Regulation of cellular immunity by photo(chemo)therapy

Frontiers in Bioscience

Volumn 14, Issue 11, 2009, Pages 4326-4336

  Grundmann, Sonja Alexandra ^a   Beissert, Stefan ^a  

^a INST OF REPRO MED OF THE UNIV   (Germany)

Author keywords

Apoptosis; Cytokines; DNA damage; Immunomodulation; Immunosupression; Immunotolerance; Photoimmunology; Phototherapy; Regulatory T cells; Ultraviolet radiation

Indexed keywords

CELLULAR IMMUNITY; DRUG EFFECT; HUMAN; PHOTOCHEMOTHERAPY; RADIATION EXPOSURE; REVIEW; ULTRAVIOLET RADIATION;

HUMANS; IMMUNITY, CELLULAR; PHOTOCHEMOTHERAPY; ULTRAVIOLET RAYS;

EID: 63849090055     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/3530     Document Type: Article

References (101)

1. Fischer T, J. Alsins, B. Berne: Ultraviolet-action spectrum and evaluation of ultraviolet lamps for psoriasis healing. Int J Dermatol, 23(10), 633-7(1984) (Pubitemid 15223164)
2. Parrish JA, K. F. Jaenicke: Action spectrum for phototherapy of psoriasis. J Invest Dermatol, 76(5), 359-62(1981) (Pubitemid 12236508)
3. van Weelden H, H. B. De LaFaille, E. Young, J. C. van der Leun: A new development in UVB phototherapy of psoriasis. Br J Dermatol, 119(1), 11-9(1988)
4. Gibbs NK, N. J. Traynor, R. M. MacKie, I. Campbell, B. E. Johnson, J. Ferguson: The phototumorigenic potential of broad-band (270-350 nm) and narrow-band (311-313 nm) phototherapy sources cannot be predicted by their edematogenic potential in hairless mouse skin. J Invest Dermatol, 104(3), 359-63(1995)
5. Kunisada M, H. Kumimoto, K. Ishizaki, K. Sakumi, Y. Nakabeppu, C. Nishigori: Narrow-band UVB induces more carcinogenic skin tumors than broad-band UVB through the formation of cyclobutane pyrimidine dimer. J Invest Dermatol, 127(12), 2865-71(2007) (Pubitemid 350134829)
6. Beissert S, R. D. Granstein: UV-induced cutaneous photobiology. Crit Rev Biochem Mol Biol, 31(5-6), 381-404(1996) (Pubitemid 27024211)
7. Beissert S, T. Schwarz: Mechanisms involved in ultraviolet light-induced immunosuppression. J Investig Dermatol Symp Proc, 4(1), 61-4(1999) (Pubitemid 29491257)
8. Strozyk E, B. Poppelmann, T. Schwarz, D. Kulms: Differential effects of NF-kappaB on apoptosis induced by DNA-damaging agents: the type of DNA damage determines the final outcome. Oncogene, 25(47), 6239-51(2006) (Pubitemid 44564741)
9. Kulms D, E. Zeise, B. Poppelmann, T. Schwarz: DNA damage, death receptor activation and reactive oxygen species contribute to ultraviolet radiation-induced apoptosis in an essential and independent way. Oncogene, 21(38), 5844-51(2002) (Pubitemid 35007234)
10. Stege H, L. Roza, A. A. Vink, M. Grewe, T. Ruzicka, S. Grether-Beck, J. Krutmann: Enzyme plus light therapy to repair DNA damage in ultraviolet-B- irradiated human skin. Proc Natl Acad Sci U S A, 97(4), 1790-5(2000) (Pubitemid 30118521)
11. Wolf P, P. Cox, D. B. Yarosh, M. L. Kripke: Sunscreens and T4N5 liposomes differ in their ability to protect against ultraviolet-induced sunburn cell formation, alterations of dendritic epidermal cells, and local suppression of contact hypersensitivity. J Invest Dermatol, 104(2), 287-92(1995)
