-
1
-
-
33750845322
-
-
Alvar, A., Yactayo, S. and Bern C. Leishmaniasis and poverty. (2006) Trends Parasital., 22, 12, 552-557.
-
Alvar, A., Yactayo, S. and Bern C. Leishmaniasis and poverty. (2006) Trends Parasital., 22, 12, 552-557.
-
-
-
-
2
-
-
84934439857
-
-
Singh, G., Jayanarayan, K.G. and Dey, C.S. Arsenite resistance in Leishmania and possible drug targets. (2008) Adv. Exp. Med. Biol., 625, 1-8.
-
Singh, G., Jayanarayan, K.G. and Dey, C.S. Arsenite resistance in Leishmania and possible drug targets. (2008) Adv. Exp. Med. Biol., 625, 1-8.
-
-
-
-
3
-
-
0022002912
-
-
Fairlamb, A.H., Blackburn, P., Ulrich, P., Chait, B.T. and Cerami, A. Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. (1985) Science, 227, 1485-1487.
-
Fairlamb, A.H., Blackburn, P., Ulrich, P., Chait, B.T. and Cerami, A. Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids. (1985) Science, 227, 1485-1487.
-
-
-
-
4
-
-
13444280474
-
-
Krauth-Siegel, R.L., Bauer, H. and Schirmer, R.H. Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia. (2005) Angew. Chem. Int. Ed., 44, 690-715.
-
Krauth-Siegel, R.L., Bauer, H. and Schirmer, R.H. Dithiol proteins as guardians of the intracellular redox milieu in parasites: old and new drug targets in trypanosomes and malaria-causing plasmodia. (2005) Angew. Chem. Int. Ed., 44, 690-715.
-
-
-
-
5
-
-
33645883558
-
-
Garcia Liñares, G.E., Ravaschino, E.L. and Rodriguez J.B. Progresses in the field of drug design to combat tropical protozoan parasitic diseases. (2006) Curr. Med. Chem., 13, 335-360.
-
Garcia Liñares, G.E., Ravaschino, E.L. and Rodriguez J.B. Progresses in the field of drug design to combat tropical protozoan parasitic diseases. (2006) Curr. Med. Chem., 13, 335-360.
-
-
-
-
6
-
-
0023051830
-
-
Shames, S.L., Fairlamb, A.H., Cerami, A. and Walsh, C.T. Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases. (1986) Biochemistry, 25, 3519-3526.
-
Shames, S.L., Fairlamb, A.H., Cerami, A. and Walsh, C.T. Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases. (1986) Biochemistry, 25, 3519-3526.
-
-
-
-
7
-
-
0023808976
-
-
Shames, S.L., Kimmel, B.E., Peoples, O.P., Agabian, N. and Walsh, C.T. Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase. (1988) Biochemistry, 27, 14, 5014-5019.
-
Shames, S.L., Kimmel, B.E., Peoples, O.P., Agabian, N. and Walsh, C.T. Trypanothione reductase of Trypanosoma congolense: gene isolation, primary sequence determination, and comparison to glutathione reductase. (1988) Biochemistry, 27, 14, 5014-5019.
-
-
-
-
8
-
-
0023278434
-
-
Henderson, G.B., Fairlamb, A.H., Ulrich, P. and Cerami, A. Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculate. (1987) Biochemistry, 26, 3023-3027.
-
Henderson, G.B., Fairlamb, A.H., Ulrich, P. and Cerami, A. Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculate. (1987) Biochemistry, 26, 3023-3027.
-
-
-
-
9
-
-
0026002958
-
-
Henderson, G.B., Murgolo, N.J., Kuriyan, J., Osapay, K., Kominos, D., Berry, A., Scrutton, N.S., Hinchliffe, N.W., Perham, R.N. and Cerami, A. Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. (1991) Proc. Natl. Acad. Sci. USA, 88, 8769-8773.
-
Henderson, G.B., Murgolo, N.J., Kuriyan, J., Osapay, K., Kominos, D., Berry, A., Scrutton, N.S., Hinchliffe, N.W., Perham, R.N. and Cerami, A. Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction. (1991) Proc. Natl. Acad. Sci. USA, 88, 8769-8773.
-
-
-
-
10
-
-
0027432023
-
-
Waer, A.F., Smith, K., McKie, J.H., Benson, T., Fairlamb, A.H. and Douglas, K.T. The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues. (1993) Biochem. Biophys. Acta, 1203, 93-98.
-
Waer, A.F., Smith, K., McKie, J.H., Benson, T., Fairlamb, A.H. and Douglas, K.T. The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues. (1993) Biochem. Biophys. Acta, 1203, 93-98.
-
-
-
-
11
-
-
0029360570
-
-
Krauth-Siegel, R.L. and Schoneck, A.R. Flavoprotein structure and mechanism. 5. Trypanothione reductase and lipoamide dehydrogenase as targets for a structure-based drug design. (1995) FASEB J., 9, 1138.
-
Krauth-Siegel, R.L. and Schoneck, A.R. Flavoprotein structure and mechanism. 5. Trypanothione reductase and lipoamide dehydrogenase as targets for a structure-based drug design. (1995) FASEB J., 9, 1138.
-
-
-
-
12
-
-
0030926411
-
-
Dumas, C., Ouellette, M., Tovar, J., Cunningham, M.L., Fairlamb, A.H., Tamar, S., Olivier, M. and Papadopoulou, B. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. (1997) EMBO J., 16, 2590-2598.
-
Dumas, C., Ouellette, M., Tovar, J., Cunningham, M.L., Fairlamb, A.H., Tamar, S., Olivier, M. and Papadopoulou, B. Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. (1997) EMBO J., 16, 2590-2598.
