How do single homeotic genes control multiple segment identities?

BioEssays

Volumn 18, Issue 2, 1996, Pages 91-94

  Duncan, Ian ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA BINDING PROTEIN; DROSOPHILA PROTEIN; HOMEODOMAIN PROTEIN; TRANSCRIPTION FACTOR; ULTRABITHORAX PROTEIN, DROSOPHILA;

ANIMAL; ARTICLE; DROSOPHILA; GENE; GENE EXPRESSION REGULATION; GENETICS; HOMEOBOX; PHYSIOLOGY; PRENATAL DEVELOPMENT; THORAX;

ANIMALS; DNA-BINDING PROTEINS; DROSOPHILA; DROSOPHILA PROTEINS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENES, HOMEOBOX; GENES, INSECT; HOMEODOMAIN PROTEINS; THORAX; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0030088039     PISSN: 02659247     EISSN: None     Source Type: Journal    
DOI: 10.1002/bies.950180203     Document Type: Article

References (42)

1. Castelli-Gair, J. and Akam, M. (1995). How the Hox gene Ultrabithorax specifies two different segments: the significance of spatial and temporal regulation within metameres. Development 121, 2973-2982.
2. Lewis, E. B. (1978). A gene complex controlling segmentation in Drosophila. Nature 276, 565-570.
3. Martin, C. H. et al. (1995). Complete sequence of the bithorax complex of Drosophila. Proc. Natl Acad. Sci. USA 92, 8398-8402.
4. Regutski, M., Harding, K., Kostriken, R., Karch, F., Levine, M. and McGinnis, W. (1985). Homeobox genes of the Antennapedia and bithorax complexes of Drosophila. Cell 42, 71-80.
5. Sánchez-Herrero, E., Vernos, I., Marco, R. and Morata, G. (1985). Genetic organization of Drosophila bithorax complex. Nature 313, 108-113.
6. Tiong, S., Bone, L. M. and Whittle, J. R. S. (1985). Recessive lethal mutations within the bithorax-complex in Drosophila. Mol. Gen. Genet. 200, 335-342.
7. Duncan, I. (1987). The bithorax complex. Annu. Rev. Genet. 21, 285-319.
8. Casanova, J., Sánchez-Herrero, E., Busturia, A. and Morata, G. (1987). Double and triple mutant combinations in the bithorax complex of Drosophila. EMBO J. 6, 3103-3109.
9. Hopmann, R., Duncan, D. and Duncan, I. (1995). Transvection in the iab-5,6,7 region of the bithorax complex of Drosophila: homology independent interactions in trans. Genetics 139, 815-833.
10. Boulet, A. M., Lloyd, A. and Sakonju, S. (1991). Molecular definition of the morphogenetic and regulatory functions and the cis-regulatory elements of the Drosophila Abd-B homeotic gene. Development 111, 393-405.
11. Celniker, S. E., Keelan, D. J. and Lewis, E. B. (1989). The molecular genetics of the bithorax complex of Drosophila: characterization of the products of the Abdominal-B domain. Genes Dev. 3, 1424-1436.
12. DeLorenzi, M. and Bienz, M. (1990). Expression of Abdominal-B homeoproteins in Drosophila embryos. Development 108, 323-329.
13. Kornfeld, K., Saint, R. B., Beachy, P. A., Harte, P. J., Peattie, D. A. and Hogness, D. S. (1989). Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. Genes Dev. 3, 243-258.
14. O'Connor, M. B., Binari, R., Perkins, L. A. and Bender, W. (1988) Alternative products from the Ultrabithorax domain of the bithorax complex. EMBO J. 7, 435-445.
15. Zavortink, M. and Sakonju, S. (1989). The morphogenetic and regulatory functions of the Drosophila Abdominal-B gene are encoded in overlapping RNAs transcribed from separate promoters. Genes Dev. 3, 1969-1981.
16. Martinez-Arias, A. and Lawrence, P. A. (1985). Parasegments and compartments in the Drosophila embryo. Nature 313, 639-642.
17. Karch, F., Bender, W. and Weiffenbach, B. (1990). abd-A expression in Drosophila embryos. Genes Dev. 4, 1573-1587.
18. Macías, A., Casanova, J. and Morata, G. (1990). Expression and regulation of the abd-A gene of Drosophila. Development 110, 1197-1207.
19. White, R. A. H. and Wilcox, M. (1985). Distribution of Ultrabithorax proteins in Drosophila. EMBO J. 4, 2035-2043.
20. Hayes, P. H., Sato, T. and Denell, R. E. (1984). Homoeosis in Drosophila: the Ultrabithorax larval syndrome. Proc. Natl Acad. Sci. USA 81, 545-549.