12. van Oosten M, H. Rebel, E. C. Friedberg, H. van Steeg, G. T. van der Horst, H. J. van Kranen, A. Westerman, A. A. van Zeeland, L. H. Mullenders, F. R. de Gruijl: Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis. Proc Natl Acad Sci U S A, 97(21), 11268-73(2000)
13. Rehemtulla A, C. A. Hamilton, A. M. Chinnaiyan, V. M. Dixit: Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95(Fas/APO-1). J Biol Chem, 272(41), 25783-6(1997) (Pubitemid 27438899)
14. Rosette C, M. Karin: Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science, 274(5290), 1194-7(1996) (Pubitemid 26389285)
15. Aragane Y, D. Kulms, D. Metze, G. Wilkes, B. Poppelmann, T. A. Luger, T. Schwarz: Ultraviolet light induces apoptosis via direct activation of CD95(Fas/APO-1) independently of its ligand CD95L. J Cell Biol, 140(1), 171-82(1998) (Pubitemid 28070905)
16. Ozawa M, K. Ferenczi, T. Kikuchi, I. Cardinale, L. M. Austin, T. R. Coven, L. H. Burack, J. G. Krueger: 312-nanometer ultraviolet B light (narrow-band UVB) induces apoptosis of T cells within psoriatic lesions. J Exp Med, 189(4), 711-8(1999) (Pubitemid 29193372)
17. Leverkus M, M. Yaar and B. A. Gilchrest: Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes. Exp Cell Res, 232(2), 255-62(1997) (Pubitemid 27194037)
18. Norval M, N. K. Gibbs and J. Gilmour: The role of urocanic acid in UV-induced immunosuppression: recent advances (1992-1994). Photochem Photobiol, 62(2), 209-17(1995)
19. De Fabo EC, F. P. Noonan: Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med, 158(1), 84-98(1983) (Pubitemid 13073514)
20. Kurimoto I, J. W. Streilein: cis-urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor-alpha. J Immunol, 148(10), 3072-8(1992)
21. Beissert S, T. Mohammad, H. Torri, A. Lonati, Z. Yan, H. Morrison, R. D. Granstein: Regulation of tumor antigen presentation by urocanic acid. J Immunol, 159(1), 92-6(1997) (Pubitemid 127493689)
22. Beissert S, D. Ruhlemann, T. Mohammad, S. Grabbe, A. El-Ghorr, M. Norval, H. Morrison, R. D. Granstein, T. Schwarz: IL-12 prevents the inhibitory effects of cisurocanic acid on tumor antigen presentation by Langerhans cells: implications for photocarcinogenesis. J Immunol, 167(11), 6232-8(2001) (Pubitemid 33081552)
23. Vestey JP, M. Norval: An open trial of topical urocanic acid for the treatment of stable plaque psoriasis. Photodermatol Photoimmunol Photomed, 13(1-2), 67-8(1997) (Pubitemid 27445911)
24. Holan V, L. Kuffova, A. Zajicova, M. Krulova, M. Filipec, P. Holler, A. Jancarek: Urocanic acid enhances IL-10 production in activated CD4+ T cells. J Immunol, 161(7), 3237-41(1998)
25. Walterscheid JP, D. X. Nghiem, N. Kazimi, L. K. Nutt, D. J. McConkey, M. Norval, S. E. Ullrich: Cis-urocanic acid, a sunlight-induced immunosuppressive factor, activates immune suppression via the 5-HT2A receptor. Proc Natl Acad Sci U S A, 103(46), 17420-5(2006) (Pubitemid 44788984)
26. Luger TA, T. Schwarz: The role of cytokines and neuroendocrine hormones in cutaneous immunity and inflammation. Allergy, 50(4), 292-302(1995)