-
-
-
-
13
-
-
0031854156
-
-
Tovar, J., Wilkinson, S., Mottram, J.C. and Fairlamb, A.H. Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus. (1998) Mol. Microbiol, 29, 653-660.
-
Tovar, J., Wilkinson, S., Mottram, J.C. and Fairlamb, A.H. Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus. (1998) Mol. Microbiol, 29, 653-660.
-
-
-
-
14
-
-
0029017095
-
-
Cunningham, M.L. and Fairlamb A.H. Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials. (1995) Eur. J. Biochem., 230, 460-468.
-
Cunningham, M.L. and Fairlamb A.H. Trypanothione reductase from Leishmania donovani. Purification, characterisation and inhibition by trivalent antimonials. (1995) Eur. J. Biochem., 230, 460-468.
-
-
-
-
15
-
-
4544289321
-
-
Wyllie, S., Cunningham, M.L. and Fairlamb, A.H. Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani. (2004) J. Biol. Chem., 279, 39925-39932.
-
Wyllie, S., Cunningham, M.L. and Fairlamb, A.H. Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani. (2004) J. Biol. Chem., 279, 39925-39932.
-
-
-
-
16
-
-
0034780949
-
-
Sundar S. Drug resistance in Indian visceral Leishmaniasis. (2001) Trop. Med. Int. Health, 6, 849-854.
-
Sundar S. Drug resistance in Indian visceral Leishmaniasis. (2001) Trop. Med. Int. Health, 6, 849-854.
-
-
-
-
17
-
-
0036319712
-
-
Guerin, P.J., Olliaro, P., Sundar, S., Boelaert, M., Croft, S.L., Desjeux, P., Wasunna, M.K. and Bryceson A.D. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. (2002) Lancet Infect. Dis., 2, 494-501.
-
Guerin, P.J., Olliaro, P., Sundar, S., Boelaert, M., Croft, S.L., Desjeux, P., Wasunna, M.K. and Bryceson A.D. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. (2002) Lancet Infect. Dis., 2, 494-501.
-
-
-
-
18
-
-
4444244846
-
-
Rijal, S., Chappuis, F., Singh, R., Bovier, P.A., Achrya, A., Karki, B.M., Das, M.L., Desjeux, P., Loutan, L. and Koirala, S. Treatment of visceral leishmaniasis in south-eastern Nepal: decreasing efficacy of sodium stibogluconate and need for a policy to limit further decline. (2003) Trans R. Soc. Trop. Med. Hyg., 97, 350-354.
-
Rijal, S., Chappuis, F., Singh, R., Bovier, P.A., Achrya, A., Karki, B.M., Das, M.L., Desjeux, P., Loutan, L. and Koirala, S. Treatment of visceral leishmaniasis in south-eastern Nepal: decreasing efficacy of sodium stibogluconate and need for a policy to limit further decline. (2003) Trans R. Soc. Trop. Med. Hyg., 97, 350-354.
-
-
-
-
19
-
-
0030773120
-
-
Garforth, J., Yin, H., McKie, J.H., Douglas, K.T. and Fairlamb, A.H. Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine. (1997) J. Enzyme Inhib., 12, 161-173.
-
Garforth, J., Yin, H., McKie, J.H., Douglas, K.T. and Fairlamb, A.H. Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine. (1997) J. Enzyme Inhib., 12, 161-173.
-
-
-
-
20
-
-
3142719178
-
-
Saravanamuthu, A., Vickers, T.J., Bond, C.S., Peterson, M.R., Hunter, W.H. and Fairlamb, A.H. Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design. (2004) J. Biol. Chem., 279, 29493-29500.
-
Saravanamuthu, A., Vickers, T.J., Bond, C.S., Peterson, M.R., Hunter, W.H. and Fairlamb, A.H. Two interacting binding sites for quinacrine derivatives in the active site of trypanothione reductase: a template for drug design. (2004) J. Biol. Chem., 279, 29493-29500.
-
-
-
-
21
-
-
34248577040
-
-
Czechowicz, J.A., Wilhelm, A.K., Spalding, M.D., Larson, A.M., Engel, L.K. and Alberg, D.G. The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductase. (2007) J. Org. Chem., 11, 72, 3689-3693.
-
Czechowicz, J.A., Wilhelm, A.K., Spalding, M.D., Larson, A.M., Engel, L.K. and Alberg, D.G. The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductase. (2007) J. Org. Chem., 11, 72, 3689-3693.
-
-
-
-
22
-
-
0031059866
-
-
Otwinowski, Z. and Minor, W. Processing of X-ray diffraction data collected in oscillation mode. (1997) Methods Enzymol., 276, 307-326.
-
Otwinowski, Z. and Minor, W. Processing of X-ray diffraction data collected in oscillation mode. (1997) Methods Enzymol., 276, 307-326.
-
-
-
-
23
-
-
0014432781
-
-
Matthews, B. W. Solvent content of protein crystals. (1968) J. Mol. Biol., 33, 491-497.
-
Matthews, B. W. Solvent content of protein crystals. (1968) J. Mol. Biol., 33, 491-497.
-
-
-
-
24
-
-
0032078747
-
-
Vagin, A. and Teplyakov, A. A translation-function approach for heavy-atom location in macromolecular crystallography. (1998) Acta Cryst. D, 54, 400-402.
-
Vagin, A. and Teplyakov, A. A translation-function approach for heavy-atom location in macromolecular crystallography. (1998) Acta Cryst. D, 54, 400-402.
-
-
-
-
25
-
-
0028103275
-
-
Collaborative Computational Project, Number 4 The CCP4 suite: programs for protein crystallography. (1994) Acta Cryst., D50, 760-763.
-
Collaborative Computational Project, Number 4 The CCP4 suite: programs for protein crystallography. (1994) Acta Cryst., D50, 760-763.
-
-
-
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