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Volumn 102, Issue 1, 2005, Pages 85-99

Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery

Author keywords

Hepatitis B; Monophosphoryl lipid A; Nanoparticles; PLGA; Vaccines

Indexed keywords

ANTIGENS; DISEASES; IMMUNIZATION; NANOSTRUCTURED MATERIALS; PHOSPHOLIPIDS; VACCINES; VIRUSES;

EID: 11844263890     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.09.014     Document Type: Article
Times cited : (175)

References (69)
  • 1
    • 0024846323 scopus 로고
    • Treatment of chronic hepatitis with interferon: Experience in Western countries
    • R.P. Perrillo Treatment of chronic hepatitis with interferon: experience in Western countries Semin. Liver Dis. 9 1989 240 248
    • (1989) Semin. Liver Dis. , vol.9 , pp. 240-248
    • Perrillo, R.P.1
  • 2
    • 0031434707 scopus 로고    scopus 로고
    • Repression of hepatitis B virus (HBV) transgene and HBV-induced liver injury by low protein diet
    • J.F. Hu, Z. Cheng, F.V. Chisari, T.H. Vu, A.R. Hoffman, and T.C. Campbell Repression of hepatitis B virus (HBV) transgene and HBV-induced liver injury by low protein diet Oncogene 15 1997 2795 2801
    • (1997) Oncogene , vol.15 , pp. 2795-2801
    • Hu, J.F.1    Cheng, Z.2    Chisari, F.V.3    Vu, T.H.4    Hoffman, A.R.5    Campbell, T.C.6
  • 3
    • 0020682268 scopus 로고
    • Postnatal infectivity of hepatitis B surface antigen-carrier mothers
    • R.P. Beasley, and L.Y. Hwang Postnatal infectivity of hepatitis B surface antigen-carrier mothers J. Infect. Dis. 1983 1983 185 190
    • (1983) J. Infect. Dis. , vol.1983 , pp. 185-190
    • Beasley, R.P.1    Hwang, L.Y.2
  • 4
    • 0016693477 scopus 로고
    • Vertical transmission of hepatitis B antigen in Taiwan
    • C.E. Stevens, R.P. Beasley, J. Tsui, and W.C. Lee Vertical transmission of hepatitis B antigen in Taiwan N. Engl. J. Med. 292 1975 771 774
    • (1975) N. Engl. J. Med. , vol.292 , pp. 771-774
    • Stevens, C.E.1    Beasley, R.P.2    Tsui, J.3    Lee, W.C.4
  • 8
    • 0030008076 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection
    • B. Rehermann, D. Lau, J.H. Hoofnagle, and F.V. Chisari Cytotoxic T lymphocyte responsiveness after resolution of chronic hepatitis B virus infection J. Clin. Invest. 97 1996 1655 1665
    • (1996) J. Clin. Invest. , vol.97 , pp. 1655-1665
    • Rehermann, B.1    Lau, D.2    Hoofnagle, J.H.3    Chisari, F.V.4
  • 10
    • 0025334196 scopus 로고
    • The cellular immune response to nucleocapsid antigens in hepatitis B virus infection
    • M.U. Mondelli, F.V. Chisari, and C. Ferrari The cellular immune response to nucleocapsid antigens in hepatitis B virus infection Springer Semin. Immunopathol. 12 1990 25 31
    • (1990) Springer Semin. Immunopathol. , vol.12 , pp. 25-31
    • Mondelli, M.U.1    Chisari, F.V.2    Ferrari, C.3
  • 12
    • 0023256269 scopus 로고
    • Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site
    • D.R. Milich, A. McLachlan, G.B. Thornton, and J.L. Hughes Antibody production to the nucleocapsid and envelope of the hepatitis B virus primed by a single synthetic T cell site Nature 329 1987 547 549
    • (1987) Nature , vol.329 , pp. 547-549
    • Milich, D.R.1    McLachlan, A.2    Thornton, G.B.3    Hughes, J.L.4
  • 13
