Bcl-3 expression promotes cell survival following interleukin-4 deprivation and is controlled by AP1 and AP1-like transcription factors

Molecular and Cellular Biology

Volumn 20, Issue 10, 2000, Pages 3407-3416

  Rebollo, Angelita ^a,c   Dumoutier, Laure ^b   Renauld, Jean Christophe ^b   Zaballos, Angel ^a   Ayllón, Verónica ^a   Martínez A , Carlos ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

^c CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

INTERLEUKIN 4; ONCOPROTEIN; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL SURVIVAL; GENE ACTIVATION; GENE EXPRESSION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; BCL-X PROTEIN; CELL DIVISION; CELL LINE; CELL SURVIVAL; CLONING, MOLECULAR; GENE EXPRESSION REGULATION; INTERLEUKIN-4; MICE; MOLECULAR SEQUENCE DATA; PROMOTER REGIONS (GENETICS); PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; PROTO-ONCOGENE PROTEINS C-JUN; RECEPTORS, INTERLEUKIN-2; SEQUENCE ANALYSIS, DNA; SEQUENCE DELETION; T-LYMPHOCYTES; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS;

EID: 0034107666     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.10.3407-3416.2000     Document Type: Article

References (47)

1. Adachi, M., J. Cossman, D. Longo, C. M. Croce, and Y. Tsujimoto. 1989. Variant translocation of the Bcl-2 gene to immunoglobulin lambda light chain gene in chronic lymphocytic leukemia. Proc. Natl. Acad. Sci. USA 86: 2771-2774.
2. Baeuerle, P. A., and D. Baltimore. 1996. NF-κB: ten years after. Cell 87:13-20.
3. Baldwin, A. S., Jr. 1996. The NF-κB and Iκ-B proteins: new discoveries and insights. Annu. Rev. Immunol. 14:649-683.
4. Beg, A. A., S. M. Ruben, R. I. Scheinman, S. Haskill, C. A. Rosen, and A. S. Baldwin. 1992. Iκ-B interacts with the nuclear localization sequences of the subunits of NF-κB: a mechanism of cytoplasmic retention. Genes Dev. 6: 1899-1913.
5. Bhatia, K., K. Huppi, T. McKeithan, D. Siwarski, J. F. Mushinski, and I. Magrath. 1991. Mouse Bcl-3: cDNA structure, mapping and stage-dependent expression in B lymphocytes. Oncogene 6:1569.
6. Bours, V., G. Franzoso, V. Azarenko, S. Park, T. Kanno, K. Brown, and U. Siebenlist. 1993. The oncoprotein Bcl-3 directly transactivates through KB motifs via association with DNA binding p50 homodimers. Cell 72:729-739.
7. Broome, H. E., C. M. Dargan, S. Krajewski, and J. C. Reed. 1995. Expression of Bcl-2. Bcl-x and Bax after T cell activation and IL-2 withdrawal. J. Immunol. 155:2311.
8. Caamaño, J. H., P. Perez, S. A. Lira, and R. Bravo. 1996. Constitutive expression of Bcl-3 in thymocytes increases the DNA binding of NF-κB homodimers in vivo. Mol. Cell. Biol. 16:1342-1348.
9. Cerezo, A., C. Martínez-A., A. González, J. Gómez, and A. Rebollo. 1999. L-2 deprivation triggers apoptosis which is mediated by c-Jun N-terminal kinase 1 activation and prevented by Bcl-2. Cell Death Differ. 6:87-94.
10. Cosman, D. 1993. The hematopoietin receptor superfamily. Cytokine 5:95-106.
11. Davis, N., W. Bargmann, M. Y. Lim, and H. J. Bose. 1990. Avian reticulo-endotheliosis virus-transformed lymphoid cells contain multiple p59 V-rel complexes. J. Virol. 64:584-591.
12. de Martin, R., B. Vanhoven, Q. Chen, E. Hofer, V. Csizmadia, H. Wincler, and F. H. Bach. 1993. Cytokine-inducible expression in endothelial cells of an Iκ-Bα like gene is regulated by NF-κB. EMBO J. 12:2773-2779.
13. Franzoso, G., L. Carlson, T. Scharton, T. Kersten, E. W. Shores, S. Epstein, A. Grinberg, T. Tran, E. Shacter, A. Leonardi, M. Anver, P. Love, A. Sher, and U. Siebenlist. 1997. Critical roles for the Bcl-3 oncoprotein in T cell mediated immunity, splenic microarchitecture and germinal centers reactions. Immunity 6:479-490.
