Rapid detection of the CYP2D6*3, CYP2D6*4, and CYP2D6*6 alleles by tetra-primer PCR and of the CYP2D6*5 allele by multiplex long PCR

Clinical Chemistry

Volumn 46, Issue 8 I, 2000, Pages 1072-1077

  Hersberger, M ^a   Marti Jaun, J ^a   Rentsch, K ^a   Hanseler, E ^a  

^a UNIVERSITY HOSPITAL ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DEBRISOQUINE 4 HYDROXYLASE; ISOENZYME;

ARTICLE; CONTROLLED STUDY; DNA DETERMINATION; ENZYME ACTIVITY; GENE AMPLIFICATION; GENE FREQUENCY; GENE MUTATION; GENOTYPE; HUMAN; NORMAL HUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SEQUENCE ANALYSIS; TECHNIQUE;

EID: 0033871198     PISSN: 00099147     EISSN: None     Source Type: Journal    
DOI: 10.1093/clinchem/46.8.1072     Document Type: Article

References (24)

1. Polymorphic cytochromes P450 and drugs used in psychiatry
2. Polymorphic human cytochrome P450 enzymes: An opportunity for individualized drug treatment
3. Pharmacogenetics: A laboratory tool for optimizing therapeutic efficiency
4. Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
5. Hydroxylation polymorphisms of debrisoquine and mephenytoin in European populations
6. Prevalence of CYP2D6 gene duplication and its repercussion on the oxidative phenotype in a white population
7. Frequent distribution of ultrarapid metabolizers of debrisoquine in an Ethiopian population carrying duplicated and multiduplicated functional CYP2D6 alleles
8. Frequent occurrence of CYP2D6 gene duplication in Saudi Arabians
9. Polymorphism of the cytochrome P450 CYP2D6 gene in a European population: Characterization of 48 mutations and 53 alleles, their frequencies and evolution
10. Nomenclature for human CYP2D6 alleles
11. Correctness of prediction of the CYP2D6 phenotype confirmed by genotyping 47 intermediate and poor metabolizers of debrisoquine
12. Interpretation of a simple PCR analysis of the CYP2D6(A) and CYP2D6(B) null alleles associated with the debrisoquine/sparteine genetic polymorphism
13. Genetic polymorphism of debrisoquine oxidation: Restriction fragment analysis and allele-specific amplification of mutant alleles of CYP2D6
14. Detection of the poor metabolizer-associated CYP2D6(D) gene deletion allele by long-PCR technology
15. PCR-based genotyping for duplicated and deleted CYP2D6 genes
16. Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies
17. Phylogenetic analysis of the apolipoprotein B mRNA-editing region. Evidence for a secondary structure between the mooring sequence and the 3' efficiency element
18. Allele specific amplification by tetra-primer PCR
19. The human debrisoquine 4-hydroxylase (CYP2D) locus: Sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene
20. Genotyping of poor metabolisers of debrisoquine by allele-specific PCR amplification
21. Methods for detection of point mutations: Performance and quality assessment. The IFCC Scientific Division, Committee on Molecular Biology Techniques
22. Ultrarapid drug metabolism: PCR-based detection of CYP2D6 gene duplication
23. Ultrarapid metabolizers of debrisoquine: Characterization and PCR-based detection of alleles with duplication of the CYP2D6 gene