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Volumn 33, Issue 2, 2009, Pages 65-76

Enantioselective analysis of citalopram and escitalopram in postmortem blood together with genotyping for CYP2D6 and CYP2C19

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; ALIMEMAZINE; CAFFEINE; CARBON MONOXIDE; CARISOPRODOL; CITALOPRAM; CODEINE; CYTOCHROME P450 2C19; CYTOCHROME P450 2D6; ESCITALOPRAM; MEPROBAMATE; NORDAZEPAM; NORTRIPTYLINE; OXAZEPAM; PARACETAMOL; TRAMADOL; ZOPICLONE;

EID: 62549104696     PISSN: 01464760     EISSN: 01464760     Source Type: Journal    
DOI: 10.1093/jat/33.2.65     Document Type: Article
Times cited : (15)

References (47)
  • 1
    • 0032975176 scopus 로고    scopus 로고
    • Psychotropics and suicide prevention. Implications from toxicological screening of 5281 suicides in Sweden 1992-1994
    • G. Isacsson, P. Holmgren, H. Druid, and U. Bergman. Psychotropics and suicide prevention. Implications from toxicological screening of 5281 suicides in Sweden 1992-1994. Br. J. Psychiatry 174: 259-265 (1999).
    • (1999) Br. J. Psychiatry , vol.174 , pp. 259-265
    • Isacsson, G.1    Holmgren, P.2    Druid, H.3    Bergman, U.4
  • 2
    • 15944396547 scopus 로고    scopus 로고
    • Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: A controlled forensic database study of 14,857 suicides
    • G. Isacsson, P. Holmgren, and J. Ahlner. Selective serotonin reuptake inhibitor antidepressants and the risk of suicide: a controlled forensic database study of 14,857 suicides. Acta Psychiatr. Scand. 111: 286-290 (2005).
    • (2005) Acta Psychiatr. Scand , vol.111 , pp. 286-290
    • Isacsson, G.1    Holmgren, P.2    Ahlner, J.3
  • 3
    • 0344110152 scopus 로고    scopus 로고
    • Pharmacokinetics of selective serotonin reuptake inhibitors
    • C. Hiemke and S. Hartter. Pharmacokinetics of selective serotonin reuptake inhibitors. Pharmacol. Ther. 85:11-28 (2000).
    • (2000) Pharmacol. Ther , vol.85 , pp. 11-28
    • Hiemke, C.1    Hartter, S.2
  • 4
    • 0025610277 scopus 로고
    • Clinical overview of serotonin reuptake inhibitors
    • K. Rickels and E. Schweizer. Clinical overview of serotonin reuptake inhibitors. J. Clin. Psychiatry 51: 9-12 (1990).
    • (1990) J. Clin. Psychiatry , vol.51 , pp. 9-12
    • Rickels, K.1    Schweizer, E.2
  • 5
    • 0025976411 scopus 로고
    • Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness
    • R.J. Milne and K.L. Goa. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs 41: 450-477 (1991).
    • (1991) Drugs , vol.41 , pp. 450-477
    • Milne, R.J.1    Goa, K.L.2
  • 6
    • 33748606126 scopus 로고    scopus 로고
    • Escitalopram: A review of its use in the management of anxiety disorders
    • S. Dhillon, L.J. Scott, and G.L. Plosker. Escitalopram: a review of its use in the management of anxiety disorders. CNS Drugs 20:763-790 (2006).
    • (2006) CNS Drugs , vol.20 , pp. 763-790
    • Dhillon, S.1    Scott, L.J.2    Plosker, G.L.3
  • 7
    • 27644432393 scopus 로고    scopus 로고
    • Escitalopram: A review of its use in the management of major depressive disorder
    • D. Murdoch and S.J. Keam. Escitalopram: A review of its use in the management of major depressive disorder. Drugs 65: 2379-2404 (2005).
    • (2005) Drugs , vol.65 , pp. 2379-2404
    • Murdoch, D.1    Keam, S.J.2
  • 8
    • 33947728974 scopus 로고    scopus 로고
    • The clinical pharmacokinetics of escitalopram
    • N. Rao. The clinical pharmacokinetics of escitalopram. Clin. Phar-macokinet. 46: 281-290 (2007).
    • (2007) Clin. Phar-macokinet , vol.46 , pp. 281-290
    • Rao, N.1
  • 9
    • 0030682236 scopus 로고    scopus 로고
    • Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans
    • J. Sidhu, M. Priskorn, M. Poulsen, A. Segonzac, G. Grollier, and F. Larsen. Steady-state pharmacokinetics of the enantiomers of citalopram and its metabolites in humans. Chirality 9: 686-692 (1997).