14. Franzoso, G., V. Bours, S. Park, T. Tomita, M. Yamaguchi, K. Kelly, and U. Siebenlist. 1992. The candidate oncoprotein Bcl-3 is an antagonist of p.50/NF-κB-mediated inhibition. Nature 359:339-342.
15. Fujita, T., G. P. Nolan, H. C. Liou, M. L. Scott, and D. Baltimore. 1993. The candidate proto-oncogene Bcl-3 encodes a transcription coactivator that activates through NF-κB p50 homodimers. Genes Dev. 7:1354-1366.
16. Giri, J., M. Ahdieh, J. Eisenman, K. Shanebeck, K. Grabstein, S. Kumaki, A. Namen, L. Park, D. Cosman, and D. Andersen. 1994. Utilization of the β and γ chains of the IL-2R by the novel cytokine IL-15. EMBO J. 13:2822-2830.
17. Gnarra, J. R., H. Otani, M. Wang, O. McBride, M. Sharon, and J. L. Warren. 1990. Human IL-2Rβ chain gene: chromosomal localization and identification of 5′ regulatory sequences. Proc. Natl. Acad. Sci. USA 87: 3440-3444.
18. Gómez, J., C. Martinez-A., A. Gonzalez, A. Garcia, and A. Rebollo. 1998. The Bcl-2 gene is differentially regulated by IL-2 and IL-4: role of the transcription factor NFAT. Oncogene 17:1235-1243.
19. Gómez, J., C. Martínez-A., B. Fernandez, A. García, and A. Rebollo. 1997. Ras activation leads to cell proliferation or apoptotic cell death upon IL-2 stimulation or lymphokine deprivation, respectively. Eur. J. Immunol. 27: 1610-1618.
20. Gurfinkel, N., T. Unger, D. Givol, and J. F. Mushinski. 1987. Expression of the Bcl-2 gene in mouse B lymphocytic cell lines is differentiation stage specific. Eur. J. Immunol. 17:567-570.
21. Hatada, E. N., N. Nieters, F. G. Wulczyn, M. Maumann, R. Meyer, G. Nucifora, T. W. McKeithan, and C. Schedereit. 1992. The ankyrin repeat domains of the NF-κB precursor p105 and the protooncogene Bcl-3 act as specific inhibitors of NF-κB DNA binding. Proc. Natl. Acad. Sci. USA 89: 2489-2493.
22. Kimura, Y., T. Takeshita, M. Kondo, N. Ishii, M. Nakamura, J. Van Snick, and K. Sugamura. 1995. Sharing of the IL-2Rγ chain with the functional IL-9 receptor complex. Int. Immunol. 7:115-120.
23. Kondo, M., T. Takeshita, M. Higuchi, M. Nakamura, T. Sudo, S. Nishikawa, and K. Sugamura. 1994. Functional participation of the IL-2Rγ chain in IL-7R complexes. Science 263:1453-1454.
24. Kondo, M., T. Takeshita, N. Ishii, M. Nakamura, S. Watanabe, K. Arai, and K. Sugamura. 1993. Sharing of the IL-2Rγ chain between receptors for IL-2 and IL-4. Science 262:1874-1877.
25. Le Bail, O., R. Schmidt-Ulrich, and A. Israel. 1993. Promoter analysis of the gene encoding the MAD3 inhibitor of NF-κB: positive regulation by members of the rel/NF-κB family. EMBO J. 12:5043-5049.
26. Liu, J. X., T. S. Migone, M. Tsang, M. Friedman, J. A. Watherbee, L. Zhou, A. Yamauchi, E. T. Bloom, J. Mietz, S. John, and W. J. Leonard. 1995. The role of shared receptor motifs and common Stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13 and IL-15. Immunity 2:331-339.
27. Lux, S. E., K. M. John, and V. Bennett. 1990. Analysis of cDNA for human erythrocyte ankyrin indicates a repeated structure with homology to tissue-differentiation and cell cycle control proteins. Nature 344:36-42.
28. Morin, P. J., and T. D. Gilmore. 1992. The C-terminus of the NF-κB p50 precursor and a Iκ-B isoform contain transcription activation domains. Nucleic Acid Res. 20:2453-2458.
29. Noguchi, M., Y. Nakamura, S. M. Russell, S. F. Ziegler, M. Tsang, X. Cao, and W. J. Leonard. 1993. IL-2Rγ chain: a functional component of the IL-4R. Science 262:1877-1880.
30. Nolan, G. P., T. Fujita, K. Bhatia, C. Huppi, H. C. Liou, M. L. Scott, and D. Baltimore. 1993. The Bcl-3 protooncogene encodes a nuclear IκB like molecule that preferentially interacts with NF-κB p50 and p52 in a phosphorylation dependent manner. Mol. Cell. Biol. 13:3557-3566.
