메뉴 건너뛰기




Volumn 21, Issue 10, 2008, Pages 533-540

Role of cannabinoid receptors in bone disorders: Alternatives for treatment

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (4 IODOPHENYL) 4 METHYL N (1 PIPERIDYL) 1H PYRAZOLE 3 CARBOXAMIDE; 1 DEOXY 3 (1,1 DIMETHYLBUTYL) DELTA8 TETRAHYDROCANNABINOL; 2 ARACHIDONOYLGLYCEROL; 2,3 DIHYDRO 5 METHYL 3 (MORPHOLINOMETHYL) 6 (1 NAPHTHOYL)PYRROLO[1,2,3 DE][1,4]BENZOXAZINE; 4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; 4 [4 (1,1 DIMETHYLHEPTYL) 2,6 DIMETHOXYPHENYL] 6,6 DIMETHYLBICYCLO[3.1.1]HEPT 2 EN 2 YLMETHANOL; 5 (4 CHLORO 3 METHYLPHENYL) 1 (4 METHYLBENZYL) N (1,3,3 TRIMETHYLBICYCLO[2.2.1]HEPTAN 2 YL) 3 PYRAZOLECARBOXAMIDE; 6 IODO 3 (4 METHOXYBENZOYL) 2 METHYL 1 (2 MORPHOLINOETHYL)INDOLE; AJULEMIC ACID; ANANDAMIDE; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 1 RECEPTOR ANTAGONIST; CANNABINOID 2 RECEPTOR AGONIST; CANNABINOID 2 RECEPTOR ANTAGONIST; CANNABINOID RECEPTOR; CANNABINOID RECEPTOR AGONIST; CANNABINOID RECEPTOR ANTAGONIST; DEXANABINOL; DRONABINOL; ENDOCANNABINOID; RIMONABANT; UNCLASSIFIED DRUG;

EID: 62649160576     PISSN: 02140934     EISSN: None     Source Type: Journal    
DOI: 10.1358/dnp.2008.21.10.1314055     Document Type: Review
Times cited : (11)

References (101)
  • 2
    • 27944440482 scopus 로고    scopus 로고
    • Cannabis and endocannabinoid modulators: Therapeutic promises and challenges
    • Grant, I. and Cahn,B.R. Cannabis and endocannabinoid modulators: Therapeutic promises and challenges. Clin Neurosci Res 2005, 5(2-4): 185-99.
    • (2005) Clin Neurosci Res , vol.5 , Issue.2-4 , pp. 185-199
    • Grant, I.1    Cahn, B.R.2
  • 3
    • 43249100162 scopus 로고    scopus 로고
    • Targeting the endocannabinoid system: To enhance or reduce?
    • Di, M.V. Targeting the endocannabinoid system: to enhance or reduce? Nat Rev Drug Discov 2008, 7: 438-55.
    • (2008) Nat Rev Drug Discov , vol.7 , pp. 438-455
    • Di, M.V.1
  • 5
    • 0036044615 scopus 로고    scopus 로고
    • Endocannabinoids and their actions
    • Maccarrone, M. and Finazzi-Agrò, A. Endocannabinoids and their actions. Vitam Horm 2002, 65: 225-55.
    • (2002) Vitam Horm , vol.65 , pp. 225-255
    • Maccarrone, M.1    Finazzi-Agrò, A.2
  • 6
    • 35649015179 scopus 로고    scopus 로고
    • The orphan receptor GPR55 is a novel cannabinoid receptor
    • Ryberg, E., Larsson, N., Sjögren, S. et al. The orphan receptor GPR55 is a novel cannabinoid receptor. Br J Pharmacol 2007, 152(7): 1092-101.
    • (2007) Br J Pharmacol , vol.152 , Issue.7 , pp. 1092-1101
    • Ryberg, E.1    Larsson, N.2    Sjögren, S.3
  • 7
    • 18144385088 scopus 로고    scopus 로고
    • Evidence for novel cannabinoid receptors
    • Begg, M., Pacher, P., Bátkai, S. et al. Evidence for novel cannabinoid receptors. Pharmacol Ther 2005, 106(2): 133-45.
    • (2005) Pharmacol Ther , vol.106 , Issue.2 , pp. 133-145
    • Begg, M.1    Pacher, P.2    Bátkai, S.3
  • 8
    • 0027215426 scopus 로고
    • Cannabinoid-receptor expression in human leukocytes
    • Bouaboula, M., Rinaldi, M., Carayon, P. et al. Cannabinoid-receptor expression in human leukocytes. Eur J Biochem 1993, 214(1): 173-80.
    • (1993) Eur J Biochem , vol.214 , Issue.1 , pp. 173-180
    • Bouaboula, M.1    Rinaldi, M.2    Carayon, P.3
  • 10
    • 31444437185 scopus 로고    scopus 로고
    • Peripheral cannabinoid receptor CB2, regulates bone mass
    • Ofek, O., Karsak, M., Leclerc, N. et al. Peripheral cannabinoid receptor CB2, regulates bone mass. Proc Natl Acad Sci USA 2006, 103(3): 696-701.
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.3 , pp. 696-701
    • Ofek, O.1    Karsak, M.2    Leclerc, N.3
  • 11
    • 22544439953 scopus 로고    scopus 로고
    • Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors
    • Idris, A.I., van 't Hof, R.J., Greig, I.R., Ridge, S.A., Baker, D., Ross, R.A., and Ralston, S.H. Regulation of bone mass, bone loss and osteoclast activity by cannabinoid receptors. Nat Med 2005, 11(7): 774-9.
    • (2005) Nat Med , vol.11 , Issue.7 , pp. 774-779
    • Idris, A.I.1    van 't Hof, R.J.2    Greig, I.R.3    Ridge, S.A.4    Baker, D.5    Ross, R.A.6    Ralston, S.H.7
  • 12
    • 84884474728 scopus 로고    scopus 로고
    • Pharmacological actions of cannabinoids
    • Pertwee, R.G. Pharmacological actions of cannabinoids. Handb Exp Pharmacol 2005, 168: 1-51.
    • (2005) Handb Exp Pharmacol , vol.168 , pp. 1-51
    • Pertwee, R.G.1
  • 13
    • 0032982010 scopus 로고    scopus 로고
    • Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630
    • Ross, R.A., Brockie, H.C., Stevenson, L.A., Murphy, V.L., Templeton, F., Makriyannis, A. and Pertwee, R.G. Agonist-inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630. Br J Pharmacol 1999, 126(3): 665-72.
