Mechanisms involved in ultraviolet light-induced immunosuppression

Journal of Investigative Dermatology Symposium Proceedings

Volumn 4, Issue 1, 1999, Pages 61-64

  Beissert, Stefan ^a   Schwarz, Thomas ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Antigen presentation; Apoptosis; Cytokines; Photoimmunology

Indexed keywords

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN PRESENTATION; APOPTOSIS; CONFERENCE PAPER; CUTANEOUS PARAMETERS; CYTOKINE PRODUCTION; IMMUNOMODULATION; MOUSE; NONHUMAN; PREMATURE AGING; SKIN CARCINOMA; SKIN DEFECT; ULTRAVIOLET RADIATION;

EID: 0032860270     PISSN: 10870024     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jidsp.5640183     Document Type: Conference Paper

References (44)

1. Aberer W. Schuler G, Stingl G, Hǒngismann H, Wolff K: Ultraviolet light depletes surface markers of Langerhans cells. J Invest Dermatol 76:202-210, 1981
2. Aragane V, Schwarz A, Luger TA, Ariizumi K. Takashima A, Schwarz T: Ultraviolet light suppresses IFN-γ-induced IL-7 gene expression in murine keratinocytes by interfering with IFN regulatory factor?. J Immunol 158:5393-5399, 1997a
3. Aragane V, Kulms D, Luger TA, Schwarz T: Downregulation of interferon-γ-activated STAT1 by ultraviolet light. Proc Natl Acad Sci USA 94:11490-11495, 1997b
4. Aragane A, Kulms D, Kothny C, Metze O, Pöppelmann B, Luger TA, Schwarz T: Ultroviolet light induces apoptosis via direct activation of CD95 (FAS/APO-1) independently from its ligand CD95L. J Cell Biol 140:171-182, 1998
5. Beissert S, Granstein RD: UV-induced cutaneous photobiology. Crit Rev Biochem Mol Biol 31:381-404, 1996
6. Beissert S, Hosoi J, Grabbe S, Asahina A, Granstein RD: IL-10 inhibits tumor antigenpresentation by epidermal anitgen-presenting cells. J Immunol 154:1280-1286, 1995
7. Beissert S, Hosoi J, Kühn R, Rajewsky K, Müller W, Granstein RD: Impaired immunosuppressive response to ultraviolet radiation in interleukin-10-deficient mice. J Invest Dermatol 107:553-557, 1996
8. Beissert S, Mohammad T, Torri H, Lonati A, Yan Z, Morrison H, Granstein RD: Regulation of tumor antigen presentation by urocanic acid. J Immunol 159:92-96, 1997
9. Caceres-Dittmar G, Ariizumi K, Xu S, Tapia PJ, Bergstresser PR, Takashima A: Hydrogen peroxide mediates UV-induced impairment of antigen presentation in a murine epidermal-derived dendritic cell line, Photochem Photobiol 62:176-183, 1995
10. DeFabo EC, Noonan FP: Mechanism of immune suppression by ultraviolet irradiation in vivo. I. Evidence for the existence of a unique photoreceptor in skin and its role in photoimmunology. J Exp Med 158:84-98, 1983
11. Devary Y, Gottlieh RA, Smeal T, Kann M: The mammalian ultraviolet response is triggered by activation of Src tyrosinc kinases. Cell 71:1081-1091, 1992
12. Elmets CA, Bergstresser PR, Tigelaar RE, Wood PJ. Streilein JW: Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation. J Exp Med 158:781-794, 1983
13. Gillardon F, Moll I, Michel S, Benrath J, Weihe E, Zimmermann M: Calcitonin gene-related peptide and nitric oxide are involved in ultraviolet radiation-induced immunosuppression. Eur J Pharmacol 293:395-400, 1995
14. Grabbe S, Bruvers S, Gallo RL, Knisely TL, Nazareno R, Granstein RD: Tumor antigen presentation by murine epidermal cells. J Immunol 146:3656-3661, 1991
15. Grabbe S, Bruvers S, Lindgren AM, Hosoi J, Tan KC, Granstein RD: Tumor antigen presentation by epidermal antigen-presenting cells in the mouse: modulation by granulocyte-macrophage colony-stimulating factor, tumor necrosis factor, and ultraviolet radiation. J Leukoc Biol 52:209-217, 1992
16. Hahne M, Rimoldi D, Schröter M. et al: Melanoma cell expression of Fas (APO-1/CD95) ligand: Implications for tumor immune escape. Science 274:1363-1366, 1996
17. + macrophages that infiltrate human epidermis after in vivo ultraviolet expsoure potently produce IL-10 and represent the major secretory source of epidermal IL-10 protein. J Immunol 153:5256-5264, 1994
18. Kibitel J, Hejmadi V, Alas L, O'Connor A, Sutherland BM, Yarosh D: UV-DNA damage in mouse and human cells induces the expression of tumor necrosis factor. Photochem Photobiol 67:541-546, 1998
19. Kondo S, Wang B, Fujisawa H, Shivji GM, Echtenacher B, Mak TW, Sauder DN: Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced immunosuppression. J Immunol 155:3801-3805, 1995
