Y27632, a Rho-activated kinase inhibitor, normalizes dysregulation in alpha1-adrenergic receptor-induced contraction of Lyon hypertensive rat artery smooth muscle

Fundamental and Clinical Pharmacology

Volumn 23, Issue 2, 2009, Pages 169-178

  Freitas, Maria Regina ^a,b   Eto, Masumi ^c   Kirkbride, Jason A ^c   Schott, Christa ^a   Sassard, Jean ^d   Stoclet, Jean Claude ^a  

^a CNRS   (France)

^b FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

^d UNIVERSITÉ LYON 1   (France)

Author keywords

CPI 17; Lyon hypertensive rats; MYPT1; Protein phosphatase; Resistance mesentery artery; RhoA; ROK

Indexed keywords

2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ALPHA 1 ADRENERGIC RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERY MUSCLE; ARTICLE; BODY WEIGHT; CALCIUM TRANSPORT; CONTROLLED STUDY; DRUG EFFECT; HYPERTENSION; MALE; MUSCLE CONTRACTION; NONHUMAN; PRIORITY JOURNAL; RAT;

AMIDES; ANIMALS; CALCIUM; CALCIUM CHLORIDE; DISEASE MODELS, ANIMAL; HYPERTENSION; MALE; MESENTERIC ARTERIES; MUSCLE CONTRACTION; MUSCLE PROTEINS; MUSCLE, SMOOTH, VASCULAR; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN PHOSPHATASE 1; PYRIDINES; RATS; RECEPTORS, ADRENERGIC, ALPHA-1; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 62849120359     PISSN: 07673981     EISSN: 14728206     Source Type: Journal    
DOI: 10.1111/j.1472-8206.2008.00658.x     Document Type: Article

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