메뉴 건너뛰기




Volumn 29, Issue 2, 1998, Pages 653-660

Evidence that trypanothione reductase is an essential enzyme in Leishmania by targeted replacement of the tryA gene locus

Author keywords

[No Author keywords available]

Indexed keywords

OXIDOREDUCTASE; TRYPANOTHIONE;

EID: 0031854156     PISSN: 0950382X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2958.1998.00968.x     Document Type: Article
Times cited : (143)

References (37)
  • 1
    • 0023369226 scopus 로고
    • Chromosome size polymorphisms of Leishmania donovani
    • Bishop, R.P., and Miles, M.A. (1987) Chromosome size polymorphisms of Leishmania donovani. Mol Biochem Parasitol 24: 263-272.
    • (1987) Mol Biochem Parasitol , vol.24 , pp. 263-272
    • Bishop, R.P.1    Miles, M.A.2
  • 2
    • 0030838722 scopus 로고    scopus 로고
    • New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase
    • Bonnet, B., Soullez, D., Davioudcharvet, E., Landry, V., Horvath, D., and Sergheraert, C. (1997) New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase. Bioorg Med Chem 5: 1249-1256.
    • (1997) Bioorg Med Chem , vol.5 , pp. 1249-1256
    • Bonnet, B.1    Soullez, D.2    Davioudcharvet, E.3    Landry, V.4    Horvath, D.5    Sergheraert, C.6
  • 3
    • 0027410144 scopus 로고
    • Plasticity in chromosome number and testing of essential genes in Leishmania by targeting
    • Cruz, A., Titus, R., and Beverley, S.M. (1993) Plasticity in chromosome number and testing of essential genes in Leishmania by targeting. Proc Natl Acad Sci USA 90: 1599-1603.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 1599-1603
    • Cruz, A.1    Titus, R.2    Beverley, S.M.3
  • 4
    • 0031054199 scopus 로고    scopus 로고
    • Characterization of the peptide substrate specificity of glutathionyl-spermidine synthetase from Crithidia fasciculata
    • Decraecker, S., Verbruggen, C., Rajan, P.K., Smith, K., Haemers, A., and Fairlamb, A.H. (1997) Characterization of the peptide substrate specificity of glutathionyl-spermidine synthetase from Crithidia fasciculata. Mol Biochem Parasitol 84: 25-32.
    • (1997) Mol Biochem Parasitol , vol.84 , pp. 25-32
    • Decraecker, S.1    Verbruggen, C.2    Rajan, P.K.3    Smith, K.4    Haemers, A.5    Fairlamb, A.H.6
  • 5
    • 0025376034 scopus 로고
    • Cassettes of the Streptoalloteichus hindustanus ble gene for transformation of lower and higher eukaryotes to phleomycin resistance
    • Drocourt, D., Calmels, T., Reynes, J.-P., Baron, M., and Tiraby, G. (1990) Cassettes of the Streptoalloteichus hindustanus ble gene for transformation of lower and higher eukaryotes to phleomycin resistance. Nucleic Acids Res 18: 4009.
    • (1990) Nucleic Acids Res , vol.18 , pp. 4009
    • Drocourt, D.1    Calmels, T.2    Reynes, J.-P.3    Baron, M.4    Tiraby, G.5
  • 6
    • 0030926411 scopus 로고    scopus 로고
    • Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages
    • Dumas, C., Ouellette, M., Tovar, J., Cunningham, M.L., Fairlamb, A.H., Tamar, S., et al. (1997) Disruption of the trypanothione reductase gene of Leishmania decreases its ability to survive oxidative stress in macrophages. EMBO J 16: 2590-2598.
    • (1997) EMBO J , vol.16 , pp. 2590-2598
    • Dumas, C.1    Ouellette, M.2    Tovar, J.3    Cunningham, M.L.4    Fairlamb, A.H.5    Tamar, S.6
  • 7
    • 15444348239 scopus 로고
    • Trypanothione metabolism in the chemotherapy of leishmaniasis and trypanosomiasis
    • Wang, C.C. (ed.). Washington, DC: American Association for the Advancement of Science
    • Fairlamb, A.H. (1991) Trypanothione metabolism in the chemotherapy of leishmaniasis and trypanosomiasis. In Molecular and Immunological Aspects of Parasitism. Wang, C.C. (ed.). Washington, DC: American Association for the Advancement of Science, pp. 107-121.
    • (1991) Molecular and Immunological Aspects of Parasitism , pp. 107-121