20. Kripke ML, Cox PA, Alas LG, Yarosh DB: Pyrimidine dimers in UNA initiate systemic immunosuppression in UV-irradiated mice. Proc Natl Acad Sci USA 89:7516-7520, 1992
21. Laihia J.K., Jansen C.T.: Up-regulation of human epidermal Langerhans' cell B7-1 and B7-2 co-srimulatory molecules in vivo by solar-simulating irradiation. Eur J Immunol 27:984-989, 1997
22. Luger TA, Schwarz T, Effects of UV-light on cytokines and neuroendocrine hormones. In: J Krutmann, C Elmets (eds). Photoimmunology, Blackwell Science, Oxford, 1995, pp. 55-76
23. Lynch DH, Ramsdell E, Alderson MR: Fas and FasL in the homeostatic regulation of immune responses. Immunol Today 16:569-574, 1995
24. Müller C, Saloga J, Germann T, Schuler G, Knop J. Enk AH: IL-12 as mediator and adjuvant for the induction of contact sensitivity in vivo. J Immunol 155:4661-4668, 1995
25. Nagata S: Apoptosis by death factor. Cell 88:355 365, 1997
26. Nishigori C, Yarosh DB, Ullrich SE, Vink AA, Bucana CB, Roza L, Kripke ML: Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes. Proc Natl Acad Sci USA 93:10354-10359, 1996
27. Norval M, Gibbs NK, Gilmour J: The role of urocanic acid in UV-induced immunosuppression: recent advances (1992-94). Photochem Photobiol 62:209-217, 1995
28. Riemann H, Schwarz A, St Grabbe Y, et al:, Neutralization of interleukin 12 in vivo prevents induction of contact hypersensitivity and induces hapten specific tolerance. J Immunol 156:1799 1803, 1996
29. Rivas JM, Ullrich SE: Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived 1L-10, J Immunol 149:3805-3871, 1992
30. Romerdahl CA, Okamoto H, Kripke ML: Immune surveillance against cutaneous malignancies in experimental animals. Immunol Series 46:749-767, 1989
31. Rosette C. Karin M: Ultraviolet light and osmotic stress: activation of the JNK cascade through multiple growth factor and cytokine receptors. Science 274:1194-1197, 1996
32. Sachsenmaier C, Radler-Pohl A, Zinck R, Nordheim A, Herrlich P, Rahmsdorf HJ: Involvement of growth factor receptors in the mammalian UVC response. Cell 78, 963-972, 1994
33. Schmitt DA, Owen-Schaub L, Ullrich SE: Effect of IL-12 on immune suppression and suppressor cell induction by ultraviolet radiation. J Immunol 154:5114-5120, 1995
34. Schwarz T: UV light affects cell membrane and cytoplasmic targets. J Photochem Photobiol B 44:91-96, 1998
35. Schwarz A, Grabbe S, Aragane Y, et al: Interleukin-12 prevents UVB-induced local immunosuppression and overcomes UVB-induced tolerance. J Invest Dermatol 106:1187-1191, 1996
36. Schwarz A, Grabbe S, Grosse-Heitmeyer K, et al: Ultraviolet light induced induced immune tolerance is mediated via the CD95/CD95-ligand system. J Immunol 160:4262-4270, 1998
37. Shimizu T, Streilein JW: Local and systemic consequences of acute, low-dose ultraviolet B radiation are mediated by different immune regulatory mechanisms. Eur J Immunol 24:1765-1770, 1994
38. Simon JC, Cruz PC, Bergstresser PR, Tigelaar RE: Low dose ultraviolet B-irradiated Langerhans cells preferentially activate CP4+ cells of the T helper 2 subset. J Immunol 145:2087-2091, 1990
39. Toews GB, Bergstresser PR, Streilein JW: Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol 124:445-453, 1980
40. Ullrich SE: Modulation of immunity by ultraviolet radiation: key effects on antigen presentation. J Invest Dermatol 105:30S-36S, 1995
41. Urbanski A, Schwarz T, Neuner P, Krutmann J, Kimbauer R, Köck A. Luger TA: Ultraviolet light induces increased circulating interleukin 6 in humans. J Invest Dermatol 94:808-811, 1990
42. Weiss JM, Renkl AC, Denfeld RW, de-Roche R, Spitzlei M, Schöpf E, Simon JC: Low-dose UVB radiation perturbs the functional expression of B7.1 and B7.2 co-stimulatory molecules on human Langerhans cells. Eur J Immunol 25:2858-2862, 1995
43. Yarosh D, Bucana C, Cox P, Alas L, Kibitel J, Kripke ML: Localization of liposomes containing a DNA repair enzyme in murine skin. J invest Dermatol 103:461-468, 1994
44. Young JW, Baggers J, Soergel SA: High-dose UVB radiation alters human dendritic cell costimulatory activity but does not allow dendritic cells to tolerize T lymphocytes to alloantigen in vitro. Blood 81:2987-2997, 1993