Engineering the substrate specificity of glutathione reductase toward that of trypanothione reduction

Proceedings of the National Academy of Sciences of the United States of America

Volumn 88, Issue 19, 1991, Pages 8769-8773

  Henderson, G B ^a   Murgolo, N J ^a   Kuriyan, J ^a   Osapay, K ^a   Kominos, D ^a   Berry, A ^a   Scrutton, N S ^a   Hinchliffe, N W ^a   Perham, R N ^a   Cerami, A ^a  

^a Schering Plough Research Bloomfield NJ 07003 ^*  (United States)

Author keywords

drug design; molecular modeling; trypanosomes

Indexed keywords

GLUTATHIONE REDUCTASE; TRYPANOTHIONE;

ARTICLE; ENZYME SPECIFICITY; GENETIC ENGINEERING; NONHUMAN; PRIORITY JOURNAL; TRYPANOSOMA;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BINDING SITES; DNA MUTATIONAL ANALYSIS; ESCHERICHIA COLI; GENETIC ENGINEERING; GLUTATHIONE; GLUTATHIONE REDUCTASE; KINETICS; MOLECULAR SEQUENCE DATA; NADH, NADPH OXIDOREDUCTASES; PSEUDOMONAS AERUGINOSA; SPERMIDINE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRYPANOSOMA;

ESCHERICHIA COLI; FELIS CATUS; TRYPANOSOMA; TRYPANOSOMA CONGOLENSE; TRYPANOSOMATIDAE;

EID: 0026002958     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.88.19.8769     Document Type: Article

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