Genome scan of Han Chinese schizophrenia families from Taiwan: Confirmation of linkage to 10q22.3

American Journal of Psychiatry

Volumn 163, Issue 10, 2006, Pages 1760-1766

  Faraone, Stephen V ^a   Hwu, Hai Gwo ^b   Liu, Chih Min ^b   Chen, Wei J ^b   Tsuang, Ming Ming ^b   Liu, Shih Kai ^b   Shieh, Ming Hsien ^b   Hwang, Tzung Jeng ^b   Ou Yang, Wen Chen ^b   Chen, Chun Ying ^b   Chen, Chwen Cheng ^b   Lin, Jin Jia ^b   Chou, Frank Huang Chih ^b   Chueh, Ching Mo ^b   Liu, Wei Ming ^b   Hall, Mei Hua ^b   Su, Jessica ^b   Van Eerdewegh, Paul ^b   Tsuang, Ming T ^b  

^a State University of New York Upstate Medical University: College of Medicine   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CHINESE; CHROMOSOME 10Q; CHROMOSOME 15Q; CHROMOSOME 1P; CHROMOSOME 2Q; CHROMOSOME 4Q; FEMALE; GENE IDENTIFICATION; GENE MAPPING; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PRIORITY JOURNAL; PSYCHIATRIC DIAGNOSIS; SCHIZOPHRENIA; SCORING SYSTEM; SEMI STRUCTURED INTERVIEW; SIMULATION; TAIWAN;

EID: 33749465267     PISSN: 0002953X     EISSN: None     Source Type: Journal    
DOI: 10.1176/ajp.2006.163.10.1760     Document Type: Article

References (42)