    • (1999) Br J Pharmacol , vol.126 , Issue.3 , pp. 665-672
    • Ross, R.A.1    Brockie, H.C.2    Stevenson, L.A.3    Murphy, V.L.4    Templeton, F.5    Makriyannis, A.6    Pertwee, R.G.7
  • 14
    • 0029989044 scopus 로고    scopus 로고
    • Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression
    • Bouaboula, M. Poinot-Chazel, C., Marchand, J. et al. Signaling pathway associated with stimulation of CB2 peripheral cannabinoid receptor. Involvement of both mitogen-activated protein kinase and induction of Krox-24 expression. Eur J Biochem 1996, 237(3): 704-11.
    • (1996) Eur J Biochem , vol.237 , Issue.3 , pp. 704-711
    • Bouaboula, M.1    Poinot-Chazel, C.2    Marchand, J.3
  • 15
    • 17144470224 scopus 로고    scopus 로고
    • Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(7) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction
    • Sanchez, M.G., Ruiz-Llorente, L., Sanchez, A.M. and Diaz-Laviada, I. Activation of phosphoinositide 3-kinase/PKB pathway by CB(1) and CB(7) cannabinoid receptors expressed in prostate PC-3 cells. Involvement in Raf-1 stimulation and NGF induction. Cell Signal 2003, 15(9): 851-9.
    • (2003) Cell Signal , vol.15 , Issue.9 , pp. 851-859
    • Sanchez, M.G.1    Ruiz-Llorente, L.2    Sanchez, A.M.3    Diaz-Laviada, I.4
  • 16
    • 0035147072 scopus 로고    scopus 로고
    • Ceramide: A new second messenger of cannabinoid action
    • Guzman, M., Galve-Roperh, I. and Sanchez, C. Ceramide: a new second messenger of cannabinoid action. Trends Pharmacol Sci 2001, 22(1): 19-22.
    • (2001) Trends Pharmacol Sci , vol.22 , Issue.1 , pp. 19-22
    • Guzman, M.1    Galve-Roperh, I.2    Sanchez, C.3
  • 17
    • 0034467577 scopus 로고    scopus 로고
    • Control of the cell survival/death decision by cannabinoids
    • Guzman, M., Sanchez, C. and Galve-Roperh, I. Control of the cell survival/death decision by cannabinoids. J Mol Med 2001, 78(11): 613-25.
    • (2001) J Mol Med , vol.78 , Issue.11 , pp. 613-625
    • Guzman, M.1    Sanchez, C.2    Galve-Roperh, I.3
  • 18
    • 0037111841 scopus 로고    scopus 로고
    • Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling
    • Molina-Holgado, E., Vela, J.M., Arévalo-Martín, A., Almazán, G., Molina-Holgado, F., Borrell, J. and Guaza, C. et al. Cannabinoids promote oligodendrocyte progenitor survival: Involvement of cannabinoid receptors and phosphatidylinositol-3 kinase/Akt signaling. J Neurosci 2002, 22(22): 9742-53.
    • (2002) J Neurosci , vol.22 , Issue.22 , pp. 9742-9753
    • Molina-Holgado, E.1    Vela, J.M.2    Arévalo-Martín, A.3    Almazán, G.4    Molina-Holgado, F.5    Borrell, J.6    Guaza, C.7
  • 19
    • 0037014598 scopus 로고    scopus 로고
    • Role of intracellular loops of cannabinoid CB(1) receptor in junctional interaction with G(alpha16)
    • Ho, B.Y., Current, L. and Drewett, J.G. Role of intracellular loops of cannabinoid CB(1) receptor in junctional interaction with G(alpha16). FEBS Lett 2002, 522(1-3): 130-4.
    • (2002) FEBS Lett , vol.522 , Issue.1-3 , pp. 130-134
    • Ho, B.Y.1    Current, L.2    Drewett, J.G.3
  • 20
    • 0030890230 scopus 로고    scopus 로고
    • Induction of interleukin-2 receptor alpha gene by delta9-tetrahydrocannabinol is mediated by nuclear factor kappaB and CB1 cannabinoid receptor
    • Daaka, Y., Zhu, W., Friedman, H. and Klein, T.W. Induction of interleukin-2 receptor alpha gene by delta9-tetrahydrocannabinol is mediated by nuclear factor kappaB and CB1 cannabinoid receptor DNA Cell Biol 1997, 16(3): 301-9.
    • (1997) DNA Cell Biol , vol.16 , Issue.3 , pp. 301-309
    • Daaka, Y.1    Zhu, W.2    Friedman, H.3    Klein, T.W.4
  • 21
    • 0033575258 scopus 로고    scopus 로고
    • Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses
    • Bouaboula, M., Dussossoy, D. and Casellas, P. Regulation of peripheral cannabinoid receptor CB2 phosphorylation by the inverse agonist SR 144528. Implications for receptor biological responses. J Biol Chem 1999, 274(29): 20397-405.
    • (1999) J Biol Chem , vol.274 , Issue.29 , pp. 20397-20405
    • Bouaboula, M.1    Dussossoy, D.2    Casellas, P.3
  • 22
    • 0030826705 scopus 로고    scopus 로고
    • A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor I. Evidence for a new model of receptor/ligand interactions
    • Bouaboula, M., Perrachon, S. Milligan, L. et al. A selective inverse agonist for central cannabinoid receptor inhibits mitogen-activated protein kinase activation stimulated by insulin or insulin-like growth factor I. Evidence for a new model of receptor/ligand interactions. J Biol Chem 1997, 272(35): 22330-9.
    • (1997) J Biol Chem , vol.272 , Issue.35 , pp. 22330-22339
    • Bouaboula, M.1    Perrachon, S.2    Milligan, L.3
  • 23
    • 0034285013 scopus 로고    scopus 로고
    • The osteoblast: A sophisticated fibroblast under central surveillance
    • Ducy, P., Schinke, T. and Karsenty, G. The osteoblast: A sophisticated fibroblast under central surveillance. Science 2000, 289(5484): 1501-4.
