Residues beyond the selectivity filter of the K+ channel Kir2.1 regulate permeation and block by external Rb+ and Cs+

Journal of Physiology

Volumn 526, Issue 2, 2000, Pages 231-240

  Thompson, G A ^a   Leyland, M L ^a   Ashmole, I ^a   Sutcliffe, M J ^a   Stanfield, P R ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ASPARTIC ACID; CESIUM ION; LEUCINE; POTASSIUM CHANNEL; POTASSIUM ION; RUBIDIUM ION; SERINE; THREONINE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; PROTEIN KCSA; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CHANNEL GATING; CHEMICAL STRUCTURE; CONTROLLED STUDY; HYDROGEN BOND; MEMBRANE CURRENT; MEMBRANE FILTER; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; MUTATION; NONHUMAN; PRIORITY JOURNAL; REGULATORY MECHANISM; STREPTOMYCES LIVIDANS; CELL MEMBRANE PERMEABILITY; CHO CELL LINE; ELECTRIC POTENTIAL; FEMALE; GENE MUTATION; POTASSIUM CURRENT; PROTEIN DOMAIN; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY; WILD TYPE;

EID: 0034661463     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1469-7793.2000.00231.x     Document Type: Article

References (36)

1. + channel Kir2.1
2. The rubidium and potassium permeability of frog muscle membrane
3. Cloning and expression of a family of inward rectifier potassium channels
4. The selectivity filter of a potassium channel, murine Kir2.1, investigated using scanning cysteine mutagenesis
5. + conduction and selectivity
6. + channels to intracellular spermine
7. + channels
8. + causes a voltage-dependent block of inward K currents in resting skeletal muscle fibres
9. Potassium current and the effect of cesium on this current during anomalous rectification of the egg cell membrane of a starfish
10. Effects of internal potassium and sodium on the anomalous rectification of the starfish egg as examined by internal perfusion
11. + channels
12. Potassium channels as multi-ion single-file pores
13. Primary structure and functional expression of a mouse inward rectifier potassium channel
14. Probing pore topology and conformational changes of Kir2.1 potassium channels by cysteine scanning mutagenesis
15. Inward rectification in frog skeletal muscle fibres and its dependence on membrane potential and external potassium
16. The possible role of a disulphide bond in forming functional Kir2.1 potassium channels
17. Potassium channel block by cytoplasmic polyamines as the mechanism of intrinsic rectification
18. +] dependence of polyamine-induced rectification in inward rectifier potassium channels (IRK1, Kir2.1)
19. Silver as a probe of pore-forming residues in a potassium channel
20. 2+
21. Transmembrane structure of an inwardly rectifying potassium channel
22. Inward rectifier potassium channels
23. The voltage-dependent block of ATP-sensitive potassium channels of frog skeletal muscle by caesium and barium ions
24. Inwardly rectifying potassium channels
25. + -selective permeation
26. Comparative protein modelling by satisfaction of spatial restraints
27. Studies of the unitary properties of adenosine 5'-triphosphate regulated potassium channels of frog skeletal muscle
28. + movement through the pore in IRK1 potassium channels
29. Rubidium block and rubidium permeability of the inward rectifier of frog skeletal muscle fibres
30. 2+ of the inward rectifier, IRK1
31. + is influenced by certain mutations of a serine residue, S165, in the M2 region
32. Clustal W: Improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice
33. Determination of the subunit stoichiometry of an inwardly rectifying potassium channel
34. Stabilization of ion selectivity filter by pore loop ion pairs in an inwardly rectifying potassium channel
35. 2+ block