In vitro differentiation of adult bone marrow progenitors into antigen-specific CD4 helper T cells using engineered stromal cells expressing a notch ligand and a major histocompatibility complex class II protein

Stem Cells and Development

Volumn 18, Issue 2, 2009, Pages 235-245

  Dai, Bingbing ^a   Wang, Pin ^a  

^a University of Southern California   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CD4 ANTIGEN; DELTA LIKE 1 PROTEIN; HISTOCOMPATIBILITY ANTIGEN; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS 2 PROTEIN; NOTCH RECEPTOR; STEM CELL FACTOR; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BONE MARROW; CD4+ T LYMPHOCYTE; CELL ASSAY; CELL DIFFERENTIATION; CELL LINE; CELL MATURATION; CELL STIMULATION; CELL TRANSFORMATION; COCULTURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; FETUS; FLOW CYTOMETRY; GENETIC TRANSDUCTION; HELPER CELL; HEMATOPOIETIC STEM CELL; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; T LYMPHOCYTE ACTIVATION;

ANIMALS; BONE MARROW CELLS; CELL CULTURE TECHNIQUES; CELL DIFFERENTIATION; COCULTURE TECHNIQUES; EPITOPES; FEMALE; HISTOCOMPATIBILITY ANTIGENS CLASS II; LIGANDS; MICE; MICE, INBRED C57BL; RECEPTORS, ANTIGEN, T-CELL; RECEPTORS, NOTCH; STEM CELLS; STROMAL CELLS; T-LYMPHOCYTES, HELPER-INDUCER; TRANSDUCTION, GENETIC;

MURINAE;

EID: 62549164316     PISSN: 15473287     EISSN: None     Source Type: Journal    
DOI: 10.1089/scd.2008.0021     Document Type: Article

References (50)