    • (2000) Science , vol.289 , Issue.5484 , pp. 1501-1504
    • Ducy, P.1    Schinke, T.2    Karsenty, G.3
  • 24
    • 0034284970 scopus 로고    scopus 로고
    • Bone resorption by osteoclasts
    • Teitelbaum, S.L. Bone resorption by osteoclasts. Science 2000, 289(5484): 1504-8.
    • (2000) Science , vol.289 , Issue.5484 , pp. 1504-1508
    • Teitelbaum, S.L.1
  • 25
    • 18244381272 scopus 로고    scopus 로고
    • Central control of bone mass: Brainstorming of the skeleton
    • Amling, M., Pagoda, P., Beil, F.T. et al. Central control of bone mass: brainstorming of the skeleton. Adv Exp Med Biol 2001, 496: 85-94.
    • (2001) Adv Exp Med Biol , vol.496 , pp. 85-94
    • Amling, M.1    Pagoda, P.2    Beil, F.T.3
  • 26
    • 0036847619 scopus 로고    scopus 로고
    • Leptin regulates bone formation via the sympathetic nervous system
    • Takeda, S., Elefteriou, F., Levasseur, R. et al Leptin regulates bone formation via the sympathetic nervous system. Cell 2002, 111(3): 305-17.
    • (2002) Cell , vol.111 , Issue.3 , pp. 305-317
    • Takeda, S.1    Elefteriou, F.2    Levasseur, R.3
  • 27
    • 27144514986 scopus 로고    scopus 로고
    • Neuronal signaling and the regulation of bone remodeling
    • Elefteriou, F. Neuronal signaling and the regulation of bone remodeling. Cell Mol Life Sci 2005, 62(19-20): 2339-49.
    • (2005) Cell Mol Life Sci , vol.62 , Issue.19-20 , pp. 2339-2349
    • Elefteriou, F.1
  • 28
    • 0037098924 scopus 로고    scopus 로고
    • Glutamatergic innervation in bone
    • Chenu, C. Glutamatergic innervation in bone. Microsc Res Tech 2002, 58(52): 70-6.
    • (2002) Microsc Res Tech , vol.58 , Issue.52 , pp. 70-76
    • Chenu, C.1
  • 29
    • 0035099851 scopus 로고    scopus 로고
    • Defective bone formation, and anabolic responses to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase
    • Armour, K.E., Armour, K.J., Gallagher, M.E., Gödecke, A., Helfrich, M.H., Reid, D.M. and Ralston, S.H. Defective bone formation, and anabolic responses to exogenous estrogen in mice with targeted disruption of endothelial nitric oxide synthase. Endocrinology 2001, 142(2): 760-6.
    • (2001) Endocrinology , vol.142 , Issue.2 , pp. 760-766
    • Armour, K.E.1    Armour, K.J.2    Gallagher, M.E.3    Gödecke, A.4    Helfrich, M.H.5    Reid, D.M.6    Ralston, S.H.7
  • 30
    • 33747598488 scopus 로고    scopus 로고
    • Involvement of neuronal cannabinoid receptor, GB1, in regulation of bone mass and bone remodeling
    • Tam, J.,Ofek, O., Fride, E. et al. Involvement of neuronal cannabinoid receptor, GB1, in regulation of bone mass and bone remodeling. Mol Pharmacol 2006, 70(3): 786-92.
    • (2006) Mol Pharmacol , vol.70 , Issue.3 , pp. 786-792
    • Tam, J.1    Ofek, O.2    Fride, E.3
  • 31
    • 62649093328 scopus 로고    scopus 로고
    • Bidirectional regulation of peak bone mass and age-related bone loss by the type I cannabinoid receptor
    • Idris, A.I., Sophocleous, A., Landao-Bassonga, E., Van't Hof R.J. and Ralston, S. Bidirectional regulation of peak bone mass and age-related bone loss by the type I cannabinoid receptor. Calcif Tissue Int 2008, 82(Suppl. 1): S57.
    • (2008) Calcif Tissue Int , vol.82 , Issue.SUPPL. 1
    • Idris, A.I.1    Sophocleous, A.2    Landao-Bassonga, E.3    Van't Hof, R.J.4    Ralston, S.5
  • 32
    • 0242304878 scopus 로고    scopus 로고
    • Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
    • Pryce, G., Ahmed, Z., Hankey, D.J. et al. Cannabinoids inhibit neurodegeneration in models of multiple sclerosis. Brain 2003, 126(Pt 10): 2191-202.
    • (2003) Brain , vol.126 , Issue.PART 10 , pp. 2191-2202
    • Pryce, G.1    Ahmed, Z.2    Hankey, D.J.3
  • 33
    • 62649137411 scopus 로고    scopus 로고
    • CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types
    • Friedman, H, Klein, T.W. and Madden, J, Eds, Kluwer Academic/Plenum Publishers: New York
    • Nong, L., Newton, C., Friedman, H. and Klein, T. CB1 and CB2 receptor mRNA expression in human peripheral blood mononuclear cells (PBMC) from various donor types. In: Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases. Friedman, H., Klein, T.W. and Madden, J. (Eds.). Kluwer Academic/Plenum Publishers: New York 2001, 223-8.
    • (2001) Neuroimmune Circuits, Drugs of Abuse, and Infectious Diseases , pp. 223-228
    • Nong, L.1    Newton, C.2    Friedman, H.3    Klein, T.4
  • 34
    • 0029094470 scopus 로고
    • Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations
    • Galiegue, S., Mary, S., Marchand, J. et al. Expression of central and peripheral cannabinoid receptors in human immune tissues and leukocyte subpopulations. Eur J Biochem 1995, 232(1): 54-61.
    • (1995) Eur J Biochem , vol.232 , Issue.1 , pp. 54-61
    • Galiegue, S.1    Mary, S.2    Marchand, J.3
  • 35
    • 33846223892 scopus 로고    scopus 로고
    • Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors
    • Scutt, A. and Williamson, E.M. Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcif Tissue Int 2007, 80(1): 50-9.
    • (2007) Calcif Tissue Int , vol.80 , Issue.1 , pp. 50-59
    • Scutt, A.1    Williamson, E.M.2
  • 36
    • 45149123400 scopus 로고    scopus 로고
    • The CB(2) cannabinoid receptors controls myeloid progenitor trafficking: Involvement in the pathogenesis of an animal model of multiple sclerosis
    • Palazuelos, J., Davoust, N., Julien, B. et al. The CB(2) cannabinoid receptors controls myeloid progenitor trafficking: involvement in the pathogenesis of an animal model of multiple sclerosis. J Biol Chem 2008, 283(19): 13320-9.
