Normal-phase HPLC and HPLC-MS studies of the metabolism of a cytosolic phospholipase A2α inhibitor with activated ketone group by rat liver microsomes

Journal of Pharmaceutical and Biomedical Analysis

Volumn 43, Issue 2, 2007, Pages 601-605

  Fabian, Jörg ^a   Lehr, Matthias ^a  

^a UNIVERSITY OF MÜNSTER   (Germany)

Author keywords

Activated ketone; Cyano phase; Hydrate; Metabolism; Normal phase chromatography; Rat liver microsomes

Indexed keywords

1 [3 (4 OCTYLPHENOXY) 2 OXOPROPYL]INDOLE 5 CARBOXYLIC ACID; CARBOXYLIC ACID DERIVATIVE; KETONE; PHOSPHOLIPASE A2; PHOSPHOLIPASE A2 INHIBITOR; PHOSPHOLIPASE A2ALPHA;

ARTICLE; DRUG METABOLISM; DRUG STRUCTURE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MASS SPECTROMETRY; NONHUMAN; PRIORITY JOURNAL; RAT; SPRAGUE DAWLEY RAT;

ALCOHOLS; ANIMALS; ANTI-INFLAMMATORY AGENTS; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ENZYME INHIBITORS; INDOLES; KETONES; MALE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PHOSPHOLIPASES A; RATS; RATS, SPRAGUE-DAWLEY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 33845634008     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jpba.2006.07.017     Document Type: Article

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