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Volumn 41, Issue 3 SPEC. ISS., 2008, Pages 233-247

NF-κB pathways in the immune system: Control of the germinal center reaction

Author keywords

B cells; Bcl 3; Bcl 6; Class switch recombination; Germinal center; NF B; p50; p52; Somatic hypermutation

Indexed keywords

I KAPPA B; I KAPPA B ALPHA; I KAPPA B KINASE ALPHA; I KAPPA B KINASE BETA; I KAPPA B KINASE GAMMA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN BCL 3; PROTEIN BCL 6; PROTEIN CREL; PROTEIN DERIVATIVE; PROTEIN P50; PROTEIN P52; PROTEIN P53; SYNAPTOTAGMIN I; TRANSCRIPTION FACTOR RELB; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR 1; UNCLASSIFIED DRUG; ONCOPROTEIN; PROTO ONCOGENE PROTEIN BCL 3; PROTO-ONCOGENE PROTEIN BCL-3; SIGNAL PEPTIDE; TRANSCRIPTION FACTOR;

EID: 62549127264     PISSN: 0257277X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12026-008-8033-1     Document Type: Review
Times cited : (29)

References (91)
  • 1
    • 4444376712 scopus 로고    scopus 로고
    • Signaling to NF-kappaB
    • MS Hayden S Ghosh 2004 Signaling to NF-kappaB Genes Dev 18 2195 224
    • (2004) Genes Dev , vol.18 , pp. 2195-224
    • Hayden, M.S.1    Ghosh, S.2
  • 2
    • 20644455960 scopus 로고    scopus 로고
    • Control of lymphocyte development by nuclear factor-kappaB
    • U Siebenlist K Brown E Claudio 2005 Control of lymphocyte development by nuclear factor-kappaB Nat Rev Immunol 5 435 45
    • (2005) Nat Rev Immunol , vol.5 , pp. 435-45
    • Siebenlist, U.1    Brown, K.2    Claudio, E.3
  • 3
    • 0442307969 scopus 로고    scopus 로고
    • IkappaB kinases: Key regulators of the NF-kappaB pathway
    • Y Yamamoto RB Gaynor 2004 IkappaB kinases: key regulators of the NF-kappaB pathway Trends Biochem Sci 29 72 9
    • (2004) Trends Biochem Sci , vol.29 , pp. 72-9
    • Yamamoto, Y.1    Gaynor, R.B.2
  • 4
    • 3042563555 scopus 로고    scopus 로고
    • Genetic dissection of antigen receptor induced-NF-kappaB activation
    • ZW Li RC Rickert M Karin 2004 Genetic dissection of antigen receptor induced-NF-kappaB activation Mol Immunol 41 701 14
    • (2004) Mol Immunol , vol.41 , pp. 701-14
    • Li, Z.W.1    Rickert, R.C.2    Karin, M.3
  • 5
    • 11844269840 scopus 로고    scopus 로고
    • Phosphorylation of NF-kappaB and IkappaB proteins: Implications in cancer and inflammation
    • P Viatour MP Merville V Bours A Chariot 2005 Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation Trends Biochem Sci 30 43 52
    • (2005) Trends Biochem Sci , vol.30 , pp. 43-52
    • Viatour, P.1    Merville, M.P.2    Bours, V.3    Chariot, A.4
  • 7
    • 49449107546 scopus 로고    scopus 로고
    • An essential role for EGFR in glutamate receptor signaling to NF-{kappa}B
    • (in press).
    • Sitcheran R, Comb WC, Cogswell PC, Baldwin AS. An essential role for EGFR in glutamate receptor signaling to NF-{kappa}B. Mol Cell Biol. 2008 (in press).
    • (2008) Mol Cell Biol.
    • Sitcheran, R.1    Comb, W.C.2    Cogswell, P.C.3    Baldwin, A.S.4
  • 8
    • 4143134494 scopus 로고    scopus 로고
    • Nuclear factor-kappaB: A friend or a foe in cancer?