    • (2008) J Biol Chem , vol.283 , Issue.19 , pp. 13320-13329
    • Palazuelos, J.1    Davoust, N.2    Julien, B.3
  • 37
    • 62649156164 scopus 로고    scopus 로고
    • Endocannabinoids are produced by bone cells and stimulate bone resorption in vitro
    • Abst S120
    • Ridge, S.A., Ford, L., Cameron, G.A., Ross, R.A. and Rogers, M.J. Endocannabinoids are produced by bone cells and stimulate bone resorption in vitro. Calcif Tissue Int 2007, Abst S120.
    • (2007) Calcif Tissue Int
    • Ridge, S.A.1    Ford, L.2    Cameron, G.A.3    Ross, R.A.4    Rogers, M.J.5
  • 38
    • 54349124546 scopus 로고    scopus 로고
    • Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type of cannabinoid receptor
    • Idris, A.I., Sophocleous, A., Landao-Basonga, E., van't Hof, R.J. and Ralston, S.H. Regulation of bone mass, osteoclast function, and ovariectomy-induced bone loss by the type of cannabinoid receptor. Endocrinology 2008, 149(11): 5619-26.
    • (2008) Endocrinology , vol.149 , Issue.11 , pp. 5619-5626
    • Idris, A.I.1    Sophocleous, A.2    Landao-Basonga, E.3    van't Hof, R.J.4    Ralston, S.H.5
  • 39
    • 62649121263 scopus 로고    scopus 로고
    • Cannabinoid receptor 2 selective agonists stimulate osteoclast formation in vitro but act as anabolic agents in vivo by stimulating bone formation
    • Sophocleous, A., Landao-Bassonga, E., Van't Hof, R.J., Idris, A.I. and Ralston, S. Cannabinoid receptor 2 selective agonists stimulate osteoclast formation in vitro but act as anabolic agents in vivo by stimulating bone formation. Calcif Tissue Int 2008, 82(Suppl. 1): S111.
    • (2008) Calcif Tissue Int , vol.82 , Issue.SUPPL. 1
    • Sophocleous, A.1    Landao-Bassonga, E.2    Van't Hof, R.J.3    Idris, A.I.4    Ralston, S.5
  • 40
    • 33846223892 scopus 로고    scopus 로고
    • Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors
    • Scutt, A. and Williamson, E.M. Cannabinoids stimulate fibroblastic colony formation by bone marrow cells indirectly via CB2 receptors. Calcif Tissue Int 2007, 80(1): 50-9.
    • (2007) Calcif Tissue Int , vol.80 , Issue.1 , pp. 50-59
    • Scutt, A.1    Williamson, E.M.2
  • 41
    • 38049132712 scopus 로고    scopus 로고
    • The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling
    • Tam, J., Trembovler, V., Di Marzo, V. et al. The cannabinoid CB1 receptor regulates bone formation by modulating adrenergic signaling. FASEB J 2008, 22(1): 285-94.
    • (2008) FASEB J , vol.22 , Issue.1 , pp. 285-294
    • Tam, J.1    Trembovler, V.2    Di Marzo, V.3
  • 42
    • 38349132542 scopus 로고    scopus 로고
    • Cannabinoid receptors and the regulation of bone mass
    • Bab, I. and Zimmer, A. Cannabinoid receptors and the regulation of bone mass. Br J Pharmacol 2008, 153(2): 182-8.
    • (2008) Br J Pharmacol , vol.153 , Issue.2 , pp. 182-188
    • Bab, I.1    Zimmer, A.2
  • 44
    • 0032510309 scopus 로고    scopus 로고
    • Treatment of Post menopausal osteoporosis [see comments]
    • Eastell, R. Treatment of Post menopausal osteoporosis [see comments]. N Engl J Med 1998, 338(11): 736-46.
    • (1998) N Engl J Med , vol.338 , Issue.11 , pp. 736-746
    • Eastell, R.1
  • 45
    • 0034284550 scopus 로고    scopus 로고
    • Therapeutic approaches to bone diseases
    • Rodan, G.A. and Martin, T.J. Therapeutic approaches to bone diseases. Science 2000, 289(5484): 1508-14.
    • (2000) Science , vol.289 , Issue.5484 , pp. 1508-1514
    • Rodan, G.A.1    Martin, T.J.2
  • 47
    • 0038709432 scopus 로고    scopus 로고
    • Glucocorticoid-induced osteoporosis: Pathophysiological data and recent treatments
    • Lafage-Proust, M.H., Boudignon, B. and Thomas, T. Glucocorticoid-induced osteoporosis: Pathophysiological data and recent treatments. Joint Bone Spine 2003, 70(2): 109-18.
    • (2003) Joint Bone Spine , vol.70 , Issue.2 , pp. 109-118
    • Lafage-Proust, M.H.1    Boudignon, B.2    Thomas, T.3
  • 48
    • 46249102927 scopus 로고    scopus 로고
    • Rimonabant in rats with a metabolic syndrome: Good news after the depression
    • Di Marzo, V. and Szallasi, A. Rimonabant in rats with a metabolic syndrome: Good news after the depression. Br J Pharmacol 2008, 154(5): 915-7.
    • (2008) Br J Pharmacol , vol.154 , Issue.5 , pp. 915-917
    • Di Marzo, V.1    Szallasi, A.2
  • 49
    • 32644441249 scopus 로고    scopus 로고
    • Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial
    • Pi-Sunyer, F.X., Aronne, L.J., Heshmati, H.M., Devin, J. and Rosenstock, J. Effect of rimonabant, a cannabinoid-1 receptor blocker, on weight and cardiometabolic risk factors in overweight or obese patients: RIO-North America: a randomized controlled trial. JAMA 2006, 295(7): 761-75.
    • (2006) JAMA , vol.295 , Issue.7 , pp. 761-775
    • Pi-Sunyer, F.X.1    Aronne, L.J.2    Heshmati, H.M.3    Devin, J.4    Rosenstock, J.5
  • 50
    • 33751001942 scopus 로고    scopus 로고
    • Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: A randomised controlled study
    • Scheen, A.J., Finer, N., Hollander, P., Jensen, M.D. and Van Gaal, L.F. Efficacy and tolerability of rimonabant in overweight or obese patients with type 2 diabetes: a randomised controlled study. Lancet 2006, 368(9548): 1660-72.