27. Urbanski A, T. Schwarz, P. Neuner, J. Krutmann, R. Kirnbauer, A. Kock, T. A. Luger: Ultraviolet light induces increased circulating interleukin-6 in humans. J Invest Dermatol, 94(6), 808-11(1990) (Pubitemid 20184383)
28. Schwarz A, A. Maeda, S. Stander, H. van Steeg, T. Schwarz: IL-18 reduces ultraviolet radiation-induced DNA damage and thereby affects photoimmunosuppression. J Immunol, 176(5), 2896-901(2006)
29. Schwarz T, A. Urbanska, F. Gschnait, T. A. Luger: UV-irradiated epidermal cells produce a specific inhibitor of interleukin 1 activity. J Immunol, 138(5), 1457-63(1987) (Pubitemid 17029440)
30. Enk AH, V. L. Angeloni, M. C. Udey, S. I. Katz: Inhibition of Langerhans cell antigen-presenting function by IL-10. A role for IL-10 in induction of tolerance. J Immunol, 151(5), 2390-8(1993) (Pubitemid 23264491)
31. Schlaak JF, M. Buslau, W. Jochum, E. Hermann, M. Girndt, H. Gallati, K. H. Meyer zum Buschenfelde, B. Fleischer: T cells involved in psoriasis vulgaris belong to the Th1 subset. J Invest Dermatol, 102(2), 145-9(1994) (Pubitemid 24060399)
32. Uyemura K, M. Yamamura, D. F. Fivenson, R. L. Modlin, B. J. Nickoloff: The cytokine network in lesional and lesion-free psoriatic skin is characterized by a T-helper type 1 cell-mediated response. J Invest Dermatol, 101(5), 701-5(1993) (Pubitemid 23322027)
33. Asadullah K, W. Sterry, K. Stephanek, D. Jasulaitis, M. Leupold, H. Audring, H. D. Volk, W. D. Docke: IL-10 is a key cytokine in psoriasis. J Clin Invest, 101(4), 783-94(1998)
34. Moodycliffe AM, I. Kimber, M. Norval: Role of tumour necrosis factor-alpha in ultraviolet B light-induced dendritic cell migration and suppression of contact hypersensitivity. Immunology, 81(1), 79-84(1994) (Pubitemid 24249836)
35. Shreedha Vr, T. Giese, V. W. Sung, S. E. Ullrich: A cytokine cascade including prostaglandin E2, IL-4, and IL-10 is responsible for UV-induced systemic immune suppression. J Immunol, 160(8), 3783-9(1998) (Pubitemid 28176081)
36. Gillardon F, I. Moll, S. Michel, J. Benrath, E. Weihe, M. Zimmermann: Calcitonin gene-related peptide and nitric oxide are involved in ultraviolet radiation-induced immunosuppression. Eur J Pharmacol, 293(4), 395-400(1995) (Pubitemid 3006663)
37. Luger TA, T. Schwarz, H. Kalden, T. Scholzen, A. Schwarz, T. Brzoska: Role of epidermal cell-derived alphamelanocyte stimulating hormone in ultraviolet light mediated local immunosuppression. Ann N Y Acad Sci, 885, 209-16(1999)
38. Walterscheid JP, S. E. Ullrich, D. X. Nghiem: Plateletactivating factor, a molecular sensor for cellular damage, activates systemic immune suppression. J Exp Med, 195(2), 171-9(2002) (Pubitemid 34461261)
39. Loser K, J. Apelt, M. Voskort, M. Mohaupt, S. Balkow, T. Schwarz, S. Grabbe and S. Beissert: IL-10 controls ultraviolet-induced carcinogenesis in mice. J Immunol, 179(1), 365-71(2007) (Pubitemid 46986553)
40. Schwarz A, S. Stander, M. Berneburg, M. Bohm, D. Kulms, H. van Steeg, K. Grosse-Heitmeyer, J. Krutmann, T. Schwarz: Interleukin-12 suppresses ultraviolet radiationinduced apoptosis by inducing DNA repair. Nat Cell Biol, 4(1), 26-31(2002) (Pubitemid 34071977)
41. Schwarz T: Regulatory T cells induced by ultraviolet radiation. Int Arch Allergy Immunol, 137(3), 187-93(2005) (Pubitemid 41202757)