1. Douek DC, LJ Picker and RA Koup. (2003). T cell dynamics in HIV-1 infection. Annu Rev Immunol 21:265-304.
2. Dudley ME and SA Rosenberg. (2003). Adoptive-cell-transfer therapy for the treatment of patients with cancer. Nat Rev Cancer 3:666-675.
3. Gattinoni L, DJ Powell, Jr., SA Rosenberg and NP Restifo. (2006). Adoptive immunotherapy for cancer: building on success. Nat Rev Immunol 6:383-393.
4. Kolb HJ and E Holler. (1997). Adoptive immunotherapy with donor lymphocyte transfusions. Curr Opin Oncol 9:139-145.
5. Bollard CM, L Aguilar, KC Straathof, B Gahn, MH Huls, A Rousseau, J Sixbey, MV Gresik, G Carrum, M Hudson, D Dilloo, A Gee, MK Brenner, CM Rooney and HE Heslop. (2004). Cytotoxic T lymphocyte therapy for Epstein-Barr virus+ Hodgkin's disease. J Exp Med 200:1623-1633.
6. Rooney CM, CA Smith, CY Ng, SK Loftin, JW Sixbey, Y Gan, DK Srivastava, LC Bowman, RA Krance, MK Brenner and HE Heslop. (1998). Infusion of cytotoxic T cells for the prevention and treatment of Epstein-Barr virus-induced lymphoma in allogeneic transplant recipients. Blood 92:1549-1555.
7. Khanna R, S Bell, M Sherritt, A Galbraith, SR Burrows, L Rafter, B Clarke, R Slaughter, MC Falk, J Douglass, T Williams, SL Elliott and DJ Moss. (1999). Activation and adoptive transfer of Epstein-Barr virus-specific cytotoxic T cells in solid organ transplant patients with posttransplant lymphoproliferative disease. Proc Natl Acad Sci USA 96:10391-10396.
8. Ceredig R, EJ Jenkinson, HR MacDonald and JJ Owen. (1982). Development of cytolytic T lymphocyte precursors in organ-cultured mouse embryonic thymus rudiments. J Exp Med 155:617-622.
9. Schmitt TM and JC Zuniga-Pflucker. (2002). Induction of T cell development from hematopoietic progenitor cells by delta-like-1 in vitro. Immunity 17:749-756.
10. Zuniga-Pflucker JC. (2004). T-cell development made simple. Nat Rev Immunol 4:67-72.
11. de Pooter R and JC Zuniga-Pflucker. (2007). T-cell potential and development in vitro: the OP9-DL1 approach. Curr Opin Immunol 19:163-168.
12. Wiktor-Jedrzejczak W, A Bartocci, AW Ferrante, Jr., A Ahmed-Ansari, KW Sell, JW Pollard and ER Stanley. (1990). Total absence of colony-stimulating factor 1 in the macrophage-deficient osteopetrotic (op/op) mouse. Proc Natl Acad Sci USA 87:4828-4832.
13. Yoshida H, S Hayashi, T Kunisada, M Ogawa, S Nishikawa, H Okamura, T Sudo, LD Shultz and S Nishikawa. (1990). The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene. Nature 345:442-444.
14. Schmitt TM, RF de Pooter, MA Gronski, SK Cho, PS Ohashi and JC Zuniga-Pflucker. (2004). Induction of T cell development and establishment of T cell competence from embryonic stem cells differentiated in vitro. Nat Immunol 5:410-417.
15. Huang J, KP Garrett, R Pelayo, JC Zuniga-Pflucker, HT Petrie and PW Kincade. (2005). Propensity of adult lymphoid progenitors to progress to DN2/3 stage thymocytes with Notch receptor ligation. J Immunol 175:4858-4865.
16. La Motte-Mohs RN, E Herer and JC Zuniga-Pflucker. (2005). Induction of T-cell development from human cord blood hematopoietic stem cells by Delta-like 1 in vitro. Blood 105:1431-1439.
17. De Smedt M, I Hoebeke and J Plum. (2004). Human bone marrow CD34+ progenitor cells mature to T cells on OP9-DL1 stromal cell line without thymus microenvironment. Blood Cells Mol Dis 33:227-232.
18. van Lent AU, M Nagasawa, MM van Loenen, R Schotte, TN Schumacher, MH Heemskerk, H Spits and N Legrand. (2007). Functional human antigen-specific T cells produced in vitro using retroviral T cell receptor transfer into hematopoietic progenitors. J Immunol 179:4959-4968.
19. Zhao Y, MR Parkhurst, Z Zheng, CJ Cohen, JP Riley, L Gattinoni, NP Restifo, SA Rosenberg and RA Morgan. (2007). Extrathymic generation of tumor-specific T cells from genetically engineered human hematopoietic stem cells via Notch signaling. Cancer Res 67:2425-2429.
20. Janssen EM, EE Lemmens, T Wolfe, U Christen, MG von Herrath and SP Schoenberger. (2003). CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes. Nature 421:852-856.
21. Shedlock DJ and H Shen. (2003). Requirement for CD4 T cell help in generating functional CD8 T cell memory. Science 300:337-339.
22. Pardoll DM and SL Topalian. (1998). The role of CD4+ T cell responses in antitumor immunity. Curr Opin Immunol 10:588-594.
23. Ostrand-Rosenberg S. (2005). CD4+ T lymphocytes: a critical component of antitumor immunity. Cancer Invest 23:413-419.
24. Zou W. (2006). Regulatory T cells, tumour immunity and immunotherapy. Nat Rev Immunol 6:295-307.
25. Van Parijs L, Y Refaeli, JD Lord, BH Nelson, AK Abbas and D Baltimore. (1999). Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death. Immunity 11:281-288.