    • (2006) Lancet , vol.368 , Issue.9548 , pp. 1660-1672
    • Scheen, A.J.1    Finer, N.2    Hollander, P.3    Jensen, M.D.4    Van Gaal, L.F.5
  • 51
    • 27944510259 scopus 로고    scopus 로고
    • Cannabinoid receptor type 2 gene is associated with human osteoporosis
    • Karsak, M., Cohen-Solal, M., Freudenberg, J. et al. Cannabinoid receptor type 2 gene is associated with human osteoporosis. Hum Mol Genet 2005, 14(22): 3389-96.
    • (2005) Hum Mol Genet , vol.14 , Issue.22 , pp. 3389-3396
    • Karsak, M.1    Cohen-Solal, M.2    Freudenberg, J.3
  • 52
    • 34248585741 scopus 로고    scopus 로고
    • Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men
    • Yamada, Y., Ando, F. and Shimokata, H. Association of candidate gene polymorphisms with bone mineral density in community-dwelling Japanese women and men. Int J Mol Med 2007, 19(5): 791-801.
    • (2007) Int J Mol Med , vol.19 , Issue.5 , pp. 791-801
    • Yamada, Y.1    Ando, F.2    Shimokata, H.3
  • 53
    • 36048995288 scopus 로고    scopus 로고
    • Efficacy and safety of the weight-loss drug rimonabant: A meta-analysis of randomised trials
    • Christensen, R., Kristensen, P.K., Bartels, E.M., Bliddal, H. and Astrup, A. Efficacy and safety of the weight-loss drug rimonabant: a meta-analysis of randomised trials. Lancet 2007, 370(9600): 1706-13.
    • (2007) Lancet , vol.370 , Issue.9600 , pp. 1706-1713
    • Christensen, R.1    Kristensen, P.K.2    Bartels, E.M.3    Bliddal, H.4    Astrup, A.5
  • 54
    • 0014138568 scopus 로고
    • Osteoporosis of rheumatoid arthritis: Influence of age, sex and corticosteroids
    • Saville, P.D. and Kharmosh, O. Osteoporosis of rheumatoid arthritis: influence of age, sex and corticosteroids. Arth Rheum 1967, 10: 423-30.
    • (1967) Arth Rheum , vol.10 , pp. 423-430
    • Saville, P.D.1    Kharmosh, O.2
  • 55
    • 0347480219 scopus 로고    scopus 로고
    • Rheumatoid arthritis: Regulation of synovial inflammation
    • Sweeney, S.E. and Firestein, G.S. Rheumatoid arthritis: regulation of synovial inflammation. Int J Biochem Cell Biol 2004, 36(3): 372-8.
    • (2004) Int J Biochem Cell Biol , vol.36 , Issue.3 , pp. 372-378
    • Sweeney, S.E.1    Firestein, G.S.2
  • 56
    • 0038011833 scopus 로고    scopus 로고
    • Evolving concepts of rheumatoid arthritis
    • Firestein, G.S. Evolving concepts of rheumatoid arthritis. Nature 2003, 423(6937): 356-61.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 356-361
    • Firestein, G.S.1
  • 57
    • 0347480219 scopus 로고    scopus 로고
    • Rheumatoid arthritis: Regulation of synovial inflammation
    • Sweeney, S.E. and Firestein, G.S. Rheumatoid arthritis: regulation of synovial inflammation, Int J Biochem Cell Biol 2004, 36(3): 372-8.
    • (2004) Int J Biochem Cell Biol , vol.36 , Issue.3 , pp. 372-378
    • Sweeney, S.E.1    Firestein, G.S.2
  • 60
    • 1542376173 scopus 로고    scopus 로고
    • The transfer of a laboratory based hypothesis to a clinically useful therapy: The development of anti-TNF therapy of rheumatoid arthritis
    • Feldmann, M., Brennan, F.M., Williams, R.O., Woody, J.N. and Maini, R.N. The transfer of a laboratory based hypothesis to a clinically useful therapy: the development of anti-TNF therapy of rheumatoid arthritis. Best Pract Res Clin Rheumatol 2004, 18(1): 59-80.
    • (2004) Best Pract Res Clin Rheumatol , vol.18 , Issue.1 , pp. 59-80
    • Feldmann, M.1    Brennan, F.M.2    Williams, R.O.3    Woody, J.N.4    Maini, R.N.5
  • 61
    • 9144261181 scopus 로고    scopus 로고
    • Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction
    • Zwerina, J., Hayer, S., Tohidast-Akrad, M. et al. Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: effects on synovial inflammation, bone erosion, and cartilage destruction. Arthritis Rheum 2004, 50(1): 277-90.
    • (2004) Arthritis Rheum , vol.50 , Issue.1 , pp. 277-290
    • Zwerina, J.1    Hayer, S.2    Tohidast-Akrad, M.3
  • 62
    • 18844400058 scopus 로고    scopus 로고
    • Cannabinoid-based drugs as anti-inflammatory therapeutics
    • Klein, T.W. Cannabinoid-based drugs as anti-inflammatory therapeutics. Nat Rev Immunol 2005, 5(5): 400-11.
    • (2005) Nat Rev Immunol , vol.5 , Issue.5 , pp. 400-411
    • Klein, T.W.1
  • 63
    • 0031047431 scopus 로고    scopus 로고
    • Cytokine production in the brain following closed head injury dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant
    • Shohami, E., Gallily, R., Mechoulam, R., Bass, R. and Ben Hur, T. Cytokine production in the brain following closed head injury dexanabinol (HU-211) is a novel TNF-alpha inhibitor and an effective neuroprotectant. J Neuroimmunol 1997, 72(2): 169-77.
    • (1997) J Neuroimmunol , vol.72 , Issue.2 , pp. 169-177
    • Shohami, E.1    Gallily, R.2    Mechoulam, R.3    Bass, R.4    Ben Hur, T.5
  • 65
    • 0034069673 scopus 로고    scopus 로고
    • Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice
    • Smith, S.R., Terminelli, C. and Denhardt, G. Effects of cannabinoid receptor agonist and antagonist ligands on production of inflammatory cytokines and anti-inflammatory interleukin-10 in endotoxemic mice. J. Pharmacol Exp Ther 2000, 293(1): 136-50.
