Proof of principle in a de novo designed protein maquette: An allosterically regulated, charge-activated conformational switch in a tetra-α-helix bundle

Biochemistry

Volumn 40, Issue 18, 2001, Pages 5474-5487

  Grosset, Anne M ^a,c   Gibney, Brian R ^a,d   Rabanal, Francesc ^a,e   Moser, Christopher C ^a   Dutton, P Leslie ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c GEORGETOWN UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e UNIVERSITY OF BARCELONA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING ENERGY; CATALYSIS; CHEMICAL ACTIVATION; CONFORMATIONS; ELECTRIC CHARGE; FREE ENERGY; POSITIVE IONS; PROTEINS; REDOX REACTIONS; TOPOLOGY;

ALLOSTERIC REGULATION;

BIOCHEMISTRY;

CARBOXYLIC ACID; COPROPORPHYRIN; HEME; METHEMOGLOBIN; PROTEIN; PROTEIN SUBUNIT;

ALLOSTERISM; ALPHA HELIX; ARTICLE; CHEMICAL BINDING; CONFORMATIONAL TRANSITION; IONIC STRENGTH; MOLECULAR INTERACTION; MOLECULAR MODEL; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL;

ALLOSTERIC REGULATION; AMINO ACID MOTIFS; AMINO ACID SEQUENCE; BINDING SITES; COPROPORPHYRINS; DIMERIZATION; DISULFIDES; ELECTROSTATICS; FERRIC COMPOUNDS; HEME; KINETICS; MOLECULAR SEQUENCE DATA; OSMOLAR CONCENTRATION; OXIDATION-REDUCTION; POTENTIOMETRY; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEINS; PYRENES; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

EID: 0035826571     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi002504f     Document Type: Article

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