26. Yang L, XF Qin, D Baltimore and L Van Parijs. (2002). Generation of functional antigen-specific T cells in defined genetic backgrounds by retrovirus-mediated expression of TCR cDNAs in hematopoietic precursor cells. Proc Natl Acad Sci USA 99:6204-6209.
27. Barnden MJ, J Allison, WR Heath and FR Carbone. (1998). Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements. Immunol Cell Biol 76:34-40.
28. Balciunaite G, R Ceredig, HJ Fehling, JC Zuniga-Pflucker and AG Rolink. (2005). The role of Notch and IL-7 signaling in early thymocyte proliferation and differentiation. Eur J Immunol 35:1292-1300.
29. Zakrzewski JL, AA Kochman, SX Lu, TH Terwey, TD Kim, VM Hubbard, SJ Muriglan, D Suh, OM Smith, J Grubin, N Patel, A Chow, J Cabrera-Perez, R Radhakrishnan, A Diab, MA Perales, G Rizzuto, E Menet, EG Pamer, G Heller, JC Zuniga-Pflucker, O Alpdogan and MR van den Brink. (2006). Adoptive transfer of T-cell precursors enhances T-cell reconstitution after allogeneic hematopoietic stem cell transplantation. Nat Med 12:1039-1047.
30. Douagi I, P Vieira and A Cumano. (2002). Lymphocyte commitment during embryonic development, in the mouse. Semin Immunol 14:361-369.
31. Crompton T, SV Outram, J Buckland and MJ Owen. (1998). Distinct roles of the interleukin-7 receptor alpha chain in fetal and adult thymocyte development revealed by analysis of interleukin-7 receptor alpha-deficient mice. Eur J Immunol 28:1859-1866.
32. - mice. J Exp Med 194:1141-1150.
33. Yang L and D Baltimore. (2005). Long-term in vivo provision of antigen-specific T cell immunity by programming hematopoietic stem cells. Proc Natl Acad Sci USA 102:4518-4523.
34. Petrie HT and JC Zuniga-Pflucker. (2007). Zoned out: functional mapping of stromal signaling microenvironments in the thymus. Annu Rev Immunol 25:649-679.
35. Godfrey DI and A Zlotnik. (1993). Control points in early T-cell development. Immunol Today 14:547-553.
36. Ceredig R and T Rolink. (2002). A positive look at double-negative thymocytes. Nat Rev Immunol 2:888-897.
37. Bhandoola A, H von Boehmer, HT Petrie and JC Zuniga-Pflucker. (2007). Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26:678-689.
38. Nishimura T, K Iwakabe, M Sekimoto, Y Ohmi, T Yahata, M Nakui, T Sato, S Habu, H Tashiro, M Sato and A Ohta. (1999). Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo. J Exp Med 190:617-627.
39. Baxevanis CN, IF Voutsas, OE Tsitsilonis, AD Gritzapis, R Sotiriadou and M Papamichail. (2000). Tumor-specific CD4+ T lymphocytes from cancer patients are required for optimal induction of cytotoxic T cells against the autologous tumor. J Immunol 164:3902-3912.
40. Marzo AL, BF Kinnear, RA Lake, JJ Frelinger, EJ Collins, BW Robinson and B Scott. (2000). Tumor-specific CD4+ T cells have a major "post- licensing" role in CTL mediated anti-tumor immunity. J Immunol 165:6047-6055.
41. Moeller M, NM Haynes, MH Kershaw, JT Jackson, MW Teng, SE Street, L Cerutti, SM Jane, JA Trapani, MJ Smyth and PK Darcy. (2005). Adoptive transfer of gene-engineered CD4+ helper T cells induces potent primary and secondary tumor rejection. Blood 106:2995-3003.
42. von Boehmer H. (1990). Developmental biology of T cells in T cell-receptor transgenic mice. Annu Rev Immunol 8:531-556.
43. Arnold PY, AR Burton and DA Vignali. (2004). Diabetes incidence is unaltered in glutamate decarboxylase 65-specific TCR retrogenic nonobese diabetic mice: generation by retroviral-mediated stem cell gene transfer. J Immunol 173:3103-3111.
44. Kessels HW, MC Wolkers, MD van den Boom, MA van der Valk and TN Schumacher. (2001). Immunotherapy through TCR gene transfer. Nat Immunol 2:957-961.
45. Morgan RA, ME Dudley, JR Wunderlich, MS Hughes, JC Yang, RM Sherry, RE Royal, SL Topalian, US Kammula, NP Restifo, Z Zheng, A Nahvi, CR de Vries, LJ Rogers-Freezer, SA Mavroukakis and SA Rosenberg. (2006). Cancer regression in patients after transfer of genetically engineered lymphocytes. Science 314:126-129.
46. Heemskerk MH, RS Hagedoorn, MA van der Hoorn, LT van der Veken, M Hoogeboom, MG Kester, R Willemze and JH Falkenburg. (2007). Efficiency of T-cell receptor expression in dual-specific T cells is controlled by the intrinsic qualities of the TCR chains within the TCR-CD3 complex. Blood 109:235-243.
47. Cohen CJ, Y Zhao, Z Zheng, SA Rosenberg and RA Morgan. (2006). Enhanced antitumor activity of murine-human hybrid T-cell receptor (TCR) in human lymphocytes is associated with improved pairing and TCR/CD3 stability. Cancer Res 66:8878-8886.
48. Kuball J, ML Dossett, M Wolfl, WY Ho, RH Voss, C Fowler and PD Greenberg. (2007). Facilitating matched pairing and expression of TCR chains introduced into human T cells. Blood 109:2331-2338.
49. Kroczek RA, HW Mages and A Hutloff. (2004). Emerging paradigms of T-cell costimulation. Curr Opin Immunol 16:321-327.
50. Ward RC and HL Kaufman. (2007). Targeting costimulatory pathways for tumor immunotherapy. Int Rev Immunol 26:161-196.