    • Fairlamb, A.H.1
  • 8
    • 0026793462 scopus 로고
    • Metabolism and functions of trypanothione in the Kinetoplastida
    • Fairlamb, A.H., and Cerami, A. (1992) Metabolism and functions of trypanothione in the Kinetoplastida. Annu Rev Microbiol 46: 695-729.
    • (1992) Annu Rev Microbiol , vol.46 , pp. 695-729
    • Fairlamb, A.H.1    Cerami, A.2
  • 9
    • 0022002912 scopus 로고
    • Trypanothione: A novel bis (glutathionyl)-spermidine cofactor for glutathione reductase in trypanosomatids
    • Fairlamb, A.H., Blackburn, P., Ulrich, P., Chait, B.T., and Cerami, A. (1985) Trypanothione: a novel bis (glutathionyl)-spermidine cofactor for glutathione reductase in trypanosomatids. Science 227: 1485-1487.
    • (1985) Science , vol.227 , pp. 1485-1487
    • Fairlamb, A.H.1    Blackburn, P.2    Ulrich, P.3    Chait, B.T.4    Cerami, A.5
  • 10
    • 0021381028 scopus 로고
    • A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity
    • Feinberg, A.P., and Vogelstein, B. (1984) A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem 137: 266-267.
    • (1984) Anal Biochem , vol.137 , pp. 266-267
    • Feinberg, A.P.1    Vogelstein, B.2
  • 11
    • 0030773120 scopus 로고    scopus 로고
    • Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine
    • Garforth, J., Yin, H., Mckie, J.H., Douglas, K.T., and Fairlamb, A.H. (1997) Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine. J Enzyme Inhib 12: 161-73.
    • (1997) J Enzyme Inhib , vol.12 , pp. 161-173
    • Garforth, J.1    Yin, H.2    Mckie, J.H.3    Douglas, K.T.4    Fairlamb, A.H.5
  • 13
    • 0030815956 scopus 로고    scopus 로고
    • A virtual screening approach applied to the search for trypanothione reductase inhibitors
    • Horvath, H. (1997) A virtual screening approach applied to the search for trypanothione reductase inhibitors. J Med Chem 40: 2412-2423.
    • (1997) J Med Chem , vol.40 , pp. 2412-2423
    • Horvath, H.1
  • 14
    • 0030921823 scopus 로고    scopus 로고
    • A structure-based approach to drug discovery: Crystallography and implications for the development of antiparasite drugs
    • Hunter, W.N. (1997) A structure-based approach to drug discovery: crystallography and implications for the development of antiparasite drugs. Parasitology 114: S17-S29.
    • (1997) Parasitology , vol.114
    • Hunter, W.N.1
  • 15
    • 0030057025 scopus 로고    scopus 로고
    • Crystal structure of the Trypanosoma cruzi trypanothione reductase-mepacrine complex
    • Jacoby, E.M., Schlichting, I., Lantwin, C.B., Kabsch, W., and Krauth-Siegel, R.L. (1996) Crystal structure of the Trypanosoma cruzi trypanothione reductase-mepacrine complex. Proteins 24: 73-80.
    • (1996) Proteins , vol.24 , pp. 73-80
    • Jacoby, E.M.1    Schlichting, I.2    Lantwin, C.B.3    Kabsch, W.4    Krauth-Siegel, R.L.5
  • 16
    • 0028853663 scopus 로고
    • Role of nitric oxide in parasitic infections
    • James, S.L. (1995) Role of nitric oxide in parasitic infections. Microbiol Rev 59: 533-547.
    • (1995) Microbiol Rev , vol.59 , pp. 533-547
    • James, S.L.1
  • 17
    • 0027494350 scopus 로고
    • Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which overexpress trypanothione reductase: Sensitivity towards agents that are thought to induce oxidative stress
    • Kelly, J.M., Taylor, M.C., Smith, K., Hunter, K.J., and Fairlamb, A.H. (1993) Phenotype of recombinant Leishmania donovani and Trypanosoma cruzi which overexpress trypanothione reductase: sensitivity towards agents that are thought to induce oxidative stress. Eur J Biochem 218: 29-37.
    • (1993) Eur J Biochem , vol.218 , pp. 29-37
    • Kelly, J.M.1    Taylor, M.C.2    Smith, K.3    Hunter, K.J.4    Fairlamb, A.H.5
  • 18
    • 0027998830 scopus 로고
    • An approach to functional complementation by introduction of large DNA fragments into Trypanosoma cruzi and Leishmania donovani using a cosmid shuttle vector
