Early-phase postmortem redistribution of the enantiomers of citalopram and its demethylated metabolites in rats

Journal of Analytical Toxicology

Volumn 29, Issue 4, 2005, Pages 223-228

  Kugelberg, Fredrik C ^a,b   Kingbäck, Maria ^a   Carlsson, Björn ^a   Druid, Henrik ^b  

^a LINKÖPING UNIVERSITY   (Sweden)

^b KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CITALOPRAM; DINORCITALOPRAM; DRUG METABOLITE; NORCITALOPRAM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPSY; CONTROLLED STUDY; DEATH; DEMETHYLATION; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG METABOLISM; DRUG RELEASE; DRUG TISSUE LEVEL; ENANTIOMER; ENANTIOSELECTIVITY; FREEZING; HEART; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LUNG; MALE; NONHUMAN; RAT; SINGLE DRUG DOSE; STORAGE TEMPERATURE;

ANIMALIA;

EID: 20444435903     PISSN: 01464760     EISSN: None     Source Type: Journal    
DOI: 10.1093/jat/29.4.223     Document Type: Article

References (42)

1. S. Rogde, H.P. Hougen, and K. Poulsen. Suicides in two Scandinavian captials - a comparative study. Forensic Sci. Int. 80: 211-219 (1996).
2. P. Crome. The toxicity of drugs used for suicide. Acta Psychiatr. Scand. 371 (suppl): 33-37 (1993).
3. H. Druid and P. Holmgren. A compilation of fatal and control concentrations of drugs in postmortem femoral blood. J. Forensic Sci. 42: 79-87 (1997).
4. K.E. Goeringer, L. Raymon, G.D. Christian, and B.K. Logan. Post-mortem forensic toxicology of selective serotonin reuptake inhibitors: a review of pharmacology and report of 168 cases. J. Forensic Sci. 45: 633-648 (2000).
5. D.J. Pounder and G.R. Jones. Post-mortem drug redistribution-a toxicological nightmare. Forensic Sci. Int. 45: 253-263 (1990).
6. R.J. Milne and K.L. Goa. Citalopram. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in depressive illness. Drugs 41: 450-477 (1991).
7. B.G. Pollock. Citalopram: a comprehensive review. Expert Opin. Pharmacother. 2: 681-698 (2001).
8. J. Hyttel, K.P. Bøgesø, J. Perregaard, and C. Sánchez. The pharmacological effect of citalopram resides in the (S)-(+)-enantiomer. J. Neural Transm. Gen. Sect. 88: 157-160 (1992).
9. M.J. Owens, D.L. Knight, and C.B. Nemeroff. Second-generation SSRIs: human monoamine transporter binding profile of escitalopram and R-fluoxetine. Biol. Psychiatry 50: 345-350 (2001).
10. C. Sánchez, P.B.F. Bergqvist, L.T. Brennum, S. Gupta, S. Hogg, A. Larsen, and O. Wiborg. Escitalopram, the S-(+)-enantiomer of citalopram, is a selective serotonin reuptake inhibitor with potent effects in animal models predictive of antidepressant and anxiolytic activities. Psychopharmacology (Berl) 167: 353-362 (2003).
11. J. Waugh and K.L. Goa. Escitalopram: a review of its use in the management of major depressive and anxiety disorders. CNS Drugs 17: 343-362 (2003).
12. J. Hyttel. Pharmacological characterization of selective serotonin reuptake inhibitors (SSRIs). Int. Clin. Psychopharmacol. 9: 19-26 (1994).
13. M. Öström, A. Eriksson, J. Thorson, and O. Spigset. Fatal overdose with citalopram. Lancet 348: 339-340 (1996).
14. K. Worm, C. Dragsholt, K. Simonsen, and B. Kringsholm. Citalopram concentrations in samples from autopsies and living persons. Int. J. Legal Med. 111: 188-190 (1998).
15. B. Levine, X. Zhang, J.E. Smialek, G.W. Kunsman, and M.E. Frontz. Citalopram distribution in postmortem cases. J. Anal. Toxicol. 25: 641-644 (2001).
16. N. Anastos, I.M. McIntyre, M.J. Lynch, and O.H. Drummer. Post-mortem concentrations of citalopram. J. Forensic Sci. 47: 882-884 (2002).
17. A.J. Jenkins and K. Gubanich. Disposition of citalopram in biological specimens from postmortem cases. J. Forensic Sci. 47: 159-164 (2002).
18. P. Holmgren, B. Carlsson, A.L. Zackrisson, B. Lindblom, M.L. Dahl, M.G. Scordo, H. Druid, and J. Ahlner. Enantioselective analysis of citalopram and its metabolites in postmortem blood and genotyping for CYP2D6 and CYP2C19. J. Anal. Toxicol. 28: 94-104 (2004).
19. F.C. Kugelberg, H. Druid, B. Carlsson, J. Ahlner, and F. Bengtsson. Postmortem redistribution of the enantiomers of citalopram and its metabolites: an experimental study in rats. J. Anal. Toxicol. 28: 631-637 (2004).
