BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop
    • Rawadi G, Vayssiere B, Dunn F, Baron R, Roman-Roman S. BMP-2 controls alkaline phosphatase expression and osteoblast mineralization by a Wnt autocrine loop. J Bone Miner Res. 2003;18:1842-1853.
    • (2003) J Bone Miner Res , vol.18 , pp. 1842-1853
    • Rawadi, G.1    Vayssiere, B.2    Dunn, F.3    Baron, R.4    Roman-Roman, S.5
  • 32
    • 25144448701 scopus 로고    scopus 로고
    • Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation
    • Li X, Liu P, Liu W, et al. Dkk2 has a role in terminal osteoblast differentiation and mineralized matrix formation. Nat Genet. 2005;37:945-952.
    • (2005) Nat Genet , vol.37 , pp. 945-952
    • Li, X.1    Liu, P.2    Liu, W.3
  • 33
    • 25844509347 scopus 로고    scopus 로고
    • Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression
    • Gaur T, Lengner CJ, Hovhannisyan H, et al. Canonical WNT signaling promotes osteogenesis by directly stimulating Runx2 gene expression. J Biol Chem. 2005;280:33132-33140.
    • (2005) J Biol Chem , vol.280 , pp. 33132-33140
    • Gaur, T.1    Lengner, C.J.2    Hovhannisyan, H.3
  • 35
    • 0037118285 scopus 로고    scopus 로고
    • High bone density due to a mutation in LDL-receptor-related protein 5
    • Boyden LM, Mao J, Belsky J, et al. High bone density due to a mutation in LDL-receptor-related protein 5. N Engl J Med. 2002;346:1513-1521.
    • (2002) N Engl J Med , vol.346 , pp. 1513-1521
    • Boyden, L.M.1    Mao, J.2    Belsky, J.3
  • 37
    • 11144296595 scopus 로고    scopus 로고
    • Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells
    • Boland GM, Perkins G, Hall DJ, Tuan RS. Wnt 3a promotes proliferation and suppresses osteogenic differentiation of adult human mesenchymal stem cells. J Cell Biochem. 2004;93:1210-1230.
    • (2004) J Cell Biochem , vol.93 , pp. 1210-1230
    • Boland, G.M.1    Perkins, G.2    Hall, D.J.3    Tuan, R.S.4
  • 38
    • 0346363760 scopus 로고    scopus 로고
    • The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
    • Tian E, Zhan F, Walker R, et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med. 2003;349:2483-2494.
    • (2003) N Engl J Med , vol.349 , pp. 2483-2494
    • Tian, E.1    Zhan, F.2    Walker, R.3
  • 39
    • 33747468221 scopus 로고    scopus 로고
    • Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation
    • Politou MC, Heath DJ, Rahemtulla A, et al. Serum concentrations of Dickkopf-1 protein are increased in patients with multiple myeloma and reduced after autologous stem cell transplantation. Int J Cancer. 2006;119:1728-1731.
    • (2006) Int J Cancer , vol.119 , pp. 1728-1731
    • Politou, M.C.1    Heath, D.J.2    Rahemtulla, A.3
  • 40
    • 3042805477 scopus 로고    scopus 로고
    • Bone lesions in molecular subtypes of multiple myeloma
    • Robbiani DF, Chesi M, Bergsagel PL. Bone lesions in molecular subtypes of multiple myeloma. N Engl J Med. 2004;351:197-198.
    • (2004) N Engl J Med , vol.351 , pp. 197-198
    • Robbiani, D.F.1    Chesi, M.2    Bergsagel, P.L.3
  • 41
    • 33744476502 scopus 로고    scopus 로고
    • A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia
    • De Toni F, Racaud-Sultan C, Chicanne G, et al. A crosstalk between the Wnt and the adhesion-dependent signaling pathways governs the chemosensitivity of acute myeloid leukemia. Oncogene. 2006;25:3113-3122.
    • (2006) Oncogene , vol.25 , pp. 3113-3122
    • De Toni, F.1    Racaud-Sultan, C.2    Chicanne, G.3
  • 42
    • 33745494534 scopus 로고    scopus 로고
    • A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    • Gunn WG, Conley A, Deininger L, Olson SD, Prockop DJ, Gregory CA. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells. 2006;24:986-991.