    • S Shishodia BB Aggarwal 2004 Nuclear factor-kappaB: a friend or a foe in cancer? Biochem Pharmacol 68 1071 80
    • (2004) Biochem Pharmacol , vol.68 , pp. 1071-80
    • Shishodia, S.1    Aggarwal, B.B.2
  • 9
    • 0035905313 scopus 로고    scopus 로고
    • Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells
    • RE Davis KD Brown U Siebenlist LM Staudt 2001 Constitutive nuclear factor kappaB activity is required for survival of activated B cell-like diffuse large B cell lymphoma cells J Exp Med 194 1861 74
    • (2001) J Exp Med , vol.194 , pp. 1861-74
    • Davis, R.E.1    Brown, K.D.2    Siebenlist, U.3    Staudt, L.M.4
  • 10
    • 33745042062 scopus 로고    scopus 로고
    • The molecular mechanisms of classic Hodgkin's lymphoma
    • RS Felberbaum 2005 The molecular mechanisms of classic Hodgkin's lymphoma Yale J Biol Med 78 203 10
    • (2005) Yale J Biol Med , vol.78 , pp. 203-10
    • Felberbaum, R.S.1
  • 11
    • 33645306041 scopus 로고    scopus 로고
    • A loss-of-function RNA interference screen for molecular targets in cancer
    • VN Ngo RE Davis L Lamy X Yu H Zhao G Lenz 2006 A loss-of-function RNA interference screen for molecular targets in cancer Nature 441 106 10
    • (2006) Nature , vol.441 , pp. 106-10
    • Ngo, V.N.1    Davis, R.E.2    Lamy, L.3    Yu, X.4    Zhao, H.5    Lenz, G.6
  • 12
    • 43549097394 scopus 로고    scopus 로고
    • Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma
    • LT Lam G Wright RE Davis G Lenz P Farinha L Dang 2008 Cooperative signaling through the signal transducer and activator of transcription 3 and nuclear factor-{kappa}B pathways in subtypes of diffuse large B-cell lymphoma Blood 111 3701 13
    • (2008) Blood , vol.111 , pp. 3701-13
    • Lam, L.T.1    Wright, G.2    Davis, R.E.3    Lenz, G.4    Farinha, P.5    Dang, L.6
  • 14
    • 33846787037 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene: A leading role during germinal center development and lymphomagenesis
    • F Jardin P Ruminy C Bastard H Tilly 2007 The BCL6 proto-oncogene: a leading role during germinal center development and lymphomagenesis Pathol Biol (Paris) 55 73 83
    • (2007) Pathol Biol (Paris) , vol.55 , pp. 73-83
    • Jardin, F.1    Ruminy, P.2    Bastard, C.3    Tilly, H.4
  • 15
    • 33750432183 scopus 로고    scopus 로고
    • Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression
    • DS Basseres AS Baldwin 2006 Nuclear factor-kappaB and inhibitor of kappaB kinase pathways in oncogenic initiation and progression Oncogene 25 6817 30
    • (2006) Oncogene , vol.25 , pp. 6817-30
    • Basseres, D.S.1    Baldwin, A.S.2
  • 16
    • 39749143925 scopus 로고    scopus 로고
    • IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL + cells
    • EA Duncan CA Goetz SJ Stein KJ Mayo BJ Skaggs K Ziegelbauer 2008 IkappaB kinase beta inhibition induces cell death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL + cells Mol Cancer Ther 7 391 7
    • (2008) Mol Cancer Ther , vol.7 , pp. 391-7
    • Duncan, E.A.1    Goetz, C.A.2    Stein, S.J.3    Mayo, K.J.4    Skaggs, B.J.5    Ziegelbauer, K.6
  • 17
    • 0029059060 scopus 로고
    • Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B
    • AA Beg WC Sha RT Bronson S Ghosh D Baltimore 1995 Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B Nature 376 167 70
    • (1995) Nature , vol.376 , pp. 167-70
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Ghosh, S.4    Baltimore, D.5
  • 18
    • 0141992937 scopus 로고    scopus 로고
    • Regulation of developing B cell survival by RelA-containing NF-kappa B complexes
    • M Prendes Y Zheng AA Beg 2003 Regulation of developing B cell survival by RelA-containing NF-kappa B complexes J Immunol 171 3963 9
    • (2003) J Immunol , vol.171 , pp. 3963-9
    • Prendes, M.1    Zheng, Y.2    Beg, A.A.3
  • 19
    • 0030837598 scopus 로고    scopus 로고
    • Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells
