Trypanothione reductase and lipoamide dehydrogenase as targets for a structure-based drug design

FASEB Journal

Volumn 9, Issue 12, 1995, Pages 1138-1146

  Krauth Siegel, R Luise ^a   Schöneck, Ralf ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Chagas' disease; drug design; flavoprotein structures; lipoamide dehydrogenase; trypanothione reductase

Indexed keywords

1,4 BENZOQUINONE; ACRIDINE; DIHYDROLIPOAMIDE DEHYDROGENASE; FLAVOPROTEIN; GLUTATHIONE REDUCTASE; NIFURTIMOX; NITROFURAN; OXIDOREDUCTASE; PHENOTHIAZINE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; THIOL; TRYPANOTHIONE; ANTITRYPANOSOMAL AGENT; TRYPANOTHIONE REDUCTASE;

AFRICAN TRYPANOSOMIASIS; BINDING SITE; CHAGAS DISEASE; DRUG DESIGN; ENZYME ANALYSIS; ENZYME STRUCTURE; FLAGELLATE; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; PRIORITY JOURNAL; REVIEW; ANIMAL; CHEMISTRY; DRUG EFFECT; ENZYME SPECIFICITY; ENZYMOLOGY; HUMAN; LEISHMANIA; LEISHMANIASIS; METABOLISM; PROTEIN SECONDARY STRUCTURE; TRYPANOSOMA; TRYPANOSOMIASIS;

KINETOPLASTIDA; MASTIGOPHORA (FLAGELLATES); PROTOZOA; TRYPANOSOMA; TRYPANOSOMA CRUZI;

ANIMAL; DRUG DESIGN; HUMAN; LEISHMANIA; LEISHMANIASIS; LIPOAMIDE DEHYDROGENASE; NADH, NADPH OXIDOREDUCTASES; PROTEIN STRUCTURE, SECONDARY; SUBSTRATE SPECIFICITY; TRYPANOCIDAL AGENTS; TRYPANOSOMA; TRYPANOSOMIASIS;

EID: 0029360570     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fasebj.9.12.7672506     Document Type: Review

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