    • (1997) Chirality , vol.9 , pp. 686-692
    • Sidhu, J.1    Priskorn, M.2    Poulsen, M.3    Segonzac, A.4    Grollier, G.5    Larsen, F.6
  • 10
    • 0029028932 scopus 로고
    • Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19
    • L. Bertilsson. Geographical/interracial differences in polymorphic drug oxidation. Current state of knowledge of cytochromes P450 (CYP) 2D6 and 2C19. Clin. Pharmacokinet. 29:192-209 (1995).
    • (1995) Clin. Pharmacokinet , vol.29 , pp. 192-209
    • Bertilsson, L.1
  • 11
  • 12
    • 0027472058 scopus 로고
    • Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms
    • S.H. Sindrup, K. Brosen, M.G. Hansen, T. Aaes-Jorgensen, K.F. Overo, and L.F. Gram. Pharmacokinetics of citalopram in relation to the sparteine and the mephenytoin oxidation polymorphisms. Ther. Drug Monit. 15:11-17 (1993).
    • (1993) Ther. Drug Monit , vol.15 , pp. 11-17
    • Sindrup, S.H.1    Brosen, K.2    Hansen, M.G.3    Aaes-Jorgensen, T.4    Overo, K.F.5    Gram, L.F.6
  • 13
    • 0032706936 scopus 로고    scopus 로고
    • Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes
    • O.V. Olesen and K. Linnet. Studies on the stereoselective metabolism of citalopram by human liver microsomes and cDNA-expressed cytochrome P450 enzymes. Pharmacology 59: 298-309 (1999).
    • (1999) Pharmacology , vol.59 , pp. 298-309
    • Olesen, O.V.1    Linnet, K.2
  • 14
    • 0030957623 scopus 로고    scopus 로고
    • Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver micro-somes
    • B. Rochat, M. Amey, M. Gillet, U.A. Meyer, and P. Baumann. Identification of three cytochrome P450 isozymes involved in N-demethylation of citalopram enantiomers in human liver micro-somes. Pharmacogenetics 7: 1-10 (1997).
    • (1997) Pharmacogenetics , vol.7 , pp. 1-10
    • Rochat, B.1    Amey, M.2    Gillet, M.3    Meyer, U.A.4    Baumann, P.5
  • 16
    • 33645225293 scopus 로고    scopus 로고
    • Heterozygous mutation in CYP2C19 significantly increases the concentration/dose ratio of racemic citalopram and escitalopram (S-citalopram)
    • I. Rudberg, M. Hendset, L.H. Uthus, E. Molden, and H. Refsum. Heterozygous mutation in CYP2C19 significantly increases the concentration/dose ratio of racemic citalopram and escitalopram (S-citalopram). Ther. DrugMonit. 28:102-105 (2006).
    • (2006) Ther. DrugMonit , vol.28 , pp. 102-105
    • Rudberg, I.1    Hendset, M.2    Uthus, L.H.3    Molden, E.4    Refsum, H.5
  • 20
    • 0034796765 scopus 로고    scopus 로고
    • Unravelling the functional genomics of the human CYP2D6 gene locus
    • M. Ingelman-Sundberg and W.E. Evans. Unravelling the functional genomics of the human CYP2D6 gene locus. Pharmacogenetics 11: 553-554 (2001).
    • (2001) Pharmacogenetics , vol.11 , pp. 553-554
    • Ingelman-Sundberg, M.1    Evans, W.E.2
  • 21
    • 2642542324 scopus 로고    scopus 로고
    • Fatal intoxications in a Swedish forensic autopsy material during 1992-2002
    • A. Jonsson, P. Holmgren, and J. Ahlner. Fatal intoxications in a Swedish forensic autopsy material during 1992-2002. Forensic Sci. Int. 143: 53-59 (2004).
    • (2004) Forensic Sci. Int , vol.143 , pp. 53-59
    • Jonsson, A.1    Holmgren, P.2    Ahlner, J.3
  • 22
    • 0030806209 scopus 로고    scopus 로고
    • The utilization of antidepressants-a key issue in the prevention of suicide: An analysis of 5281 suicides in Sweden during the period 1992-1994
    • G. Isacsson, P. Holmgren, H. Druid, and U. Bergman. The utilization of antidepressants-a key issue in the prevention of suicide: an analysis of 5281 suicides in Sweden during the period 1992-1994. Acta Psychiatr. Scand. 96: 94-100 (1997).
    • (1997) Acta Psychiatr. Scand , vol.96 , pp. 94-100
    • Isacsson, G.1    Holmgren, P.2    Druid, H.3    Bergman, U.4
  • 23
    • 4444284449 scopus 로고    scopus 로고
    • Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose
    • G.K. Isbister, S.J. Bowe, A. Dawson, and I.M. Whyte. Relative toxicity of selective serotonin reuptake inhibitors (SSRIs) in overdose. J. Toxicol. Clin. Toxicol. 42: 277-285 (2004).