20. B. Rochat, M. Amey, and P. Baumann. Analysis of enantiomers of citalopram and its demethylated metabolites in plasma of depressive patients using chiral reverse-phase liquid chromatography. Ther. Drug Monit. 17: 273-279 (1995).
21. B. Carlsson and B. Norlander. Optimization and characterization of the chiral separation of citalopram and its demethylated metabolites by response surface methodology. Chromatographia 53: 266-272 (2001).
22. B. Carlsson, G. Olsson, M. Reis, J. Wålinder, C. Nordin, J. Lundmark, M.G. Scordo, M.L. Dahl, F. Bengtsson, and J Ahlner. Enantioselective analysis of citalopram and metabolites in adolescents. Ther. Drug Monit. 23: 658-664 (2001).
23. F.C. Kugelberg, G. Apelqvist, B. Carlsson, J. Ahlner, and F. Bengtsson. In vivo steady-state pharmacokinetic outcome following clinical and toxic doses of racemic citalopram to rats. Br. J. Pharmacol. 132: 1683-1690 (2001).
24. B. Carlsson and B. Norlander. Solid-phase extraction with end-capped C2 columns for the routine measurement of racemic citalopram and metabolites in plasma by high-performance liquid chromatography. J. Chromatogr. B 702: 234-239 (1997).
25. F.C. Kugelberg, B. Carlsson, J. Ahlner, and F. Bengtsson. Stereoselective single-dose kinetics of citalopram and its metabolites in rats. Chirality 15: 622-629 (2003).
26. D.B. Feldman and B.N. Gupta. Histopathologic changes in laboratory animals resulting from various methods of euthanasia. Lab. Anim. Sci. 26: 218-221 (1976).
27. W.R. Sawyer, D.R. Steup, B.S. Martin, and R.B. Forney. Cardiac blood pH as a possible indicator of postmortem interval. J. Forensic Sci. 33: 1439-1444 (1988).
28. M.W. Anderson, T.C. Orton, R.D. Pickett, and T.E. Eling. Accumulation of amines in the isolated perfused rabbit lung. J. Pharmacol. Exp. Ther. 189: 456-466 (1974).
29. A.C. MacIntyre and D.J. Cutler. The potential role of lysosomes in tissue distribution of weak bases. Biopharm. Drug Dispos. 9: 513-526 (1988).
30. R.E. Vestal, D.M. Kornhauser, and D.G. Shand. Active uptake of propanolol by isolated rabbit alveolar macrophages and its inhibition by other basic amines. J. Pharmacol. Exp. Ther. 214: 106-111 (1980).
31. A.G.E. Wilson, M. Sar, and W.E. Stumpf. Autoradiographic study of imipramine localization in the isolation perfused rabbit lung. Drug Metab. Dispos. 10: 281-283 (1982).
32. G.R. Jones and D.J. Pounder. Site dependence of drug concentrations in postmortem blood-a case study. J. Anal. Toxicol. 11: 186-190 (1987).
33. T. Suhara, Y. Sudo, K. Yoshida, Y. Okubo, H. Fukuda, T. Obata, K. Yoshikawa, K. Suzuki, and Y. Sasaki. Lung as reservoir for antidepressants in pharmacokinetic drug interactions. Lancet 351: 332-335 (1998).
34. D.J. Pounder. The nightmare of postmortem drug changes. Leg. Med. 163-191 (1993).
35. T. Hilberg, J. Mørland, and A. Bjørneboe. Postmortem release of amitriptyline from the lungs; a mechanism of postmortem drug redistribution. Forensic Sci. Int. 64: 47-55 (1994).
36. A.L. Pélissier-Alicot, J.M. Gaulier, P. Champsaur, and P. Marquet. Mechanisms underlying postmortem redistribution of drugs: a review. J. Anal. Toxicol. 27: 533-544 (2003).
37. R.W. Prouty and W.H. Anderson. The forensic science implications of site and temporal influences on postmortem blood-drug concentrations. J. Forensic Sci. 35: 243-270 (1990).
38. F. Moriya and Y. Hashimoto. Redistribution of basic drugs into cardiac blood from surrounding tissues during early-stages post-mortem. J. Forensic Sci. 44: 10-16 (1999).
39. K. Fu, R.J. Konrad, R.W. Hardy, R.M. Brissie, and C.A. Robinson. An unusual multiple drug intoxication case involving citalopram. J. Anal. Toxicol. 24: 648-650 (2000).
40. T. Hilberg, Å. Ripel, L. Slørdal, A. Bjørneboe, and J. Mørland. The extent of postmortem drug redistribution in a rat model. J. Forensic Sci. 44: 956-962 (1999).
41. D.J. Pounder and D.R.W. Smith. Postmortem diffusion of alcohol from the stomach. Am. J. Forensic Med. Pathol. 16: 89-96 (1995).
42. F.S. Apple. Postmortem tricyclic antidepressant concentrations: assessing cause of death using parent drug to metabolite ratio. J. Anal. Toxicol. 13: 197-198 (1989).