The substates with mutants that negatively charged aspartate in position 172 was replaced with positive charge in murine inward rectifier potassium channel (murine Kir2.1)

Korean Journal of Physiology and Pharmacology

Volumn 7, Issue 5, 2003, Pages 267-273

  So, I ^b,c   Ashmole, I ^a,b   Stanfield, P R ^a,b  

^a UNIVERSITY OF WARWICK   (United Kingdom)

^b UNIVERSITY OF LEICESTER   (United Kingdom)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

Channel gating; Potassium channel; Substate

Indexed keywords

ASPARTIC ACID; COMPLEMENTARY DNA; DIMER; EDETIC ACID; INWARDLY RECTIFYING POTASSIUM CHANNEL; MAGNESIUM ION; MONOMER; POTASSIUM ION;

ANIMAL CELL; ARTICLE; CHANNEL GATING; CONTROLLED STUDY; COVALENT BOND; ELECTRIC CURRENT; ELECTRIC POTENTIAL; GENETIC TRANSFECTION; LATENT PERIOD; LINEAR SYSTEM; MEMBRANE ELECTROPHYSIOLOGY; MOUSE; MUTATIONAL ANALYSIS; NONHUMAN; PH; PHASE TRANSITION; PROTEIN DOMAIN; RECORDING;

EID: 0347756671     PISSN: 12264512     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. 2+ channels. J Gen Physiol 108: 363-374, 1996
2. + block of a potassium channel, murine Kir2.1, on a cysteine residue in the selectivity filter. J Physiol 511.1: 25-32, 1998
3. Korchev YE, Bashford CL, Alder GM, Apel PY, Edmonds DT, Lev AA, Nandi K, Zima AV, Pasternak CA. A novel explanation for fluctuations of ion current through narrow pores. FASEB J 11: 600- 608, 1997
4. + channel inner pore revealed by stoichiometric covalent modification. Neuron 22: 571-580, 1999
5. + channel. Nature 371: 243-246, 1994
6. Lu Z, MacKinnon R. Probing a potassium channel pore with an engineered protonatable site. Biochemistry 34: 13133-13138, 1995
7. 2+ block. J Physiol 510.3: 675-683, 1998
8. Root MJ, MacKinnon R. Two identical noninteracting sites in an ion channel revealed by proton transfer. Science 265: 1852-1865, 1994
9. ATP channels by the Kir6.2 subunit. J Gen Physiol 110: 141-153, 1997
10. So I, Ashmole I, Soh H, Park CS, Spencer PJ, Leyalnd M, Stanfield PR. Instrinsic gating in inward rectifier potassium channels (Kir2.1) with low polyamine affinity generated by site directed mutagenesis. Kor J Physiol Pharmacol 7: 131-142, 2003
11. So I, Ashmole I, Stanfield PR. Conductance substates in mutants of the murine inward rectifier potassium channel Kir2.1. Biophys J 78: 2032Pos, 2000
12. 2+. J Physiol 475: 1-7, 1994