    • (2000) J. Pharmacol Exp Ther , vol.293 , Issue.1 , pp. 136-150
    • Smith, S.R.1    Terminelli, C.2    Denhardt, G.3
  • 66
    • 0034662868 scopus 로고    scopus 로고
    • The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
    • Malfait, A.M., Gallily, R., Sumariwalla, P.F., Malik, A.S., Andreakos, E., Mechoulam, R. and Feldmann, M. The nonpsychoactive cannabis constituent cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis. Proc Natl Acad Sci USA 2000, 97(17): 9561-6.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.17 , pp. 9561-9566
    • Malfait, A.M.1    Gallily, R.2    Sumariwalla, P.F.3    Malik, A.S.4    Andreakos, E.5    Mechoulam, R.6    Feldmann, M.7
  • 67
    • 0042061323 scopus 로고    scopus 로고
    • Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes
    • Bidinger, B., Torres, R., Rossetti, R.G. et al. Ajulemic acid, a nonpsychoactive cannabinoid acid, induces apoptosis in human T lymphocytes. Clin Immunol 2003, 108(2): 95-102.
    • (2003) Clin Immunol , vol.108 , Issue.2 , pp. 95-102
    • Bidinger, B.1    Torres, R.2    Rossetti, R.G.3
  • 68
    • 0032821731 scopus 로고    scopus 로고
    • 1′,1′-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: A novel, orally effective cannabinoid with analgesic and anti-inflammatory properties
    • Dajani, E.Z., Larsen, K.R., Taylor, J. et al. 1′,1′-Dimethylheptyl-delta-8-tetrahydrocannabinol-11-oic acid: A novel, orally effective cannabinoid with analgesic and anti-inflammatory properties. J Pharmacol Exp Ther 1999, 291(1): 31-8.
    • (1999) J Pharmacol Exp Ther , vol.291 , Issue.1 , pp. 31-38
    • Dajani, E.Z.1    Larsen, K.R.2    Taylor, J.3
  • 69
    • 0035883892 scopus 로고    scopus 로고
    • Lipopolysaccharide down-regulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes
    • Maccarrone, M., De Petrocellis, L., Bari, M., Fezza, F., Salvati, S., Di Marzo, V. and Finazzi-Agrò, A. Lipopolysaccharide down-regulates fatty acid amide hydrolase expression and increases anandamide levels in human peripheral lymphocytes. Arch Biochem Biophys 2001, 393(2): 321-8.
    • (2001) Arch Biochem Biophys , vol.393 , Issue.2 , pp. 321-328
    • Maccarrone, M.1    De Petrocellis, L.2    Bari, M.3    Fezza, F.4    Salvati, S.5    Di Marzo, V.6    Finazzi-Agrò, A.7
  • 70
    • 0029756752 scopus 로고    scopus 로고
    • Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells
    • Di Marzo, V., De Petrocellis, L., Sepe, N. and Buono, A. Biosynthesis of anandamide and related acylethanolamides in mouse J774 macrophages and N18 neuroblastoma cells. Biochem J 1996, 316(Pt. 3): 977-84.
    • (1996) Biochem J , vol.316 , Issue.PART. 3 , pp. 977-984
    • Di Marzo, V.1    De Petrocellis, L.2    Sepe, N.3    Buono, A.4
  • 71
    • 0036373102 scopus 로고    scopus 로고
    • Presence and regulation of the endocannabinoid system in human dendritic cells
    • Matias, I., Pochard, P., Orlando, P., Salzet, M., Pestel, J. and Di Marzo, V. Presence and regulation of the endocannabinoid system in human dendritic cells. Eur J Biochem 2002, 269(15): 3771-8.
    • (2002) Eur J Biochem , vol.269 , Issue.15 , pp. 3771-3778
    • Matias, I.1    Pochard, P.2    Orlando, P.3    Salzet, M.4    Pestel, J.5    Di Marzo, V.6
  • 72
    • 2442706289 scopus 로고    scopus 로고
    • 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells
    • Kishimoto, S., Kobayashi, Y., Oka, S., Gokoh, M., Waku, K. and Sugiura, T. 2-Arachidonoylglycerol, an endogenous cannabinoid receptor ligand, induces accelerated production of chemokines in HL-60 cells. J Biochem 2004, 135(4): 517-24.
    • (2004) J Biochem , vol.135 , Issue.4 , pp. 517-524
    • Kishimoto, S.1    Kobayashi, Y.2    Oka, S.3    Gokoh, M.4    Waku, K.5    Sugiura, T.6
  • 73
    • 0034717138 scopus 로고    scopus 로고
    • Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation
    • Derocq, J.M., Jbilo, O., Bouaboula, M., Ségui, M., Clère, C. and Casellas, P. Genomic and functional changes induced by the activation of the peripheral cannabinoid receptor CB2 in the promyelocytic cells HL-60. Possible involvement of the CB2 receptor in cell differentiation. J Biol Chem 2000, 275(21): 15621-8.
    • (2000) J Biol Chem , vol.275 , Issue.21 , pp. 15621-15628
    • Derocq, J.M.1    Jbilo, O.2    Bouaboula, M.3    Ségui, M.4    Clère, C.5    Casellas, P.6
  • 74
    • 37149044115 scopus 로고    scopus 로고
    • Cannabinoid CB(2)-selective inverse agonist protects against antigen-induced bone loss
    • Lunn, C.A., Fine, J., Rojas-Triana, A. et al. Cannabinoid CB(2)-selective inverse agonist protects against antigen-induced bone loss. Immunopharmacol Immunotoxicol 2007, 29(3-4): 387-401.
    • (2007) Immunopharmacol Immunotoxicol , vol.29 , Issue.3-4 , pp. 387-401
    • Lunn, C.A.1    Fine, J.2    Rojas-Triana, A.3
  • 75
    • 0030879065 scopus 로고    scopus 로고
    • Mechanisms of bone metastasis
    • Mundy, G.R. Mechanisms of bone metastasis. Cancer 1997, 80(8 Suppl.): 1546-56.