    • BH Horwitz ML Scott SR Cherry RT Bronson D Baltimore 1997 Failure of lymphopoiesis after adoptive transfer of NF-kappaB-deficient fetal liver cells Immunity 6 765 72
    • (1997) Immunity , vol.6 , pp. 765-72
    • Horwitz, B.H.1    Scott, M.L.2    Cherry, S.R.3    Bronson, R.T.4    Baltimore, D.5
  • 20
    • 0030999057 scopus 로고    scopus 로고
    • NF-kappa B RelA-deficient lymphocytes: Normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses
    • TS Doi T Takahashi O Taguchi T Azuma Y Obata 1997 NF-kappa B RelA-deficient lymphocytes: normal development of T cells and B cells, impaired production of IgA and IgG1 and reduced proliferative responses J Exp Med 185 953 61
    • (1997) J Exp Med , vol.185 , pp. 953-61
    • Doi, T.S.1    Takahashi, T.2    Taguchi, O.3    Azuma, T.4    Obata, Y.5
  • 21
    • 0032473405 scopus 로고    scopus 로고
    • B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells
    • RJ Grumont IJ Rourke LA O'Reilly A Strasser K Miyake W Sha S Gerondakis 1998 B lymphocytes differentially use the Rel and nuclear factor kappaB1 (NF-kappaB1) transcription factors to regulate cell cycle progression and apoptosis in quiescent and mitogen-activated cells J Exp Med 187 663 74
    • (1998) J Exp Med , vol.187 , pp. 663-74
    • Grumont, R.J.1    Rourke, I.J.2    O'Reilly, L.A.3    Strasser, A.4    Miyake, K.5    Sha, W.6    Gerondakis, S.7
  • 22
    • 0029150389 scopus 로고
    • Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression
    • F Kontgen RJ Grumont A Strasser D Metcalf R Li D Tarlinton 1995 Mice lacking the c-rel proto-oncogene exhibit defects in lymphocyte proliferation, humoral immunity, and interleukin-2 expression Genes Dev 9 1965 77
    • (1995) Genes Dev , vol.9 , pp. 1965-77
    • Kontgen, F.1    Grumont, R.J.2    Strasser, A.3    Metcalf, D.4    Li, R.5    Tarlinton, D.6
  • 23
    • 0035500505 scopus 로고    scopus 로고
    • C-Rel is required for the protection of B cells from antigen receptor-mediated, but not Fas-mediated, apoptosis
    • AM Owyang JR Tumang BR Schram CY Hsia TW Behrens TL Rothstein 2001 c-Rel is required for the protection of B cells from antigen receptor-mediated, but not Fas-mediated, apoptosis J Immunol 167 4948 56
    • (2001) J Immunol , vol.167 , pp. 4948-56
    • Owyang, A.M.1    Tumang, J.R.2    Schram, B.R.3    Hsia, C.Y.4    Behrens, T.W.5    Rothstein, T.L.6
  • 24
    • 44449102037 scopus 로고    scopus 로고
    • Melnick A: BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells
    • SM Ranuncolo JM Polo 2008 Melnick A: BCL6 represses CHEK1 and suppresses DNA damage pathways in normal and malignant B-cells Blood Cells Mol Dis 41 95 9
    • (2008) Blood Cells Mol Dis , vol.41 , pp. 95-9
    • Ranuncolo, S.M.1    Polo, J.M.2
  • 28
    • 0034268780 scopus 로고    scopus 로고
    • Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme
    • M Muramatsu K Kinoshita S Fagarasan S Yamada Y Shinkai T Honjo 2000 Class switch recombination and hypermutation require activation-induced cytidine deaminase (AID), a potential RNA editing enzyme Cell 102 553 63
    • (2000) Cell , vol.102 , pp. 553-63
    • Muramatsu, M.1    Kinoshita, K.2    Fagarasan, S.3    Yamada, S.4    Shinkai, Y.5    Honjo, T.6
  • 29
    • 0141567432 scopus 로고    scopus 로고
    • Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway
    • F Weih J Caamano 2003 Regulation of secondary lymphoid organ development by the nuclear factor-kappaB signal transduction pathway Immunol Rev 195 91 105
    • (2003) Immunol Rev , vol.195 , pp. 91-105
    • Weih, F.1    Caamano, J.2
  • 30
    • 34250762588 scopus 로고    scopus 로고
    • Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR
    • SM Ranuncolo JM Polo J Dierov M Singer T Kuo J Greally 2007 Bcl-6 mediates the germinal center B cell phenotype and lymphomagenesis through transcriptional repression of the DNA-damage sensor ATR Nat Immunol 8 705 14
    • (2007) Nat Immunol , vol.8 , pp. 705-14
    • Ranuncolo, S.M.1    Polo, J.M.2    Dierov, J.3    Singer, M.4    Kuo, T.5    Greally, J.6
  • 31