    • Kelly, J.M., Das, P., and Tomas, A.M. (1994) An approach to functional complementation by introduction of large DNA fragments into Trypanosoma cruzi and Leishmania donovani using a cosmid shuttle vector. Mol Biochem Parasitol 65: 51-62.
    • (1994) Mol Biochem Parasitol , vol.65 , pp. 51-62
    • Kelly, J.M.1    Das, P.2    Tomas, A.M.3
  • 19
    • 0025020371 scopus 로고
    • A modified colorimetric assay of macrophage activation for intracellular cytotoxicity against Leishmania parasites
    • Kiderlen, A.F., and Kaye, P.M. (1990) A modified colorimetric assay of macrophage activation for intracellular cytotoxicity against Leishmania parasites. J Immunol Methods 127: 11-18.
    • (1990) J Immunol Methods , vol.127 , pp. 11-18
    • Kiderlen, A.F.1    Kaye, P.M.2
  • 20
    • 0030994263 scopus 로고    scopus 로고
    • Convenient isolation and kinetic mechanism of glutathionylspermidine synthetase from Crithidia fasciculata
    • Koenig, K., Menge, U., Kiess, M., Wray, V., and Flohe, L. (1997) Convenient isolation and kinetic mechanism of glutathionylspermidine synthetase from Crithidia fasciculata. J Biol Chem 272: 11908-11915.
    • (1997) J Biol Chem , vol.272 , pp. 11908-11915
    • Koenig, K.1    Menge, U.2    Kiess, M.3    Wray, V.4    Flohe, L.5
  • 21
    • 0027193605 scopus 로고
    • Coupling of poly (A) site selection and trans-splicing in Leishmania
    • Lebowitz, J.H., Smith, H.Q., Rusche, L., and Beverley, S.M. (1993) Coupling of poly (A) site selection and trans-splicing in Leishmania. Genes Dev 7: 996-1007.
    • (1993) Genes Dev , vol.7 , pp. 996-1007
    • Lebowitz, J.H.1    Smith, H.Q.2    Rusche, L.3    Beverley, S.M.4
  • 23
    • 0024462527 scopus 로고
    • The oxidative response of rabbit peritoneal neutrophils to leishmanias and other trypanosomatids
    • Mallinson, D.J., Lackie, J.M., and Coombs, G.H. (1989) The oxidative response of rabbit peritoneal neutrophils to leishmanias and other trypanosomatids. Int J Parasitol 19: 639-645.
    • (1989) Int J Parasitol , vol.19 , pp. 639-645
    • Mallinson, D.J.1    Lackie, J.M.2    Coombs, G.H.3
  • 24
    • 0027262263 scopus 로고
    • Rapid isolation of DNA from trypanosomatid protozoa using a simple miniprep procedure
    • Medina-Acosta, E., and Cross, G.A.M. (1993) Rapid isolation of DNA from trypanosomatid protozoa using a simple miniprep procedure. Mol Biochem Parasitol 59: 327-329.
    • (1993) Mol Biochem Parasitol , vol.59 , pp. 327-329
    • Medina-Acosta, E.1    Cross, G.A.M.2
  • 25
    • 0002112085 scopus 로고    scopus 로고
    • Current public health status of the Trypanosomiases and Leishmaniases
    • Hide, G., Mottram, J.C., Coombs, G.H., and Holmes, P.H. (eds). Oxford: CAB International
    • Molyneux, D.H. (1997) Current public health status of the Trypanosomiases and Leishmaniases. In Trypanosomiasis and Leishmaniasis: Biology and Control. Hide, G., Mottram, J.C., Coombs, G.H., and Holmes, P.H. (eds). Oxford: CAB International, pp. 39-50.
    • (1997) Trypanosomiasis and Leishmaniasis: Biology and Control , pp. 39-50
    • Molyneux, D.H.1
  • 26
    • 0029830610 scopus 로고    scopus 로고
    • Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana
    • Mottram, J.C., McCready, B.P., Brown, K.G, and Grant, K.M. (1996) Gene disruptions indicate an essential function for the LmmCRK1 cdc2-related kinase of Leishmania mexicana. Mol Microbiol 22: 573-582.
    • (1996) Mol Microbiol , vol.22 , pp. 573-582
    • Mottram, J.C.1    McCready, B.P.2    Brown, K.G.3    Grant, K.M.4
  • 27
    • 0026161681 scopus 로고
    • Trypanosoma cruzi: Flow cytometric analysis of developmental stage differences in DNA
    • Nozaki, T., and Dvorak, J.A. (1991) Trypanosoma cruzi: flow cytometric analysis of developmental stage differences in DNA. J Protozool 18: 234-243.