    • (1997) Cancer , vol.80 , Issue.8 SUPPL. , pp. 1546-1556
    • Mundy, G.R.1
  • 76
    • 0035425227 scopus 로고    scopus 로고
    • Biology of osteoclast activation in cancer
    • Roodman, G.D. Biology of osteoclast activation in cancer. J Clin Oncol 2001, 19(15): 3562-71.
    • (2001) J Clin Oncol , vol.19 , Issue.15 , pp. 3562-3571
    • Roodman, G.D.1
  • 77
    • 33750720949 scopus 로고    scopus 로고
    • Future treatment of bone metastases
    • Lipton, A. Future treatment of bone metastases. Clin Cancer Res 2006, 12(20 Pt. 2): 6305s-8s.
    • (2006) Clin Cancer Res , vol.12 , Issue.20 PART. 2
    • Lipton, A.1
  • 78
    • 0035010803 scopus 로고    scopus 로고
    • Metastatic bone disease: Clinical features, pathophysiology and treatment strategies
    • Coleman, R.E. Metastatic bone disease: clinical features, pathophysiology and treatment strategies. Cancer Treat Rev 2001, 27(3): 165-76.
    • (2001) Cancer Treat Rev , vol.27 , Issue.3 , pp. 165-176
    • Coleman, R.E.1
  • 79
    • 0025850907 scopus 로고
    • Mechanisms of osteolytic bone destruction
    • Mundy, G.R. Mechanisms of osteolytic bone destruction. Bone 1991, 12(Suppl. 1): S1-S6.
    • (1991) Bone , vol.12 , Issue.SUPPL. 1
    • Mundy, G.R.1
  • 80
    • 0036223310 scopus 로고    scopus 로고
    • RANK (receptor activator of nuclear factor-kappaB) and RANKL expression in multiple myeloma
    • Roux, S., Meignin, V., Quillard, J. et al. RANK (receptor activator of nuclear factor-kappaB) and RANKL expression in multiple myeloma. Br J Haematol 2002, 117(1): 86-92.
    • (2002) Br J Haematol , vol.117 , Issue.1 , pp. 86-92
    • Roux, S.1    Meignin, V.2    Quillard, J.3
  • 81
    • 0141765902 scopus 로고    scopus 로고
    • New insights into the pathophysiology of multiple myeloma
    • Seidl, S., Kaufmann, H. and Drach, J. New insights into the pathophysiology of multiple myeloma. Lancet Oncol 2003, 4(9): 557-64
    • (2003) Lancet Oncol , vol.4 , Issue.9 , pp. 557-564
    • Seidl, S.1    Kaufmann, H.2    Drach, J.3
  • 82
    • 33846139014 scopus 로고    scopus 로고
    • Molecular interactions between breast cancer cells and the bone microenvironment drive skeletal metastases
    • Siclari, V.A., Guise, T.A. and Chirgwin, J.M. Molecular interactions between breast cancer cells and the bone microenvironment drive skeletal metastases. Cancer Metastasis Rev 2006, 25(4): 621-33.
    • (2006) Cancer Metastasis Rev , vol.25 , Issue.4 , pp. 621-633
    • Siclari, V.A.1    Guise, T.A.2    Chirgwin, J.M.3
  • 83
    • 0142166330 scopus 로고    scopus 로고
    • Cannabinoids: Potential anti-cancer agents
    • Guzman, M. Cannabinoids: Potential anti-cancer agents. Nat Rev Cancer 2003, 3(10): 745-55.
    • (2003) Nat Rev Cancer , vol.3 , Issue.10 , pp. 745-755
    • Guzman, M.1
  • 84
    • 33745013193 scopus 로고    scopus 로고
    • Cannabinoids and cancer: Pros and cons of an antitumour strategy
    • Bifulco, M., Laezza, C., Pisanti, S. and Gazzerro, P. Cannabinoids and cancer: pros and cons of an antitumour strategy. Br J Pharmacol 2006, 148(2): 123-35.
    • (2006) Br J Pharmacol , vol.148 , Issue.2 , pp. 123-135
    • Bifulco, M.1    Laezza, C.2    Pisanti, S.3    Gazzerro, P.4
  • 86
    • 39049104489 scopus 로고    scopus 로고
    • Cannabinoids for cancer treatment progress and promise
    • Sarfaraz, S., Adhami, V.M., Syed, D.N., Afaq, F. and Mukhtar, H. Cannabinoids for cancer treatment progress and promise. Cancer Res 2008, 68(2): 339-42.
    • (2008) Cancer Res , vol.68 , Issue.2 , pp. 339-342
    • Sarfaraz, S.1    Adhami, V.M.2    Syed, D.N.3    Afaq, F.4    Mukhtar, H.5
  • 87
    • 4544275181 scopus 로고    scopus 로고
    • The endocannabinoid system and its therapeutic exploitation
    • Di Marzo, V., Bifulco, M. and De Petrocellis, L. The endocannabinoid system and its therapeutic exploitation. Nat Rev Drug Discov 2004, 3(9): 771-84.
    • (2004) Nat Rev Drug Discov , vol.3 , Issue.9 , pp. 771-784
    • Di Marzo, V.1    Bifulco, M.2    De Petrocellis, L.3
  • 88
    • 34249933789 scopus 로고    scopus 로고
    • Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review)
    • Bifulco, M., Laezza, C., Gazzerro, P. and Pentimalli, F. Endocannabinoids as emerging suppressors of angiogenesis and tumor invasion (review). Oncol Rep 2007, 17(4): 813-6.
    • (2007) Oncol Rep , vol.17 , Issue.4 , pp. 813-816
    • Bifulco, M.1    Laezza, C.2    Gazzerro, P.3    Pentimalli, F.4
  • 89
    • 29144447456 scopus 로고    scopus 로고
    • Anandamide inhibits adhesion and migration of breast cancer cells
    • Grimaldi, C., Pisanti, S., Laezza, C. et al. Anandamide inhibits adhesion and migration of breast cancer cells. Exp Cell Res 2006, 312(4): 363-73.
    • (2006) Exp Cell Res , vol.312 , Issue.4 , pp. 363-373
    • Grimaldi, C.1    Pisanti, S.2    Laezza, C.3
  • 90
    • 16444375370 scopus 로고    scopus 로고
    • Cannabinoid receptor as a novel target for the treatment of prostate cancer
    • Sarfaraz, S., Afaq, F., Adhami, V.M. and Mukhtar, H. Cannabinoid receptor as a novel target for the treatment of prostate cancer. Cancer Res 2005, 65(5): 1635-41.