    • 33845422163 scopus 로고    scopus 로고
    • Control of B lymphocyte apoptosis by the transcription factor NF-kappaB
    • R Sen 2006 Control of B lymphocyte apoptosis by the transcription factor NF-kappaB Immunity 25 871 83
    • (2006) Immunity , vol.25 , pp. 871-83
    • Sen, R.1
  • 33
    • 30444457243 scopus 로고    scopus 로고
    • FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses
    • P Victoratos J Lagnel S Tzima MB Alimzhanov K Rajewsky M Pasparakis 2006 FDC-specific functions of p55TNFR and IKK2 in the development of FDC networks and of antibody responses Immunity 24 65 77
    • (2006) Immunity , vol.24 , pp. 65-77
    • Victoratos, P.1    Lagnel, J.2    Tzima, S.3    Alimzhanov, M.B.4    Rajewsky, K.5    Pasparakis, M.6
  • 34
    • 0029989339 scopus 로고    scopus 로고
    • Immune and inflammatory responses in TNF alpha-deficient mice: A critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response
    • M Pasparakis L Alexopoulou V Episkopou G Kollias 1996 Immune and inflammatory responses in TNF alpha-deficient mice: a critical requirement for TNF alpha in the formation of primary B cell follicles, follicular dendritic cell networks and germinal centers, and in the maturation of the humoral immune response J Exp Med 184 1397 411
    • (1996) J Exp Med , vol.184 , pp. 1397-411
    • Pasparakis, M.1    Alexopoulou, L.2    Episkopou, V.3    Kollias, G.4
  • 35
    • 0038446862 scopus 로고    scopus 로고
    • Cutting edge: Germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function
    • KA Vora LC Wang SP Rao ZY Liu GR Majeau AH Cutler 2003 Cutting edge: germinal centers formed in the absence of B cell-activating factor belonging to the TNF family exhibit impaired maturation and function J Immunol 171 547 51
    • (2003) J Immunol , vol.171 , pp. 547-51
    • Vora, K.A.1    Wang, L.C.2    Rao, S.P.3    Liu, Z.Y.4    Majeau, G.R.5    Cutler, A.H.6
  • 36
    • 33744989924 scopus 로고    scopus 로고
    • Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation
    • Y Sasaki E Derudder E Hobeika R Pelanda M Reth K Rajewsky 2006 Canonical NF-kappaB activity, dispensable for B cell development, replaces BAFF-receptor signals and promotes B cell proliferation upon activation Immunity 24 729 39
    • (2006) Immunity , vol.24 , pp. 729-39
    • Sasaki, Y.1    Derudder, E.2    Hobeika, E.3    Pelanda, R.4    Reth, M.5    Rajewsky, K.6
  • 37
    • 42149168527 scopus 로고    scopus 로고
    • ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction
    • F Vu U Dianzani CF Ware T Mak JL Gommerman 2008 ICOS, CD40, and lymphotoxin beta receptors signal sequentially and interdependently to initiate a germinal center reaction J Immunol 180 2284 93
    • (2008) J Immunol , vol.180 , pp. 2284-93
    • Vu, F.1    Dianzani, U.2    Ware, C.F.3    Mak, T.4    Gommerman, J.L.5
  • 38
    • 0033537739 scopus 로고    scopus 로고
    • Severe liver degeneration in mice lacking the IkappaB kinase 2 gene
    • Q Li D Van Antwerp F Mercurio KF Lee IM Verma 1999 Severe liver degeneration in mice lacking the IkappaB kinase 2 gene Science 284 321 5
    • (1999) Science , vol.284 , pp. 321-5
    • Li, Q.1    Van Antwerp, D.2    Mercurio, F.3    Lee, K.F.4    Verma, I.M.5
  • 39
    • 0034175632 scopus 로고    scopus 로고
    • Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice
    • D Rudolph WC Yeh A Wakeham B Rudolph D Nallainathan J Potter 2000 Severe liver degeneration and lack of NF-kappaB activation in NEMO/IKKgamma-deficient mice Genes Dev 14 854 62
    • (2000) Genes Dev , vol.14 , pp. 854-62
    • Rudolph, D.1    Yeh, W.C.2    Wakeham, A.3    Rudolph, B.4    Nallainathan, D.5    Potter, J.6
  • 40
    • 0037119628 scopus 로고    scopus 로고
    • IkappaB kinase signaling is essential for maintenance of mature B cells
    • M Pasparakis M Schmidt-Supprian K Rajewsky 2002 IkappaB kinase signaling is essential for maintenance of mature B cells J Exp Med 196 743 52
    • (2002) J Exp Med , vol.196 , pp. 743-52
    • Pasparakis, M.1    Schmidt-Supprian, M.2    Rajewsky, K.3
