Optimization of amide-based inhibitors of soluble epoxide hydrolase with improved water solubility

Journal of Medicinal Chemistry

Volumn 48, Issue 10, 2005, Pages 3621-3629

  Kim, In Hae ^a   Heirtzler, Fenton R ^a   Morisseau, Christophe ^a   Nishi, Kosuke ^a   Tsai, Hsing Ju ^a   Hammock, Bruce D ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Department of Entomology ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 ADAMANTYLACETYLAMINOBUTYRIC ACID PENTYL ESTER; 4 (3 CHLOROPHENYLCARBAMOYLOXY)BUTYRIC ACID PENTYL ESTER; 4 [2 (3 CHLOROPHENYL)ACETYLAMINO]BUTYRIC ACID PENTYL ESTER; 5 (3 CHLOROPHENYLCARBAMOYL)PENTANOIC ACID PENTYL ESTER; AMIDE; CARBENE; EPOXIDE HYDROLASE; ESTER DERIVATIVE; HYDROLASE INHIBITOR; OCTANOL; UNCLASSIFIED DRUG; UREA; WATER;

ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG INHIBITION; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; LIPOPHILICITY; MELTING POINT; NONHUMAN; PARTITION COEFFICIENT; PHARMACOPHORE; SOLUBILITY;

1-OCTANOL; ADAMANTANE; AMIDES; ANIMALS; BUTYRATES; EPOXIDE HYDROLASES; HUMANS; MICE; MODELS, MOLECULAR; SOLUBILITY; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; UREA; WATER;

EID: 18644374475     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0500929     Document Type: Article

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