    • (2005) Cancer Res , vol.65 , Issue.5 , pp. 1635-1641
    • Sarfaraz, S.1    Afaq, F.2    Adhami, V.M.3    Mukhtar, H.4
  • 91
    • 0141613823 scopus 로고    scopus 로고
    • High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma
    • Islam, T.C., Asplund, A.C., Lindvall, J.M. et al. High level of cannabinoid receptor 1, absence of regulator of G protein signalling 13 and differential expression of Cyclin D1 in mantle cell lymphoma. Leukemia 2003, 17(9): 1880-90.
    • (2003) Leukemia , vol.17 , Issue.9 , pp. 1880-1890
    • Islam, T.C.1    Asplund, A.C.2    Lindvall, J.M.3
  • 92
    • 0036141517 scopus 로고    scopus 로고
    • Leukemia predisposition of pSca-1/Cb2 transgenic mice
    • Joosten, M., Valk, P.J., Jordà, M.A. et al. Leukemia predisposition of pSca-1/Cb2 transgenic mice. Exp Hematol 2002, 30(2): 142-9.
    • (2002) Exp Hematol , vol.30 , Issue.2 , pp. 142-149
    • Joosten, M.1    Valk, P.J.2    Jordà, M.A.3
  • 93
    • 0034834552 scopus 로고    scopus 로고
    • 1. delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1
    • Velasco, L., Ruiz, L., Sanchez, M.G. and Diaz-Laviada, 1. delta(9)-Tetrahydrocannabinol increases nerve growth factor production by prostate PC-3 cells. Involvement of CB1 cannabinoid receptor and Raf-1. Eur J Biochem 2001, 268(3): 531-5.
    • (2001) Eur J Biochem , vol.268 , Issue.3 , pp. 531-535
    • Velasco, L.1    Ruiz, L.2    Sanchez, M.G.3    Laviada, D.4
  • 94
    • 0032586054 scopus 로고    scopus 로고
    • Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism
    • Ruiz, L., Miguel, A. and Diaz-Laviada, I. Delta9-tetrahydrocannabinol induces apoptosis in human prostate PC-3 cells via a receptor-independent mechanism. FEBS Lett 1999, 458(3): 400-4.
    • (1999) FEBS Lett , vol.458 , Issue.3 , pp. 400-404
    • Ruiz, L.1    Miguel, A.2    Diaz-Laviada, I.3
  • 95
    • 0034696960 scopus 로고    scopus 로고
    • Anandamide induces apoptosis of PC-12 cells: Involvement of superoxide and caspase-3
    • Sarker, K.P., Obara, S., Nakata, M., Kitajima, I. and Maruyama, I. Anandamide induces apoptosis of PC-12 cells: Involvement of superoxide and caspase-3. FEBS Lett 2000, 472(1): 39-44.
    • (2000) FEBS Lett , vol.472 , Issue.1 , pp. 39-44
    • Sarker, K.P.1    Obara, S.2    Nakata, M.3    Kitajima, I.4    Maruyama, I.5
  • 96
    • 33747624175 scopus 로고    scopus 로고
    • Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma
    • Ligresti, A., Moriello, A.S., Starowicz, K. et al. Antitumor activity of plant cannabinoids with emphasis on the effect of cannabidiol on human breast carcinoma. J Pharmacol Exp Ther 2006, 318(3): 1375-87.
    • (2006) J Pharmacol Exp Ther , vol.318 , Issue.3 , pp. 1375-1387
    • Ligresti, A.1    Moriello, A.S.2    Starowicz, K.3
  • 97
    • 36749015683 scopus 로고    scopus 로고
    • Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells
    • McAllister, S.D., Christian, R.T., Horowitz, M.P., Garcia, A. and Desprez, P.Y. Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells. Mol Cancer Ther 2007, 6(11): 2921-7.
    • (2007) Mol Cancer Ther , vol.6 , Issue.11 , pp. 2921-2927
    • McAllister, S.D.1    Christian, R.T.2    Horowitz, M.P.3    Garcia, A.4    Desprez, P.Y.5
  • 98
    • 1542510624 scopus 로고    scopus 로고
    • Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor
    • Hart, S., Fischer, O.M. and Ullrich, A. Cannabinoids induce cancer cell proliferation via tumor necrosis factor alpha-converting enzyme (TACE/ADAM17)-mediated transactivation of the epidermal growth factor receptor. Cancer Res 2004, 64(6): 1943-050.
    • (2004) Cancer Res , vol.64 , Issue.6 , pp. 1943-2050
    • Hart, S.1    Fischer, O.M.2    Ullrich, A.3
  • 99
    • 14844362003 scopus 로고    scopus 로고
    • Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the anti-tumor immune response
    • McKallip, R.J., Nagarkatti, M. and Nagarkatti, P.S. Delta-9-tetrahydrocannabinol enhances breast cancer growth and metastasis by suppression of the anti-tumor immune response. J Immunol 2005, 174(6): 3281-9.
    • (2005) J Immunol , vol.174 , Issue.6 , pp. 3281-3289
    • McKallip, R.J.1    Nagarkatti, M.2    Nagarkatti, P.S.3
  • 100
    • 35649008926 scopus 로고    scopus 로고
    • Cannabinoids go nuclear: Evidence for detivation of peroxisome proliferator-activated receptors
    • O'Sullivan, S.E. Cannabinoids go nuclear: evidence for detivation of peroxisome proliferator-activated receptors. Br J Pharmacol 2007, 152(5): 576-82.
    • (2007) Br J Pharmacol , vol.152 , Issue.5 , pp. 576-582
    • O'Sullivan, S.E.1
  • 101
    • 0038745585 scopus 로고    scopus 로고
    • Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid
    • Liu, J., Li, H., Burstein, S.H., Zurier, R.B. and Chen, J.D. Activation and binding of peroxisome proliferator-activated receptor gamma by synthetic cannabinoid ajulemic acid. Mol Pharmacol 2003, 63(5): 983-92.
    • (2003) Mol Pharmacol , vol.63 , Issue.5 , pp. 983-992
    • Liu, J.1    Li, H.2    Burstein, S.H.3    Zurier, R.B.4    Chen, J.D.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.