Multiple residues in the P-region and M2 of murine Kir 2.1 regulate blockage by external Ba2+

Korean Journal of Physiology and Pharmacology

Volumn 13, Issue 1, 2009, Pages 61-70

  Lee, Young Mee ^a   Thompson, Gareth A ^c   Ashmole, Ian ^b,d   Leyland, Mark ^c   So, Insuk ^a   Stanfield, Peter R ^b  

^a Seoul National University   (South Korea)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY OF LEICESTER   (United Kingdom)

^d Ion Channel Group

Author keywords

Barium blockage; Inward rectifier; Ionic selectivity; Potassium channel

Indexed keywords

BARIUM ION; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; POTASSIUM CHANNEL; POTASSIUM ION;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHANNEL GATING; CHO CELL; CONTROLLED STUDY; FEMALE; GENE MUTATION; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; WILD TYPE;

EID: 62749107098     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: 10.4196/kjpp.2009.13.1.61     Document Type: Article

References (51)

1. - channel Kii-2.1. J Physiol 493: 643-649, 1996.
2. 2- block of a mouse inwardly rectifying K channel: differential contribution by two discrete residues. J Physiol 534: 381-393, 2001.
3. Dart C, Leyland ML, Barrett-Jolley R, Shelton PJ, Spencer PJ, Conley EC, Sutcliffe MJ, Stanfield PR. The dependence of Ag block of a potassium channel, murine Kir2.1. on a cysteine residue in the selectivity filter. J Physiol 511; 15-94. 1998,
4. Doring F, Derst C, Wischmeyer E, Karschin C, Schneggenburger R, Daut J, Karschin A. The epithelial inward rectifier channel Kir7.1 displays unusual K permeation properties. J Neurosci 18: 8625-8636, 1998.
5. Doyle DA, Morais CJ, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, Mackinnon R. The structure of the potassium channel: molecular basis of K conduction and selectivity. Science 280: 69-77, 1998.
6. Duprat F, Lesage F, Fink M, Reyes R, Heurateaux C, Lazdunski M. TASK, a human background K channel to sense external pH variations near physiological pH. EMBO J 17: 5464-5471. 1997.
7. Fakler B, Brandle U, Bond CH, Glowatzki E, Konig C, Adelman JP, Zenner HP, Ruppersberg JP. A Stractural determinant of differential sensitivity of cloned inward rectifier K channels to intracellular spermine. FEBS Lett 356: 199-203, 1991.
8. Fakler B, Brandle U, Glowatzki E, Weidemann S, Zenner HP, Ruppersberg JP. Strong voltage-dependent inward rectification of inward rectifier K channels is caused by intracellular spermine. Cell 80: 149-154. 1995.
9. Ficker E, Taglialatela M, WIBLE BA, Henley CM, Brown AM. Spermine and spermidine as gating molecules for inward rectifier K channels. Science 266: 1068-1072, 1994.
10. Hagiwara S, Miyazaki S, Moody W, Patlak J. Blocking effects of' barium and hydrogen ions on the potassium current during anomalous rectification in the starfish egg. J Physiol 279: 167-185, 1978.
11. Hagiwara S, Yoshii M. Effects of internal potassium and sodium on the anomalous rectification of the starfish egg as examined by internal perfusion. J Physiol 292: 251-265, 1979.
12. Harris RE, Larsson HP, Isakoff EY. A permanent ion binding site located between two gates of the Shaker K channel. Biophys J 74: 1808-1820, 1998.
13. Heginbotham L, Lu Z, Abramson T, Mackinnon R. Mutations in the K Channel signature sequence. Biophys J 66: 1061-1067, 1994.
14. Hidalgo P, Mackinnon R. Revealing the architecture of a K channel pore through mutant cycles with a peptide inhibitor. Science 268: 307-310, 1995.
15. Hurst RS, Toro L, Stefani E. Molecular determinants of external barium block in Shaker potassium channels. FEBS Lett 388: 59-65, 1996.
16. Jiang Y, Mackinnon R. The barium site in it potassium channel by x-ray crystallogryaphy. J Gen Physiol 115: 269-272, 2000.
17. Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. A novel inward rectifier K channel with unique pore properties. Neuron 20: 995-1005, 1998.
18. Kunkel TA. Rapid and efficient site-specific mutagenesis without phenotypic selection. Proc Natl Acad Sci USA 82: 488-192, 1985.
