A chemoenzymatic approach to enantiomerically pure amines using dynamic kinetic resolution: application to the synthesis of norsertraline

Chemistry - A European Journal

Volumn 15, Issue 14, 2009, Pages 3403-3410

  Thalén, Lisa K ^a   Zhao, Dongbo ^a   Sortais, Jean Baptiste ^a   Paetzold, Jens ^a   Hoben, Christine ^a   Bäckvall, Jan E ^a  

^a STOCKHOLM UNIVERSITY   (Sweden)

Author keywords

Amines; Asymmetric catalysis; Dynamic kinetic resolution; Enzymes; Ruthenium

Indexed keywords

1-PHENYLETHYLAMINE; ACYL DONORS; ASYMMETRIC CATALYSIS; CANDIDA ANTARCTICA LIPASE B; CHEMOENZYMATIC APPROACHES; DYNAMIC KINETIC RESOLUTION; FREE AMINES; HYDRIDE ELIMINATIONS; ISOLATED YIELDS; ISOPROPYL ACETATES; KINETIC ISOTOPE EFFECTS; NOVEL ROUTES; ONE POTS; PRIMARY AMINES; RATE-DETERMINING STEPS; REACTION CONDITIONS; RU CATALYSTS;

AMIDES; AMINATION; CATALYSIS; CATALYSTS; DEUTERIUM; ELECTRONIC PROPERTIES; ENZYMES; RUTHENIUM;

AMINES;

1 NAPHTHYLAMINE; AMINE; DRUG DERIVATIVE; LIPASE B, CANDIDA ANTARCTICA; NORSERTRALINE; ORGANOMETALLIC COMPOUND; TRIACYLGLYCEROL LIPASE;

ARTICLE; BIOCATALYSIS; CATALYSIS; CHEMISTRY; ENZYME SPECIFICITY; KINETICS; METABOLISM; STEREOISOMERISM; SYNTHESIS;

1-NAPHTHYLAMINE; AMINES; BIOCATALYSIS; CATALYSIS; KINETICS; LIPASE; ORGANOMETALLIC COMPOUNDS; STEREOISOMERISM; SUBSTRATE SPECIFICITY;

EID: 63749090004     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200802303     Document Type: Article

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