Evidence for functional relevance of CTLA-4 in ultraviolet-radiation- induced tolerance

Journal of Immunology

Volumn 165, Issue 4, 2000, Pages 1824-1831

  Schwarz, A ^a   Beissert, S ^a   Grosse Heitmeyer, K ^a   Gunzer, M ^a   Bluestone, J A ^a   Grabbe, S ^a   Schwarz, T ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

1 FLUORO 2,4 DINITROBENZENE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; GAMMA INTERFERON; HAPTEN; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; TRANSFORMING GROWTH FACTOR BETA;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTACT ALLERGY; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNOLOGICAL TOLERANCE; LYMPH NODE CELL; LYMPHOCYTE DEPLETION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION; ULTRAVIOLET RADIATION;

EID: 0034663943     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.165.4.1824     Document Type: Article

References (42)

1. Molecular basis of sun-induced premature skin ageing and retinoid antagonism
2. Wavelength dependence of skin cancer induction by ultraviolet irradiation of albino hairless mice
3. Solar ultraviolet radiation and the risk of infectious disease
4. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB
5. + epidermal macrophage induction, and Langerhans cell depletion
6. Analysis of the mechanism of unresponsiveness produced by haptens painted on skin exposed to low dose ultraviolet radiation
7. Ultraviolet radiation induced tolerance
8. CTLA-4 and T cell activation
9. CTLA-4 ligation blocks CD28-dependent T cell activation
10. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
11. CTLA-4 regulates tolerance induction and T cell differentiation in vivo
12. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement
13. CTLA-4 can function as a negative regulator of T cell activation
14. Interleukin-12 prevents UVB-induced local immunosuppression and overcomes UVB-induced tolerance
15. Dissection of antigenic and irritative effects of epicutaneously applied haptens in mice: Evidence that not the antigenic component but non- specific proinflammatory effects of haptens determine the concentration dependent elicitation of allergic contact dermatitis
16. + T cells
17. + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis
18. Regulatory T cells and inflammatory bowel disease
19. The role of epidermal cytokines in the generation of cutaneous immune reactions and ultraviolet radiation-induced immune suppression
20. Evidence that ultraviolet B radiation induces tolerance and impairs induction of contact hypersensitivity by different mechanisms
21. Ultraviolet light depletes surface markers of Langerhans cells
22. Immunoregulatory mechanisms involved in elicitation of allergic contact hypersensitivity
23. Origin and characteristics of ultraviolet-B radiation-induced suppressor T lymphocytes
24. UVB radiation and DNFB skin painting induce suppressor cells universally in mice
25. The role of IL-4, IL-10, and TNF-α in the immune suppression induced by ultraviolet radiation
26. Hapten-specific tolerance induced by acute, low-dose ultraviolet B radiation of skin is mediated via interleukin-10
27. + Th2 cells mediate UVB-induced suppression of murine contact photosensitivity by releasing IL-10
28. Does exposure to UV radiation induce a shift to a Th-2-like immune reaction?
29. Suppression of murine allergic contact dermatitis by CTLA4Ig: Tolerance induction of Th2 responses requires additional blockade of CD40- ligand
30. The emerging role of CTLA-4 as an immune attenuator
31. Inhibition of Langerhans cell antigen-presenting function by IL-10: A role for IL-10 in induction of tolerance
32. Induction of hapten-specific tolerance by interleukin 10 in vivo
33. + T cells
34. Transforming growth factor-β is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation
35. Production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth
36. Transforming growth factor β1 suppresses acute and chronic arthritis in experimental animals
37. Protective effect of transforming growth factor β1 on experimental autoimmune diseases in mice
38. Regulatory T cell clones induced by oral tolerance: Suppression of autoimmune encephalomyelitis
39. Local and systemic consequences of acute, low-dose ultraviolet B radiation are mediated by different immune regulatory mechanisms
40. Mechanisms in ultraviolet light-induced immunosuppression
41. Ultraviolet light-induced immune tolerance is mediated via the Fas/Fas-ligand system
42. A critical role for Fas ligand in the active suppression of systemic immune responses by ultraviolet radiation