1. Tsuang MT, Faraone SV, Johnson P: Schizophrenia: The Facts. Oxford, UK, Oxford University Press, 1997
2. Seidman LJ, Faraone SV, Goldstein JM, Goodman JM, Kremen WS, Toomey R, Tourville J, Kennedy D, Makris N, Caviness VS, Tsuang MT: Thalamic and amygdala-hippocampal volume reductions in first degree relatives of schizophrenic patients: an MRI-based morphometric analysis. Biol Psychiatry 1999; 46:941-954
3. Faraone SV, Glatt SJ, Taylor L: The genetic basis of schizophrenia, in Early Clinical Intervention and Prevention in Schizophrenia. Edited by Stone WS, Faraone SV, Tsuang MT. Totowa, NJ, Humana Press, 2004, pp 3-25
4. Gottesman I, Shields J: A polygenic theory of schizophrenia, in Proceedings of the National Academy of Sciences of the United States of America 1967; 58:199-205
5. Gottesman II: Twins: en route to QTLS for cognition. Science 1997; 276:1522-1523
6. Risch N: Linkage strategies for genetically complex traits, I: multilocus models. Am J Hum Genet 1990; 46:222-228
7. Faraone SV, Glatt SJ, Taylor L (eds): The Genetic Basis of Schizophrenia. Totowa, NJ, Humana Press, 2003
8. Sullivan PF, Kendler KS, Neale MC: Schizophrenia as a complex trait: evidence from a meta-analysis of twin studies. Arch Gen Psychiatry 2003; 60:1187-1192
9. Heston LL: Psychiatric disorders in foster home-reared children of schizophrenic mothers. Br J Psychiatry 1966; 112:819-825
10. Kety SS, Rosenthal D, Wender PH, Schulsinger F: The types and prevalence of mental illness in the biological and adoptive families of adopted schizophrenics. J Psychiatr Res 1968; 1(suppl):345-362
11. Kendler KS, Gruenberg AM, Kinney DK: Independent diagnoses of adoptees and relatives as defined by DSM-III in the provincial and national samples of the Danish adoption study of schizophrenia. Arch Gen Psychiatry 1994; 51:456-468
12. Lewis CM, Levinson DF, Wise LH, DeLisi LE, Straub RE, Hovatta I, Williams NM, Schwab SG, Pulver AE, Faraone SV, Brzustowicz LM, Kaufmann CA, Garver DL, Gurling HM, Lindholm E, Coon H, Moises HW, Byerley W, Shaw SH, Mesen A, Sherrington R, O'Neill FA, Walsh D, Kendler KS, Ekelund J, Paunio T, Lonnqvist J, Peltonen L, O'Donovan MC, Owen MJ, Wildenauer DB, Maier W, Nestadt G, Blouin JL, Antonarakis SE, Mowry BJ, Silverman JM, Crowe RR, Cloninger CR, Tsuang MT, Malaspina D, Harkavy-Friedman JM, Svrakic DM, Bassett AS, Holcomb J, Kalsi G, McQuillin A, Brynjolfson J, Sigmundsson T, Petursson H, Jazin E, Zoega T, Helgason T: Genome scan meta-analysis of schizophrenia and bipolar disorder, part II: schizophrenia. Am J Hum Genet 2003; 73:34-48
13. Risch N, Merikangas K: The future of genetic studies of complex human diseases. Science 1996; 273:1516-1517
14. Suarez BK, Hampe CL, Van Eerdewegh P: Problems of replicating linkage claims in psychiatry, in Genetic Approaches in Mental Disorders. Edited by Gershon ES, Cloninger CR, Barrett JE. Washington, DC, American Psychiatric Press, 1994, pp 23-46
15. Hwu HG, Faraone SV, Liu CM, Chen WJ, Liu SK, Shieh MH, Hwang TJ, Tsuang MM, Ou-Yang WC, Chen CY, Chen CC, Lin JJ, Chou FH, Chueh CM, Liu WM, Hall MH, Tsuang MT: Taiwan schizophrenia linkage study: the field study. Am J Med Genet B Neuropsychiatr Genet 2005; 134:30-36
16. American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Washington, DC, American Psychiatric Association, 1994
17. Faraone SV, Blehar M, Pepple J, Moldin S, Norton J, Tsuang MT, Nurnberger JI, Malaspina D, Kaufmann CA, Reich T, Cloninger CR, DePaulo JR, Berg K, Gershon ES, Kirch DG, Tsuang MT: Diagnostic accuracy and confusability analyses: an application to the diagnostic interview for genetic studies. Psychol Med 1996; 26:401-410
18. Nurnberger JI Jr, Blehar MC, Kaufmann CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T, Miller M, Bowman ES, DePaulo JR, Cloninger CR, Robinson G, Moldin S, Gershon ES, Maxwell E, Guroff JJ, Kirch D, Wynne D, Berg K, Tsuang MT, Faraone SV, Pepple JR, Ritz AL: Diagnostic Interview for Genetic Studies: rationale, unique features, and training. Arch Gen Psychiatry 1994; 51:849-859
19. Chen WJ, Liu SK, Chang CJ, Lien YJ, Chang YH, Hwu HG: Sustained attention deficit and schizotypal personality features in nonpsychotic relatives of schizophrenic patients. Am J Psychiatry 1998; 155:1214-1220
20. Broman KW, Murray JC, Sheffield VC, White RL, Weber JL: Comprehensive human genetic maps: individual and sex-specific variation in recombination. Am J Hum Genet 1998; 63:861-869
21. Young A: Genetic Analysis System, 1995
