A novel PDE2A reporter cell line: Characterization of the cellular activity of PDE inhibitors

Molecular Pharmaceutics

Volumn 6, Issue 1, 2009, Pages 326-336

  Wunder, Frank ^a   Gnoth, Mark Jean ^a   Geerts, Andreas ^a   Barufe, Daniel ^a  

^a BAYER PHARMA AG   (Germany)

Author keywords

Anp receptor; Cgmp; Cng channel; PDE2A; Reporter assay

Indexed keywords

1 (2 CHLOROPHENYL) 6 (3,3,3 TRIFLUORO 2 METHYLPROPYL) 1,5 DIHYDRO 4H PYRAZOLO[3,4 D]PYRIMIDINE 4 ONE; 2 (3,4 DIMETHOXYBENZYL 7 [1 (1 HYDROXYETHYL) 4 PHENYLBUTYL] 5 METHYLIMIDAZO[5,1 F]TRIAZIN 4(3H) ONE; 2 METHYL 5 NITROBENZENESULFONIC ACID DIMETHYLAMIDE; 9 (6 PHENYL 2 OXOHEX 3 YL) 2 (3,4 DIMETHOXYBENZYL)PURIN 6 ONE; AEQUORIN; BAY 607550; BAY 736691; CYCLIC GMP; CYCLIC NUCLEOTIDE GATED CHANNEL; DIPYRIDAMOLE; ISOBUTYLMETHYLXANTHINE; MILRINONE; PHOSPHODIESTERASE 2A; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; SILDENAFIL; SPLEEN EXONUCLEASE; TREQUINSIN; UNCLASSIFIED DRUG; VINPOCETINE; ZAPRINAST; ATRIAL NATRIURETIC FACTOR RECEPTOR; CYCLIC NUCLEOTIDE PHOSPHODIESTERASE 2;

ANIMAL CELL; ARTICLE; CALCIUM TRANSPORT; CELL LINE; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; DRUG ACTIVITY; LUMINESCENCE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL SEPARATION; DRUG ANTAGONISM; GENETICS; HAMSTER; HUMAN; KINETICS; METABOLISM; METHODOLOGY; REPORTER GENE;

ANIMALS; CELL LINE; CELL SEPARATION; CRICETINAE; CYCLIC GMP; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 2; GENES, REPORTER; HUMANS; KINETICS; PHOSPHODIESTERASE INHIBITORS; RECEPTORS, ATRIAL NATRIURETIC FACTOR;

EID: 62649166527     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp800127n     Document Type: Article

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