  • 41
    • 0028174105 scopus 로고
    • Visualization of the endogenous NF-kappa B p50 subunit in the nucleus of follicular dendritic cells in germinal centers
    • J Feuillard M Korner C Fourcade A Costa JL Binet P Debre 1994 Visualization of the endogenous NF-kappa B p50 subunit in the nucleus of follicular dendritic cells in germinal centers J Immunol 152 12 21
    • (1994) J Immunol , vol.152 , pp. 12-21
    • Feuillard, J.1    Korner, M.2    Fourcade, C.3    Costa, A.4    Binet, J.L.5    Debre, P.6
  • 42
    • 33847102791 scopus 로고    scopus 로고
    • Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB
    • P Gourzi T Leonova FN Papavasiliou 2007 Viral induction of AID is independent of the interferon and the Toll-like receptor signaling pathways but requires NF-kappaB J Exp Med 204 259 65
    • (2007) J Exp Med , vol.204 , pp. 259-65
    • Gourzi, P.1    Leonova, T.2    Papavasiliou, F.N.3
  • 43
    • 0028804551 scopus 로고
    • Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses
    • WC Sha HC Liou EI Tuomanen D Baltimore 1995 Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses Cell 80 321 30
    • (1995) Cell , vol.80 , pp. 321-30
    • Sha, W.C.1    Liou, H.C.2    Tuomanen, E.I.3    Baltimore, D.4
  • 44
    • 26444513287 scopus 로고    scopus 로고
    • Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-kappaB p50-deficient mice
    • Ferguson AR, Corley RB. Accumulation of marginal zone B cells and accelerated loss of follicular dendritic cells in NF-kappaB p50-deficient mice. BMC Immunol 2005;6:8
    • (2005) BMC Immunol , vol.6 , pp. 8
    • Ferguson, A.R.1    Corley, R.B.2
  • 45
    • 0030048332 scopus 로고    scopus 로고
    • B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching
    • CM Snapper P Zelazowski FR Rosas MR Kehry M Tian D Baltimore WC Sha 1996 B cells from p50/NF-kappa B knockout mice have selective defects in proliferation, differentiation, germ-line CH transcription, and Ig class switching J Immunol 156 183 91
    • (1996) J Immunol , vol.156 , pp. 183-91
    • Snapper, C.M.1    Zelazowski, P.2    Rosas, F.R.3    Kehry, M.R.4    Tian, M.5    Baltimore, D.6    Sha, W.C.7
  • 47
    • 0029903486 scopus 로고    scopus 로고
    • B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching
    • CM Snapper FR Rosas P Zelazowski MA Moorman MR Kehry R Bravo 1996 B cells lacking RelB are defective in proliferative responses, but undergo normal B cell maturation to Ig secretion and Ig class switching J Exp Med 184 1537 41
    • (1996) J Exp Med , vol.184 , pp. 1537-41
    • Snapper, C.M.1    Rosas, F.R.2    Zelazowski, P.3    Moorman, M.A.4    Kehry, M.R.5    Bravo, R.6
  • 48
    • 0035881959 scopus 로고    scopus 로고
    • Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines
    • DS Weih ZB Yilmaz F Weih 2001 Essential role of RelB in germinal center and marginal zone formation and proper expression of homing chemokines J Immunol 167 1909 19
    • (2001) J Immunol , vol.167 , pp. 1909-19
    • Weih, D.S.1    Yilmaz, Z.B.2    Weih, F.3
  • 50
    • 0033537767 scopus 로고    scopus 로고
    • Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase
    • Y Hu V Baud M Delhase P Zhang T Deerinck M Ellisman 1999 Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase Science 284 316 20
    • (1999) Science , vol.284 , pp. 316-20
    • Hu, Y.1    Baud, V.2    Delhase, M.3    Zhang, P.4    Deerinck, T.5    Ellisman, M.6
  • 52
  • 53
    • 34547535924 scopus 로고    scopus 로고
    • Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals
    • DM Mills G Bonizzi M Karin RC Rickert 2007 Regulation of late B cell differentiation by intrinsic IKKalpha-dependent signals Proc Natl Acad Sci U S A 104 6359 64
    • (2007) Proc Natl Acad Sci U S a , vol.104 , pp. 6359-64
    • Mills, D.M.1    Bonizzi, G.2    Karin, M.3    Rickert, R.C.4
  • 54
    • 3242781555 scopus 로고    scopus 로고
    • I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion
