The mitochondrial effects of novel apoptogenic molecules generated by psoralen photolysis as a crucial mechanism in PUVA therapy

Blood

Volumn 109, Issue 11, 2007, Pages 4988-4994

  Caffieri, Sergio ^a   Di Lisa, Fabio ^a   Bolesani, Federico ^a   Facco, Monica ^a   Semenzato, Gianpietro ^a   Dall'Acqua, Francesco ^a   Canton, Marcella ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

6 FORMYL 7 HYDROXYCOUMARIN; COUMARIN DERIVATIVE; CYCLOSPORIN A; MITOCHONDRIAL PERMEABILITY TRANSITION PORE; PSORALEN; PSORALEN DERIVATIVE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; CUTANEOUS T CELL LYMPHOMA; DISORDERS OF MITOCHONDRIAL FUNCTIONS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; IRRADIATION; LEUKEMIA CELL LINE; MITOCHONDRIAL PERMEABILITY; PHOTOLYSIS; PRIORITY JOURNAL; PUVA;

EID: 34249710292     PISSN: 00064971     EISSN: 00064971     Source Type: Journal    
DOI: 10.1182/blood-2006-08-037192     Document Type: Article

References (34)

1. Stadler R, Otte HG, Luger T, et al. Prospective randomized multicenter clinical trial on the use of interferon α-2a plus acitretin versus interferon α-2a plus PUVA in patients with cutaneous T-cell lymphoma stages I and II. Blood. 1998;92:3578-3581.
2. Bethea D, Fullmer B, Syed S, et al. Psoralen photobiology and photochemotherapy: 50 years of science and medicine. J Dermatol Sci. 1999;19:78-88.
3. Marshall SR. Technology insight: ECP for the treatment of GvHD-can we offer selective immune control without generalized immunosuppression? Nat Clin Pract Oncol. 2006;3:302-314.
4. Cutler C, Antin JH. Chronic graft-versus-host disease. Curr Opin Oncol. 2006;18:126-131.
5. Dall'Acqua F, Martelli P. Photosensitizing action of furocoumarins on membrane components and consequent intracellular events. J Photochem Photobiol B. 1991;8:235-254.
6. Gasparro FP. Psoralen DNA Photobiology, Vols. I and II. 1988; Boca Raton, FL: CRC Press.
7. Laskin JD, Lee E, Yurkow EJ, Laskin DL, Gallo MA. A possible mechanism of psoralen phototoxicity not involving direct interaction with DNA. Proc Natl Acad Sci U S A. 1985;82:6158-6162.
8. Yoo EK, Rook AH, Elenitsas R, Gasparro FP, Vowels BR. Apoptosis induction of ultraviolet light A and photochemotherapy in cutaneous T-cell lymphoma: relevance to mechanism of therapeutic action. J Invest Dermatol. 1996;107:235-242.
9. Canton M, Caffieri S, Dall'Acqua F, Di Lisa F. PUVA-induced apoptosis involves mitochondrial dysfunction caused by the opening of the permeability transition pore. FEBS Lett. 2002;522:168-172.
10. Potapenko AYa. Mechanisms of photodynamic effects of furocoumarins. J Photochem Photobiol B. 1991;9:1-33.
11. Potapenko AYa, Kyagova AA, Bezdetnaya LN, et al. Products of psoralen photooxidation possess immunomodulative and antileukemic effects. Photochem Photobiol. 1994;60:171-174.
12. Gulliya KS, Chanh T, Newman J, Pervaiz S, Matthews JL. Preactivation-a novel antitumour and antiviral approach. Eur J Cancer. 1990;26:551-553.
13. Gulliya KS, Pervaiz S, Dowben RM, Matthews JL. Tumor cell specific dark cytotoxicity of light-exposed merocyanine 540: implications for systemic therapy without light. Photochem Photobiol. 1990;52:831-838.
14. Gulliya KS, Sharma R, Liu HW, Arnold L, Matthews JL. Relationship of mitochondrial function and cellular adenosine triphosphate levels to pMC540 and merodantoin cytotoxicity in MCF-7 human breast cancer cells. Anticancer Drugs. 1995;6:545-552.