    • 0031794588 scopus 로고    scopus 로고
    • Quantitative and functional analysis of core-specific T-helper cell and CTL activities in acute and chronic hepatitis B
    • H.F. Lohr, S. Krug, W. Herr, S. Weyer, J. Schlaak, T. Wolfel, G. Gerken, and K.H. Meyer zum Buschenfelde Quantitative and functional analysis of core-specific T-helper cell and CTL activities in acute and chronic hepatitis B Liver 18 1998 405 413
    • (1998) Liver , vol.18 , pp. 405-413
    • Lohr, H.F.1    Krug, S.2    Herr, W.3    Weyer, S.4    Schlaak, J.5    Wolfel, T.6    Gerken, G.7    Meyer Zum Buschenfelde, K.H.8
  • 14
    • 0035031531 scopus 로고    scopus 로고
    • Coadministration of gamma interferon with DNA vaccine expressing Woodchuck Hepatitis Virus (WHV) core antigen enhances the specific immune response and protects against WHV infection
    • F. Siegel, M. Lu, and M. Roggendorf Coadministration of gamma interferon with DNA vaccine expressing Woodchuck Hepatitis Virus (WHV) core antigen enhances the specific immune response and protects against WHV infection J. Virol. 75 2001 5036 5042
    • (2001) J. Virol. , vol.75 , pp. 5036-5042
    • Siegel, F.1    Lu, M.2    Roggendorf, M.3
  • 16
    • 2442682870 scopus 로고    scopus 로고
    • Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: Implications for immunotherapy
    • G.J. Webster, S. Reignat, D. Brown, G.S. Ogg, L. Jones, S.L. Seneviratne, R. Williams, G. Dusheiko, and A. Bertoletti Longitudinal analysis of CD8+ T cells specific for structural and nonstructural hepatitis B virus proteins in patients with chronic hepatitis B: implications for immunotherapy J. Virol. 78 2004 5707 5719
    • (2004) J. Virol. , vol.78 , pp. 5707-5719
    • Webster, G.J.1    Reignat, S.2    Brown, D.3    Ogg, G.S.4    Jones, L.5    Seneviratne, S.L.6    Williams, R.7    Dusheiko, G.8    Bertoletti, A.9
  • 18
    • 0036073843 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of depot leuprorelin
    • P. Periti, T. Mazzei, and E. Mini Clinical pharmacokinetics of depot leuprorelin Clin. Pharmacokinet. 41 2002 485 504
    • (2002) Clin. Pharmacokinet. , vol.41 , pp. 485-504
    • Periti, P.1    Mazzei, T.2    Mini, E.3
  • 20
    • 0037424130 scopus 로고    scopus 로고
    • Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro
    • R. Audran, K. Peter, J. Dannull, Y. Men, E. Scandella, M. Groettrup, B. Gander, and G. Corradin Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro Vaccine 21 2003 1250 1255
    • (2003) Vaccine , vol.21 , pp. 1250-1255
    • Audran, R.1    Peter, K.2    Dannull, J.3    Men, Y.4    Scandella, E.5    Groettrup, M.6    Gander, B.7    Corradin, G.8
  • 21
    • 0037435833 scopus 로고    scopus 로고
    • Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro
    • H. Sun, K.G.J. Pollock, and J.M. Brewer Analysis of the role of vaccine adjuvants in modulating dendritic cell activation and antigen presentation in vitro Vaccine 21 2003 849 855
    • (2003) Vaccine , vol.21 , pp. 849-855
    • Sun, H.1    Pollock, K.G.J.2    Brewer, J.M.3
  • 22
    • 0031616647 scopus 로고    scopus 로고
    • Modulation of the immune response to tetanus toxoid by polylactide-polyglycolide microspheres
    • K.B. Walker, D.K. Xing, D. Sesardic, and M.J. Corbel Modulation of the immune response to tetanus toxoid by polylactide-polyglycolide microspheres Dev. Biol. Stand. 92 1998 259 267