42. Schwarz A, A. Maeda, K. Kernebeck, H. van Steeg, S. Beissert, T. Schwarz: Prevention of UV radiation-induced immunosuppression by IL-12 is dependent on DNA repair. J Exp Med, 201(2), 173-9(2005) (Pubitemid 40189425)
43. Jonuleit H, E. Schmitt, G. Schuler, J. Knop, A. H. Enk: Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J Exp Med, 192(9), 1213-22(2000)
44. Schwarz T: Photoimmunosuppression. Photodermatol Photoimmunol Photomed, 18(3), 141-5(2002) (Pubitemid 34960193)
45. Toews GB, P. R. Bergstresser, J. W. Streilein: Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol, 124(1), 445-53(1980) (Pubitemid 10182298)
46. Elmets CA, P. R. Bergstresser, R. E. Tigelaar, P. J. Wood, J. W. Streilein: Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med, 158(3), 781-94(1983) (Pubitemid 13051345)
47. Beissert S, A. Schwarz, T. Schwarz: Regulatory T cells. J Invest Dermatol, 126(1), 15-24(2006) (Pubitemid 43336089)
48. Bopp T, H. Jonuleit, E. Schmitt: Regulatory T cells-the renaissance of the suppressor T cells. Ann Med, 39(5), 322-34(2007) (Pubitemid 47262686)
49. Schwarz A, A. Maeda, M. K. Wild, K. Kernebeck, N. Gross, Y. Aragane, S. Beissert, D. Vestweber, T. Schwarz: Ultraviolet radiation-induced regulatory T cells not only inhibit the induction but can suppress the effector phase of contact hypersensitivity. J Immunol, 172(2), 1036-43(2004) (Pubitemid 38113763)
50. Schwarz A, S. Beissert, K. Grosse-Heitmeyer, M. Gunzer, J. A. Bluestone, S. Grabbe, T. Schwarz: Evidence for functional relevance of CTLA-4 in ultraviolet-radiationinduced tolerance. J Immunol, 165(4), 1824-31(2000) (Pubitemid 30643132)
51. Aragane Y, A. Maeda, A. Schwarz, T. Tezuka, K. Ariizumi, T. Schwarz: Involvement of dectin-2 in ultraviolet radiation-induced tolerance. J Immunol, 171(7), 3801-7(2003) (Pubitemid 37254586)
52. Schwarz A, S. Grabbe, K. Grosse-Heitmeyer, B. Roters, H. Riemann, T. A. Luger, G. Trinchieri, T. Schwarz: Ultraviolet light-induced immune tolerance is mediated via the Fas/Fas-ligand system. J Immunol, 160(9), 4262-70(1998) (Pubitemid 28217281)
53. Glass MJ, P. R. Bergstresser, R. E. Tigelaar, J. W. Streilein: UVB radiation and DNFB skin painting induce suppressor cells universally in mice. J Invest Dermatol, 94(3), 273-8(1990) (Pubitemid 20061632)
54. Schwarz T: Ultraviolet radiation-induced tolerance. Allergy, 54(12), 1252-61(1999) (Pubitemid 30070311)
55. Ferguson TA, P. Dube, T. S. Griffith: Regulation of contact hypersensitivity by interleukin 10. J Exp Med, 179(5), 1597-604(1994) (Pubitemid 24129576)
56. Schwarz A, S. Grabbe, H. Riemann, Y. Aragane, M. Simon, S. Manon, S. Andrade, T. A. Luger, A. Zlotnik, T. Schwarz: In vivo effects of interleukin-10 on contact hypersensitivity and delayed-type hypersensitivity reactions. J Invest Dermatol, 103(2), 211-6(1994) (Pubitemid 24234610)
57. Catalina MD, P. Estess, M. H. Siegelman: Selective requirements for leukocyte adhesion molecules in models of acute and chronic cutaneous inflammation: participation of E-and P-but not L-selectin. Blood, 93(2), 580-9(1999) (Pubitemid 29035739)