    • M Schmidt-Supprian J Tian H Ji C Terhorst AK Bhan EP Grant 2004 I kappa B kinase 2 deficiency in T cells leads to defects in priming, B cell help, germinal center reactions, and homeostatic expansion J Immunol 173 1612 9
    • (2004) J Immunol , vol.173 , pp. 1612-9
    • Schmidt-Supprian, M.1    Tian, J.2    Ji, H.3    Terhorst, C.4    Bhan, A.K.5    Grant, E.P.6
  • 55
    • 0028971291 scopus 로고
    • Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice
    • AA Beg WC Sha RT Bronson D Baltimore 1995 Constitutive NF-kappa B activation, enhanced granulopoiesis, and neonatal lethality in I kappa B alpha-deficient mice Genes Dev 9 2736 46
    • (1995) Genes Dev , vol.9 , pp. 2736-46
    • Beg, A.A.1    Sha, W.C.2    Bronson, R.T.3    Baltimore, D.4
  • 56
    • 0034670001 scopus 로고    scopus 로고
    • Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function
    • CL Chen N Singh FE Yull D Strayhorn L Van Kaer LD Kerr 2000 Lymphocytes lacking I kappa B-alpha develop normally, but have selective defects in proliferation and function J Immunol 165 5418 27
    • (2000) J Immunol , vol.165 , pp. 5418-27
    • Chen, C.L.1    Singh, N.2    Yull, F.E.3    Strayhorn, D.4    Van Kaer, L.5    Kerr, L.D.6
  • 57
    • 0033044091 scopus 로고    scopus 로고
    • An intact NF-kappa B signaling pathway is required for maintenance of mature B cell subsets
    • HH Bendall ML Sikes DW Ballard EM Oltz 1999 An intact NF-kappa B signaling pathway is required for maintenance of mature B cell subsets Mol Immunol 36 187 95
    • (1999) Mol Immunol , vol.36 , pp. 187-95
    • Bendall, H.H.1    Sikes, M.L.2    Ballard, D.W.3    Oltz, E.M.4
  • 58
    • 0031964855 scopus 로고    scopus 로고
    • Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture
    • G Franzoso L Carlson L Poljak EW Shores S Epstein A Leonardi 1998 Mice deficient in nuclear factor (NF)-kappa B/p52 present with defects in humoral responses, germinal center reactions, and splenic microarchitecture J Exp Med 187 147 59
    • (1998) J Exp Med , vol.187 , pp. 147-59
    • Franzoso, G.1    Carlson, L.2    Poljak, L.3    Shores, E.W.4    Epstein, S.5    Leonardi, A.6
  • 59
    • 0031985287 scopus 로고    scopus 로고
    • Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses
    • JH Caamano CA Rizzo SK Durham DS Barton C Raventos-Suarez CM Snapper 1998 Nuclear factor (NF)-kappa B2 (p100/p52) is required for normal splenic microarchitecture and B cell-mediated immune responses J Exp Med 187 185 96
    • (1998) J Exp Med , vol.187 , pp. 185-96
    • Caamano, J.H.1    Rizzo, C.A.2    Durham, S.K.3    Barton, D.S.4    Raventos-Suarez, C.5    Snapper, C.M.6
  • 60
    • 0032736186 scopus 로고    scopus 로고
    • Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: Functions enhanced by Bcl-3
    • L Poljak L Carlson K Cunningham MH Kosco-Vilbois U Siebenlist 1999 Distinct activities of p52/NF-kappa B required for proper secondary lymphoid organ microarchitecture: functions enhanced by Bcl-3 J Immunol 163 6581 8
    • (1999) J Immunol , vol.163 , pp. 6581-8
    • Poljak, L.1    Carlson, L.2    Cunningham, K.3    Kosco-Vilbois, M.H.4    Siebenlist, U.5
  • 62
    • 0031045073 scopus 로고    scopus 로고
    • Immunological defects in mice with a targeted disruption in Bcl-3
    • EM Schwarz P Krimpenfort A Berns IM Verma 1997 Immunological defects in mice with a targeted disruption in Bcl-3 Genes Dev 11 187 97
    • (1997) Genes Dev , vol.11 , pp. 187-97
    • Schwarz, E.M.1    Krimpenfort, P.2    Berns, A.3    Verma, I.M.4
  • 63
    • 17144433112 scopus 로고    scopus 로고
    • Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions
    • G Franzoso L Carlson T Scharton-Kersten EW Shores S Epstein A Grinberg 1997 Critical roles for the Bcl-3 oncoprotein in T cell-mediated immunity, splenic microarchitecture, and germinal center reactions Immunity 6 479 90
    • (1997) Immunity , vol.6 , pp. 479-90
    • Franzoso, G.1    Carlson, L.2    Scharton-Kersten, T.3    Shores, E.W.4    Epstein, S.5    Grinberg, A.6
  • 64