    • (1998) Dev. Biol. Stand. , vol.92 , pp. 259-267
    • Walker, K.B.1    Xing, D.K.2    Sesardic, D.3    Corbel, M.J.4
  • 23
    • 0036805063 scopus 로고    scopus 로고
    • Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants
    • R.S. Raghuvanshi, Y.K. Katare, K. Lalwani, M.M. Ali, O. Singh, and A.K. Panda Improved immune response from biodegradable polymer particles entrapping tetanus toxoid by use of different immunization protocol and adjuvants Int. J. Pharm. 245 2002 109 121
    • (2002) Int. J. Pharm. , vol.245 , pp. 109-121
    • Raghuvanshi, R.S.1    Katare, Y.K.2    Lalwani, K.3    Ali, M.M.4    Singh, O.5    Panda, A.K.6
  • 24
    • 0036285313 scopus 로고    scopus 로고
    • Pharmaceutical and immunological evaluation of a single-shot hepatitis B vaccine formulated with PLGA microspheres
    • L. Shi, M.J. Caulfield, R.T. Chern, R.A. Wilson, G. Sanyal, and D.B. Volkin Pharmaceutical and immunological evaluation of a single-shot hepatitis B vaccine formulated with PLGA microspheres J. Pharm. Sci. 91 2002 1019 1035
    • (2002) J. Pharm. Sci. , vol.91 , pp. 1019-1035
    • Shi, L.1    Caulfield, M.J.2    Chern, R.T.3    Wilson, R.A.4    Sanyal, G.5    Volkin, D.B.6
  • 25
    • 0037006608 scopus 로고    scopus 로고
    • Tetanus toxoid microspheres consisting of biodegradable poly(lactide-co-glycolide)- and ABA-triblock-copolymers: Immune response in mice
    • T. Jung, R. Koneberg, K.D. Hungerer, and T. Kissel Tetanus toxoid microspheres consisting of biodegradable poly(lactide-co-glycolide)- and ABA-triblock-copolymers: immune response in mice Int. J. Pharm. 234 2002 75 90
    • (2002) Int. J. Pharm. , vol.234 , pp. 75-90
    • Jung, T.1    Koneberg, R.2    Hungerer, K.D.3    Kissel, T.4
  • 26
    • 0032755036 scopus 로고    scopus 로고
    • Monophosphoryl lipid a (MPL) formulations for the next generation of vaccines
    • J.R. Baldridge, and R.T. Crane Monophosphoryl lipid A (MPL) formulations for the next generation of vaccines Methods 19 1999 103 107
    • (1999) Methods , vol.19 , pp. 103-107
    • Baldridge, J.R.1    Crane, R.T.2
  • 27
    • 0033522812 scopus 로고    scopus 로고
    • The adjuvant combination monophosphoryl lipid a and QS21 switches T cell responses induced with a soluble recombinant HIV protein from Th2 to Th1
    • A. Moore, L. McCarthy, and K.H.G. Mills The adjuvant combination monophosphoryl lipid A and QS21 switches T cell responses induced with a soluble recombinant HIV protein from Th2 to Th1 Vaccine 17 1999 2517 2527
    • (1999) Vaccine , vol.17 , pp. 2517-2527
    • Moore, A.1    McCarthy, L.2    Mills, K.H.G.3
  • 28
    • 0029201182 scopus 로고
    • Monophosphoryl lipid a as an adjuvant. Past experiences and new directions
    • J.T. Ulrich, and K.R. Myers Monophosphoryl lipid A as an adjuvant. Past experiences and new directions Pharm. Biotechnol. 6 1995 495 524
    • (1995) Pharm. Biotechnol. , vol.6 , pp. 495-524
    • Ulrich, J.T.1    Myers, K.R.2
  • 31
    • 0042873015 scopus 로고    scopus 로고
    • Synthetic vaccines: The role of adjuvants in immune targeting
    • Bentham Science Publishers
    • Z.-H. Jiang, and R.R. Koganty Synthetic vaccines: the role of adjuvants in immune targeting Curr. Med. Chem. vol. 10 2003 Bentham Science Publishers 1423 1439