    • (2006) Stem Cells , vol.24 , pp. 986-991
    • Gunn, W.G.1    Conley, A.2    Deininger, L.3    Olson, S.D.4    Prockop, D.J.5    Gregory, C.A.6
  • 43
    • 27644473781 scopus 로고    scopus 로고
    • Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2
    • Oshima T, Abe M, Asano J, et al. Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2. Blood. 2005;106:3160-3165.
    • (2005) Blood , vol.106 , pp. 3160-3165
    • Oshima, T.1    Abe, M.2    Asano, J.3
  • 44
    • 33646414025 scopus 로고    scopus 로고
    • Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo
    • Kulkarni NH, Onyia JE, Zeng Q, et al. Orally bioavailable GSK-3alpha/beta dual inhibitor increases markers of cellular differentiation in vitro and bone mass in vivo. J Bone Miner Res. 2006;21:910-920.
    • (2006) J Bone Miner Res , vol.21 , pp. 910-920
    • Kulkarni, N.H.1    Onyia, J.E.2    Zeng, Q.3
  • 45
    • 33845489063 scopus 로고    scopus 로고
    • Blocking DKK1 activity in primary myeloma-bearing SCID-rab mice is associated with increased osteoblast activity and bone formation and inhibition of tumor growth
    • [abstract]
    • Yaccoby S, Zhan F, Barlogie B, Shaughnessy JD. Blocking DKK1 activity in primary myeloma-bearing SCID-rab mice is associated with increased osteoblast activity and bone formation and inhibition of tumor growth [abstract]. J Bone Miner Res. 2005;20(suppl 1):s32.
    • (2005) J Bone Miner Res , vol.20 , Issue.SUPPL. 1
    • Yaccoby, S.1    Zhan, F.2    Barlogie, B.3    Shaughnessy, J.D.4
  • 46
    • 11144355390 scopus 로고    scopus 로고
    • Illegitimate WNT signaling promotes proliferation of multiple myeloma cells
    • Derksen PW, Tjin E, Meijer HP, et al. Illegitimate WNT signaling promotes proliferation of multiple myeloma cells. Proc Natl Acad Sci U S A. 2004;101:6122-6127.
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 6122-6127
    • Derksen, P.W.1    Tjin, E.2    Meijer, H.P.3
  • 47
    • 23744507989 scopus 로고    scopus 로고
    • IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma
    • Ehrlich LA, Chung HY, Ghobrial I, et al. IL-3 is a potential inhibitor of osteoblast differentiation in multiple myeloma. Blood. 2005;106:1407-1414.
    • (2005) Blood , vol.106 , pp. 1407-1414
    • Ehrlich, L.A.1    Chung, H.Y.2    Ghobrial, I.3
  • 48
    • 1542313900 scopus 로고    scopus 로고
    • IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells
    • Lee JW, Chung HY, Ehrlich LA, et al. IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cells. Blood. 2004;103:2308-2315.
    • (2004) Blood , vol.103 , pp. 2308-2315
    • Lee, J.W.1    Chung, H.Y.2    Ehrlich, L.A.3
  • 49
    • 30444432403 scopus 로고    scopus 로고
    • Interleukin-3 (IL-3) is overexpressed by T lymphocytes in multiple myeloma patients
    • Giuliani N, Morandi F, Tagliaferri S, et al. Interleukin-3 (IL-3) is overexpressed by T lymphocytes in multiple myeloma patients. Blood. 2006;107:841-842.
    • (2006) Blood , vol.107 , pp. 841-842
    • Giuliani, N.1    Morandi, F.2    Tagliaferri, S.3
  • 50
    • 0026558465 scopus 로고
    • Myeloma affects both the growth and function of human osteoblast-like cells
    • Evans CE, Ward C, Rathour L, Galasko CB. Myeloma affects both the growth and function of human osteoblast-like cells. Clin Exp Metastasis. 1992;10:33-38.