19. Kuo A, Gulbis JM, Antcliff JF, Rahman T, Lowe ED, Zimmer J, Cuthbertson J, Ashcroft FM, Ezaki T, Doyle DA. Crystal structure of the potassium channel KirBac1.1 in the closed state. Science 300: 1922-1926, 2003.
20. 2- block of the cardiac muscarinic K channel Kir3.1/Kir:3.4. J Biol Chem 275: 35831-35839, 2000.
21. 2 blockage. Biophysical J 80: 631A, 2001.
22. Leech CA, Stanfield PR. Inward rectification in frog skeletal muscle fibres and its dependence on membrane potential and external potassium. J Physiol 319: 295-309, 1981.
23. Lesage F, Guillemare E, Fink M, Duprat F, Lazdunski M, Romely G, Barhanin J. TWIK-1, a ubiquitous human weakly inward rectifying K channel with a novel structure. EMBO J 15: 1004-1011, 1996.
24. Lockless SW, Zhou M, Mackinnon R. Structural and thermodynamic properties of selective ion binding in a K channel. PLoS Biology 5: 1079-1088, 2007.
25. Lopatin AN, Makhina EN, Nichols CG. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectiflication. Nature 372: 366-369, 1994.
26. Lopatin AN, Makhina EN, Nichols CG. The mechanism of inward rectification of potassium channels: "long-pore plugging" by cytoplasmic polyamines. J Gen Physiol 106: 923-955, 1995.
27. -] Dependence of polyamine-induced rectification in iniward rectifier potassium channels (IRK1. Kir2.1). J Gen Physiol 108: 105-113, 1996.
28. - channel with backbone mutation in the selectivity filter. Nature Neurosci 4: 239-246, 2001.
29. 2- Nature: 325: 156-159, 1987.
30. Minor DL, Masseling SJ, Jan YN, Jan LY. Transmembrane structure of an inwardly rectifying potassium channel. Cell 96: 879-891, 1999.
31. - channel cloned from the chick inner ear. J Biol Chem 270: 19238-19245, 1995.
32. Neyton J, Miller C. Potassium blocks barium permeation through a calcium-activated potassium channel. J Gen Physiol 92: 549-567, 1988a.
33. + channel. J Gen Physiol 92: 569-586, 1988b.
34. Nishida M, Cadene M, Chait BT, Mackinnon R. Crystal Structure of a Kir3.1-prokaryotic Kir channel chimera. EMBO J 26: 4005-4015, 2007.
35. - channel to K-selective permeation. Biophys J 70: 754-761, 1996.
36. Sabirov RZ, Tominaga T, Miwa A, Okada Y, Oiki S. A conserved arginine residue in The pore region of an inward rectifier K channel (IRK1) ns an external barrier for cationic blockers. J Gen Physiol 110: 665-677, 1997.
37. - channels Kir2.1 expressed in Xenopus oocytes. Biophys J 75: 2313-2322, 1998.
38. - channel by external divalent cations in guinea-pig cardiac myocytes. Pfliigers Arch 422: 427-435, 1993.
39. - channel signature sequence of murine Kir2.1: mutations that affect microscopic gating but not ionic selectivity. J Physiol 531: 37-50, 2001.
40. So I, Ashmole I, Soh H, Park CS, Spencer PJ, Leyland M, Stanfield PR. Intrinsic gating in inward rectifier potassium channels (Kir2.1) with low polyamine affirity generated by site directed mutagenesis. Kor J Physiol Pharmacol 7: 131-142, 2003a.
41. So I. Ashmole I, Stanfield PR. The substates with mutants that negatively charged aspartate in position 172 was replaced with positive charge in inurine inward rectifier potassium channel (murine-Kir2.1). Kor J Physiol Pharmacol 7: 267-273, 2003b.
42. Standen NB, Stanfield PR. A potential and time-dependent blockade of inward rectification in frog skeletal muscle fibres by barium and strontium ions. J Physiol 280: 169-191, 1978.
43. 2- of the inward rectifier. IRK1. J Physiol 478: 1-6, 1994.
44. - channels: Kir2.0 and Kir3.0. Rev Physiol Biochem Pharmacol 145: 47-179, 2002.
45. 2- is influenced by an aspartate residue (D172). J Physiol 511P: 146P, 1998.
46. -. J Physiol 526: 231-240, 2000a.
47. Thompson GA, Leyland ML, Ashmole I, Stanfield PR. Residues in H.5 and M2 of murine Kir2.1 regulate Ba6- block. J Physiol 526P: 10S. 2000b.
48. - inward rectifier channel associated with motoneurons of cranial nerve nuclei. J Neurosci 18: 4096-4105, 1998.
49. Woodhull AM. lonic blockage of sodium channels in nerve. J Gen Physiol 61: 687-708, 1973.
50. Yang J, Jan YN, Jan LY. Determination of the Subunit stoichiometry of an inwardly rectifying potassium channel. Neuron 15: 1441-1447, 1995.
51. 2- block. Am J Physiol 271: C1949-C1956, 1996.