    • (2003) Curr. Med. Chem. , vol.10 , pp. 1423-1439
    • Jiang, Z.-H.1    Koganty, R.R.2
  • 32
    • 0037152579 scopus 로고    scopus 로고
    • Novel lipid a mimetics derived from pentaerythritol: Synthesis and their potent agonistic activity
    • Z.H. Jiang, W.A. Budzynski, L.N. Skeels, M.J. Krantz, and R.R. Koganty Novel lipid A mimetics derived from pentaerythritol: synthesis and their potent agonistic activity Tetrahedron 58 2002 8833 8842
    • (2002) Tetrahedron , vol.58 , pp. 8833-8842
    • Jiang, Z.H.1    Budzynski, W.A.2    Skeels, L.N.3    Krantz, M.J.4    Koganty, R.R.5
  • 33
    • 0023901210 scopus 로고
    • A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid
    • Y. Ogawa, M. Yamamoto, H. Okada, T. Yashiki, and T. Shimamoto A new technique to efficiently entrap leuprolide acetate into microcapsules of polylactic acid or copoly(lactic/glycolic) acid Chem. Pharm. Bull. (Tokyo) 36 1988 1095 1103
    • (1988) Chem. Pharm. Bull. (Tokyo) , vol.36 , pp. 1095-1103
    • Ogawa, Y.1    Yamamoto, M.2    Okada, H.3    Yashiki, T.4    Shimamoto, T.5
  • 35
    • 0027305289 scopus 로고
    • Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles
    • D.T. O'Hagan, H. Jeffery, and S.S. Davis Long-term antibody responses in mice following subcutaneous immunization with ovalbumin entrapped in biodegradable microparticles Vaccine 11 1993 965 969
    • (1993) Vaccine , vol.11 , pp. 965-969
    • O'Hagan, D.T.1    Jeffery, H.2    Davis, S.S.3
  • 36
    • 0030990443 scopus 로고    scopus 로고
    • Analysis of a monophosphoryl lipid a immunostimulant preparation from Salmonella minnesota R595 by high-performance liquid chromatography
    • S.R. Hagen, J.D. Thompson, D.S. Snyder, and K.R. Myers Analysis of a monophosphoryl lipid A immunostimulant preparation from Salmonella minnesota R595 by high-performance liquid chromatography J. Chromatogr., A 767 1997 53 61
    • (1997) J. Chromatogr., a , vol.767 , pp. 53-61
    • Hagen, S.R.1    Thompson, J.D.2    Snyder, D.S.3    Myers, K.R.4
  • 37
    • 0017874586 scopus 로고
    • Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphrenylglycoluril
    • P.J. Fraker, and J.C. Speck Jr. Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a- diphrenylglycoluril Biochem. Biophys. Res. Commun. 80 1978 849 857
    • (1978) Biochem. Biophys. Res. Commun. , vol.80 , pp. 849-857
    • Fraker, P.J.1    Speck Jr., J.C.2
  • 39
    • 0026622867 scopus 로고
    • Modification of the bicinchoninic acid protein assay to eliminate lipid interference in determining lipoprotein protein content
    • R.E. Morton, and T.A. Evans Modification of the bicinchoninic acid protein assay to eliminate lipid interference in determining lipoprotein protein content Anal. Biochem. 204 1992 332 334
    • (1992) Anal. Biochem. , vol.204 , pp. 332-334
    • Morton, R.E.1    Evans, T.A.2
  • 40
    • 0027169876 scopus 로고
    • Determinants of release rate of tetanus vaccine from polyester microspheres
    • M.J. Alonso, S. Cohen, T.G. Park, R.K. Gupta, G.R. Siber, and R. Langer Determinants of release rate of tetanus vaccine from polyester microspheres Pharm. Res. 10 1993 945 953
    • (1993) Pharm. Res. , vol.10 , pp. 945-953