58. Maloy KJ, F. Powrie: Regulatory T cells in the control of immune pathology. Nat Immunol, 2(9), 816-22(2001)
59. Schwarz A, A. Maeda, T. Schwarz: Alteration of the migratory behavior of UV-induced regulatory T cells by tissue-specific dendritic cells. J Immunol, 178(2), 877-86(2007) (Pubitemid 46095160)
60. Mutzhas MF, E. Holzle, C. Hofmann, G. Plewig: A new apparatus with high radiation energy between 320-460 nm: physical description and dermatological applications. J Invest Dermatol, 76(1), 42-7(1981) (Pubitemid 11173536)
61. Krutmann J, W. Czech, T. Diepgen, R. Niedner, A. Kapp, E. Schopf: High-dose UVA1 therapy in the treatment of patients with atopic dermatitis. J Am Acad Dermatol, 26(2 Pt 1), 225-30(1992)
62. Morita A, T. Werfel, H. Stege, C. Ahrens, K. Karmann, M. Grewe, S. Grether-Beck, T. Ruzicka, A. Kapp, L. O. Klotz, H. Sies, J. Krutmann: Evidence that singlet oxygen-induced human T helper cell apoptosis is the basic mechanism of ultraviolet-A radiation phototherapy. J Exp Med, 186(10), 1763-8(1997) (Pubitemid 27506289)
63. Godar DE: UVA1 radiation triggers two different final apoptotic pathways. J Invest Dermatol, 112(1), 3-12(1999) (Pubitemid 29024698)
64. Godar DE, A. D. Lucas: Ultraviolet-A1(340-400 nm)-mediated receptor and cytokine changes of transformed lymphocytes. Photodermatol Photoimmunol Photomed, 21(1), 23-31(2005) (Pubitemid 40214717)
65. Krutmann J, E. Schopf: High-dose-UVA1 phototherapy: a novel and highly effective approach for the treatment of acute exacerbation of atopic dermatitis. Acta Derm Venereol Suppl (Stockh), 176, 120-2(1992)
66. Wolff K, T. B. Fitzpatrick, L. A. Goldsmith: Fitzpatrick's dermatology in general medicine. McGraw-Hill, Medical Pub. Division, New York (2008)
67. Plettenberg H, H. Stege, M. Megahed, T. Ruzicka, Y. Hosokawa, T. Tsuji, A. Morita, J. Krutmann: Ultraviolet A1(340-400 nm) phototherapy for cutaneous T-cell lymphoma. J Am Acad Dermatol, 41(1), 47-50(1999) (Pubitemid 29336852)
68. Zane C, C. Leali, P. Airo, G. De Panfilis, P. C. Pinton: "High-dose" UVA1 therapy of widespread plaque-type, nodular, and erythrodermic mycosis fungoides. J Am Acad Dermatol, 44(4), 629-33(2001) (Pubitemid 32249520)
69. Yamauchi R, A. Morita, Y. Yasuda, S. Grether-Beck, L. O. Klotz, T. Tsuji, J. Krutmann: Different susceptibility of malignant versus nonmalignant human T cells toward ultraviolet A-1 radiation-induced apoptosis. J Invest Dermatol, 122(2), 477-83(2004) (Pubitemid 38281072)
70. Verhagen J, M. Akdis, C. Traidl-Hoffmann, P. Schmid-Grendelmeier, D. Hijnen, E. F. Knol, H. Behrendt, K. Blaser, C. A. Akdis: Absence of T-regulatory cell expression and function in atopic dermatitis skin. J Allergy Clin Immunol, 117(1), 176-83(2006) (Pubitemid 43017157)
71. Gruss C, J. A. Reed, P. Altmeyer, N. S. McNutt, M. Kerscher: Induction of interstitial collagenase (MMP-1) by UVA-1 phototherapy in morphea fibroblasts. Lancet, 350(9087), 1295-6(1997) (Pubitemid 28036641)
72. Scharffetter K, M. Wlaschek, A. Hogg, K. Bolsen, A. Schothorst, G. Goerz, T. Krieg, G. Plewig: UVA irradiation induces collagenase in human dermal fibroblasts in vitro and in vivo. Arch Dermatol Res, 283(8), 506-11(1991)