    • (2004) J. Toxicol. Clin. Toxicol , vol.42 , pp. 277-285
    • Isbister, G.K.1    Bowe, S.J.2    Dawson, A.3    Whyte, I.M.4
  • 24
    • 27744476463 scopus 로고    scopus 로고
    • Newer antidepressants: Evaluation of fatal toxicity index and interaction with alcohol based on Finnish postmortem data
    • A. Koski, E. Vuori, and I. Ojanpera. Newer antidepressants: evaluation of fatal toxicity index and interaction with alcohol based on Finnish postmortem data. Int. J. Legal Med. 119: 344-348 (2005).
    • (2005) Int. J. Legal Med , vol.119 , pp. 344-348
    • Koski, A.1    Vuori, E.2    Ojanpera, I.3
  • 26
    • 1842367966 scopus 로고    scopus 로고
    • Citalopram overdose-review of cases treated in Swedish hospitals
    • M. Personne, G. Sjoberg, and H. Persson. Citalopram overdose-review of cases treated in Swedish hospitals. J. Toxicol. Clin. Toxicol. 35: 237-240(1997).
    • (1997) J. Toxicol. Clin. Toxicol , vol.35 , pp. 237-240
    • Personne, M.1    Sjoberg, G.2    Persson, H.3
  • 28
    • 0031805141 scopus 로고    scopus 로고
    • Citalo-pram concentrations in samples from autopsies and living persons
    • K. Worm, C. Dragsholt, K. Simonsen, and B. Kringsholm. Citalo-pram concentrations in samples from autopsies and living persons. Int. J. Legal Med. 111:188-190 (1998).
    • (1998) Int. J. Legal Med , vol.111 , pp. 188-190
    • Worm, K.1    Dragsholt, C.2    Simonsen, K.3    Kringsholm, B.4
  • 29
    • 0031012173 scopus 로고    scopus 로고
    • A compilation of fatal and control concentrations of drugs in postmortem femoral blood
    • H. Druid and P. Holmgren. A compilation of fatal and control concentrations of drugs in postmortem femoral blood. J. Forensic Sci. 42: 79-87 (1997).
    • (1997) J. Forensic Sci , vol.42 , pp. 79-87
    • Druid, H.1    Holmgren, P.2
  • 31
    • 34247148153 scopus 로고    scopus 로고
    • Escitalopram-associated serotonin toxicity
    • G. Vari and M. Beckson. Escitalopram-associated serotonin toxicity. J. Clin. Psychopharmacol. 27: 229-230 (2007).
    • (2007) J. Clin. Psychopharmacol , vol.27 , pp. 229-230
    • Vari, G.1    Beckson, M.2
  • 32
    • 0035087051 scopus 로고    scopus 로고
    • Optimization and characterization of the chiral separation of citalopram and its demethylated metabolites by response surface methodology
    • B. Carlsson and B. Norlander. Optimization and characterization of the chiral separation of citalopram and its demethylated metabolites by response surface methodology. Chromatographia 53:266-272 (2001).
    • (2001) Chromatographia , vol.53 , pp. 266-272
    • Carlsson, B.1    Norlander, B.2
  • 34
    • 0029035234 scopus 로고
    • Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography
    • B. Rochat, M. Amey, and P. Baumann. Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography. Ther. Drug Monit. 17: 273-279 (1995).
    • (1995) Ther. Drug Monit , vol.17 , pp. 273-279
    • Rochat, B.1    Amey, M.2    Baumann, P.3
  • 35
    • 0031582894 scopus 로고    scopus 로고
    • Solid-phase extraction with end-capped C2 columns for the routine measurement of racemic citalo-pram and metabolites in plasma by high-performance liquid chromatography
    • B. Carlsson and B. Norlander. Solid-phase extraction with end-capped C2 columns for the routine measurement of racemic citalo-pram and metabolites in plasma by high-performance liquid chromatography. J. Chromatogr. B Biomed. Sci. Appl. 702:234-239 (1997).
    • (1997) J. Chromatogr. B Biomed. Sci. Appl , vol.702 , pp. 234-239
    • Carlsson, B.1    Norlander, B.2
  • 36
    • 0026230139 scopus 로고
    • A fast method for high-quality genomic DNA extraction from whole human blood
    • S. Gustincich, G. Manfioletti, G. Del Sal, C. Schneider, and P. Carninci. A fast method for high-quality genomic DNA extraction from whole human blood. Biotechniques 11: 298-300, 302 (1991).