    • (1991) J Protozool , vol.18 , pp. 234-243
    • Nozaki, T.1    Dvorak, J.A.2
  • 30
    • 0027092987 scopus 로고
    • Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata
    • Smith, K., Nadeau, K., Bradley, M., Walsh, C., and Fairlamb, A.H. (1992) Purification of glutathionylspermidine and trypanothione synthetases from Crithidia fasciculata. Protein Sci 7: 874-883.
    • (1992) Protein Sci , vol.7 , pp. 874-883
    • Smith, K.1    Nadeau, K.2    Bradley, M.3    Walsh, C.4    Fairlamb, A.H.5
  • 31
    • 0028234946 scopus 로고
    • The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase
    • Taylor, M.C., Kelly, J.M., Chapman, C.J., Fairlamb, A.H., and Miles, M.A. (1994) The structure, organization, and expression of the Leishmania donovani gene encoding trypanothione reductase. Mol Biochem Parasitol 64: 293-301.
    • (1994) Mol Biochem Parasitol , vol.64 , pp. 293-301
    • Taylor, M.C.1    Kelly, J.M.2    Chapman, C.J.3    Fairlamb, A.H.4    Miles, M.A.5
  • 32
    • 0030057147 scopus 로고    scopus 로고
    • Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi
    • Tovar, J., and Fairlamb, A.H. (1996) Extrachromosomal, homologous expression of trypanothione reductase and its complementary mRNA in Trypanosoma cruzi. Nucleic Acids Res 24: 2942-2949.
    • (1996) Nucleic Acids Res , vol.24 , pp. 2942-2949
    • Tovar, J.1    Fairlamb, A.H.2
  • 33
    • 0000393634 scopus 로고
    • Somatic and meiotic chromosomal recombination between inverted duplications in transgenic tobacco plants
    • Tovar, J., and Lichtenstein, C.L. (1992) Somatic and meiotic chromosomal recombination between inverted duplications in transgenic tobacco plants. Plant Cell 4: 319-332.
    • (1992) Plant Cell , vol.4 , pp. 319-332
    • Tovar, J.1    Lichtenstein, C.L.2
  • 34
    • 0032574808 scopus 로고    scopus 로고
    • Downregulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: Effect on parasite intracellular survival
    • Tovar, J., Cunningham, M.L., Smith, A.C., Croft, S.L., and Fairlamb, A.H. (1998) Downregulation of Leishmania donovani trypanothione reductase by heterologous expression of a trans-dominant mutant homologue: effect on parasite intracellular survival. Proc Natl Acad Sci USA 95: 5311-5316.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 5311-5316
    • Tovar, J.1    Cunningham, M.L.2    Smith, A.C.3    Croft, S.L.4    Fairlamb, A.H.5
  • 35
    • 0028263734 scopus 로고
    • Control of polyadenylation and alternative splicing of transcripts from adjacent genes in a procyclin expression site: Dual role for polypyrimidine tracts in trypanosomes?
    • Vassella, E., Braun, R., and Roditi, I. (1994) Control of polyadenylation and alternative splicing of transcripts from adjacent genes in a procyclin expression site: dual role for polypyrimidine tracts in trypanosomes? Nucleic Acids Res 22: 1359-1364.
    • (1994) Nucleic Acids Res , vol.22 , pp. 1359-1364
    • Vassella, E.1    Braun, R.2    Roditi, I.3
  • 36
    • 0030883947 scopus 로고    scopus 로고
    • Validating targets for antiparasite chemotherapy
    • Wang, C.C. (1997) Validating targets for antiparasite chemotherapy. Parasitology 114: S31-S44.
    • (1997) Parasitology , vol.114
    • Wang, C.C.1
  • 37
    • 0030045604 scopus 로고    scopus 로고
    • The crystal-structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Angstrom resolution
    • Zhang, Y.H, Bond, C.S., Bailey, S., Cunningham, M.L., Fairlamb, A.H., and Hunter, W.N. (1996) The crystal-structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 Angstrom resolution. Protein Sci 5: 52-61.
    • (1996) Protein Sci , vol.5 , pp. 52-61
    • Zhang, Y.H.1    Bond, C.S.2    Bailey, S.3    Cunningham, M.L.4    Fairlamb, A.H.5    Hunter, W.N.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.