Linkage analysis of schizophrenia in African-American families

Schizophrenia Research

Volumn 109, Issue 1-3, 2009, Pages 70-79

  Wiener, H W ^a   Klei, L ^b   Irvin, M D ^a   Perry, R T ^a   Aliyu, M H ^a   Allen, T B ^c   Bradford, L D ^d   Calkins, M E ^e   Devlin, B ^b   Edwards, N ^f   Gur, R E ^e   Gur, R C ^e   Kwentus, J ^g   Lyons, P D ^a,j   McEvoy, J P ^e   Nasrallah, H A ^h   Nimgaonkar, V L ^b   O'Jile, J ^g   Santos, A B ⁱ   Savage, R M ^a   Go, R C P ^a   more..

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^c DUKE UNIVERSITY MEDICAL CENTER   (United States)

^d MOREHOUSE SCHOOL OF MEDICINE   (United States)

^e UNIVERSITY OF PENNSYLVANIA   (United States)

^f UNIVERSITY OF TENNESSEE COLLEGE OF MEDICINE   (United States)

^g UNIVERSITY OF MISSISSIPPI MEDICAL CENTER   (United States)

^h UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

ⁱ MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^j The University of Alabama at Birmingham   (United States)

more..

Author keywords

African American; Linkage; Schizophrenia

Indexed keywords

AFRICAN AMERICAN; ARTICLE; CHROMOSOME 16Q; CHROMOSOME 20Q; CHROMOSOME 8Q; CONTROLLED STUDY; GENETIC LINKAGE; GENOTYPE; HETEROZYGOSITY; HUMAN; MAJOR CLINICAL STUDY; PHENOTYPE; PRIORITY JOURNAL; SCHIZOAFFECTIVE PSYCHOSIS; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

AFRICAN AMERICANS; CHROMOSOME MAPPING; FAMILY; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; LINKAGE (GENETICS); MALE; PEDIGREE; POLYMORPHISM, SINGLE NUCLEOTIDE; RISK FACTORS; SCHIZOPHRENIA;

EID: 62649160892     PISSN: 09209964     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.schres.2009.02.007     Document Type: Article

References (59)