    • (1991) Biotechniques , vol.11 , Issue.298-300 , pp. 302
    • Gustincich, S.1    Manfioletti, G.2    Del Sal, G.3    Schneider, C.4    Carninci, P.5
  • 37
    • 0242637084 scopus 로고    scopus 로고
    • Identification of CYP2D6 alleles by single nucleotide polymorphism analysis using pyrosequencing
    • A.L. Zackrisson and B. Lindblom. Identification of CYP2D6 alleles by single nucleotide polymorphism analysis using pyrosequencing. Eur. J. Clin. Pharmacol. 59: 521-526 (2003).
    • (2003) Eur. J. Clin. Pharmacol , vol.59 , pp. 521-526
    • Zackrisson, A.L.1    Lindblom, B.2
  • 38
  • 39
    • 0033871198 scopus 로고    scopus 로고
    • Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6* 6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR
    • M. Hersberger, J. Marti-Jaun, K. Rentsch, and E. Hanseler. Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6* 6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR. Clin. Chem. 46: 1072-1077 (2000).
    • (2000) Clin. Chem , vol.46 , pp. 1072-1077
    • Hersberger, M.1    Marti-Jaun, J.2    Rentsch, K.3    Hanseler, E.4
  • 40
    • 0042843050 scopus 로고    scopus 로고
    • Cytochrome p450 genotyping by multiplexed real-time dna sequencing with pyrosequencing technology
    • S. Eriksson, L.M. Berg, M. Wadelius, and A. Alderborn. Cytochrome p450 genotyping by multiplexed real-time dna sequencing with pyrosequencing technology. Assay Drug Dev. Technol. 1:49-59 (2002).
    • (2002) Assay Drug Dev. Technol , vol.1 , pp. 49-59
    • Eriksson, S.1    Berg, L.M.2    Wadelius, M.3    Alderborn, A.4
  • 43
    • 36549013763 scopus 로고    scopus 로고
    • Therapeutic drug monitoring of escitalopram in an outpatient setting
    • M. Reis, M.D. Cherma, B. Carlsson, and F. Bengtsson. Therapeutic drug monitoring of escitalopram in an outpatient setting. Ther. Drug Monit. 29: 758-766 (2007).
    • (2007) Ther. Drug Monit , vol.29 , pp. 758-766
    • Reis, M.1    Cherma, M.D.2    Carlsson, B.3    Bengtsson, F.4
  • 44
    • 33750519655 scopus 로고    scopus 로고
    • The redistribution of selected psychiatric drugs in post-mortem cases
    • K.E. Rodda and O.H. Drummer. The redistribution of selected psychiatric drugs in post-mortem cases. Forensic Sci. Int. 164:235-239 (2006).
    • (2006) Forensic Sci. Int , vol.164 , pp. 235-239
    • Rodda, K.E.1    Drummer, O.H.2
  • 45
    • 34250364501 scopus 로고    scopus 로고
    • Reference concentrations of antidepressants. A compilation of postmortem and therapeutic levels
    • M. Reis, T. Aamo, J. Ahlner, and H. Druid. Reference concentrations of antidepressants. A compilation of postmortem and therapeutic levels. J. Anal. Toxicol. 31: 254-264 (2007).
    • (2007) J. Anal. Toxicol , vol.31 , pp. 254-264
    • Reis, M.1    Aamo, T.2    Ahlner, J.3    Druid, H.4
  • 46
    • 20444435903 scopus 로고    scopus 로고
    • Early-phase postmortem redistribution of the enantiomers of citalopram and its demethylated metabolites in rats
    • F.C. Kugelberg, M. Kingback, B. Carlsson, and H. Druid. Early-phase postmortem redistribution of the enantiomers of citalopram and its demethylated metabolites in rats. J. Anal. Toxicol. 29:223-228 (2005).
    • (2005) J. Anal. Toxicol , vol.29 , pp. 223-228
    • Kugelberg, F.C.1    Kingback, M.2    Carlsson, B.3    Druid, H.4
  • 47
    • 8444223100 scopus 로고    scopus 로고
    • Postmortem redistribution of the enantiomers of citalopram and its metabolites: An experimental study in rats
    • F.C. Kugelberg, H. Druid, B. Carlsson, J. Ahlner, and F. Bengtsson. Postmortem redistribution of the enantiomers of citalopram and its metabolites: an experimental study in rats. J. Anal. Toxicol. 28: 631-637 (2004).
    • (2004) J. Anal. Toxicol , vol.28 , pp. 631-637
    • Kugelberg, F.C.1    Druid, H.2    Carlsson, B.3    Ahlner, J.4    Bengtsson, F.5


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