Phosphorylation of the amino-terminal region of X11L regulates its interaction with APP

Journal of Neurochemistry

Volumn 109, Issue 2, 2009, Pages 465-475

  Sakuma, Megumi ^a   Tanaka, Emi ^a   Taru, Hidenori ^a   Tomita, Susumu ^b   Gandy, Sam ^c   Nairn, Angus C ^b   Nakaya, Tadashi ^a   Yamamoto, Tohru ^a   Suzuki, Toshiharu ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Amyloid protein precursor; Cell stress; Protein phosphorylation; X11; X11 like

Indexed keywords

ADAPTOR PROTEIN; ALANINE; AMYLOID BETA PROTEIN; PHOSPHOTYROSINE; PROTEIN X11L; SERINE; UNCLASSIFIED DRUG;

AMINO ACID BRAIN LEVEL; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CELL STRESS; CYTOPLASM; EMBRYO; HUMAN; HUMAN CELL; OSMOTIC STRESS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM;

AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CADHERINS; CARRIER PROTEINS; CELL LINE; CONSERVED SEQUENCE; HUMANS; MICE; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; OSMOLAR CONCENTRATION; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY;

EID: 62649164235     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2009.05988.x     Document Type: Article

References (33)

1. Ando K., Oishi M., Takeda S., Iijima K., Isohara T., Nairn A. C., Kirino Y., Greengard P. Suzuki T. (1999) Role of phosphorylation of Alzheimer's amyloid precursor protein during neuronal differentiation. J. Neurosci. 19, 4421 4427.
2. Ando K., Iijima K. I., Elliott J. I., Kirino Y. Suzuki T. (2001) Phosphorylation-dependent regulation of the interaction of amyloid precursor protein with Fe65 affects the production of β-amyloid. J. Biol. Chem. 276, 40353 40361.
3. Araki Y., Tomita S., Yamaguchi H., Miyagi N., Sumioka A., Kirino Y. Suzuki T. (2003) Novel cadherin-related membrane proteins, alcadeins, enhance the X11-like protein-mediated stabilization of amyloid β-protein precursor metabolism. J. Biol. Chem. 278, 49448 49458.
4. Araki Y., Miyagi N., Kato N. et al. (2004) Coordinated metabolism of alcadein and amyloid β-protein precursor regulates FE65-dependent gene transactivation. J. Biol. Chem. 279, 24343 24354.
5. Araki Y., Kawano T., Taru H. et al. (2007) The novel cargo alcadein induces vesicle association of kinesin-1 motor components and activates axonal transport. EMBO J. 26, 1475 1486.
6. Borg J. P., Yang Y., De Taddeo-Borg M., Margolis B. Turner R. S. (1998) The X11αprotein slows cellular amyloid precursor protein processing and reduces Aβ40 and Aβ42 secretion. J. Biol. Chem. 273, 14761 14766.
7. Borg J. P., Lopez-Figueroa M. O., de Taddeo-Borg M., Kroon D. E., Turner R. S., Watson S. J. Margolis B. (1999) Molecular analysis of the X11-mLin-2/cask complex in brain. J. Neurosci. 19, 1307 1316.
8. Chen W. J., Goldstein J. L. Brown M. S. (1990) NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor. J. Biol. Chem. 265, 3116 3123.
9. Fiore F., Zambrano N., Minopoli G., Donini V., Duilio A. Russo T. (1995) The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. J. Biol. Chem. 270, 30853 30856.
10. Gandy S. (2005) The role of cerebral amyloid β accumulation in common forms of Alzheimer disease. J. Clin. Invest. 115, 1121 1129.
11. Ho A., Morishita W., Hammer R. E., Malenka R. C. Sudhof T. C. (2003) A role for mints in transmitter release: mint 1 knockout mice exhibit impaired GABAergic synaptic transmission. Proc. Natl. Acad. Sci. U S A 100, 1409 1414.
12. Ip Y. T. Davis R. J. (1998) Signal transduction by the c-JUN N-terminal kinase (JNK)-from inflammation to development. Curr. Opin. Cell Biol. 10, 205 219.
13. Lee J. H., Lau K. F., Perkinton M. S., Standen C. L., Shemilt S. J., Mercken L., Cooper J. D., McLoughlin D. M. Miller C. C. (2003) The neuronal adaptor protein X11α reduces Aβ levels in the brains of Alzheimer's APPswe Tg2576 transgenic mice. J. Biol. Chem. 278, 47025 47029.