1. Abecasis G.R., Cherny S.S., Cookson W.O., and Cardon L.R. Merlin-rapid analysis of dense genetic maps using sparse gene flow trees. Nat. Genet. 30 (2002) 97-101
2. Aliyu M.H., Calkins M.E., Swanson Jr. C.L., Lyons P.D., Savage R.M., and May R. Project among African-Americans to explore risks for schizophrenia (PAARTNERS): Recruitment and assessment methods. Schizophr. Res. 87 (2006) 32-44
3. Badner J.A., and Gershon E.S. Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol. Psychiatry 7 (2002) 405-411
4. Blasi F., Bacchelli E., Pesaresi G., Carone S., Bailey A.J., and Maestrini E. Absence of coding mutations in the X-linked genes neuroligin 3 and neuroligin 4 in individuals with autism from the IMGSAC collection. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 141B (2006) 220-221
5. Camp N.J., Neuhausen S.L., Tiobech J., Polloi A., Coon H., and Myles-Worsley M. Genomewide multipoint linkage analysis of seven extended Palauan pedigrees with schizophrenia, by a Markov-chain Monte Carlo method. Am. J. Hum. Genet. 69 (2001) 1278-1289
6. Chen P.L., Avramopoulos D., Lasseter V.K., McGrath J.A., Fallin M.D., and Liang K.Y. Fine mapping on chromosome 10q22-q23 implicates neuregulin 3 in schizophrenia. Am. J. Hum. Genet. 84 (2009) 21-34
7. Consortium T.I.S. Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature 455 (2008) 237-241
8. Cooper-Casey K., Mesen-Fainardi A., Galke-Rollins B., Llach M., Laprade B., and Rodriguez C. Suggestive linkage of schizophrenia to 5p13 in Costa Rica. Mol. Psychiatry 10 (2005) 651-656
9. Craddock N., O'Donovan M.C., and Owen M.J. The genetics of schizophrenia and bipolar disorder: dissecting psychosis. J. Med. Genet. 42 (2005) 193-204
10. Faraone S.V., Skol A.D., Tsuang D.W., Young K.A., Haverstock S.L., and Prabhudesai S. Genome scan of schizophrenia families in a large Veterans Affairs Cooperative Study sample: evidence for linkage to 18p11.32 and for racial heterogeneity on chromosomes 6 and 14. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 139 (2005) 91-100
11. Faraone S.V., Hwu H.G., Liu C.M., Chen W.J., Tsuang M.M., and Liu S.K. Genome scan of Han Chinese schizophrenia families from Taiwan: confirmation of linkage to 10q22.3. Am. J. Psychiatry 163 (2006) 1760-1766
12. Fukui N., Muratake T., Kaneko N., Amagane H., and Someya T. Supportive evidence for neuregulin 1 as a susceptibility gene for schizophrenia in a Japanese population. Neurosci. Lett. 396 (2006) 117-120
13. Gottesman I. Schizophrenia Genesis: The Origins of Madness (1991), WH Freeman, New York
14. Gottesman I.I., and Shields J. Schizophrenia: The Epigenetic Puzzle, 1 ed, Vol 1. (1982), Cambridge University Press, Cambridge
15. group Jss-pl. Initial genome-wide scan for linkage with schizophrenia in the Japanese Schizophrenia Sib-Pair Linkage Group (JSSLG) families. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 120B (2003) 22-28
16. Harrison P.J., and Weinberger D.R. Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol. Psychiatry 10 (2005) 40-68 image 45
17. Jamain S., Quach H., Betancur C., Rastam M., Colineaux C., and Gillberg I.C. Mutations of the X-linked genes encoding neuroligins NLGN3 and NLGN4 are associated with autism. Nat. Genet. 34 (2003) 27-29
18. Kates W.R., Antshel K.M., Fremont W.P., Shprintzen R.J., Strunge L.A., and Burnette C.P. Comparing phenotypes in patients with idiopathic autism to patients with velocardiofacial syndrome (22q11 DS) with and without autism. Am. J. Med. Genet. A. 143A (2007) 2642-2650
19. Kaufmann C.A., Suarez B., Malaspina D., Pepple J., Svrakic D., and Markel P.D. NIMH Genetics Initiative Millenium Schizophrenia Consortium: linkage analysis of African-American pedigrees. Am. J. Med. Genet. 81 (1998) 282-289
20. Kendler K.S., and Diehl S.R. The genetics of schizophrenia: a current, genetic-epidemiologic perspective. Schizophr. Bull. 19 (1993) 261-285
