A conserved arginine residue in the pore region of an inward rectifier K channel (IRK1) as an external barrier for cationic blockers

Journal of General Physiology

Volumn 110, Issue 6, 1997, Pages 665-677

  Sabirov, Ravshan Z ^a   Tominaga, Tomoko ^a   Miwa, Akiko ^a   Okada, Yasunobu ^a   Oiki, Shigetoshi ^a  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Coexpression; Electrical distance; Mg2+ block; Mutagenesis; Open channel blocker

Indexed keywords

ARGININE; BARIUM ION; CALCIUM ION; CATION; CESIUM ION; MAGNESIUM ION; MESSENGER RNA; MUTANT PROTEIN; POTASSIUM CHANNEL; POTASSIUM ION; PROTEIN SUBUNIT; RUBIDIUM ION;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; CELL MEMBRANE POTENTIAL; CELL PH; CHANNEL GATING; CONTROLLED STUDY; NONHUMAN; PROTEIN DOMAIN; XENOPUS;

ANIMALS; ARGININE; BARIUM; CALCIUM; CATIONS; CELLS, CULTURED; CESIUM; ELECTROPHYSIOLOGY; GENE EXPRESSION; HYDROGEN-ION CONCENTRATION; ION CHANNEL GATING; MAGNESIUM; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; OOCYTES; POTASSIUM CHANNELS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; SENSITIVITY AND SPECIFICITY; SEQUENCE HOMOLOGY, AMINO ACID; XENOPUS;

EID: 15444344062     PISSN: 00221295     EISSN: None     Source Type: Journal    
DOI: 10.1085/jgp.110.6.665     Document Type: Article

References (33)

1. Baumann, A., A. Grupe, A. Ackermann, and O. Pongs. 1988. Structure of the voltage-dependent potassium channel is highly conserved from Drosophila to vertebrate central nervous systems. EMBO (Eur. Mol. Biol. Organ.) J. 7:2457-2463.
2. Biermans, G., J. Vereecke, and E. Carmeliet. 1987. The mechanism of the inactivation of the inward-rectifying K current during hyperpolarizing steps in guinea-pig ventricular myocytes. Pflügers Archiv. 410:604-613.
3. Chandy, K.G., and G.A. Gutman. 1993. Nomenclature for mammalian potassium channel genes. Trends Pharmacol. Sci. 14:434.
4. Doupnik, C.A., N. Davidson, and H.A.P. Lester. 1995. The inward rectifier potassium channel family. Curr. Opin. Neurobiol. 5:268-277.
5. 2-terminal addition or deletion. Consequences of missing a residue at the join in the channel. J. Mol. Biol. 231:1102-1121.
6. 2+ in the inactivation of inwardly rectifying K+ channels in aortic endothelial cells. J. Gen. Physiol. 105:463-484.
7. Frech, G.C., A.M. VanDongen, G. Schuster, A.M. Brown, and R.H. Joho. 1989. A novel potassium channel with delayed rectifier properties isolated from rat brain by expression cloning. Nature. 340:642-645.
8. Heginbotham, L, Z. Lu, T. Abramson, and R. MacKinnon. 1994. Mutations in the K+ channel signature sequence. Biophys. J. 66: 1061-1067.
9. Hille, B. 1992. Ionic Channels of Excitable Membranes. 2nd ed. Sinauer Associates, Inc., Sunderland, MA. 607 pp.
10. Ho, K., C.G. Nichols, W.J. Lederer, J. Lytton, P.M. Vassilev, M.V. Kanazirska, and S.C. Hebert. 1993. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature. 362:31-38.
11. KATP: an inward rectifier subunit plus the sulfonylurea receptor. Science. 270:1166-1170.
12. Kell, M.J., and L.J. DeFelice. 1988. Surface charge near the cardiac inward-rectifier channel measured from single-channel conductance. J. Membr. Biol. 102:1-10.
13. Koyama, H., K. Morishige, N. Takahashi, J.S. Zanelli, D.N. Fass, and Y. Kurachi. 1994. Molecular cloning, functional expression and localization of a novel inward rectifier potassium channel in the rat brain. FEBS Lett. 341:303-307.
14. +-channel proteins. Nature. 374:135-141.
15. Kubo, Y., T.J. Baldwin, Y.N. Jan, and L.Y. Jan. 1993a. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature. 362:127-133.
16. Kubo, Y., E. Reuveny, P.A. Slesinger, Y.N. Jan, and L.Y. Jan. 1993a. Primary structure and functional expression of a rat G-protein-coupled muscarinic potassium channel. Nature. 364:802-806.
17. + channel IRK1. Receptors Channels. 4:73-83.
18. + channels in the brain. FEBS Lett. 353:37-42.
19. MacKinnon, R. 1991. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature. 350:232-235.
20. + channel. Annu. Rev. Physiol. 53:289-298.
21. Methfessel, C., V. Witzemann, T. Takahashi, M. Mishina, S. Numa, and B. Sakmann. 1986. Patch clamp measurements on Xenopus laevis oocytes: currents through endogenous channels and implanted acetylcholine receptor and sodium channels. Pflügers Archiv. 407:577-588.
22. Morishige, K., N. Takahashi, A. Jahangir, M. Yamada, H. Koyama, J.S. Zanelli, and Y. Kurachi. 1994. Molecular cloning and functional expression of a novel brain-specific inward rectifier potassium channel. FEBS Lett. 346:251-256.
23. Nichols, C.G., and A.N. Lopatin. 1997. Inward rectifier potassium channels. Annu. Rev. Physiol. 59:171-191.
24. Oiki, S., T. Yamamoto, and Y. Okada. 1994. Apparent stability constants and purity of Ca-chelating agents evaluated using Ca-selective electrodes by the double-log optimization method. Cell Calcium. 15:209-216.
25. + channel (IRK1). Pflügers Arch. 433: 428-434.
26. + channel by external divalent cations in guinea-pig cardiac myocytes. Pflügers Archiv. 422:427-435.
27. Shuck, M.E., J.H. Bock, C.W. Benjamin, T.D. Tsai, K.S. Lee, J.L. Slightom, and M.J. Bienkowski. 1994. Cloning and characterization of multiple forms of the human kidney ROMK potassium channel. J. Biol. Chem. 269:24261-24270.
28. Tempel, B.L., D.M. Papazian, T.L. Schwarz, Y.N. Jan, and L.Y. Jan. 1987. Sequence of a probable potassium channel component encoded at Shaker locus of Drosophila. Science (Wash. DC). 237:770-775.
29. Woodhull, A.M. 1973. Ionic blockage of sodium channels in nerve. J. Gen. Physiol. 61:687-708.
30. Yang, J., Y.N. Jan, and L.Y. Jan. 1995. Determination of the subunit stoichiometry of an inwardly rectifying potassium channel. Neuron. 15:1441-1447.
31. Yang, J., M. Yu, Y.N. Jan, and L.Y. Jan. 1997. Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel. Proc. Natl. Acad. Sci. USA. 94:1568-1572.
32. Yokoyama, S., K. Imoto, T. Kawamura, H. Higashida, N. Iwabe, T. Miyata, and S. Numa. 1989. Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells. Primary structure and functional expression from cDNAs. FEBS Lett. 259:37-42.
33. Zhou, H., S.S. Tate, and L.G. Palmer. 1994. Primary structure and functional properties of an epithelial K channel. Am. J. Physiol. 266:C809-C824.