73. Stander H, M. Schiller and T. Schwarz: UVA1 therapy for sclerodermic graft-versus-host disease of the skin. J Am Acad Dermatol, 46(5), 799-800(2002)
74. Sakakibara N, S. Sugano, A. Morita: Ultrastructural changes induced in cutaneous collagen by ultraviolet-A1 and psoralen plus ultraviolet A therapy in systemic sclerosis. J Dermatol, 35(2), 63-9(2008) (Pubitemid 351229595)
75. Kerscher M, T. Dirschka, M. Volkenandt: Treatment of localised scleroderma by UVA1 phototherapy. Lancet, 346(8983), 1166(1995)
76. Stege H, M. Berneburg, S. Humke, M. Klammer, M. Grewe, S. Grether-Beck, R. Boedeker, T. Diepgen, K. Dierks, G. Goerz, T. Ruzicka, J. Krutmann: High-dose UVA1 radiation therapy for localized scleroderma. J Am Acad Dermatol, 36(6 Pt 1), 938-44(1997) (Pubitemid 27265906)
77. Krutmann J: Dermatological phototherapy and photodiagnostic methods. Springer, Berlin, New York (2001)
78. Wolnicka-Glubisz A, J. M. Rijnkels, T. Sarna and G. M. Beijersbergen van Henegouwen: Apoptosis in leukocytes induced by UVA in the presence of 8-methoxypsoralen, chlorpromazine or 4, 6, 4'-trimethylangelicin. J Photochem Photobiol B, 68(2-3), 65-72(2002) (Pubitemid 35469824)
79. Stadler R, H. G. Otte, T. Luger, B. M. Henz, P. Kuhl, T. Zwingers, W. Sterry: Prospective randomized multicenter clinical trial on the use of interferon-2a plus acitretin versus interferon-2a plus PUVA in patients with cutaneous T-cell lymphoma stages I and II. Blood, 92(10), 3578-81(1998) (Pubitemid 28525182)
80. Luftl M, M. Rocken, G. Plewig, K. Degitz: PUVA inhibits DNA replication, but not gene transcription at nonlethal dosages. J Invest Dermatol, 111(3), 399-405(1998) (Pubitemid 28400084)
81. Dall'Acqua F, P. Martelli: Photosensitizing action of furocoumarins on membrane components and consequent intracellular events. J Photochem Photobiol B, 8(3), 235-54(1991)
82. Gasparro FP: Psoralen DNA photobiology. CRC Press Inc., Boca Raton, FL, United States (1988)
83. Johnson R, L. Staiano-Coico, L. Austin, I. Cardinale, R. Nabeya-Tsukifuji, J. G. Krueger: PUVA treatment selectively induces a cell cycle block and subsequent apoptosis in human T-lymphocytes. Photochem Photobiol, 63(5), 566-71(1996) (Pubitemid 126467130)
84. Marks DI, R. M. Fox: Mechanisms of photochemotherapyinduced apoptotic cell death in lymphoid cells. Biochem Cell Biol, 69(10-11), 754-60(1991)
85. Yoo EK, A. H. Rook, R. Elenitsas, F. P. Gasparro, B. R. Vowels: Apoptosis induction of ultraviolet light A and photochemotherapy in cutaneous T-cell Lymphoma: relevance to mechanism of therapeutic action. J Invest Dermatol, 107(2), 235-42(1996) (Pubitemid 26254840)
86. Potapenko A: Mechanisms of photodynamic effects of furocoumarins. J Photochem Photobiol B, 9(1), 1-33(1991)
87. Potapenko A, A. A. Kyagova, L. N. Bezdetnaya, E. P. Lysenko, I. Chernyakhovskaya, V. A. Bekhalo, E. V. Nagurskaya, V. A. Nesterenko, N. G. Korotky, S. N. Akhtyamov, T. M. Lanshchikova: Products of psoralen photooxidation possess immunomodulative and antileukemic effects. Photochem Photobiol, 60(2), 171-4(1994) (Pubitemid 2130001)
