Improving power in genome-wide association studies: Weights tip the scale

Genetic Epidemiology

Volumn 31, Issue 7, 2007, Pages 741-747

  Roeder, Kathryn ^a   Devlin, B ^b   Wasserman, Larry ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

Bonferroni correction; Genome wide association analysis; Multiple testing; Weighted P values

Indexed keywords

ARTICLE; GENE LINKAGE DISEQUILIBRIUM; GENOME ANALYSIS; MATHEMATICAL COMPUTING; MATHEMATICAL MODEL; PHENOTYPE; SINGLE NUCLEOTIDE POLYMORPHISM; STATISTICAL ANALYSIS;

GENOME, HUMAN; HUMANS; MODELS, GENETIC;

EID: 36248977635     PISSN: 07410395     EISSN: 10982272     Source Type: Journal    
DOI: 10.1002/gepi.20237     Document Type: Article

References (10)

1. Benjamini Y, Hochberg Y. 1995. Controlling the false discovery rate: a practical and powerful approach to multiple testing. J R Stat Soc B 57:289-300.
2. Bickel PJ, Klaassen CAJ, Ritov Y, Wellner JA. 1993. Efficient and Adaptive Estimation for Semiparametric Models. Johns Hopkins Series in the Mathematical Statistics. Baltimore, Maryland.
3. Genovese CR, Roeder K, Wasserman L. 2006. False discovery control with P-value weighting. Biometrika 93:509-524.
4. Hastie T, Tibshirani R, Friedman J. 2001. The Elements of Statistical Learning: Data Mining, Inference, and Prediction. New York, NY: Verlag.
5. Roeder K, Bacanu SA, Wasserman L, Devlin B. 2006. Using linkage genome scans to improve power of association in genome scans. Am J Hum Genet 78:243-252.
6. Rubin D, van der Laan M, Dudoit S. 2006. Multiple testing procedures which are optimal at a simple alternative. Collection of Biostatistics Research Archive, http://www.bepress.com/ucbbiostat/paper171/
7. Satagopan JM, Elston RC. 2003. Optimal two-stage genotyping in population-based association studies. Genet Epidemiol 25:149-157.
8. Skol AD, Scott LJ, Abecasis GR, Boehnke M. 2006. Joint analysis is more efficient than replication-based analysis for two-stage genome-wide association studies. Nat Genet 38:209-213.
9. Wang H, Thomas DC, Pe'er I, Stram DO. 2006. Optimal two-stage genotyping designs for genome-wide association scans. Genet Epidemiol 30:356-368.
10. Wasserman L, Roeder K. 2006. Weighted hypothesis testing. http://arxiv.org/abs/math.ST/0604172