Development of a large-scale stereoselective process for (1 R,4S)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydronaphthalen-1-amine hydrochloride

Organic Process Research and Development

Volumn 11, Issue 4, 2007, Pages 726-730

  Han, Zhengxu ^a   Koenig, Stefan G ^a   Zhao, Hang ^a   Su, Xiping ^a   Singh, Surendra P ^a   Bakale, Roger P ^a  

^a SUNOVION PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 34547891014     PISSN: 10836160     EISSN: None     Source Type: Journal    
DOI: 10.1021/op7000589     Document Type: Article

References (44)

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44. 2O, 95:5:0.05:0.01; flow rate of 0.8 mL/minute; ambient temperature; 220 nm wavelength. Approximate retention times for (1R,4S)-1, 39 min; for (1S,4S)-1, 36 min. In addition, this verified that no epimerization of the 45 center occurred during processing.