    • 0036082959 scopus 로고    scopus 로고
    • Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3
    • S Paxian H Merkle M Riemann M Wilda G Adler H Hameister 2002 Abnormal organogenesis of Peyer's patches in mice deficient for NF-kappaB1, NF-kappaB2, and Bcl-3 Gastroenterology 122 1853 68
    • (2002) Gastroenterology , vol.122 , pp. 1853-68
    • Paxian, S.1    Merkle, H.2    Riemann, M.3    Wilda, M.4    Adler, G.5    Hameister, H.6
  • 65
    • 34548679394 scopus 로고    scopus 로고
    • A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance
    • X Zhang H Wang E Claudio K Brown U Siebenlist 2007 A role for the IkappaB family member Bcl-3 in the control of central immunologic tolerance Immunity 27 438 52
    • (2007) Immunity , vol.27 , pp. 438-52
    • Zhang, X.1    Wang, H.2    Claudio, E.3    Brown, K.4    Siebenlist, U.5
  • 67
    • 0034107666 scopus 로고    scopus 로고
    • Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors
    • A Rebollo L Dumoutier JC Renauld A Zaballos V Ayllon AC Martinez 2000 Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors Mol Cell Biol 20 3407 16
    • (2000) Mol Cell Biol , vol.20 , pp. 3407-16
    • Rebollo, A.1    Dumoutier, L.2    Renauld, J.C.3    Zaballos, A.4    Ayllon, V.5    Martinez, A.C.6
  • 68
    • 0036963470 scopus 로고    scopus 로고
    • A short domain within Bcl-3 is responsible for its lymphocyte survival activity
    • TC Mitchell BS Thompson JO Trent CR Casella 2002 A short domain within Bcl-3 is responsible for its lymphocyte survival activity Ann N Y Acad Sci 975 132 47
    • (2002) Ann N Y Acad Sci , vol.975 , pp. 132-47
    • Mitchell, T.C.1    Thompson, B.S.2    Trent, J.O.3    Casella, C.R.4
  • 70
    • 0033596124 scopus 로고    scopus 로고
    • Aberrant rel/nfkb genes and activity in human cancer
    • B Rayet C Gelinas 1999 Aberrant rel/nfkb genes and activity in human cancer Oncogene 18 6938 47
    • (1999) Oncogene , vol.18 , pp. 6938-47
    • Rayet, B.1    Gelinas, C.2
  • 72
    • 0036962440 scopus 로고    scopus 로고
    • Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival
    • TC Mitchell TK Teague DA Hildeman J Bender WA Rees RM Kedl 2002 Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival Ann N Y Acad Sci 975 114 31
    • (2002) Ann N Y Acad Sci , vol.975 , pp. 114-31
    • Mitchell, T.C.1    Teague, T.K.2    Hildeman, D.A.3    Bender, J.4    Rees, W.A.5    Kedl, R.M.6
  • 73
    • 11844272711 scopus 로고    scopus 로고
    • Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells
    • JO Valenzuela CD Hammerbeck MF Mescher 2005 Cutting edge: Bcl-3 up-regulation by signal 3 cytokine (IL-12) prolongs survival of antigen-activated CD8 T cells J Immunol 174 600 4
    • (2005) J Immunol , vol.174 , pp. 600-4
    • Valenzuela, J.O.1    Hammerbeck, C.D.2    Mescher, M.F.3
  • 77
    • 34548201126 scopus 로고    scopus 로고
    • The endless complexity of lymphocyte differentiation and lymphomagenesis: IRF-4 downregulates BCL6 expression
    • IS Lossos 2007 The endless complexity of lymphocyte differentiation and lymphomagenesis: IRF-4 downregulates BCL6 expression Cancer Cell 12 189 91
    • (2007) Cancer Cell , vol.12 , pp. 189-91
    • Lossos, I.S.1
  • 78
    • 33745273911 scopus 로고    scopus 로고
    • JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells
    • E Arguni M Arima N Tsuruoka A Sakamoto M Hatano T Tokuhisa 2006 JunD/AP-1 and STAT3 are the major enhancer molecules for high Bcl6 expression in germinal center B cells Int Immunol 18 1079 89
    • (2006) Int Immunol , vol.18 , pp. 1079-89
    • Arguni, E.1    Arima, M.2    Tsuruoka, N.3    Sakamoto, A.4    Hatano, M.5    Tokuhisa, T.6
  • 80
    • 10844275574 scopus 로고    scopus 로고
    • BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit
    • Z Li X Wang RY Yu BB Ding JJ Yu XM Dai 2005 BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit J Immunol 174 205 14
    • (2005) J Immunol , vol.174 , pp. 205-14
    • Li, Z.1    Wang, X.2    Yu, R.Y.3    Ding, B.B.4    Yu, J.J.5    Dai, X.M.6
