(S)-selective dynamic kinetic resolution of secondary alcohols by the combination of subtilisin and an aminocyclopentadienylruthenium complex as the catalysts

Journal of the American Chemical Society

Volumn 125, Issue 38, 2003, Pages 11494-11495

  Kim, Mahn Joo ^a   Chung, Yong Il ^a   Choi, Yoon Kyung ^a   Lee, Han Ki ^a   Kim, Daeho ^a   Park, Jaiwook ^a  

^a Pohang University of Science and Technology (POSTECH)   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

1 PHENYLETHANOL; ALCOHOL; AMINOCYCLOPENTADIENYLRUTHENIUM COMPLEX; RUTHENIUM COMPLEX; SUBTILISIN; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; CATALYSIS; CATALYST; ENANTIOMER; KINETICS; STEREOCHEMISTRY;

BENZYL ALCOHOLS; CATALYSIS; CYCLOPENTANES; KINETICS; ORGANOMETALLIC COMPOUNDS; RUTHENIUM; STEREOISOMERISM; SUBTILISIN;

EID: 0141757457     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja036766r     Document Type: Article

References (24)

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19. Ruthenium complex 3 is activated by the treatment with potassium tertbutoxide just before use (see ref 4f). It is now available from Strem.
20. It was purchased from Sigma.
21. 2O, 4.4 mL) was sonicated for 5 min, followed by the addition of subtilisin (40 mg). The resulting mixture was stirred for 12 h at 35 °C and then centrifuged to isolate undissolved solid. The solid was dried in vacuo and stored at 4 °C.
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24. It was observed in our previous studies that the racemizations of aliphatic secondary alcohols were about two times slower than those of benzylic alcohols. See ref 4f.