14. Lee J. H., Lau K. F., Perkinton M. S., Standen C. L., Rogelj B., Falinska A., McLoughlin D. M. Miller C. C. (2004) The neuronal adaptor protein X11β reduces amyloid β-protein levels and amyloid plaque formation in the brains of transgenic mice. J. Biol. Chem. 279, 49099 49104.
15. McLoughlin D. M., Irving N. G., Brownlees J., Brion J. P., Leroy K. Miller C. C. (1999) Mint2/X11-like colocalizes with the Alzheimer's disease amyloid precursor protein and is associated with neuritic plaques in Alzheimer's disease. Eur. J. Neurosci. 11, 1988 1994.
16. Miller C. C., McLoughlin D. M., Lau K. F., Tennant M. E. Rogelj B. (2006) The X11 proteins, Aβ production and Alzheimer's disease. Trends Neurosci. 29, 280 285.
17. Nakaya T. Suzuki T. (2006) Role of APP phosphorylation in FE65-dependent gene transactivation mediated by AICD. Genes Cells 11, 633 645.
18. Nakaya T., Kawai T. Suzuki T. (2008) Regulation of FE65 nuclear translocation and function by amyloid β-protein precursor in osmotically stressed cells. J. Biol. Chem. 283, 19119 19131.
19. Norstedt C., Caporaso G. L., Thyberg J., Gandy E. Greengard P. (1993) Identification of the Alzheimer β/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells. J. Biol. Chem. 268, 608 612.
20. Ramelot T. A. Nicholson L. K. (2001) Phosphorylation-induced structural changes in the amyloid precursor protein cytoplasmic tail detected by NMR. J. Mol. Biol. 307, 871 884.
21. Ramelot T. A., Gentile L. N. Nicholson L. K. (2000) Transient structure of the amyloid precursor protein cytoplasmic tail indicates preordering of structure for binding to cytosolic factors. Biochemistry 39, 2714 2725.
22. Saito Y., Sano Y., Vassar R., Gandy S., Nakaya T., Yamamoto T. Suzuki T. (2008) X11 proteins regulate the translocation of amyloid β-protein precursor (APP) into detergent-resistant membrane and suppress the amyloidogenic cleavage of APP by β-site cleaving enzyme in brain. J. Biol. Chem. 283, 35763 35771.
23. Sano Y., Syuzo-Takabatake A., Nakaya T., Saito Y., Tomita S., Itohara S. Suzuki T. (2006) Enhanced amyloidogenic metabolism of the amyloid β-protein precursor in the X11L-deficient mouse brain. J. Biol. Chem. 281, 37853 37860.
24. Selkoe D. J. (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81, 741 766.
25. Setou M., Nakagawa T., Seog D. H. Hirokawa N. (2000) Kinesin superfamily motor protein KIF17 and mLin-10 in NMDA receptor-containing vesicle transport. Science 288, 1796 1802.
26. Suzuki T. Nakaya T. (2008) Regulation of APP by phosphorylation and protein interactions. J. Biol. Chem. 283, 29633 29637.
27. Suzuki T., Araki Y., Yamamoto T. Nakaya T. (2006) Trafficking of Alzheimer's disease-related membrane proteins and its participation in disease pathogenesis. J. Biochem. 139, 949 955.
28. Tanahashi H. Tabira T. (1999) X11L2, a new member of the X11 protein family, interacts with Alzheimer's β-amyloid precursor protein. Biochem. Biophys. Res. Commun. 255, 663 667.
29. Taru H. Suzuki T. (2004) Facilitation of stress-induced phosphorylation of β-amyloid precursor protein family members by X11-like/Mint2 protein. J. Biol. Chem. 279, 21628 21636.
30. Taru H., Iijima K., Hase M., Kirino Y., Yagi Y. Suzuki T. (2002) Interaction of Alzheimer's β-amyloid precursor family proteins with scaffold proteins of the JNK signaling cascade. J. Biol. Chem. 277, 20070 20078.
31. Tomita S., Ozaki T., Taru H., Oguchi S., Takeda S., Yagi Y., Sakiyama S., Kirino Y. Suzuki T. (1999) Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein. J. Biol. Chem. 274, 2243 2254.
32. Tomita S., Stein V., Stocker T. J., Nicoll R. A. Bredt D. S. (2005) Bidirectional synaptic plasticity regulated by phosphorylation of stargazing-like TARPs. Neuron, 45, 269 277.
33. Zhang Z., Lee C. H., Mandiyan V., Borg J. P., Margolis B., Schlessinger J. Kuriyan J. (1997) Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J. 16, 6141 6150.