31. Ohno, H., G. Takimoto, and T. W. McKeithan. 1990. The candidate protooncogene Bcl-3 is related to genes implicated in cell lineage determination and cell cycle control. Cell 60:991-999.
32. Paul, W. 1991. Interleukin 4: a prototypic immunoregulatory lymphokine. Blood 77:1859-1870.
33. Pitton, C., A. Rebollo, J. Van Snick, J. Theze, and A. Garcia. 1993. High affinity and intermediate affinity forms of the human interleukin 2 receptor expressed in an IL-9-dependent murine T cell line, deliver proliferative signals via differences in their transduction pathways. Cytokine 5:362-371.
34. Quelle, F. W., K. Shimoda, W. Thierfelder, C. Fischer, A. Kim, S. M. Reuben, J. L. Cleveland, J. H. Pierce, A. D. Keegan, K. Nelms, W. E. Paul, and J. N. Ihle. 1995. Cloning of murine Stat 6, proteins that are tyrosine phosphorylated in response to IL-4 and IL-13 but are not required for mitogenesis. Mol. Cell. Biol. 15:3336-3343.
35. Richard, M., J. Louahed, J. P. Demoulin, and J. C. Renauld. 1999. Interleukin 9 regulates NF-κB activity through Bcl-3 gene induction. Blood 93: 4318-4327.
36. Russell, S., J. Johnston, M. Noguchi, M. Kawamura, C. Bacon, M. Friedman, M. Berg, D. McVicar, B. Witthuhn, O. Silvenhoinen, A. Goldman, F. Schmaistieg, J. Ihle, J. O'Shea, and W. Leonard. 1994. Interaction of IL-2R β and γ chin with Jak1 and Jak3: implications for XSCID and XCIC. Science 266:1042-1045.
37. Russell, S. M., A. D. Keegan, N. Harada, Y. Nakamura, M. Noguchi, P. Leland, M. C. Friedmann, A. Miyajima, R. Puri, W. E. Paul, and W. J. Leonard. 1993. IL-2Rγ chain: a functional component of the IL-4R. Science 262:1880-1883.
38. Schwarz, E. M., P. Krimpenfort, A. Berns, and I. M. Verma. 1997. Immunological defects in mice with a targeted disruption in Bcl-3. Genes Dev. 11: 187-197.
39. Sharon, M., J. P. Siegel, G. Tosato, J. Yodoi, T. L. Gerrard, and W. Leonard. 1988. The human IL-2Rβ chain: direct identification, partial purification and patterns of expression on peripheral blood mononuclear cells. J. Exp. Med. 167:1265-1270.
40. Shiio, Y., J. Sawada, H. Handa, T. Yamamoto, and J. Inoue. 1996. Activation of the Rb gene expression by Bcl-3: implication for muscle cell differentiation. Oncogene 12:1837-1845.
41. Siebenlist, U. 1997. NF-κB/IκB proteins: their role in the cell growth, differentiation and development. Biochim. Biophys. Acta 1332:7-13.
42. Siegel, J. P., M. Sharon, P. L. Smith, and W. J. Leonard. 1987. The IL-2Rβ chain: role in mediating signaling for LAK, NK and proliferative activities. Science 238:75-78.
43. Wulczyn, F. G., D. Krappmann, and C. Scheidereit. 1992. Candidate protooncogene Bcl-3 encodes a subunit-specific inhibitor of transcription factor NF-κB. J. Mol. Med. 74:749-769.
44. Wulczyn, F. G., M. Naumann, and C. Scheidereit. 1992. Candidate protooncogene Bcl-3 encodes a subunit specific inhibitor of transcription factor NF-κB. Nature 358:597-599.
45. Zabel, U., T. Henkel, M. D. Silva, and P. A. Baeuerle. 1993. Nuclear uptake control of NF-κB by MAD-3, an Iκ-B protein present in the nucleus. EMBO J. 12:201-211.
46. Zhang, M., E. Harhaj, L. Bell, S. Sun, and B. A. Miller. 1998. Bcl-3 expression and nuclear translocation are induced by granulocyte-macrophage colony-stimulating factor and erythropoietin in proliferating human erythroid precursors. Blood 92:1225-1234.
47. Zhang, Q., J. A. Didonato, M. Karin, and T. W. McKeithan. 1994. Bcl-3 encodes a nuclear protein which can alter the subcellular location of NF-κB proteins. Mol. Cell. Biol. 14:3915-3926.