    • Alonso, M.J.1    Cohen, S.2    Park, T.G.3    Gupta, R.K.4    Siber, G.R.5    Langer, R.6
  • 41
    • 0036549881 scopus 로고    scopus 로고
    • Correlation between in vitro release and in vivo immune response from biodegradable polymer particles entrapping tetanus toxoid
    • R.S. Raghuvanshi, O. Singh, and A.K. Panda Correlation between in vitro release and in vivo immune response from biodegradable polymer particles entrapping tetanus toxoid Drug Deliv. 9 2002 113 120
    • (2002) Drug Deliv. , vol.9 , pp. 113-120
    • Raghuvanshi, R.S.1    Singh, O.2    Panda, A.K.3
  • 42
    • 1842375707 scopus 로고    scopus 로고
    • The hepatitis B virus core and e antigens elicit different Th cell subsets: Antigen structure can affect Th cell phenotype
    • D.R. Milich, F. Schodel, J.L. Hughes, J.E. Jones, and D.L. Peterson The hepatitis B virus core and e antigens elicit different Th cell subsets: antigen structure can affect Th cell phenotype J. Virol. 71 1997 2192 2201
    • (1997) J. Virol. , vol.71 , pp. 2192-2201
    • Milich, D.R.1    Schodel, F.2    Hughes, J.L.3    Jones, J.E.4    Peterson, D.L.5
  • 43
    • 0029558085 scopus 로고
    • Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells
    • A. Moore, P. McGuirk, S. Adams, W.C. Jones, J. Paul McGee, D.T. O'Hagan, and K.H.G. Mills Immunization with a soluble recombinant HIV protein entrapped in biodegradable microparticles induces HIV-specific CD8+ cytotoxic T lymphocytes and CD4+ Th1 cells Vaccine 13 1995 1741 1749
    • (1995) Vaccine , vol.13 , pp. 1741-1749
    • Moore, A.1    McGuirk, P.2    Adams, S.3    Jones, W.C.4    Paul McGee, J.5    O'Hagan, D.T.6    Mills, K.H.G.7
  • 44
    • 0028876363 scopus 로고
    • Synthetic delivery system for tuberculosis vaccines: Immunological evaluation of the M. tuberculosis 38 kDa protein entrapped in biodegradable PLG microparticles
    • H.M. Vordermeier, A.G.A. Coombes, P. Jenkins, J.P. McGee, D.T. O'Hagan, S.S. Davis, and M. Singh Synthetic delivery system for tuberculosis vaccines: immunological evaluation of the M. tuberculosis 38 kDa protein entrapped in biodegradable PLG microparticles Vaccine 13 1995 1576 1582
    • (1995) Vaccine , vol.13 , pp. 1576-1582
    • Vordermeier, H.M.1    Coombes, A.G.A.2    Jenkins, P.3    McGee, J.P.4    O'Hagan, D.T.5    Davis, S.S.6    Singh, M.7
  • 45
    • 0025834747 scopus 로고
    • Biodegradable and biocompatible poly(d,l-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies
    • J.H. Eldridge, J.K. Staas, J.A. Meulbroek, T.R. Tice, and R.M. Gilley Biodegradable and biocompatible poly(d,l-lactide-co-glycolide) microspheres as an adjuvant for staphylococcal enterotoxin B toxoid which enhances the level of toxin-neutralizing antibodies Infect. Immun. 59 1991 2978 2986
    • (1991) Infect. Immun. , vol.59 , pp. 2978-2986
    • Eldridge, J.H.1    Staas, J.K.2    Meulbroek, J.A.3    Tice, T.R.4    Gilley, R.M.5
  • 46
    • 0036805438 scopus 로고    scopus 로고
    • Analysis of poly(d,l-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro
    • M.E. Lutsiak, D.R. Robinson, C. Coester, G.S. Kwon, and J. Samuel Analysis of poly(d,l-lactic-co-glycolic acid) nanosphere uptake by human dendritic cells and macrophages in vitro Pharm. Res. 19 2002 1480 1487
    • (2002) Pharm. Res. , vol.19 , pp. 1480-1487