    • (1992) Clin Exp Metastasis , vol.10 , pp. 33-38
    • Evans, C.E.1    Ward, C.2    Rathour, L.3    Galasko, C.B.4
  • 51
    • 0038345395 scopus 로고    scopus 로고
    • Upregulation of osteoblast apoptosis by malignant plasma cells: A role in myeloma bone disease
    • Silvestris F, Cafforio P, Tucci M, Grinello D, Dammacco F. Upregulation of osteoblast apoptosis by malignant plasma cells: a role in myeloma bone disease. Br J Haematol. 2003;122:39-52.
    • (2003) Br J Haematol , vol.122 , pp. 39-52
    • Silvestris, F.1    Cafforio, P.2    Tucci, M.3    Grinello, D.4    Dammacco, F.5
  • 54
    • 0038819051 scopus 로고    scopus 로고
    • Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro
    • Garrett IR, Chen D, Gutierrez G, et al. Selective inhibitors of the osteoblast proteasome stimulate bone formation in vivo and in vitro. J Clin Invest. 2003;111:1771-1782.
    • (2003) J Clin Invest , vol.111 , pp. 1771-1782
    • Garrett, I.R.1    Chen, D.2    Gutierrez, G.3
  • 55
    • 0041845297 scopus 로고    scopus 로고
    • E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation
    • Zhao M, Qiao M, Oyajobi BO, Mundy GR, Chen D. E3 ubiquitin ligase Smurf1 mediates core-binding factor alpha1/Runx2 degradation and plays a specific role in osteoblast differentiation. J Biol Chem. 2003;278:27939-27944.
    • (2003) J Biol Chem , vol.278 , pp. 27939-27944
    • Zhao, M.1    Qiao, M.2    Oyajobi, B.O.3    Mundy, G.R.4    Chen, D.5
  • 56
    • 27744557499 scopus 로고    scopus 로고
    • Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma
    • Zangari M, Esseltine D, Lee CK, et al. Response to bortezomib is associated to osteoblastic activation in patients with multiple myeloma. Br J Haematol. 2005;131:71-73.
    • (2005) Br J Haematol , vol.131 , pp. 71-73
    • Zangari, M.1    Esseltine, D.2    Lee, C.K.3
  • 57
    • 20844451019 scopus 로고    scopus 로고
    • High serum bone-specific alkaline phosphatase level after bortezomib-combined therapy in refractory multiple myeloma: Possible role of bortezomib on osteoblast differentiation
    • Shimazaki C, Uchida R, Nakano S, et al. High serum bone-specific alkaline phosphatase level after bortezomib-combined therapy in refractory multiple myeloma: possible role of bortezomib on osteoblast differentiation. Leukemia. 2005;19:1102-1103.
    • (2005) Leukemia , vol.19 , pp. 1102-1103
    • Shimazaki, C.1    Uchida, R.2    Nakano, S.3
  • 58
    • 0034012201 scopus 로고    scopus 로고
    • Human myeloma cells promote the production of interleukin-6 by primary human osteoblasts
    • Karadag A, Oyajobi BO, Apperley JF, Russell RG, Croucher PI. Human myeloma cells promote the production of interleukin-6 by primary human osteoblasts. Br J Haematol. 2000;108:383-390.
    • (2000) Br J Haematol , vol.108 , pp. 383-390
    • Karadag, A.1    Oyajobi, B.O.2    Apperley, J.F.3    Russell, R.G.4    Croucher, P.I.5
  • 59
    • 0037374460 scopus 로고    scopus 로고
    • Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells
    • Shipman CM, Croucher PI. Osteoprotegerin is a soluble decoy receptor for tumor necrosis factor-related apoptosis-inducing ligand/Apo2 ligand and can function as a paracrine survival factor for human myeloma cells. Cancer Res. 2003;63:912-916.
    • (2003) Cancer Res , vol.63 , pp. 912-916
    • Shipman, C.M.1    Croucher, P.I.2
  • 60
    • 33644558753 scopus 로고    scopus 로고
    • Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model
    • Yaccoby S, Wezeman MJ, Zangari M, et al. Inhibitory effects of osteoblasts and increased bone formation on myeloma in novel culture systems and a myelomatous mouse model. Haematologica. 2006;91:192-199.
    • (2006) Haematologica , vol.91 , pp. 192-199
    • Yaccoby, S.1    Wezeman, M.J.2    Zangari, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.