15. Pervaiz S, Seyed MA, Hirpara JL, Clement MV, Loh KW. Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells. Blood. 1999;93:4096-4108.
16. Hirpara JL, Seyed MA, Loh KW et al. Induction of mitochondrial permeability transition and cytochrome C release in the absence of caspase activation is insufficient for effective apoptosis in human leukemia cells. Blood. 2000;95:1773-1780.
17. Pervaiz S. Reactive oxygen-dependent production of novel photochemotherapeutic agents. FASEB J. 2001;15:612-617.
18. Pervaiz S, Olivo M. Art and science of photodynamic therapy. Clin Exp Pharmacol Physiol. 2006;33:551-556.
19. Logani MK, Austin WA, Shah B, Davies RE. Photooxidation of 8-MOP with singlet oxygen. Photochem Photobiol. 1982;35:569-573.
20. Wasserman HH, Berdahl DR. The photooxidation of 8-methoxypsoralen. Photochem Photobiol. 1982;35:565-567.
21. Facco M, Trentin L, Nicolardi L, et al. T cells in the lung of patients with hypersensitivity pneumonitis accumulate in a clonal manner. J Leukoc Biol. 2004;75:798-804.
22. Petronilli V, Miotto G, Canton M, et al. Transient and long-lasting openings of the mitochondrial permeability transition pore can be monitored directly in intact cells by changes in mitochondrial calcein fluorescence. Biophys J. 1999;76:725-734.
23. Scorrano L, Petronilli V, Di Lisa F, Bernardi P. Commitment to apoptosis by GD3 ganglioside is mediated by selective opening of the mitochondrial permeability transition pore. J Biol Chem. 1999;274:22581-22585.
24. Barbato R, Menabò R, Dainese P, et al. Binding of cytosolic proteins to myofibrils in ischemic rat hearts. Circ Res. 1996;78:821-828.
25. Gajate C, An F, Mollinedo F. Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95- and mitochondrialmediated mechanism. Clin Cancer Res. 2003;9:1535-1545.
26. Bernardi P, Petronilli V, Di Lisa F, Forte M. A mitochondrial perspective on cell death. Trends Biochem Sci. 2001;26:112-117.
27. Costantini P, Petronilli V, Colonna R, Bernardi P. On the effects of paraquat on isolated mitochondria: evidence that paraquat causes opening of the cyclosporin A-sensitive permeability transition pore synergistically with nitric oxide. Toxicology. 1995;99:77-88.
28. Canton M, Luvisetto S, Schmehl I, Azzone GF. The nature of mitochondrial respiration and discrimination between membrane and pump properties. Biochem J. 1995;310:477-481.
29. Caffieri S. Furocoumarin photolysis: chemical and biological aspects. Photochem Photobiol Sci. 2002;1:149-157.
30. Bernardi P, Krauskopf A, Basso E, et al. The mitochondrial permeability transition from in vitro artifact to disease target. FEBS J. 2006;273:2077-2099.
31. Irwin WA, Gaspers LD, Thomas JA. Inhibition of the mitochondrial permeability transition by aldehydes. Biochem Biophys Res Commun. 2002;291:215-219.
32. Mizuno N, Esaki K, Sakakibara J, Murakami N, Nagai S. Structural elucidation of the 8-methoxypsoralen oxidized product that inhibits the chemotactic activity of polymorphonuclear neutrophils toward anaphylatoxin C5a. Photochem Photobiol. 1991;54:697-701.
33. Rhodes J, Chen H, Hall SR et al. Therapeutic potentiation of the immune system by costimulatory Schiff-base-forming drugs. Nature. 1995;377:71-75.
34. Gori A, Trabattoni D, Bandera A, et al. Immunomodulation induced by tucaresol in HIV infection: results of a 16 week pilot Phase I/II trial. Antivir Ther. 2004;9:603-614.