    • Lutsiak, M.E.1    Robinson, D.R.2    Coester, C.3    Kwon, G.S.4    Samuel, J.5
  • 48
    • 0033179403 scopus 로고    scopus 로고
    • Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance
    • P.R. Rogers, and M. Croft Peptide dose, affinity, and time of differentiation can contribute to the Th1/Th2 cytokine balance J. Immunol. 163 1999 1205 1213
    • (1999) J. Immunol. , vol.163 , pp. 1205-1213
    • Rogers, P.R.1    Croft, M.2
  • 49
    • 0034655189 scopus 로고    scopus 로고
    • Repeated intratracheal challenge with particulate antigen modulates murine lung cytokines: 2
    • J. Todt, J. Sonstein, T. Polak, G.D. Seitzman, B. Hu, and J.L. Curtis Repeated intratracheal challenge with particulate antigen modulates murine lung cytokines: 2. J. Immunol. 164 2000 4037 4047
    • (2000) J. Immunol. , vol.164 , pp. 4037-4047
    • Todt, J.1    Sonstein, J.2    Polak, T.3    Seitzman, G.D.4    Hu, B.5    Curtis, J.L.6
  • 50
    • 0031783218 scopus 로고    scopus 로고
    • Ovalbumin peptide encapsulated in poly(d,l-lactic-co-glycolic acid) microspheres is capable of inducing a T helper type 1 immune response
    • K.D. Newman, J. Samuel, and G. Kwon Ovalbumin peptide encapsulated in poly(d,l-lactic-co-glycolic acid) microspheres is capable of inducing a T helper type 1 immune response J. Control. Release 54 1998 49 59
    • (1998) J. Control. Release , vol.54 , pp. 49-59
    • Newman, K.D.1    Samuel, J.2    Kwon, G.3
  • 51
    • 0031765186 scopus 로고    scopus 로고
    • Delivery of MUC1 mucin peptide by Poly(d,l-lactic-co-glycolic acid) microspheres induces type 1 T helper immune responses
    • K.D. Newman, D.L. Sosnowski, G.S. Kwon, and J. Samuel Delivery of MUC1 mucin peptide by Poly(d,l-lactic-co-glycolic acid) microspheres induces type 1 T helper immune responses J. Pharm. Sci. 87 1998 1421 1427
    • (1998) J. Pharm. Sci. , vol.87 , pp. 1421-1427
    • Newman, K.D.1    Sosnowski, D.L.2    Kwon, G.S.3    Samuel, J.4
  • 53
    • 0037093771 scopus 로고    scopus 로고
    • Coating of cationized protein on engineered nanoparticles results in enhanced immune responses
    • Z. Cui, and R.J. Mumper Coating of cationized protein on engineered nanoparticles results in enhanced immune responses Int. J. Pharm. 238 2002 229 239
    • (2002) Int. J. Pharm. , vol.238 , pp. 229-239
    • Cui, Z.1    Mumper, R.J.2
  • 54
    • 2342474615 scopus 로고    scopus 로고
    • A single vaccination with protein-microspheres elicits a strong CD8 T-cell-mediated immune response against Mycobacterium tuberculosis antigen Mtb8.4
    • J.T. Evans, J.R. Ward, J. Kern, and M.E. Johnson A single vaccination with protein-microspheres elicits a strong CD8 T-cell-mediated immune response against Mycobacterium tuberculosis antigen Mtb8.4 Vaccine 22 2004 1964 1972
    • (2004) Vaccine , vol.22 , pp. 1964-1972
    • Evans, J.T.1    Ward, J.R.2    Kern, J.3    Johnson, M.E.4
  • 58
    • 0033050827 scopus 로고    scopus 로고
    • Specific vaccine therapy in chronic hepatitis B: Induction of T cell proliferative responses specific for envelope antigens
    • I. Couillin, S. Pol, M. Mancini, F. Driss, C. Brechot, P. Tiollais, and M.L. Michel Specific vaccine therapy in chronic hepatitis B: induction of T cell proliferative responses specific for envelope antigens J. Infect. Dis. 180 1999 15 26 (erratum appears in J Infect Dis 1999 Nov;180(5):1756)