21. Kim J.W., Lee Y.S., Cho E.Y., Jang Y.L., Park D.Y., and Choi K.S. Linkage and association of schizophrenia with genetic variations in the locus of neuregulin 1 in Korean population. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 141B (2006) 281-286
22. Klei L., Bacanu S.A., Myles-Worsley M., Galke B., Xie W., and Tiobech J. Linkage analysis of a completely ascertained sample of familial schizophrenics and bipolars from Palau, Micronesia. Hum. Genet. 117 (2005) 349-356
23. Kong A., and Cox N.J. Allele-sharing models: LOD scores and accurate linkage tests. Am. J. Hum. Genet. 61 (1997) 1179-1188
24. Koochek M., Harvard C., Hildebrand M.J., Van Allen M., Wingert H., and Mickelson E. 15q duplication associated with autism in a multiplex family with a familial cryptic translocation t(14;15)(q11.2;q13.3) detected using array-CGH. Clin. Genet. 69 (2006) 124-134
25. Kruglyak L., and Daly M.J. Linkage thresholds for two-stage genome scans. Am. J. Hum. Genet. 62 (1998) 994-997
26. Laumonnier F., Bonnet-Brilhault F., Gomot M., Blanc R., David A., and Moizard M.P. X-linked mental retardation and autism are associated with a mutation in the NLGN4 gene, a member of the neuroligin family. Am. J. Hum. Genet. 74 (2004) 552-557
27. Lerer B., Segman R.H., Hamdan A., Kanyas K., Karni O., and Kohn Y. Genome scan of Arab Israeli families maps a schizophrenia susceptibility gene to chromosome 6q23 and supports a locus at chromosome 10q24. Mol. Psychiatry 8 (2003) 488-498
28. Lencz T., Morgan T.V., Athanasiou M., Dain B., Reed C.R., and Kane J.M. Converging evidence for a pseudoautosomal cytokine receptor gene locus in schizophrenia. Mol. Psychiatry 12 (2007) 572-580
29. Lewis C.M., Levinson D.F., Wise L.H., DeLisi L.E., Straub R.E., and Hovatta I. Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: Schizophrenia. Am. J. Hum. Genet. 73 (2003) 34-48
30. Li T., Stefansson H., Gudfinnsson E., Cai G., Liu X., and Murray R.M. Identification of a novel neuregulin 1 at-risk haplotype in Han schizophrenia Chinese patients, but no association with the Icelandic/Scottish risk haplotype. Mol. Psychiatry 9 (2004) 9
31. Li D., Collier D.A., and He L. Meta-analysis shows strong positive association of the neuregulin 1 (NRG1) gene with schizophrenia. Hum. Mol. Genet. 15 (2006) 1995-2002
32. Luca D., Ringquist S., Klei L., Lee A.B., Gieger C., and Wichmann H.E. On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am. J. Hum. Genet. 82 (2008) 453-463
33. Mah S., Nelson M.R., Delisi L.E., Reneland R.H., Markward N., and James M.R. Identification of the semaphorin receptor PLXNA2 as a candidate for susceptibility to schizophrenia. Mol. Psychiatry 11 (2006) 471-478
34. Mefford H.C., Sharp A.J., Baker C., Itsara A., Jiang Z., and Buysse K. Recurrent rearrangements of chromosome 1q21.1 and variable pediatric phenotypes. N. Engl. J. Med. 359 (2008) 1685-1699
35. Mochel F., Missirian C., Reynaud R., and Moncla A. Normal intelligence and social interactions in a male patient despite the deletion of NLGN4X and the VCX genes. Eur. J. Med. Genet. 51 (2008) 68-73
36. Murthy S.K., Nygren A.O., El Shakankiry H.M., Schouten J.P., Al Khayat A.I., and Ridha A. Detection of a novel familial deletion of four genes between BP1 and BP2 of the Prader-Willi/Angelman syndrome critical region by oligo-array CGH in a child with neurological disorder and speech impairment. Cytogenet. Genome Res. 116 (2007) 135-140
37. Norton N., Williams H.J., and Owen M.J. An update on the genetics of schizophrenia. Curr. Opin. Psychiatry 19 (2006) 158-164
38. Nurnberger Jr. J.I., Blehar M.C., Kaufmann C.A., York-Cooler C., Simpson S.G., and Harkavy-Friedman J. Diagnostic interview for genetic studies. Rationale, unique features, and training. NIMH Genetics Initiative. Arch. Gen. Psychiatry 51 (1994) 849-859 discussion 863-844