88. Bernardi P: Mitochondrial transport of cations: channels, exchangers, and permeability transition. Physiol Rev, 79(4), 1127-55(1999) (Pubitemid 29473313)
89. Canton M, S. Caffieri, F. Dall'Acqua, F. Di Lisa: PUVA-induced apoptosis involves mitochondrial dysfunction caused by the opening of the permeability transition pore. FEBS Lett, 522(1-3), 168-72(2002) (Pubitemid 34722518)
90. Caffieri S, F. Di Lisa, F. Bolesani, M. Facco, G. Semenzato, F. Dall'Acqua, M. Canton: The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy. Blood, 109(11), 4988-94(2007) (Pubitemid 46827798)
91. Santamaria AB, D. W. Davis, D. X. Nghiem, D. J. McConkey, S. E. Ullrich, M. Kapoor, G. Lozano, H. N. Ananthaswamy: p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells. Cell Death Differ, 9(5), 549-60(2002) (Pubitemid 34521182)
92. Deng H, C. L. Yan, Y. Hu, Y. Xu, K. H. Liao: Photochemotherapy inhibits angiogenesis and induces apoptosis of endothelial cells in vitro. Photodermatol Photoimmunol Photomed, 20(4), 191-9(2004) (Pubitemid 39077015)
93. Kripke ML, W. L. Morison, J. A. Parrish: Systemic suppression of contact hypersensitivity in mice by psoralen plus UVA radiation (PUVA). J Invest Dermatol, 81(2), 87-92(1983) (Pubitemid 13026308)
94. Alcalay J, S. E. Ullrich, M. L. Kripke: Local suppression of contact hypersensitivity in mice by a monofunctional psoralen plus UVA radiation. Photochem Photobiol, 50(2), 217-20(1989)
95. van de Stolpe A, P. T. van der Saag: Intercellular adhesion molecule-1. J Mol Med, 74(1), 13-33(1996) (Pubitemid 26035754)
96. Urano R, K. Urano, T. Matsuyama, I. Matsuo, M. Ohkido: PUVA treatment of human keratinocytes suppresses the surface expression of intercellular adhesion molecule 1(ICAM-1) and inhibits adherence of PHA-blasts in vitro. Tokai J Exp Clin Med, 22(2), 71-6(1997)
97. Petzelbauer P, G. Stingl, K. Wolff, B. Volc-Platzer: Cyclosporin A suppresses ICAM-1 expression by papillary endothelium in healing psoriatic plaques. J Invest Dermatol, 96(3), 362-9(1991)
98. Neuner P, B. Charvat, R. Knobler, R. Kirnbauer, A. Schwarz, T. A. Luger, T. Schwarz: Cytokine release by peripheral blood mononuclear cells is affected by 8-methoxypsoralen plus UV-A. Photochem Photobiol, 59(2), 182-8(1994)
99. Wolf P, D. X. Nghiem, J. P. Walterscheid, S. Byrne, Y. Matsumura, C. Bucana, H. N. Ananthaswamy, S. E. Ullrich: Platelet-activating factor is crucial in psoralen and ultraviolet A-induced immune suppression, inflammation, and apoptosis. Am J Pathol, 169(3), 795-805(2006) (Pubitemid 44411947)
100. Rook AH, K. R. Suchin, D. M. Kao, E. K. Yoo, W. H. Macey, B. J. De Nardo, P. G. Bromely, Y. Geng, J. M. Junkins-Hopkins, S. R. Lessin: Photopheresis: clinical applications and mechanism of action. J Investig Dermatol Symp Proc, 4(1), 85-90(1999) (Pubitemid 29491262)
101. Maeda A, A. Schwarz, K. Kernebeck, N. Gross, Y. Aragane, D. Peritt and T. Schwarz: Intravenous infusion of syngeneic apoptotic cells by photopheresis induces antigen-specific regulatory T cells. J Immunol, 174(10), 5968-76(2005) (Pubitemid 40663783)