22. Boehnke M, Cox NJ: Accurate inference of relationships in sibpair linkage studies. Am J Hum Genet 1997; 61:423-429
23. Abecasis GR, Cherny SS, Cookson WO, Cardon LR: MERLIN: rapid analysis of dense genetic maps using sparse gene flow trees. Nat Genet 2002; 30:97-101
24. Whittemore AS, Halpern J: A class of tests for linkage using affected pedigree members. Biometrics 1994; 50:118-127
25. Lander E, Kruglyak L: Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 1995; 11:241-247
26. Fallin MD, Lasseter VK, Wolyniec PS, McGrath JA, Nestadt G, Valle D, Liang KY, Pulver AE: Genomewide linkage scan for schizophrenia susceptibility loci among Ashkenazi Jewish families shows evidence of linkage on chromosome 10q22. Am J Hum Genet 2003; 73:601-611
27. Badner J, Gershon E: Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia. Mol Psychiatry 2002; 7:405-411
28. DeLisi LE, Shaw SH, Crow TJ, Shields G, Smith AB, Larach VW, Wellman N, Loftus J, Nanthakumar B, Razi K, Stewart J, Comazzi M, Vita A, Heffner T, Sherrington R: A genome-wide scan for linkage to chromosomal regions in 382 sibling pairs with schizophrenia or schizoaffective disorder. Am J Psychiatry 2002; 159:803-812
29. Levinson DF, Mahtani MM, Nancarrow DJ, Brown DM, Kruglyak L, Kirby A, Hayward NK, Crowe RR, Andreasen NC, Black DW, Silverman JM, Endicott J, Sharpe L, Mohs RC, Siever LJ, Walters MK, Lennon DP, Jones HL, Nertney DA, Daly MJ, Gladis M, Mowry BJ: Genome scan of schizophrenia. Am J Psychiatry 1998; 155:741-750
30. Moises HW, Yang L, Kristbjarnarson H, Wiese C, Byerley W, Macciardi F, Arolt V, Blackwood D, Liu X, Sjogren B, et al: An international two-stage genome-wide search for schizophrenia susceptibility genes. Nat Genet 1995; 11:321-324
31. Coon H, Worsley MM, Tiobech J, Hoff M, Rosenthal J, Bennett P, Reimherr F, Wender P, Dale P, Polloi A, Byerley W: Evidence for a chromosome 2p13-14 schizophrenia susceptibility locus in families from Palau, Micronesia. Mol Psychiatry 1998; 3:521-527
32. Straub RE, MacLean CJ, Ma Y, Webb BT, Myakishev MV, Harris-Kerr C, Wormley B, Sadek H, Kadambi B, O'Neill FA, Walsh D, Kendler KS: Genome-wide scans of three independent sets of 90 Irish multiplex schizophrenia families and follow-up of selected regions in all families provides evidence for multiple susceptibility genes. Mol Psychiatry 2002; 7:542-559
33. Brzustowicz LM, Hodgkinson KA, Chow EWC, Honer WG, Basett AS: Location of a major susceptibility locus for familial schizophrenia on chromosome 1q21-q22. Science 2000; 288:678-682
34. Gurling HM, Kalsi G, Brynjolfson J, Sigmundsson T, Sherrington R, Mankoo BS, Read T, Murphy P, Blaveri E, McQuillin A, Petursson H, Curtis D: Genomewide genetic linkage analysis confirms the presence of susceptibility loci for schizophrenia on chromosomes 1q32.2, 5q33.2, and 8p21-22 and provides support for linkage to schizophrenia on chromosomes 11q23.3-24 and 20q12.1-11.23. Am J Hum Genet 2001; 68:661-673
35. Zornberg GL, Buka SL, Tsuang MT: The problem of obstetrical complications and schizophrenia. Schizophr Bull 2000; 26:249-256
36. Faraone SV, Brown CH, Glatt SJ, Tsuang MT: Preventing schizophrenia and psychotic behaviour: definitions and methodological issues. Can J Psychiatry 2002; 47:527-537
37. Hutchinson G, Takei N, Fahy TA, Bhugra D, Gilvarry C, Moran P, Mallett R, Sham P, Leff J, Murray RM: Morbid risk of schizophrenia in first-degree relatives of white and African-Caribbean patients with psychosis. Br J Psychiatry 1996; 169:776-780
38. Liu C, Hwu H, Lin M, Ou-Yang W, Lee S, Fann CSJ, Wong S, Hsieh S: Suggestive evidence for linkage of schizophrenia to markers at chromosome 15q13-14 in Taiwanese families. Am J Med Genetics (Neuropsychiatric Genetics) 2001; 105:658-661
39. Hwu HG, Lin MW, Lee PC, Lee SF, Ou-Yang WC, Liu CM: Evaluation of linkage of markers on chromosome 6p with schizophrenia in Taiwanese families. Am J Med Genetics (Neuropsychiatric Genetics) 2000; 96:74-78
40. Li T, Ball D, Zhao J, Murray RM, Liu X, Sham PC, Collier DA: Family-based linkage disequilibrium mapping using SNP marker haplotypes: application to a potential locus for schizophrenia at chromosome 22q11. Mol Psychiatry 2000; 5:77-84
41. Hwu HG, Liu CM, Fann CS, Ou-Yang WC, Lee SF: Linkage of schizophrenia with chromosome 1q loci in Taiwanese families. Mol Psychiatry 2003; 8:445-452
42. Liu CM, Hwu HG, Fann CS, Lin CY, Liu YL, Ou-Yang WC, Lee SF: Linkage evidence of schizophrenia to loci near neuregulin 1 gene on chromosome 8p21 in Taiwanese families. Am J Med Genet B Neuropsychiatr Genet 2005; 134:79-83