  • 81
    • 17144439800 scopus 로고    scopus 로고
    • The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation
    • BH Ye G Cattoretti Q Shen J Zhang N Hawe R de Waard 1997 The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation Nat Genet 16 161 70
    • (1997) Nat Genet , vol.16 , pp. 161-70
    • Ye, B.H.1    Cattoretti, G.2    Shen, Q.3    Zhang, J.4    Hawe, N.5    De Waard, R.6
  • 82
    • 10344247666 scopus 로고    scopus 로고
    • The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells
    • RT Phan R Dalla-Favera 2004 The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells Nature 432 635 9
    • (2004) Nature , vol.432 , pp. 635-9
    • Phan, R.T.1    Dalla-Favera, R.2
  • 83
    • 32644434044 scopus 로고    scopus 로고
    • BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma
    • O Margalit H Amram N Amariglio AJ Simon S Shaklai G Granot 2006 BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma Blood 107 1599 607
    • (2006) Blood , vol.107 , pp. 1599-607
    • Margalit, O.1    Amram, H.2    Amariglio, N.3    Simon, A.J.4    Shaklai, S.5    Granot, G.6
  • 84
    • 27144462049 scopus 로고    scopus 로고
    • BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells
    • RT Phan M Saito K Basso H Niu R Dalla-Favera 2005 BCL6 interacts with the transcription factor Miz-1 to suppress the cyclin-dependent kinase inhibitor p21 and cell cycle arrest in germinal center B cells Nat Immunol 6 1054 60
    • (2005) Nat Immunol , vol.6 , pp. 1054-60
    • Phan, R.T.1    Saito, M.2    Basso, K.3    Niu, H.4    Dalla-Favera, R.5
  • 85
    • 34548237299 scopus 로고    scopus 로고
    • A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma
    • M Saito J Gao K Basso Y Kitagawa PM Smith G Bhagat 2007 A signaling pathway mediating downregulation of BCL6 in germinal center B cells is blocked by BCL6 gene alterations in B cell lymphoma Cancer Cell 12 280 92
    • (2007) Cancer Cell , vol.12 , pp. 280-92
    • Saito, M.1    Gao, J.2    Basso, K.3    Kitagawa, Y.4    Smith, P.M.5    Bhagat, G.6
  • 86
    • 34548706562 scopus 로고    scopus 로고
    • Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells
    • RT Phan M Saito Y Kitagawa AR Means R Dalla-Favera 2007 Genotoxic stress regulates expression of the proto-oncogene Bcl6 in germinal center B cells Nat Immunol 8 1132 9
    • (2007) Nat Immunol , vol.8 , pp. 1132-9
    • Phan, R.T.1    Saito, M.2    Kitagawa, Y.3    Means, A.R.4    Dalla-Favera, R.5
  • 88
    • 0038409927 scopus 로고    scopus 로고
    • P53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1
    • S Rocha AM Martin DW Meek ND Perkins 2003 p53 represses cyclin D1 transcription through down regulation of Bcl-3 and inducing increased association of the p52 NF-kappaB subunit with histone deacetylase 1 Mol Cell Biol 23 4713 27
    • (2003) Mol Cell Biol , vol.23 , pp. 4713-27
    • Rocha, S.1    Martin, A.M.2    Meek, D.W.3    Perkins, N.D.4
  • 89
    • 33750214678 scopus 로고    scopus 로고
    • Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit
    • K Schumm S Rocha J Caamano ND Perkins 2006 Regulation of p53 tumour suppressor target gene expression by the p52 NF-kappaB subunit Embo J 25 4820 32
    • (2006) Embo J , vol.25 , pp. 4820-32
    • Schumm, K.1    Rocha, S.2    Caamano, J.3    Perkins, N.D.4
  • 90
    • 30944468153 scopus 로고    scopus 로고
    • Expression of the Bcl-3 proto-oncogene suppresses p53 activation
    • D Kashatus P Cogswell AS Baldwin 2006 Expression of the Bcl-3 proto-oncogene suppresses p53 activation Genes Dev 20 225 35
    • (2006) Genes Dev , vol.20 , pp. 225-35
    • Kashatus, D.1    Cogswell, P.2    Baldwin, A.S.3
  • 91
    • 0032427630 scopus 로고    scopus 로고
    • Mouse models in tumor suppression
    • N Ghebranious LA Donehower 1998 Mouse models in tumor suppression Oncogene 17 3385 400
    • (1998) Oncogene , vol.17 , pp. 3385-400
    • Ghebranious, N.1    Donehower, L.A.2


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