21. Struhl, G. (1984). Splitting the bithorax complex of Drosophila. Nature 308, 454-457.
22. Hooper, J. E. (1986). Homeotic gene function in the muscles of Drosophila larvae. EMBO J. 5, 2321-2329.
23. Vachon, G., Cohen, B., Pfeifle, C., McGuffin, M. E., Botas, J. and Cohen, S. M. (1992). Homeotic genes of the bithorax complex repress limb development in the abdomen of the Drosophila embryo through the target gene Distal-less. Cell 71, 437-450.
24. Mann, R. S. (1994). engrailed-mediated repression of Ultrabithorax is necessary for the parasegment 6 identity in Drosophila. Development 120, 3205-3212.
25. González-Reyes, A. and Morata, G. (1990). The developmental effect of overexpressing a Ubx product in Drosophila embryos is dependent on its interactions with other homeotic products. Cell 61, 515-522.
26. Mann, R. S. and Hogness, D. S. (1990). Functional dissection of Ultrabithorax proteins in D. melanogaster. Cell 60, 597-610.
27. Warren, R. W., Nagy, L., Selegue, J., Gates, J. and Carroll, S. (1994). Evolution of homeotic gene regulation and function in flies and butterflies. Nature 372, 458-461.
28. Frayne, E. G. and Sato, T. (1991). The Ultrabithorax gene of Drosophila and the specification of abdominal histoblasts. Dev. Biol. 146, 265-277.
29. Smolik-Utlaut, S. M. (1990). Dosage requirements of Ultrabithorax and bithoraxoid in the determination of segment identity in Drosophila melanogaster. Genetics 124, 357-366.
30. Irvine, K. D., Botas, J., Jha, S., Mann, R. S. and Hogness, D. S. (1993). Negative autoregulation by Ultrabithorax controls the level and pattern of its expression. Development 117, 387-399.
31. Lopez, A. J. and Hogness, D. S. (1991). Immunochemical dissection of the Ultrabithorax homeoprotein family in Drosophila melanogaster. Proc. Natl Acad. Sci. USA 88, 9924-9928.
32. Subramaniam, V., Bomze, H. M. and López, A. J. (1994). Functional differences between Ultrabithorax protein isoforms in Drosophila melanogaster. evidence from elimination, substitution and ectopic expression of specific isoforms. Genetics 136, 979-991.
33. Karch, F. et al. (1985). The abdominal region of the bithorax complex. Cell 43, 81-96.
34. Kuziora, M. A. (1993). Abdominal-B protein isoforms exhibit distinct cuticular transformations and regulatory activities when ectopically expressed in Drosophila embryos. Mech. Dev. 42, 125-137.
35. Lamka, M. L., Boulet, A. M. and Sakonju, S. (1992). Ectopic expression of UBX and ABD-B proteins during Drosophila embryogenesis: competition, not a functional hierarchy, explains phenotypic suppression. Development 116, 841-854.
36. Fasano, L. et al. (1991). The gene teashirt is required for the development of Drosophila embryonic trunk segments and encodes a protein with widely spaced zinc finger motifs. Cell 64, 63-79.
37. Röder, L., Vola, C. and Kerridge, S. (1992). The role of the teashirt gene in trunk segmental identity in Drosophila. Development 115,1017-1033
38. Kühnlein, R. P. et al. (1995). Spalt encodes an evolutionarily conserved zinc finger protein of novel structure which provides homeotic gene function in the head and tail region of the Drosophila embryo. EMBO J. 13, 168-179.
39. Jürgens, G. (1988). Head and tail development of the Drosophila embryo involves spalt, a novel homeotic gene. EMBO J. 7, 189-196.
40. DeZulueta, P. D., Alexandre, E., Jacq, B. and Kerridge, S. (1994). Homeotic complex and teashirt genes co-operate to establish trunk segmental identities in Drosophila. Development 120, 2278-2296
41. Cumberledge, S., Zaratzian, A. and Sakonju, S. (1990). Characterization of two RNAs transcribed from the cis-regulatory region of the abd-A domain within the Drosophila bithorax complex. Proc. Natl Acad. Sci. USA 87, 3259-3263.
42. Lipshitz, H. D., Peattie, D. A. and Hogness, D. S. (1987). Novel transcripts from the Ultrabithorax domain of the bithorax complex. Genes Dev. 1, 307-322.