39. O'Donovan M.C., Craddock N., Norton N., Williams H., Peirce T., and Moskvina V. Identification of loci associated with schizophrenia by genome-wide association and follow-up. Nat. Genet. 40 (2008) 1053-1055
40. Owen M.J., Craddock N., and O'Donovan M.C. Schizophrenia: genes at last?. Trends Genet. 21 (2005) 518-525
41. Parra E.J., Marcini A., Akey J., Martinson J., Batzer M.A., and Cooper R. Estimating African American admixture proportions by use of population-specific alleles. Am. J. Hum. Genet. 63 (1998) 1839-1851
42. Parra E.J., Kittles R.A., Argyropoulos G., Pfaff C.L., Hiester K., and Bonilla C. Ancestral proportions and admixture dynamics in geographically defined African Americans living in South Carolina. Am. J. Phys. Anthropol. 114 (2001) 18-29
43. Perry R.T., Collins J.S., Harrell L.E., Acton R.T., and Go R.C. Investigation of association of 13 polymorphisms in eight genes in southeastern African American Alzheimer disease patients as compared to age-matched controls. Am. J. Med. Genet. 105 (2001) 332-342
44. Rinaldo A., Bacanu S.A., Devlin B., Sonpar V., Wasserman L., and Roeder K. Characterization of multilocus linkage disequilibrium. Genet. Epidemiol. 28 (2005) 193-206
45. Risch N., and Merikangas K. The future of genetic studies of complex human diseases. Science 273 (1996) 1516-1517
46. Roeder K., Bacanu S.A., Wasserman L., and Devlin B. Using linkage genome scans to improve power of association in genome scans. Am. J. Hum. Genet. 78 (2006) 243-252
47. Roeder K., Devlin B., and Wasserman L. Improving power in genome-wide association studies: weights tip the scale. Genet. Epidemiol. 31 (2007) 741-747
48. Sawcer S., Jones H.B., Judge D., Visser F., Compston A., and Goodfellow P.N. Empirical genomewide significance levels established by whole genome simulations. Genet. Epidemiol. 14 (1997) 223-229
49. Shirts B.H., and Nimgaonkar V. The genes for schizophrenia: finally a breakthrough?. Curr. Psychiatry Rep. 6 (2004) 303-312
50. Stefansson H., Sigurdsson E., Steinthorsdottir V., Bjornsdottir S., Sigmundsson T., and Ghosh S. Neuregulin 1 and susceptibility to schizophrenia. Am. J. Hum. Genet. 71 (2002) 877-892
51. Stefansson H., Sarginson J., Kong A., Yates P., Steinthorsdottir V., and Gudfinnsson E. Association of neuregulin 1 with schizophrenia confirmed in a Scottish population. Am. J. Hum. Genet. 72 (2003) 83-87 Electronic publication 2002 Dec 2011
52. Stefansson H., Rujescu D., Cichon S., Pietilainen O.P., Ingason A., and Steinberg S. Large recurrent microdeletions associated with schizophrenia. Nature 455 (2008) 232-236
53. Suarez B.K., Duan J., Sanders A.R., Hinrichs A.L., Jin C.H., and Hou C. Genomewide linkage scan of 409 European-ancestry and African American families with schizophrenia: suggestive evidence of linkage at 8p23.3-p21.2 and 11p13.1-q14.1 in the combined sample. Am. J. Hum. Genet. 78 (2006) 315-333
54. Todd J.A. Statistical false positive or true disease pathway?. Nat. Genet. 38 (2006) 731-733
55. Vincent J.B., Kolozsvari D., Roberts W.S., Bolton P.F., Gurling H.M., and Scherer S.W. Mutation screening of X-chromosomal neuroligin genes: no mutations in 196 autism probands. Am. J. Med. Genet. B. Neuropsychiatr. Genet. 129B (2004) 82-84
56. Walss-Bass C., Montero A.P., Armas R., Dassori A., Contreras S.A., and Liu W. Linkage disequilibrium analyses in the Costa Rican population suggests discrete gene loci for schizophrenia at 8p23.1 and 8q13.3. Psychiatr. Genet. 16 (2006) 159-168
57. Whittemore A.S., and Halpern J. A class of tests for linkage using affected pedigree members. Biometrics 50 (1994) 118-127
58. Whittemore A.S., and Tu I.P. Simple, robust linkage tests for affected sibs. Am. J. Hum. Genet. 62 (1998) 1228-1242
59. Yan J., Feng J., Schroer R., Li W., Skinner C., and Schwartz C.E. Analysis of the neuroligin 4Y gene in patients with autism. Psychiatr. Genet. 18 (2008) 204-207