    • (1999) J. Infect. Dis. , vol.180 , pp. 15-26
    • Couillin, I.1    Pol, S.2    Mancini, M.3    Driss, F.4    Brechot, C.5    Tiollais, P.6    Michel, M.L.7
  • 61
    • 0031964789 scopus 로고    scopus 로고
    • Protective efficacy of DNA vaccines against duck hepatitis B virus infection
    • M. Triyatni, A.R. Jilbert, M. Qiao, D.S. Miller, and C.J. Burrell Protective efficacy of DNA vaccines against duck hepatitis B virus infection J. Virol. 72 1998 84 94
    • (1998) J. Virol. , vol.72 , pp. 84-94
    • Triyatni, M.1    Jilbert, A.R.2    Qiao, M.3    Miller, D.S.4    Burrell, C.J.5
  • 62
    • 0037472466 scopus 로고    scopus 로고
    • Progress in DNA vaccine for prophylaxis and therapy of hepatitis B
    • A. Thermet, C. Rollier, F. Zoulim, C. Trepo, and L. Cova Progress in DNA vaccine for prophylaxis and therapy of hepatitis B Vaccine 21 2003 659 662
    • (2003) Vaccine , vol.21 , pp. 659-662
    • Thermet, A.1    Rollier, C.2    Zoulim, F.3    Trepo, C.4    Cova, L.5
  • 63
    • 0029913027 scopus 로고    scopus 로고
    • DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice
    • A. Kuhober, H. Pudollek, K. Reifenberg, F. Chisari, H. Schlicht, J. Reimann, and R. Schirmbeck DNA immunization induces antibody and cytotoxic T cell responses to hepatitis B core antigen in H-2b mice J. Immunol. 156 1996 3687 3695
    • (1996) J. Immunol. , vol.156 , pp. 3687-3695
    • Kuhober, A.1    Pudollek, H.2    Reifenberg, K.3    Chisari, F.4    Schlicht, H.5    Reimann, J.6    Schirmbeck, R.7
  • 65
    • 0242580118 scopus 로고    scopus 로고
    • Cutting edge: Different toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos
    • S. Agrawal, A. Agrawal, B. Doughty, A. Gerwitz, J. Blenis, T. Van Dyke, and B. Pulendran Cutting edge: different toll-like receptor agonists instruct dendritic cells to induce distinct Th responses via differential modulation of extracellular signal-regulated kinase-mitogen-activated protein kinase and c-Fos J. Immunol. 171 2003 4984 4989
    • (2003) J. Immunol. , vol.171 , pp. 4984-4989
    • Agrawal, S.1    Agrawal, A.2    Doughty, B.3    Gerwitz, A.4    Blenis, J.5    Van Dyke, T.6    Pulendran, B.7
  • 67
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: Critical proteins linking innate and acquired immunity
    • S. Akira, K. Takeda, and T. Kaisho Toll-like receptors: critical proteins linking innate and acquired immunity Nat. Immunol. 2 2001 675 680
    • (2001) Nat. Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 68
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • C. Pasare, and R. Medzhitov Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells Science 299 2003 1033 1036
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 69
    • 11844301735 scopus 로고    scopus 로고
    • Dose sparing of CpG oligodeoxynucleotide vaccine adjuvants by nanoparticle delivery
    • M. Diwan, P. Elamanchili, M. Cao, and J. Samuel Dose sparing of CpG oligodeoxynucleotide vaccine adjuvants by nanoparticle delivery Curr. Drug Deliv. 1 2004 405 412
    • (2004) Curr. Drug Deliv. , vol.1 , pp. 405-412
    • Diwan, M.1    Elamanchili, P.2    Cao, M.3    Samuel, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.